Chemotherapy-induced neutropenia as a prognostic factor in advanced non-small-cell lung cancer: results from Japan Multinational Trial Organization LC00-03
Open accessAbstract
BACKGROUND: Neutropenia is a common adverse reaction of chemotherapy. We assessed whether chemotherapy-induced neutropenia could be a predictor of survival for patients with non-small-cell lung cancer (NSCLC). METHODS: A total of 387 chemotherapy-naïve patients who received chemotherapy (vinorelbine and gemcitabine followed by docetaxel, or paclitaxel and carboplatin) in a randomised controlled trial were evaluated. The proportional-hazards regression model was used to examine the effects of chemotherapy-induced neutropenia and tumour response on overall survival. Landmark analysis was used to lessen the bias of more severe neutropenia resulting from more treatment cycles allowed by longer survival, whereby patients who died within 126 days of starting chemotherapy were excluded. RESULTS: The adjusted hazard ratios for patients with grade-1 to 2 neutropenia or grade-3 to 4 neutropenia compared with no neutropenia were 0.59 (95% confidence interval (CI), 0.36-0.97) and 0.71 (95% CI, 0.49-1.03), respectively. The hazard ratios did not differ significantly between the patients who developed neutropenia with stable disease (SD), and those who lacked neutropenia with partial response (PR). CONCLUSION: Chemotherapy-induced neutropenia is a predictor of better survival for patients with advanced NSCLC. Prospective randomised trials of early-dose increases guided by chemotherapy-induced toxicities are warranted.
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Chemotherapy-induced neutropenia has predicted improved survival rates among cancer patients.
“chemotherapy induced neutropenia has also predicted improved survival rates among cancer patients [12–17]”
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- Authors
- Kishida, Y., Kawahara, M., Teramukai, S., Kubota, K., Komuta, K., Minato, K., Mio, T., Fujita, Y., Yonei, T., Nakano, K., Tsuboi, M., Shibata, K., Atagi, S., Kawaguchi, T., Furuse, K., & Fukushima, M.
- Affiliations
- Kyoto University (JP)
- NHO Kinki Chuo Chest Medical Center (JP)
- National Cancer Center Hospital (JP)
- Osaka Police Hospital (JP)
- Gunma Prefectural Cancer Center (JP)
- National Hospital Organization (JP)
- Okayama Medical Center (JP)
- Kure Medical Center (JP)
- Kanagawa Cancer Center (JP)
- Kouseiren Takaoka Hospital (JP)
- The Japan-Multinational Trial Organization (JP)
- Translational Research Informatics Center (Japan) (JP)
- Corresponding author
- Kishida, Y
- Venue
- British Journal of Cancer
- Published
- 2009-09-29
- Volume
- 101
- Issue
- 9
- Pages
- 1537-1542
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- PMC
- PMC2778518
- OpenAlex
- W2133578198
- Cited by
- 87
- References
- 21
- Citations by year
- 2026: 5 · 2025: 6 · 2023: 5 · 2021: 9 · 2020: 6 · 2019: 5 · 2018: 3 · 2017: 8 · 2016: 4 · 2015: 10 · 2014: 2 · 2013: 8 · 2012: 6
- FWCI
- 4.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- www.springer.com/tdm (unspecified)
- Locations
- British Journal of Cancer (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Kyoto University Research Information Repository (Kyoto University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
- Health Sciences › Medicine › Oncology › Lung Cancer Research Studies
- Keywords
- chemotherapy-induced neutropenia, non-small cell lung cancer, prognostic factors, overall survival, vinorelbine, gemcitabine, docetaxel, paclitaxel, carboplatin, tumor response, chemotherapy toxicity
- MeSH terms
- Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Non-Small-Cell Lung, Female, Humans, Lung Neoplasms, Male, Middle Aged, Neutropenia, Prognosis, Multicenter Studies as Topic, Incidence, Randomized Controlled Trials as Topic, Granulocyte Colony-Stimulating Factor
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