The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
miR-145 and miR-133a function as tumour suppressors and directly regulate FSCN1 expression in bladder cancer
Open accessAbstract
BACKGROUND: We have recently identified down-regulated microRNAs including miR-145 and miR-133a in bladder cancer (BC). The aim of this study is to determine the genes targeted by miR-145, which is the most down-regulated microRNA in BC. METHODS: We focused on fascin homologue 1 (FSCN1) from the gene expression profile in miR-145 transfectant. The luciferase assay was used to confirm the actual binding sites of FSCN1 mRNA. Cell viability was evaluated by cell growth, wound-healing, and matrigel invasion assays. BC specimens were subjected to immunohistochemistry of FSCN1 and in situ hybridisation of miR-145. RESULTS: The miR-133a as well as miR-145 had the target sequence of FSCN1 mRNA by the database search, and both microRNAs repressed the mRNA and protein expression of FSCN1. The luciferase assay revealed that miR-145 and miR-133a were directly bound to FSCN1 mRNA. Cell viability was significantly inhibited in miR-145, miR-133a, and si-FSCN1 transfectants. In situ hybridisation revealed that miR-145 expression was markedly repressed in the tumour lesion in which FSCN1 was strongly stained. The immunohistochemical score of FSCN1 in invasive BC (n=46) was significantly higher than in non-invasive BC (n=20) (P=0.0055). CONCLUSION: Tumour suppressive miR-145 and miR-133a directly control oncogenic FSCN1 in BC.
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Identification of Novel Genes Coding for Small Expressed RNAs
Lagos-Quintana, M., Rauhut, R., Lendeckel, W., & Tuschl, T. (2001) · Science · doi:10.1126/science.1064921 · Cited by 4,956
Maitra, A., Adsay, N. V., Argani, P., Iacobuzio-Donahue, C., De Marzo, A., Cameron, J. L., Yeo, C. J., & Hruban, R. H. (2003) · Modern Pathology · doi:10.1097/01.mp.0000086072.56290.fb · Cited by 429
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Self-citationmicroRNA-1/133a and microRNA-206/133b clusters: Dysregulation and functional roles in human cancers
Nohata, N., Hanazawa, T., Enokida, H., & Seki, N. (2012) · Oncotarget · doi:10.18632/oncotarget.424 · Cited by 253
Self-citationSUZUKI, S., YOKOBORI, T., TANAKA, N., SAKAI, M., SANO, A., INOSE, T., SOHDA, M., NAKAJIMA, M., MIYAZAKI, T., KATO, H., et al. (2012) · Oncology Reports · doi:10.3892/or.2012.1831 · Cited by 100
The emerging functions of the p53-miRNA network in stem cell biology
Lin, C.-P., Choi, Y. J., Hicks, G. G., & He, L. (2012) · Cell Cycle · doi:10.4161/cc.20207 · Cited by 38
Metadata
- Authors
- Chiyomaru, T., Enokida, H., Tatarano, S., Kawahara, K., Uchida, Y., Nishiyama, K., Fujimura, L., Kikkawa, N., Seki, N., & Nakagawa, M.
- Venue
- British Journal of Cancer
- Published
- 2010-02-16
- Volume
- 102
- Issue
- 5
- Pages
- 883-891
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- OpenAlex
- W2114557056
- Cited by
- 325
- References
- 2
- FWCI
- 10.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Chiyomaru, T., Enokida, H., Tatarano, S., Kawahara, K., Uchida, Y., Nishiyama, K., Fujimura, L., Kikkawa, N., Seki, N., & Nakagawa, M. (2010). miR-145 and miR-133a function as tumour suppressors and directly regulate FSCN1 expression in bladder cancer. British Journal of Cancer. https://doi.org/10.1038/sj.bjc.6605570
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