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Generation of Human-Induced Pluripotent Stem Cells in the Absence of Exogenous Sox2

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Regulation of somatic cell reprogramming through inducible mir-302 expression

Lin, S.-L., Chang, D. C., Lin, C., Ying, S., Leu, D., & Wu, D. T. S. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq850 · Cited by 328 · see citing works

miR-145 and miR-133a function as tumour suppressors and directly regulate FSCN1 expression in bladder cancer

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p53 and MicroRNA-34 Are Suppressors of Canonical Wnt Signaling

Kim, N. H., Kim, N.-G., Kim, N.-G., Lee, I., Choi, H.-S., Li, X.-Y., Kang, S. E., Cha, S. Y., Ryu, J. K., Na, J. M., et al. (2011) · Science Signaling · doi:10.1126/scisignal.2001744 · Cited by 308 · see citing works

microRNA-34a is tumor suppressive in brain tumors and glioma stem cells

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Small RNA‐mediated regulation of iPS cell generation

Li, Z., Yang, C., Nakashima, K., & Rana, T. M. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.2 · Cited by 301 · see citing works

The MYCN oncogene is a direct target of miR-34a

Wei, J. S., Song, Y., Durinck, S., Chen, Q.-R., Cheuk, A., Tsang, P., Zhang, Q., Thiele, C. J., Slack, A., Shohet, J. M., et al. (2008) · Oncogene · doi:10.1038/onc.2008.154 · Cited by 294 · see citing works

MicroRNA profiling identifies miR-34a and miR-21 and their target genes JAG1 and WNT1 in the coordinate regulation of dendritic cell differentiation

Hashimi, S. T., Fulcher, J. A., Chang, M. H., Gov, L., Wang, S., & Lee, B. (2009) · Blood · doi:10.1182/blood-2008-09-179150 · Cited by 291 · see citing works

Role of miR-34c microRNA in the late steps of spermatogenesis

Bouhallier, F., Allioli, N., Lavial, F., Chalmel, F., Perrard, M., Durand, P., Samarut, J., Pain, B., & Rouault, J.-P. (2010) · RNA · doi:10.1261/rna.1963810 · Cited by 291 · see citing works

Decreased Expression of MicroRNA-143 and -145 in Human Gastric Cancers

Takagi, T., Iio, A., Nakagawa, Y., Naoe, T., Tanigawa, N., & Akao, Y. (2009) · Oncology · doi:10.1159/000218166 · Cited by 286 · see citing works

A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidizationPreprint

Aylon, Y., Michael, D., Shmueli, A., Yabuta, N., Nojima, H., & Oren, M. (2006) · Genes & Development · doi:10.1101/gad.1447006 · Cited by 284 · see citing works

The promises and perils of p53

Krizhanovsky, V., & Lowe, S. W. (2009) · Nature · doi:10.1038/4601085a · Cited by 274 · see citing works

MicroRNA-145 Regulates Chondrogenic Differentiation of Mesenchymal Stem Cells by Targeting Sox9

Yang, B., Guo, H., Zhang, Y., Chen, L., Ying, D., & Dong, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021679 · Cited by 268 · see citing works

Regulation of Axl receptor tyrosine kinase expression by miR-34a and miR-199a/b in solid cancer

Mudduluru, G., Ceppi, P., Kumarswamy, R., Scagliotti, G. V., Papotti, M., & Allgayer, H. (2011) · Oncogene · doi:10.1038/onc.2011.13 · Cited by 254 · see citing works

Restoration of an absent G 1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiation

Hong, Y., & Stambrook, P. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401346101 · Cited by 248 · see citing works

Capture of MicroRNA–Bound mRNAs Identifies the Tumor Suppressor miR-34a as a Regulator of Growth Factor Signaling

Lal, A., Thomas, M. P., Altschuler, G. M., Navarro, F., O’Day, E. M., Li, X. L., Concepcion, C. P., Han, Y.-C., Thiery, J., Rajani, D. K., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002363 · Cited by 245 · see citing works

Regulation of Apoptosis and Differentiation by p53 in Human Embryonic Stem Cells

Qin, H., Yu, T., Qing, T., Liu, Y., Zhao, Y., Cai, J., Li, J., Song, Z., Qu, X., Zhou, P., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m610464200 · Cited by 244 · see citing works

MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells

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The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging

Dumble, M. L., Moore, L. M., Chambers, S. M., Geiger, H., Zant, G. E. V., Goodell, M. A., & Donehower, L. A. (2006) · Blood · doi:10.1182/blood-2006-03-010413 · Cited by 241 · see citing works

MicroRNA-34a Perturbs B Lymphocyte Development by Repressing the Forkhead Box Transcription Factor Foxp1

Rao, D. S., O’Connell, R. M., Chaudhuri, A. A., Garcia-Flores, Y., Geiger, T. L., & Baltimore, D. (2010) · Immunity · doi:10.1016/j.immuni.2010.06.013 · Cited by 235 · see citing works

p53 Regulates Cell Cycle and MicroRNAs to Promote Differentiation of Human Embryonic Stem Cells

Jain, A. K., Allton, K. L., Iacovino, M., Mahen, E. M., Milczarek, R. J., Zwaka, T. P., Kyba, M., & Barton, M. C. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001268 · Cited by 226 · see citing works

MiR-145 inhibits cell proliferation of human lung adenocarcinoma by targeting EGFR and NUDT1

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p53, ROS and senescence in the control of aging

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Loss ofp53Induces Changes in the Behavior of Subventricular Zone Cells: Implication for the Genesis of Glial Tumors

Gil‐Perotín, S., Marin‐Husstege, M., Li, J., Soriano‐Navarro, M., Zindy, F., Roussel, M. F., García‐Verdugo, J. M., & Casaccia-Bonnefil, P. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3970-05.2006 · Cited by 215 · see citing works

Dynamic single-cell imaging of direct reprogramming reveals an early specifying event

Smith, Z. D., Nachman, I., Regev, A., & Meissner, A. (2010) · Nature Biotechnology · doi:10.1038/nbt.1632 · Cited by 205 · see citing works

Genome-wide Characterization of miR-34a Induced Changes in Protein and mRNA Expression by a Combined Pulsed SILAC and Microarray Analysis

Kaller, M., Liffers, S., Oeljeklaus, S., Kuhlmann, K., Röh, S., Hoffmann, R. F. G., Warscheid, B., & Hermeking, H. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.010462 · Cited by 203 · see citing works

The role of p53 in tumour suppression: lessons from mouse models

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miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma

Swarbrick, A., Woods, S. L., Shaw, A., Balakrishnan, A., Phua, Y. W., Nguyen, A., Chanthery, Y. H., Lim, L., Ashton, L. J., Judson, R. L., et al. (2010) · Nature Medicine · doi:10.1038/nm.2227 · Cited by 199 · see citing works

p53-dependent Induction of PVT1 and miR-1204

Barsotti, A. M., Beckerman, R., Laptenko, O., Huppi, K. E., Caplen, N. J., & Prives, C. L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.322875 · Cited by 186 · see citing works

miR-34a Regulates Mouse Neural Stem Cell Differentiation

Aranha, M. M., dos Santos, D. M., Solá, S., Steer, C. J., & Rodrigues, C. M. P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021396 · Cited by 185 · see citing works

microRNA-34a regulates neurite outgrowth, spinal morphology, and function

Agostini, M., Tucci, P., Steinert, J. R., Shalom‐Feuerstein, R., Rouleau, M., Aberdam, D., Forsythe, I. D., Young, K. W., Ventura, A., Concepcion, C. P., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112063108 · Cited by 185 · see citing works

Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets

Agostini, M., Tucci, P., Killick, R., Candi, E., Sayan, B. S., Cervo, P. R. D. V., Nicotera, P., McKeon, F., Knight, R. A., Mak, T. W., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112061109 · Cited by 172 · see citing works

p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewalPreprint

Zhao, Z., Zuber, J. A., Díaz-Flores, E., Lintault, L., Kogan, S. C., Shannon, K., & Lowe, S. W. (2010) · Genes & Development · doi:10.1101/gad.1940710 · Cited by 167 · see citing works

Modeling Disease in Human ESCs Using an Efficient BAC-Based Homologous Recombination System

Song, H., Chung, S.-K., & Xu, Y. (2010) · Cell stem cell · doi:10.1016/j.stem.2009.11.016 · Cited by 163 · see citing works

MicroRNA-145 Targets YES and STAT1 in Colon Cancer Cells

Gregersen, L. H., Skanderup, A. J., Frankel, L. B., Wen, J., Krogh, A., & Lund, A. H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008836 · Cited by 162 · see citing works

p53 Plays a Role in Mesenchymal Differentiation Programs, in a Cell Fate Dependent Manner

Molchadsky, A., Shats, I., Goldfinger, N., Pevsner‐Fischer, M., Olson, M., Rinon, A., Tzahor, E., Lozano, G., Zipori, D., Sarig, R., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003707 · Cited by 160 · see citing works

Regulation of ES cell differentiation by functional and conformational modulation of p53

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MicroRNA-192 targeting retinoblastoma 1 inhibits cell proliferation and induces cell apoptosis in lung cancer cells

Feng, S., Cong, S., Zhang, X., Bao, X., Wang, W., Li, H., Wang, Z., Wang, G., Xu, J., Du, B., et al. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr232 · Cited by 158 · see citing works

Restoration of miR-145 expression suppresses cell proliferation, migration and invasion in prostate cancer by targeting FSCN1

Seki (2011) · International Journal of Oncology · doi:10.3892/ijo.2011.919 · Cited by 145 · see citing works

A genomewide study identifies the Wnt signaling pathway as a major target of p53 in murine embryonic stem cells

Lee, K. H., Li, M., Michalowski, A. M., Zhang, X., Liao, H., Chen, L., Xu, Y., Wu, X., & Huang, J. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909734107 · Cited by 144 · see citing works

A p53-CBP/p300 transcription module is required for GAP-43 expression, axon outgrowth, and regeneration

Tedeschi, A., Nguyen, T. N., Puttagunta, R., Gaub, P., & Giovanni, S. D. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.175 · Cited by 139 · see citing works

miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells

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microRNAs modulate iPS cell generation

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Activation of p53 by nutlin leads to rapid differentiation of human embryonic stem cells

Maimets, T., Neganova, I. E., Armstrong, L., & Lako, M. (2008) · Oncogene · doi:10.1038/onc.2008.166 · Cited by 127 · see citing works

miR-107 targets cyclin-dependent kinase 6 expression, induces cell cycle G1 arrest and inhibits invasion in gastric cancer cells

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Roles for p53 and p73 during oligodendrocyte development

Billon, N., Terrinoni, A., Jolicoeur, C., McCarthy, A., Richardson, W. D., Melino, G., & RAFF, M. C. (2004) · Development · doi:10.1242/dev.01035 · Cited by 113 · see citing works

MicroRNA 125a and its regulation of the p53 tumor suppressor gene

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miR-33-mediated downregulation of p53 controls hematopoietic stem cell self-renewal

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New plays in the p53 theater

Aylon, Y., & Oren, M. (2011) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.10.002 · Cited by 106 · see citing works

Nuclear accumulation and activation of p53 in embryonic stem cells after DNA damage

Solozobova, V., Rolletschek, A., & Blattner, C. (2009) · BMC Cell Biology · doi:10.1186/1471-2121-10-46 · Cited by 105 · see citing works

A Latent Pro-Survival Function for the Mir-290-295 Cluster in Mouse Embryonic Stem Cells

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p53 regulates the proliferation, differentiation and spontaneous transformation of mesenchymal stem cells

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MicroRNA Profiling Reveals Two Distinct p53-Related Human Pluripotent Stem Cell States

Neveu, P. A., Kye, M. J., Qi, S., Buchholz, D. E., Clegg, D., Şahin, M., Park, I., Kim, K., Daley, G. Q., Kornblum, H. I., et al. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.11.012 · Cited by 99 · see citing works

p53 regulates the self-renewal and differentiation of neural precursors

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Regulation of hematopoietic stem cell growth

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Systematic Proteome Analysis Identifies Transcription Factor YY1 as a Direct Target of miR-34a

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p53 in stem cells

Solozobova, V. (2011) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v2.i9.202 · Cited by 85 · see citing works

p53: Guardian of reprogramming

Ménendez, S., Camus, S., & Belmonte, J. C. I. (2010) · Cell Cycle · doi:10.4161/cc.9.19.13301 · Cited by 84 · see citing works

Growth Factor Stimulation Reduces Residual Quiescent Chronic Myelogenous Leukemia Progenitors Remaining after Imatinib Treatment

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microRNA-107 functions as a candidate tumor-suppressor gene in head and neck squamous cell carcinoma by downregulation of protein kinase Cɛ

Datta, J., Smith, A., Lang, J. C., Islam, M., Dutt, D., Teknos, T. N., & Pan, Q. (2011) · Oncogene · doi:10.1038/onc.2011.565 · Cited by 76 · see citing works

Coordinated control of self-renewal and differentiation of neural stem cells by Myc and the p19ARF–p53 pathway

Nagao, M., Campbell, K., Burns, K. A., Kuan, C.-Y., Trumpp, A., & Nakafuku, M. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200807130 · Cited by 74 · see citing works

Overexpression of sPRDM16 coupled with loss of p53 induces myeloid leukemias in mice.

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The emerging role of p53 in stem cells

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Interdependent regulation of p53 and miR-34a in chronic lymphocytic leukemia

Merkel, O., Asslaber, D., Pinon, J., Egle, A., & Greil, R. (2010) · Cell Cycle · doi:10.4161/cc.9.14.12267 · Cited by 50 · see citing works

p53: Pro-aging or pro-longevity?

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A microRNA-dependent circuit controlling p63/p73 homeostasis: p53 family cross-talk meets therapeutic opportunity

Ory, B., & Ellisen, L. W. (2011) · Oncotarget · doi:10.18632/oncotarget.244 · Cited by 47 · see citing works

Regulation of p53 in embryonic stem cells

Solozobova, V., & Blattner, C. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.06.006 · Cited by 43 · see citing works

P53 and aging: A fresh look at an old paradigm

Poyurovsky, M. V., & Prives, C. L. (2010) · Aging · doi:10.18632/aging.100179 · Cited by 41 · see citing works

Full-length hdmX transcripts decrease following genotoxic stress

Markey, M., & Berberich, S. J. (2008) · Oncogene · doi:10.1038/onc.2008.266 · Cited by 38 · see citing works

p53-mediated regulation of neuronal differentiation via regulation of dual oxidase maturation factor 1

Ostrakhovitch, E. A., & Semenikhin, O. A. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.02.061 · Cited by 20 · see citing works

Unravelling mechanisms of p53-mediated tumour suppression

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MDM2, MDMX and p53 in oncogenesis and cancer therapy

Wade, M., Li, Y.-C., & Wahl, G. M. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3430 · Cited by 1,279 · see citing works

Long noncoding RNAs: Novel insights into hepatocelluar carcinoma

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A positive feedback between p53 and miR-34 miRNAs mediates tumor suppressionPreprint

Okada, N., Lin, C., Ribeiro, M. C., Biton, A., Lai, G., He, X., Bu, P., Vogel, H. S., Jablons, D. M., Keller, A., et al. (2014) · Genes & Development · doi:10.1101/gad.233585.113 · Cited by 297 · see citing works

Clinical implications of miRNAs in the pathogenesis, diagnosis and therapy of pancreatic cancer

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A p53‐Dependent Tumor Suppressor Network Is Induced by Selective miR‐125a‐5p Inhibition in Multiple Myeloma Cells

Leotta, M., Biamonte, L., Raimondi, L., Ronchetti, D., Martino, M. T. D., Botta, C., Leone, E., Pitari, M. R., Neri, A., Giordano, A., et al. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24669 · Cited by 99 · see citing works

The relationship between prenatal exposure to BP-3 and Hirschsprung's disease

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Nuclear matrix, nuclear envelope and premature aging syndromes in a translational research perspective

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Role of Sex Hormones in the Development and Progression of Hepatitis B Virus-Associated Hepatocellular Carcinoma

Montella, M., D'Arena, G. F., Crispo, A., Capunzo, M., Nocerino, F., Grimaldi, M., Barbieri, A., D’Ursi, A. M., Tecce, M. F., Amore, A., et al. (2015) · International Journal of Endocrinology · doi:10.1155/2015/854530 · Cited by 66 · see citing works

p53 orchestrates between normal differentiation and cancer

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Role of the long non-coding RNA HOTAIR in hepatocellular carcinoma

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CHIR99021 promotes self-renewal of mouse embryonic stem cells by modulation of protein-encoding gene and long intergenic non-coding RNA expression

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Effect of bisphenol A on pluripotency of mouse embryonic stem cells and differentiation capacity in mouse embryoid bodies

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MicroRNAs as regulators and effectors of hematopoietic transcription factors

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The roles of MicroRNAs in neural regenerative medicine

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LncRNA TP73-AS1/miR-539/MMP-8 axis modulates M2 macrophage polarization in hepatocellular carcinoma via TGF-β1 signaling.

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Conditional mutation of Smc5 in mouse embryonic stem cells perturbs condensin localization and mitotic progression

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The involvement of a Nanog, Klf4 and c-Myc transcriptional circuitry in the intertwining between neoplastic progression and reprogramming

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Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies

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Mutation rate in stem cells: an underestimated barrier on the way to therapy

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