Evidence for characteristic vascular patterns in solid tumours: Quantitative studies using corrosion casts
Open accessAbstract
The vascular architecture of four different tumour cell lines (CaX, CaNT, SaS, HEC-1B) transplanted subcutaneously in mice was examined by means of microvascular corrosion casting in order to determine whether there is a characteristic vascular pattern for different tumour types and whether it differs significantly from two normal tissues, muscle and gut. Three-dimensional reconstructed scanning electron microscope images were used for quantitative measurements. Vessel diameters, intervessel and interbranch distances showed large differences between tumour types, whereas the branching angles were similar. In all tumours, the variability of the vessel diameters was significantly higher than in normal tissue. The quantitative data provide strong evidence for a characteristic vascular network determined by the tumour cells themselves.
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Tumor-associated blood vessels are structurally aberrant, displaying irregular diameters, lack of hierarchical architecture, and increased permeability and fragility.
“Unlike normal vasculature, tumor-associated blood vessels are structurally aberrant [54]. They display irregular diameters, lack the hierarchical architecture typical of the arterial-arteriolar-capillary network, and exhibit increased permeability and fragility [55,56].”
From Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis (2025) · cites this paper as [56]
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- Authors
- Konerding, M. A., Malkusch, W., Klapthor, B., Ackern, C. V., Fait, E., Hill, S. A., Parkins, C., Chaplin, D. J., Presta, M., & Denekamp, J.
- Affiliations
- Johannes Gutenberg University Mainz (DE)
- Carl Zeiss (Germany) (DE)
- Mount Vernon Hospital (GB)
- University of Brescia (IT)
- Umeå University (SE)
- Venue
- British Journal of Cancer
- Published
- 1999-04-23
- Volume
- 80
- Issue
- 5-6
- Pages
- 724-732
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- PMC
- PMC2362271
- OpenAlex
- W2034665577
- Cited by
- 221
- References
- 24
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 4 · 2023: 7 · 2022: 32 · 2021: 6 · 2020: 6 · 2019: 8 · 2018: 7 · 2017: 7 · 2016: 11 · 2015: 6 · 2014: 10 · 2013: 12 · 2012: 12
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- www.springer.com/tdm (unspecified)
- Locations
- British Journal of Cancer (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Physical Sciences › Mathematics › Modeling and Simulation › Mathematical Biology Tumor Growth
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- tumor vasculature, corrosion casting, cancer cell lines, vessel diameter, branch angle, tumor angiogenesis
- MeSH terms
- Adenocarcinoma, Animals, Carcinoma, Female, Humans, Mice, Inbred CBA, Mice, Nude, Microscopy, Electron, Scanning, Neoplasm Transplantation, Neoplasms, Experimental, Sarcoma, Experimental, Transplantation, Heterologous, Tumor Cells, Cultured, Corrosion Casting, Endometrial Neoplasms, Mice
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