The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Distribution and regulation of cyclooxygenase‐2 in carrageenan‐induced inflammation
Open accessAbstract
We characterized the regulation of cyclooxygenase‐2 (COX‐2) at the mRNA, protein and mediator level in two rat models of acute inflammation, carrageenan‐induced paw ædema and mechanical hyperalgesia. Carrageenan was injected in the hind paw of rat at low (paw ædema) and high doses (hyperalgesia). COX‐2 and prostaglandin E 2 (PGE 2) levels were measured by RT–PCR and immunological assays. We also determined the distribution of COX‐2 by immunohistochemistry. The injection of carrageenan produced a significant and parallel induction of both COX‐2 and PGE 2. This induction was significantly higher in hyperalgesia than in paw ædema. This was probably due to the 9 fold higher concentration of carrageenan used to provoke hyperalgesia. Immunohistochemical examination showed COX‐2 immunoreactivity in the epidermis, skeletal muscle and inflammatory cells of rats experiencing hyperalgesia. In paw ædema however, only the epidermis showed positive COX‐2 immunoreactivity. Pretreatment with indomethacin completely abolished the induction of COX‐2 in paw ædema but not in hyperalgesia. These results suggest that multiple mechanisms regulate COX‐2 induction especially in the more severe model. In carrageenan‐induced paw ædema, prostanoid production have been linked through the expression of the COX‐2 gene which suggest the presence of a positive feedback loop mechanism. British Journal of Pharmacology (1999) 128, 853–859; doi:10.1038/sj.bjp.0702866
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Pharmacological analysis of cyclooxygenase-1 in inflammation
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Carrageenan-Induced Paw Edema in the Rat and Mouse
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Metadata
- Authors
- Nantel, F., Denis, D., Gordon, R., Northey, A., Cirino, M., Metters, K. M., & Chan, C. C.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 1999-10
- Volume
- 128
- Issue
- 4
- Pages
- 853-859
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W1970652854
- Cited by
- 333
- References
- 36
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Nantel, F., Denis, D., Gordon, R., Northey, A., Cirino, M., Metters, K. M., & Chan, C. C. (1999). Distribution and regulation of cyclooxygenase‐2 in carrageenan‐induced inflammation. British Journal of Pharmacology. https://doi.org/10.1038/sj.bjp.0702866
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