The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Gingerols: a novel class of vanilloid receptor (VR1) agonists
Open accessAbstract
Gingerols, the pungent constituents of ginger, were synthesized and assessed as agonists of the capsaicin‐activated VR1 (vanilloid) receptor. [6]‐Gingerol and [8]‐gingerol evoked capsaicin‐like intracellular Ca 2+ transients and ion currents in cultured DRG neurones. These effects of gingerols were blocked by capsazepine, the VR1 receptor antagonist. The potency of gingerols increased with increasing size of the side chain and with the overall hydrophobicity in the series. We conclude that gingerols represent a novel class of naturally occurring VR1 receptor agonists that may contribute to the medicinal properties of ginger, which have been known for centuries. The gingerol structure may be used as a template for the development of drugs acting as moderately potent activators of the VR1 receptor. British Journal of Pharmacology (2002) 137, 793–798. doi:10.1038/sj.bjp.0704925
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Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
Zygmunt, P. M., Petersson, J., Andersson, D. A., Chuang, H.-H., Sørgård, M., Di Marzo, V., Julius, D., & Högestätt, E. D. (1999) · Nature · doi:10.1038/22761 · Cited by 2,142
Mezey, É., Tóth, Z. E., Cortright, D. N., Arzubi, M. K., Krause, J. E., Elde, R., Guo, A., Blumberg, P. M., & Szallasi, A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3655 · Cited by 850
Cited by
Zingiberis rhizoma: A comprehensive review on the ginger effect and efficacy profiles
Chrubasik, S., Pittler, M. H., & Roufogalis, B. D. (2005) · Phytomedicine · doi:10.1016/j.phymed.2004.07.009 · Cited by 623
Self-citationEffects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1)
McNamara, F. N., Randall, A., & Gunthorpe, M. J. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706040 · Cited by 310
Chemosensory properties of the trigeminal system
Viana, F. (2011) · ACS Chemical Neuroscience · doi:10.1021/cn100102c · Cited by 196
Mansour, M. S., Ni, Y.-M., Roberts, A. L., Kelleman, M., RoyChoudhury, A., & St-Onge, M.-P. (2012) · Metabolism · doi:10.1016/j.metabol.2012.03.016 · Cited by 96
Ginger Orally Disintegrating Tablets to Improve Swallowing in Older People
Hirata, A., Funato, H., Nakai, M., Iizuka, M., Abe, N., Yagi, Y., Shiraishi, H., Jobu, K., Yokota, J., Hirose, K., et al. (2016) · Biological & Pharmaceutical Bulletin · doi:10.1248/bpb.b15-01045 · Cited by 17
Metadata
- Authors
- Dedov, V. N., Tran, V. H., Duke, C. C., Connor, M., Christie, M. J., Mandadi, S., & Roufogalis, B. D.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2002-11
- Volume
- 137
- Issue
- 6
- Pages
- 793-798
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W2067200668
- Cited by
- 218
- References
- 2
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- bronze
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