Tachykinins and tachykinin receptors in human uterus
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Studies were undertaken to determine the nature of the receptors mediating contractile effects of tachykinins in the uteri of nonpregnant women, and to analyse the expression of preprotachykinins (PPT), tachykinin receptors and the cell‐surface peptidase, neprilysin (NEP), in the myometrium from pregnant and nonpregnant women. The neurokinin B (NKB) precursor PPT‐B was expressed in higher levels in the myometrium from nonpregnant than from pregnant women. Faint expression of PPT‐A mRNA was detectable in the myometrium from nonpregnant but not pregnant women. PPT‐C, the gene encoding the novel tachykinin peptide hemokinin‐1 (HK‐1), was present in trace amounts in the uteri from both pregnant and nonpregnant women. Tachykinin NK 2 receptors were more strongly expressed in tissues from nonpregnant than from pregnant women. NK 1 receptor mRNA was present in low levels in tissues from both pregnant and nonpregnant women. A low abundance transcript corresponding to the NK 3 receptor was present only in tissues from nonpregnant women. The mRNA expression of the tachykinin‐degrading enzyme NEP was lower in tissues from nonpregnant than from pregnant women. Substance P (SP), neurokinin A (NKA) and NKB, in the presence of the peptidase inhibitors thiorphan, captopril and bestatin, produced contractions of myometrium from nonpregnant women. The order of potency was NKA≫SP≥NKB. The potency of NKA was unchanged in the absence of peptidase inhibitors. The tachykinin NK 2 receptor‐selective agonist [Lys 5 MeLeu 9 Nle 10]NKA(4–l0) was approximately equipotent with NKA, but the tachykinin NK 1 and NK 3 receptor‐selective agonists [Sar 9 Met(O 2)11]SP and [MePhe 7]NKB were ineffective in the myometrium from nonpregnant women. The uterotonic effects of [Lys 5 MeLeu 9 Nle 10]NKA(4–10) were antagonized by the tachykinin NK 2 receptor‐selective antagonist SR48968. Neither atropine, nor phentolamine nor tetrodotoxin affected responses to [Lys 5 MeLeu 9 Nle 10]NKA(4–10). These data are consistent with a role of tachykinins in the regulation of human uterine function, and reinforce the importance of NK 2 receptors in the regulation of myometrial contraction. British Journal of Pharmacology (2003) 139, 523–532. doi:10.1038/sj.bjp.0705279
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NK1R is expressed in human and rodent uterus, as are CRLR and RAMP1.
“NK1R is expressed in human and rodent uterus66–69, so are CRLR and RAMP170.”
From Neuropeptides Substance P and Calcitonin Gene Related Peptide Accelerate the Development and Fibrogenesis of Endometriosis (2019) · cites this paper as [66]
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Hu, G., Lin, C., He, M., & Wong, A. (2014) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2014.08.009 · Cited by 45 · see citing works
Experimental Ventilator-induced Lung Injury
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Self-citationSubstance P‐induced cyclooxygenase‐2 expression in human umbilical vein endothelial cells
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Patak, E., Pinto, F. M., Story, M. E., Pintado, C. O., Fleming, A., Page, N. M., Pennefather, J. N., & Candenas, M. L. (2005) · Biology of Reproduction · doi:10.1095/biolreprod.104.036814 · Cited by 37 · see citing works
Self-citationKanda, A., Takuwa‐Kuroda, K., Aoyama, M., & Satake, H. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.05760.x · Cited by 37 · see citing works
Seda, M., Pinto, F. M., Wray, S., Cintado, C. G., Noheda, P., Buschmann, H., & Candenas, L. (2007) · Biology of Reproduction · doi:10.1095/biolreprod.107.063016 · Cited by 36 · see citing works
Self-citationRole of hemokinin-1 in health and disease
Borbély, É., & Helyes, Z. (2016) · Neuropeptides · doi:10.1016/j.npep.2016.12.003 · Cited by 34 · see citing works
Mammalian tachykinins and uterine smooth muscle: the challenge escalates
Pennefather, J. N., Patak, E., Pinto, F. M., & Candenas, L. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.07.007 · Cited by 33 · see citing works
Self-citationThe Voltage-Gated Sodium Channel Nav1.8 Is Expressed in Human Sperm
Cejudo-Román, A., Pinto, F. M., Subirán, N., Ravina, C. G., Sánchez, M. F., Pérez-Hernández, N., Pérez, R., Pacheco, A., Irazusta, J., & Candenas, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076084 · Cited by 32 · see citing works
Self-citationAoyama, M., Kawada, T., & Satake, H. (2011) · Peptides · doi:10.1016/j.peptides.2011.07.019 · Cited by 31 · see citing works
Ovarian steroids regulate tachykinin and tachykinin receptor gene expression in the mouse uterus
Pinto, F. M., Pintado, C. O., Pennefather, J. N., Patak, E., & Candenas, L. (2009) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-7-77 · Cited by 29 · see citing works
Self-citationTachykinin peptides and receptors: Putting amphibians into perspective
Liu, L., & Burcher, E. (2005) · Peptides · doi:10.1016/j.peptides.2005.03.027 · Cited by 29 · see citing works
Angiotensin-converting enzymes (ACE and ACE2) are downregulated in renal tumors
Larrinaga, G., Pérez, I., Sanz, B., Blanco, L., Lopez, J. I., Candenas, L., Pinto, F. M., Gil, J., Irazusta, J., & Varona, A. (2010) · Regulatory Peptides · doi:10.1016/j.regpep.2010.07.170 · Cited by 27 · see citing works
Self-citationCampo, A., Dufour, S., & Rousseau, K. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1056939 · Cited by 23 · see citing works
Pennefather, J. N., Patak, E., Ziccone, S., Lilley, A., Pinto, F. M., Page, N., Story, M. E., Grover, S. R., & Candenas, L. (2006) · Biology of Reproduction · doi:10.1095/biolreprod.106.051508 · Cited by 22 · see citing works
Self-citationKasimanickam, R. K., Kasimanickam, V. R., Gold, J. R., Moore, D., Kastelic, J. P., Pyrdek, D., & Ratzburg, K. (2019) · Theriogenology · doi:10.1016/j.theriogenology.2019.08.011 · Cited by 21 · see citing works
Progesterone differentially affects the transcriptomic profiles of cow endometrial cell types
Pereira, G., Guo, Y., Silva, E., Bevilacqua, C., Charpigny, G., Lopes-da-Costa, L., & Humblot, P. (2022) · BMC Genomics · doi:10.1186/s12864-022-08323-z · Cited by 20 · see citing works
Differentially regulated expression of neurokinin B (NKB)/NK3 receptor system in uterine leiomyomata
Cañete, H., Dorta, I., Hernández, M., Cejudo-Román, A., Candenas, L., Pinto, F. M., Valladares, F., Báez, D., de Oca, F. M., Bello, A. R., et al. (2013) · Human Reproduction · doi:10.1093/humrep/det128 · Cited by 20 · see citing works
Self-citationSalt formation improved the properties of a candidate drug during early formulation development
Sigfridsson, K., Ahlqvist, M., Lindsjö, M., & Paulsson, S. (2018) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2018.04.048 · Cited by 18 · see citing works
Löffler, S., Schulz, A., Brylla, E., Nieber, K., & Spanel‐Borowski, K. (2004) · Regulatory Peptides · doi:10.1016/j.regpep.2004.06.009 · Cited by 18 · see citing works
Losco, P. E., Leach, M. W., Sinha, D., Davis, P., Schmahai, T. J., Nomier, A., Kakkar, T., Reyderman, L., & Lynch, M. E. (2007) · Toxicologic Pathology · doi:10.1080/01926230701198766 · Cited by 17 · see citing works
Tachykinins and Kisspeptins in the Regulation of Human Male Fertility
Blasco, V., Pinto, F. M., González-Ravina, C., Santamaría‐López, E., Candenas, L., & Sánchez, M. F. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm9010113 · Cited by 16 · see citing works
Self-citationThe Antiemetic Mechanisms of Gingerols against Chemotherapy-Induced Nausea and Vomiting
Dai, Y., Zhao, Y., & Nie, K. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/1753430 · Cited by 15 · see citing works
Two Concepts on the Immunological Aspect of Blastocyst Implantation
Yoshinaga, K. (2012) · Journal of Reproduction and Development · doi:10.1262/jrd.2011-027 · Cited by 15 · see citing works
Petraglia, F., Florio, P., & Torricelli, M. (2006) · Elsevier eBooks · doi:10.1016/b978-012515400-0/50058-0 · Cited by 15 · see citing works
Altered glutamyl-aminopeptidase activity and expression in renal neoplasms
Blanco, L., Sanz, B., Pérez, I., Sanchez, C. E., Candenas, L., Pinto, F. M., Gil, J., Casis, L., Lopez, J. I., & Larrinaga, G. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-386 · Cited by 14 · see citing works
Self-citationBellucci, F., Meini, S., Catalioto, R., Catalani, C., Giuliani, S., Quartara, L., Giolitti, A., Faiella, A., Rotondaro, L., Candenas, L., et al. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.07.075 · Cited by 14 · see citing works
Self-citationGonzález-Santana, A., Marrero-Hernández, S., Dorta, I., Hernández, M., Pinto, F. M., Báez, D., Bello, A. R., Candenas, L., & Almeida, T. A. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.07.007 · Cited by 11 · see citing works
Self-citationGhosh, P., Saha, S., Bhattacharya, S., Bhattacharya, S., Mukherjee, S., & Roy, S. S. (2007) · Cellular Physiology and Biochemistry · doi:10.1159/000107521 · Cited by 11 · see citing works
Increased formation of corpora lutea in neurokinin 1‐receptor deficient mice
Löffler, S., Schulz, A., Hunt, S. P., & Spanel‐Borowski, K. (2004) · Molecular Reproduction and Development · doi:10.1002/mrd.20093 · Cited by 11 · see citing works
Substance P and the Tachykinins
Howard, M. R., Haddley, K., Thippeswamy, T., Vasiliou, S., & Quinn, J. P. (2006) · Springer eBooks · doi:10.1007/0-387-30395-2_20 · Cited by 10 · see citing works
Evaluation of Enkephalin-Degrading Enzymes in Sperm from Heroin-Addicted Men.
Rezaei-Mojaz, S., Nazmara, Z., Najafi, M., Movahedin, M., Zandieh, Z., Shirinbayan, P., Roshanpajouh, M., Asgari, H. R., Abbasi, M., & Koruji, M. (2020) · PubMed Central · doi:10.22074/ijfs.2020.5817 · Cited by 9 · see citing works
Selective and Combined Neurokinin Receptor Antagonists
Gerspacher, M. (2005) · Progress in medicinal chemistry · doi:10.1016/s0079-6468(05)43003-9 · Cited by 9 · see citing works
Early development evaluation of AZD8081: a substrate for the NK receptors
Sigfridsson, K., Ahlqvist, M. M., Carlsson, A., & Fridström, A. (2011) · Drug Development and Industrial Pharmacy · doi:10.3109/03639045.2010.535823 · Cited by 7 · see citing works
Functional characterisation of hemokinin-1 in mouse uterus
Patak, E., Pennefather, J. N., Gozali, M., Candenas, L., Kerr, K. P., Exintaris, B., Ziccone, S., Potteck, H., Chetty, N., Page, N., et al. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.10.036 · Cited by 7 · see citing works
Self-citationSerum neprilysin levels are elevated in preeclampsia
Tüten, N., Malik, E., Gök, K., Canbolat, K. H., Makul, M., Öner, Y. Ö., Bulut, H., Tüten, A., & Güralp, O. (2021) · Taiwanese Journal of Obstetrics and Gynecology · doi:10.1016/j.tjog.2021.07.015 · Cited by 6 · see citing works
Blasco, V., Pinto, F. M., Fernández‐Atutxa, A., Prados, N., Sánchez, M. F., & Candenas, L. (2022) · Reproductive Sciences · doi:10.1007/s43032-022-00998-9 · Cited by 6 · see citing works
Self-citationSignificance of Sensory Neuropeptides and the Immune Response
van der Kleij, H. P. M., & Bienenstock, J. (2007) · Elsevier eBooks · doi:10.1016/b978-012088576-3/50008-3 · Cited by 6 · see citing works
Role of Neurokinin B in gametogenesis and steroidogenesis of freshwater catfish, Clarias batrachus
Singh, A., Lal, B., Kumar, P., Parhar, I. S., & Millar, R. P. (2023) · Cell and Tissue Research · doi:10.1007/s00441-023-03788-0 · Cited by 4 · see citing works
Pinto, F. M., Bello, A. R., Gallardo-Castro, M., Valladares, F., Almeida, T. A., Tena‐Sempere, M., & Candenas, L. (2015) · Biology of Reproduction · doi:10.1095/biolreprod.115.130617 · Cited by 4 · see citing works
Self-citationJain, A. R., Britton, Z. T., Markwalter, C. E., & Robinson, A. S. (2019) · Protein Engineering Design and Selection · doi:10.1093/protein/gzaa009 · Cited by 3 · see citing works
Expression of NK1 receptor at the protein and mRNA level in the porcine female reproductive system
Bukowski, R. (2014) · Polish Journal of Veterinary Sciences · doi:10.2478/pjvs-2014-0068 · Cited by 3 · see citing works
Early development evaluation of AZD2738, a substrate for the NK receptors
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Smooth muscle neurokinin-2 receptors mediate contraction in human saphenous veins
Mechiche, H., Grassin‐Delyle, S., Pinto, F. M., Buenestado, A., Candenas, L., & Devillier, P. (2011) · Pharmacological Research · doi:10.1016/j.phrs.2011.01.010 · Cited by 1 · see citing works
Self-citationEndocrine and paracrine mechanisms in human placenta and fetal membranes in preterm birth
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Kinetic and docking studies of inhibitors targeting the catalytic zinc in MA clan enzymes
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MECHANISMS OF CUTANEOUS WOUND HEALING ARE MEDIATED VIA PERIPHERAL NEUROPEPTIDE ACTIVITY
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- Authors
- Patak, E., Luz Candenas, M., Pennefather, J. N., Ziccone, S., Lilley, A., Martín, J. D., Flores, C., Mantecón, A. G., Story, M. E., & Pinto, F. M.
- Affiliations
- Royal Women's Hospital (AU)
- Hospital Universitario Nuestra Señora de Candelaria (ES)
- Centro de Investigaciones Científicas Isla de la Cartuja (ES)
- Monash University (AU)
- Corresponding author
- Pennefather, Jocelyn N
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2003-06
- Volume
- 139
- Issue
- 3
- Pages
- 523-532
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- PMC
- PMC1573878
- OpenAlex
- W1980556620
- Cited by
- 82
- References
- 72
- Citations by year
- 2026: 1 · 2023: 1 · 2022: 6 · 2021: 1 · 2020: 1 · 2019: 5 · 2018: 2 · 2016: 3 · 2015: 1 · 2014: 5 · 2013: 2 · 2012: 5
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Pharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Keywords
- tachykinins, tachykinin receptors, myometrium, preprotachykinin, neprilysin, neurokinin B, hemokinin-1, NK2 receptor, neurokinin-1 receptor, NK3 receptor, substance P, neurokinin A, pregnancy, receptor mRNA expression, protease inhibitors
- MeSH terms
- Adult, Aged, Analysis of Variance, Dose-Response Relationship, Drug, Female, Humans, Middle Aged, Muscle Contraction, Pregnancy, RNA, Messenger, Uterus, Neprilysin, Tachykinins, Receptors, Tachykinin
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