Cited by 271Redox biology and oxidative stressNitric Oxide and Endothelin EffectsMetal-Catalyzed Oxygenation Mechanisms

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On the selectivity of superoxide dismutase mimetics and its importance in pharmacological studies

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Muscoli, Carolina, Cuzzocrea, Salvatore, Riley, Dennis P, Zweier, Jay L, Thiemermann, Christoph, Wang, Zhi‐Qiang, Salvemini, Daniela·2003·British Journal of Pharmacology

DOI 10.1038/sj.bjp.0705430PMC PMC1574047

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Abstract

The list of pathophysiological conditions associated with the overproduction of superoxide expands every day. Much of the knowledge compiled on the role of this radical in disease has been gathered using the native superoxide dismutase enzyme and, more recently, by the use of superoxide dismutase knockout models or transgenic models that overexpress the various isoforms of the enzyme. Although the native enzyme has shown promising anti‐inflammatory properties in both preclinical and clinical studies, there were drawbacks and issues associated with its use as a therapeutic agent and pharmacological tool. Based on the concept that removal of superoxide modulates the course of inflammation, synthetic, low‐molecular‐weight mimetics of the superoxide dismutase enzymes that could overcome some of the limitations associated with the use of the native enzyme have been designed. In this review, we will discuss the advances made using various superoxide dismutase mimetics that led to the proposal that superoxide (and/or the product of its interaction with nitric oxide, peroxynitrite) is an important mediator of inflammation, and to the conclusion that superoxide dismutase mimetics can be utilized as therapeutic agents in diseases of various etiologies. The importance of the selectivity of such compounds in pharmacological studies will be discussed. British Journal of Pharmacology (2003) 140 , 445–460. doi: 10.1038/sj.bjp.0705430

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Authors: Muscoli, C., Cuzzocrea, S., Riley, D. P., Zweier, J. L., Thiemermann, C., Wang, Z., & Salvemini, D.
Affiliations: Magna Graecia University (IT)
University of Messina (IT)
The Ohio State University (US)
William Harvey Research Institute (GB)
Corresponding author: Salvemini, Daniela
ORCID: Muscoli, Carolina
Cuzzocrea, Salvatore
Riley, Dennis P
Zweier, Jay L
Thiemermann, Christoph
Venue: British Journal of Pharmacology
Publisher: Wiley
Published: 2003-10
Volume: 140
Issue: 3
Pages: 445-460
ISSN: 0007-1188 (ISSN-L)
1476-5381
DOI: 10.1038/sj.bjp.0705430
PMC: PMC1574047
OpenAlex: W2095342832
Cited by: 271
References: 217
Citations by year: 2026: 5 · 2025: 7 · 2024: 10 · 2023: 7 · 2022: 6 · 2021: 12 · 2020: 6 · 2019: 11 · 2018: 13 · 2017: 11 · 2016: 11 · 2015: 7 · 2014: 12 · 2013: 14 · 2012: 19
FWCI: 0.75
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1951 d)
Locations: British Journal of Pharmacology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
Keywords: superoxide dismutase mimetic, superoxide, peroxynitrite, nitric oxide, inflammation, anti-inflammatory therapy, enzyme selectivity, superoxide dismutase isoforms, reactive oxygen species
MeSH terms: Animals, Humans, Superoxide Dismutase, Drug Delivery Systems, Biomimetic Materials

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On the selectivity of superoxide dismutase mimetics and its importance in pharmacological studies

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