Captopril improves cerebrovascular structure and function in old hypertensive rats
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We examined the effects of an angiotensin‐converting enzyme inhibitor (ACEI), captopril, on cerebral arterioles in young and old spontaneously hypertensive rats (SHR). Animals were anesthetized with sodium pentobarbitone (60 mg kg−1 day−1). We measured cerebral blood flow (CBF, arbitrary units) and cerebral arteriolar internal diameter (ID, μ m) prior to and during stepwise hypotension (SH) in 6‐ (WKY‐6) and 15‐month‐old (WKY‐15) Wistar Kyoto rats and in age‐matched SHR that were untreated (SHR‐6 and SHR‐15) or treated for 3 months with captopril (SHR‐6C, 105±2 mg kg−1 day−1 and SHR‐15C, 94±1 mg kg−1 day−1). ID and cross‐sectional area of the vessel wall (CSA) were measured in deactivated (EDTA) cerebral arterioles during a second SH. Captopril decreased the lower limit of CBF autoregulation (61±6 in SHR‐6C and 51±2 in SHR‐15C versus 52±6 in WKY‐6 and 62±7 in WKY‐15 and 83±14 mmHg in SHR‐6 and 120±19 mmHg in SHR‐15; P<0.05) and CSA (510±21 in SHR‐6C and 585±25 in SHR‐15C versus 529±12 in WKY‐6 and 549±20 in WKY‐15 and 644±38 mmHg in SHR‐6 and 704±38 mmHg in SHR‐15; P<0.05). Captopril increased cerebral arteriolar external diameter of SHR (105±5 in SHR‐6C and 94±4 in SHR‐15C vs 125±8 in WKY‐6 and 108±3 in WKY‐15 and 83±2 mmHg in SHR‐6 and 80±2 mmHg in SHR‐15 for a pial arteriolar pressure step of 35–39 mmHg; P<0.05). Captopril attenuated increases in cerebral arteriolar distensibility in young SHR. Thus, ACEIs attenuate eutrophic and hypertrophic inward remodeling of cerebral arterioles in young and old SHR, thus decreasing the lower limit of CBF autoregulation. British Journal of Pharmacology (2005) 144, 349–356. doi:10.1038/sj.bjp.0706001
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ACEIs and ARBs may improve cerebral hemodynamics.
“Angiotensin converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) may improve cerebral hemodynamics185 and endothelial function186, and preserve cognitive function in hypertensive populations187.”
From Mechanisms and treatment of late-life depression (2019) · cites this paper as [185]
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Mechanisms and treatment of late-life depression
Alexopoulos, G. S. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0514-6 · Cited by 592 · see citing works
Mechanisms and treatment of late-life depression
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- Authors
- Dupuis, F., Atkinson, J., Limiñana, P., & Chillon, J.
- Affiliations
- Université Henri Poincaré (FR)
- Corresponding author
- Atkinson, Jeffrey
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2005-02
- Volume
- 144
- Issue
- 3
- Pages
- 349-356
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- PMC
- PMC1576005
- OpenAlex
- W2125928046
- Cited by
- 39
- References
- 36
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 2 · 2014: 4 · 2013: 2 · 2012: 2
- FWCI
- 0.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Pharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- captopril, ACE inhibitors, cerebral arterioles, cerebral autoregulation, cerebral blood flow, spontaneously hypertensive rats, aging, hypertension, pial arterioles, cerebral microvasculature, endothelium-dependent vasodilation
- MeSH terms
- Aging, Angiotensin-Converting Enzyme Inhibitors, Animals, Arterioles, Blood Pressure, Brain, Captopril, Cerebral Hemorrhage, Cerebrovascular Circulation, Hypertension, Male, Muscle Contraction, Muscle, Smooth, Vascular, Rats, Inbred SHR, Rats, Inbred WKY, Rats
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