Mechanisms and treatment of late-life depression

Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression

Miller, A. H., Maletic, V., & Raison, C. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.029 · Cited by 3,848 · see citing works

Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis

Cipriani, A., Furukawa, T. A., Salanti, G., Chaimani, A., Atkinson, L. Z., Ogawa, Y., Leucht, S., Ruhe, H. G., Turner, E. H., Higgins, J. P. T., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(17)32802-7 · Cited by 3,541 · see citing works

From stress to inflammation and major depressive disorder: A social signal transduction theory of depression.

Slavich, G. M., & Irwin, M. R. (2014) · Psychological Bulletin · doi:10.1037/a0035302 · Cited by 2,206 · see citing works

Depression in the elderly

Alexopoulos, G. S. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66665-2 · Cited by 2,024 · see citing works

'Vascular Depression' Hypothesis

Alexopoulos, G. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830220033006 · Cited by 1,843 · see citing works

A Randomized Controlled Trial of the Tumor Necrosis Factor Antagonist Infliximab for Treatment-Resistant Depression: The Role of Baseline Inflammatory Biomarkers

Raison, C. L., Rutherford, R. E., Woolwine, B. J., Shuo, C., Schettler, P., Drake, D. F., Haroon, E., & Miller, A. H. (2013) · JAMA Psychiatry · doi:10.1001/2013.jamapsychiatry.4 · Cited by 1,617 · see citing works

Peripheral cytokine and chemokine alterations in depression: a meta‐analysis of 82 studies

Köhler, C. A., Freitas, T. H., Maes, M., de Andrade, N. Q., Liu, C. S., Fernandes, B. S., Stubbs, B., Solmi, M., Veronese, N., Herrmann, N., et al. (2017) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12698 · Cited by 1,443 · see citing works

Sertraline treatment of major depression in patients with acute MI or unstable angina

Glassman, A. H. (2002) · JAMA · doi:10.1001/jama.288.6.701 · Cited by 1,414 · see citing works

Mood disorders and allostatic load

McEwen, B. S. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00177-x · Cited by 1,135 · see citing works

Effect of Anti-inflammatory Treatment on Depression, Depressive Symptoms, and Adverse Effects: A Systematic Review and Meta-analysis of Randomized Clinical Trials

Köhler, O., Benros, M. E., Nordentoft, M., Farkouh, M. E., Iyengar, R. L., Mors, O., & Krogh, J. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.1611 · Cited by 941 · see citing works

The vascular depression hypothesis: mechanisms linking vascular disease with depression

Taylor, W. D., Aizenstein, H. J., & Alexopoulos, G. S. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.20 · Cited by 923 · see citing works

Reciprocal regulation of the neural and innate immune systems

Irwin, M. R., & Cole, S. W. (2011) · Nature Reviews Immunology · doi:10.1038/nri3042 · Cited by 910 · see citing works

CYTOKINE TARGETS IN THE BRAIN: IMPACT ON NEUROTRANSMITTERS AND NEUROCIRCUITS: Review: Cytokine Targets in the Brain

Miller, A. H., Haroon, E., Raison, C. L., & Felger, J. C. (2013) · Depression and Anxiety · doi:10.1002/da.22084 · Cited by 892 · see citing works

Management of Depression in Older Adults: A Review

Kok, R. M., & Reynolds, C. F. (2017) · JAMA · doi:10.1001/jama.2017.5706 · Cited by 890 · see citing works

Resting-state functional connectivity in major depressive disorder: A review

Mulders, P. C., van Eijndhoven, P. F., Schene, A. H., Beckmann, C. F., & Tendolkar, I. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.07.014 · Cited by 884 · see citing works

Inflammation: Depression Fans the Flames and Feasts on the Heat

Kiecolt-Glaser, J. K., Derry, H. M., & Fagundes, C. P. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.15020152 · Cited by 844 · see citing works

Immunosenescence of ageing

Gruver, A., Hudson, L., & Sempowski, G. (2007) · The Journal of Pathology · doi:10.1002/path.2104 · Cited by 834 · see citing works

Depression and Risk of Stroke Morbidity and Mortality: A Meta-analysis and Systematic Review

Pan, A., Sun, Q., Okereke, O. I., Rexrode, K. M., & Hu, F. B. (2011) · JAMA · doi:10.1001/jama.2011.1282 · Cited by 819 · see citing works

MRI-defined vascular depression

(1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.4.497 · Cited by 770 · see citing works

Inflammation Causes Mood Changes Through Alterations in Subgenual Cingulate Activity and Mesolimbic Connectivity

Harrison, N. A., Brydon, L., Walker, C., Gray, M. A., Steptoe, A., & Critchley, H. D. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.03.015 · Cited by 756 · see citing works

Inflammation-associated depression: From serotonin to kynurenine

Dantzer, R., O’Connor, J. C., Lawson, M. A., & Kelley, K. W. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.09.012 · Cited by 726 · see citing works

Immune activation in brain aging and neurodegeneration: too much or too little?

Lucin, K. M., & Wyss-Coray, T. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.039 · Cited by 679 · see citing works

Nortriptyline and Interpersonal Psychotherapy as Maintenance Therapies for Recurrent Major Depression: A Randomized Controlled Trial in Patients Older Than 59 Years

Reynolds III, C. F., Frank, E., Perel, J. M., Imber, S. D., Cornes, C., Miller, M. D., Mazumdar, S., Houck, P. R., Dew, M. A., Stack, J. A., et al. (1999) · JAMA · doi:10.1001/jama.281.1.39 · Cited by 659 · see citing works

Effects of Citalopram and Interpersonal Psychotherapy on Depression in Patients With Coronary Artery Disease: The Canadian Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy (CREATE) Trial

Lespérance, F., Frasure-Smith, N., Koszycki, D., Laliberté, M.-A., van Zyl, L. T., Baker, B., Swenson, J. R., Ghatavi, K., Abramson, B. L., Dorian, P., et al. (2007) · JAMA · doi:10.1001/jama.297.4.367 · Cited by 658 · see citing works

Depression and cardiovascular disease: Epidemiological evidence on their linking mechanisms

Penninx, B. W. J. H. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.003 · Cited by 576 · see citing works

Pramipexole for the treatment of depressive symptoms in patients with Parkinson's disease: a randomised, double-blind, placebo-controlled trial

Barone, P., Poewe, W., Albrecht, S., Debieuvre, C., Massey, D., Rascol, O., Tolosa, E., & Weintraub, D. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70106-x · Cited by 562 · see citing works

Associations of C-reactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of the Whitehall II study

Gimeno, D., Kivimäki, M., Brunner, E. J., Elovainio, M., De Vogli, R., Steptoe, A., Kumari, M., Lowe, G. D. O., Rumley, A., Marmot, M. G., et al. (2009) · Psychological Medicine · doi:10.1017/s0033291708003723 · Cited by 561 · see citing works

Clinically defined vascular depression

(1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.4.562 · Cited by 557 · see citing works

Interleukin-6 is elevated in the cerebrospinal fluid of suicide attempters and related to symptom severity

Lindqvist, D., Janelidze, S., Hagell, P., Erhardt, S., Samuelsson, M., Minthon, L., Hansson, O., Björkqvist, M., Träskman-Bendz, L., & Brundin, L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.01.030 · Cited by 524 · see citing works

Executive Dysfunction and Long-term Outcomes of Geriatric Depression

Alexopoulos, G. S., Meyers, B. S., Young, R. C., Kalayam, B., Kakuma, T., Gabrielle, M., Sirey, J. A., & Hull, J. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.3.285 · Cited by 486 · see citing works

Maintenance Treatment of Major Depression in Old Age

Reynolds, C. F., Dew, M. A., Pollock, B. G., Mulsant, B. H., Frank, E., Miller, M. D., Houck, P. R., Mazumdar, S., Butters, M. A., Stack, J. A., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052619 · Cited by 476 · see citing works

Functional connectivity in the cognitive control network and the default mode network in late-life depression

Alexopoulos, G. S., Hoptman, M. J., Kanellopoulos, D., Murphy, C. F., Lim, K. O., & Gunning, F. M. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.12.002 · Cited by 437 · see citing works

An Inflammatory Biomarker as a Differential Predictor of Outcome of Depression Treatment With Escitalopram and Nortriptyline

Uher, R., Tansey, K. E., Dew, T., Maier, W., Mors, O., Hauser, J., Dernovsek, M. Z., Henigsberg, N., Souery, D., Farmer, A., et al. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14010094 · Cited by 418 · see citing works

Depression in the Elderly

Taylor, W. D. (2014) · New England Journal of Medicine · doi:10.1056/nejmcp1402180 · Cited by 403 · see citing works

Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system

Dilger, R. N., & Johnson, R. W. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0208108 · Cited by 391 · see citing works

Increased Hippocampal Plaques and Tangles in Patients With Alzheimer Disease With a Lifetime History of Major Depression

Rapp, M. A., Beeri, M. S., Grossman, H. T., Sano, M. C., Perl, D. P., Purohit, D. P., Gorman, J. M., & Haroutunian, V. H. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.2.161 · Cited by 386 · see citing works

Serotonin signaling is associated with lower amyloid-β levels and plaques in transgenic mice and humans

Cirrito, J. R., Disabato, B. M., Restivo, J. L., Verges, D. K., Goebel, W. D., Sathyan, A., Hayreh, D., D'Angelo, G., Benzinger, T., Yoon, H., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107411108 · Cited by 370 · see citing works

Clinical Presentation of the "Depression-Executive Dysfunction Syndrome" of Late Life

Alexopoulos, G. S., Kiosses, D. N., Klimstra, S., Kalayam, B., & BRUCE, M. L. (2002) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200201000-00012 · Cited by 363 · see citing works

Prognosis of Depression in Old Age Compared to Middle Age: A Systematic Review of Comparative Studies

Mitchell, A. J., & Subramaniam, H. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.9.1588 · Cited by 348 · see citing works

Potential U.S. Population Impact of the 2017 ACC/AHA High Blood Pressure Guideline

Muntner, P., Carey, R. M., Gidding, S., Jones, D. W., Taler, S. J., Wright, J. T., & Whelton, P. K. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.10.073 · Cited by 339 · see citing works

Neuroinflammation Associated with Aging Sensitizes the Brain to the Effects of Infection or Stress

Sparkman, N. L., & Johnson, R. W. (2008) · NeuroImmunoModulation · doi:10.1159/000156474 · Cited by 330 · see citing works

Cerebral small vessel disease and risk of incident stroke, dementia and depression, and all-cause mortality: A systematic review and meta-analysis

Rensma, S. P., van Sloten, T. T., Launer, L. J., & Stehouwer, C. D. A. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.04.003 · Cited by 326 · see citing works

Association of Microvascular Dysfunction With Late-Life Depression

van Agtmaal, M. J. M., Houben, A. J. H. M., Pouwer, F., Stehouwer, C. D. A., & Schram, M. T. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.0984 · Cited by 313 · see citing works

Circulating IL-6 and CRP are associated with MRI findings in the elderly

Satizábal, C. L., Zhu, Y., Mazoyer, B. M., Dufouil, C., & Tzourio, C. (2012) · Neurology · doi:10.1212/wnl.0b013e318248e50f · Cited by 303 · see citing works

Microstructural White Matter Abnormalities and Remission of Geriatric Depression

Alexopoulos, G. S., Murphy, C. F., Gunning‐Dixon, F. M., Latoussakis, V., Kanellopoulos, D., Klimstra, S., Lim, K. O., & Hoptman, M. J. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07050744 · Cited by 297 · see citing works

Support for the Vascular Depression Hypothesis in Late-Life Depression: Results of a 2-Site, Prospective, Antidepressant Treatment Trial

Sheline, Y. I., Pieper, C. F., Barch, D. M., Welsh-Boehmer, K., McKinstry, R. C., MacFall, J. R., D’Angelo, G., Garcia, K. S., Gersing, K., Wilkins, C., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.204 · Cited by 291 · see citing works

Dorsolateral Prefrontal Cortex and Anterior Cingulate Cortex White Matter Alterations in Late-Life Depression

Bae, J. N., MacFall, J. R., Krishnan, K. R. R., Payne, M. E., Steffens, D. C., & Taylor, W. D. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.052 · Cited by 288 · see citing works

A Systematic Review and Meta‐Analysis of Placebo‐Controlled Antidepressant Studies in People with Depression and Dementia: [See Editorial Comments by Eric J. Lenze, MD on pp 0000–0000]

Nelson, J. C., & Devanand, D. P. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03355.x · Cited by 284 · see citing works

Efficacy, safety, and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in late life: a randomised, double-blind, placebo-controlled trial

Lenze, E. J., Mulsant, B. H., Blumberger, D. M., Karp, J. F., Newcomer, J. W., Anderson, S. J., Dew, M. A., Butters, M. A., Stack, J. A., Begley, A. E., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)00308-6 · Cited by 283 · see citing works

Problem-Solving Therapy and Supportive Therapy in Older Adults With Major Depression and Executive Dysfunction

Areán, P. A., Raue, P., Mackin, R. S., Kanellopoulos, D., McCulloch, C., & Alexopoulos, G. S. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09091327 · Cited by 275 · see citing works

Longitudinal Association of Amyloid Beta and Anxious-Depressive Symptoms in Cognitively Normal Older Adults

Donovan, N. J., Locascio, J. J., Marshall, G. A., Gatchel, J., Hanseeuw, B. J., Rentz, D. M., Johnson, K. A., Sperling, R. A., & Study, F. T. H. A. B. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2017.17040442 · Cited by 272 · see citing works

Efficacy of Antidepressants for Late-Life Depression: A Meta-Analysis and Meta-Regression of Placebo-Controlled Randomized Trials

Tedeschini, E., Levkovitz, Y., Iovieno, N., Ameral, V. E., Nelson, J. C., & Papakostas, G. I. (2011) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.10r06531 · Cited by 269 · see citing works

Right unilateral ultrabrief pulse ECT in geriatric depression: phase 1 of the pride study

Kellner, C. H., Husain, M. M., Knapp, R. G., McCall, W. V., Petrides, G., Rudorfer, M. V., Young, R. C., Sampson, S., McClintock, S. M., Mueller, M., et al. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.15081101 · Cited by 269 · see citing works

Lithium Treatment and Risk of Dementia

Kessing, L. V., Søndergård, L., Forman, J. L., & Andersen, P. K. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.11.1331 · Cited by 267 · see citing works

Prefrontal Dysfunction and Treatment Response in Geriatric Depression

Kalayam, B., & Alexopoulos, G. S. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.8.713 · Cited by 263 · see citing works

Epigenetic aging in major depressive disorder

Han, L. K. M., Aghajani, M., Clark, S. L., Chan, R. F., Hattab, M. W., Shabalin, A. A., Zhao, M., Kumar, G., Xie, L. Y., Jansen, R., et al. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2018.17060595 · Cited by 260 · see citing works

Conceptual convergence: increased inflammation is associated with increased basal ganglia glutamate in patients with major depression

Haroon, E., Fleischer, C. C., Felger, J. C., Chen, X., Woolwine, B. J., Patel, T., Hu, X. P., & Miller, A. H. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.206 · Cited by 250 · see citing works

Association of translocator protein total distribution volume with duration of untreated major depressive disorder: a cross-sectional study

Setiawan, E., Attwells, S., Wilson, A. A., Mizrahi, R., Rusjan, P., Miler, L., Xu, C., Sharma, S. K., Kish, S. J., Houle, S., et al. (2018) · The Lancet Psychiatry · doi:10.1016/s2215-0366(18)30048-8 · Cited by 245 · see citing works

The relationship between depression and frailty syndrome: a systematic review

Buigues, C., Padilla-Sánchez, C., Garrido, J. F., Navarro-Martínez, R., Ruiz-Ros, V., & Cauli, O. (2015) · Aging & Mental Health · doi:10.1080/13607863.2014.967174 · Cited by 235 · see citing works

A Systematic Review and Meta-Analysis of Brief Versus Ultrabrief Right Unilateral Electroconvulsive Therapy for Depression

Tor, P.-C., Bautovich, A., Wang, M.-J., Martin, D., Harvey, S. B., & Loo, C. (2015) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.14r09145 · Cited by 230 · see citing works

The inflammation hypothesis in geriatric depression

Alexopoulos, G. S., & Morimoto, S. S. (2011) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2672 · Cited by 225 · see citing works

Anterior Cingulate Activation and Error Processing During Interferon-Alpha Treatment

Capuron, L., Pagnoni, G., Demetrashvili, M., Woolwine, B. J., Nemeroff, C. B., Berns, G. S., & Miller, A. H. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.03.033 · Cited by 222 · see citing works

Cerebrovascular Disease and Evolution of Depressive Symptoms in the Cardiovascular Health Study

Steffens, D. C., Krishnan, K., Crump, C., & Burke, G. L. (2002) · Stroke · doi:10.1161/01.str.0000018405.59799.d5 · Cited by 221 · see citing works

Cerebral Hemodynamics and Vascular Risk Factors: Setting the Stage for Alzheimer's Disease

de la Torre, J. C. (2012) · Journal of Alzheimer's Disease · doi:10.3233/jad-2012-120793 · Cited by 219 · see citing works

Neuropsychological Differences Between Late-Onset and Recurrent Geriatric Major Depression

Rapp, M. A., Dahlman, K., Sano, M., Grossman, H. T., Haroutunian, V., & Gorman, J. M. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.4.691 · Cited by 219 · see citing works

Regional White Matter Hyperintensity Burden in Automated Segmentation Distinguishes Late-Life Depressed Subjects From Comparison Subjects Matched for Vascular Risk Factors

Sheline, Y. I., Price, J. L., Vaishnavi, S. N., Mintun, M. A., Barch, D. M., Epstein, A. A., Wilkins, C. H., Snyder, A. Z., Couture, L., Schechtman, K., et al. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07010175 · Cited by 213 · see citing works

Treatment of Vascular Depression Using Repetitive Transcranial Magnetic Stimulation

Jorge, R. E., Moser, D. J., Acion, L., & Robinson, R. G. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.45 · Cited by 211 · see citing works

Effect of Escitalopram vs Placebo Treatment for Depression on Long-term Cardiac Outcomes in Patients With Acute Coronary Syndrome: A Randomized Clinical Trial

Kim, J.-M., Stewart, R., Lee, Y.-S., Lee, H.-J., Kim, M. C., Kim, J.-W., Kang, H.-J., Bae, K.-Y., Kim, S.-W., Shin, I.-S., et al. (2018) · JAMA · doi:10.1001/jama.2018.9422 · Cited by 204 · see citing works

Treatments for Later-Life Depressive Conditions: A Meta-Analytic Comparison of Pharmacotherapy and Psychotherapy

Pinquart, M., Duberstein, P. R., & Lyness, J. M. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.9.1493 · Cited by 204 · see citing works

Meta-Analysis of Selective Serotonin Reuptake Inhibitors in Patients With Depression and Coronary Heart Disease

Pizzi, C., Rutjes, A. W. S., Costa, G. M., Fontana, F., Mezzetti, A., & Manzoli, L. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2010.11.017 · Cited by 203 · see citing works

Impact of SSRI Therapy on Risk of Conversion From Mild Cognitive Impairment to Alzheimer’s Dementia in Individuals With Previous Depression

Bartels, C., Wagner, M., Wolfsgruber, S., Ehrenreich, H., Schneider, A., & Initiative, F. T. A. D. N. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2017.17040404 · Cited by 202 · see citing works

Problem-Solving Therapy and Supportive Therapy in Older Adults With Major Depression and Executive Dysfunction: Effect on Disability

Alexopoulos, G. S., Raue, P. J., Kiosses, D. N., Mackin, R. S., Kanellopoulos, D., McCulloch, C., & Areán, P. A. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.177 · Cited by 199 · see citing works

The Interleukin 1 Beta (IL1B) Gene Is Associated with Failure to Achieve Remission and Impaired Emotion Processing in Major Depression

Baune, B. T., Dannlowski, U., Domschke, K., Janssen, D. G. A., Jordan, M. A., Ohrmann, P., Bauer, J., Biroš, E., Arolt, V., Kugel, H., et al. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.11.004 · Cited by 193 · see citing works

Depression as a Risk Factor for the Initial Presentation of Twelve Cardiac, Cerebrovascular, and Peripheral Arterial Diseases: Data Linkage Study of 1.9 Million Women and Men

Daskalopoulou, M., George, J., Walters, K. R., Osborn, D., Batty, G. D., Stogiannis, D., Rapsomaniki, E., Pujades‐Rodríguez, M., Denaxas, S., Udumyan, R., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153838 · Cited by 187 · see citing works

Altered Functioning of the Executive Control Circuit in Late-Life Depression: Episodic and Persistent Phenomena

Aizenstein, H. J., Butters, M. A., Wu, M., Mazurkewicz, L. M., Stenger, V. A., Gianaros, P. J., Becker, J. T., Reynolds, C. F., & Carter, C. S. (2009) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e31817b60af · Cited by 187 · see citing works

Citalopram, Methylphenidate, or Their Combination in Geriatric Depression: A Randomized, Double-Blind, Placebo-Controlled Trial

Lavretsky, H., Reinlieb, M., St. Cyr, N., Siddarth, P., Ercoli, L. M., & Senturk, D. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14070889 · Cited by 184 · see citing works

Neuropathological correlates of late-life depression in older people

Tsopelas, C., Stewart, R., Savva, G. M., Brayne, C., Ince, P., Thomas, A., & Matthews, F. E. (2011) · British Journal of Psychiatry · doi:10.1192/bjp.bp.110.078816 · Cited by 182 · see citing works

A Systematic Review of Treatments for Refractory Depression in Older People

Cooper, C., Katona, C., Lyketsos, K., Blazer, D., Brodaty, H., Rabins, P., de Mendonça Lima, C. A., & Livingston, G. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.10081165 · Cited by 176 · see citing works

Amyloid-Associated Depression: A Prodromal Depression of Alzheimer Disease?

Sun, X., Steffens, D. C., Au, R., Folstein, M., Summergrad, P., Yee, J., Rosenberg, I., Mwamburi, D. M., & Qiu, W. Q. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.5.542 · Cited by 174 · see citing works

Efficacy, tolerability, and cognitive effects of deep transcranial magnetic stimulation for late-life depression: a prospective randomized controlled trial

Kaster, T. S., Daskalakis, Z. J., Noda, Y., Knyahnytska, Y., Downar, J., Rajji, T. K., Levkovitz, Y., Zangen, A., Butters, M. A., Mulsant, B. H., et al. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0121-x · Cited by 174 · see citing works

Maintenance Treatment of Depression in Old Age: A Randomized, Double-blind, Placebo-Controlled Evaluation of the Efficacy and Safety of Donepezil Combined With Antidepressant Pharmacotherapy

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Dopaminergic mechanism of antidepressant action in depressed patients

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Amyloid Hypothesis: Is There a Role for Antiamyloid Treatment in Late-Life Depression?

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Personalised intervention for people with depression and severe COPD

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Two Behavioral Interventions for Patients with Major Depression and Severe COPD

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State of the Science of Neural Systems in Late‐Life Depression: Impact on Clinical Presentation and Treatment Outcome

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Exploration of 27 plasma immune markers: a cross-sectional comparison of 64 old psychiatric inpatients having unipolar major depression and 18 non-depressed old persons

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Neuropathological analysis of lacunes and microvascular lesions in late-onset depression: Vascular pathology in late-onset depression

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Clinical Case Management versus Case Management with Problem-Solving Therapy in Low-Income, Disabled Elders with Major Depression: A Randomized Clinical Trial

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Tau in Late-Life Depression: A Systematic Review and Meta-Analysis

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Olmesartan, an Angiotensin II Receptor Blocker, Restores Cerebral Hypoperfusion in Elderly Patients With Hypertension

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Network-Guided Transcranial Magnetic Stimulation for Depression

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“Engage” therapy: Prediction of change of late-life major depression

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Inflammation and Late-Life Depression: Unraveling the Complex Relationship and Potential Therapeutic Strategies

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Magnetic Resonance Spectroscopy Insights Into Late‐Life Depression: Advances in Brain Metabolic Profiling

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Relationship Between Socioeconomic Status and Depression in Older Adults: The Roles of Cognitive Function and Sleep Quality

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Depressive Disorders

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Der multimodale Behandlungsansatz der Altersdepression

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Der multimodale Behandlungsansatz der Altersdepression

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Depression as an early symptom and risk factor of dementia - a narrative review

Permoda-Pachuta, A., Obszański, P., Grad, Z., Futyma-Jędrzejewska, M., Ziemecki, P., & Dominiak, M. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1786179

Grip strength in the association between frailty and new-onset depression in older adults: a multinational longitudinal study

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The Mediating Role of Eudaimonic Well‐Being in the Effect of Perceived Poverty on Quality of Life in the Elderly

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Der multimodale Behandlungsansatz der Altersdepression

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Trends and disparities in depression-related mortality among older adults in the United States, 1999–2020

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Cerebrovascular Disease, Aging, and Depression: Clinical Features, Pathophysiology, and Treatment

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State of the Science of Neural Systems in Late‐Life Depression: Impact on Clinical Presentation and Treatment Outcome

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The enigma of vascular depression in old age: a critical update

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Pathomechanisms of Vascular Depression in Older Adults

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Late-Onset Depression in an Aging World: A Multidimensional Perspective on Risks, Mechanisms, and Treatment

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