Cited by 167Sesquiterpenes and Asteraceae StudiesNatural Compounds in Disease TreatmentPhytochemistry and Biological Activities

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Effect of two active compounds obtained from the essential oil of Cordia verbenacea on the acute inflammatory responses elicited by LPS in the rat paw

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Medeiros, R, Passos, G F, Vitor, C E, Koepp, J, Mazzuco, T L, Pianowski, L F, Campos, M M, Calixto, J B·2007·British Journal of Pharmacology

DOI 10.1038/sj.bjp.0707270PMC PMC2013990

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Abstract

BACKGROUND AND PURPOSE: alpha-Humulene and trans-caryophyllene are sesquiterpene compounds identified in the essential oil of Cordia verbenacea which display topical and systemic anti-inflammatory effects in different experimental models. However, the molecular mechanisms through which they exert their anti-inflammatory activity still remain unclear. Here, we evaluate the effects of alpha-humulene and trans-caryophyllene on the acute inflammatory responses elicited by LPS. EXPERIMENTAL APPROACH: The biological activities of alpha-humulene and trans-caryophyllene were investigated in a model of acute inflammation in rat paw, induced by LPS and characterized by paw oedema, neutrophil recruitment, cytokine production, activation of MAP kinases and NF-kappaB and up-regulated expression of kinin B(1) receptors. KEY RESULTS: Treatment with either alpha-humulene or trans-caryophyllene effectively reduced neutrophil migration and activation of NF-kappaB induced by LPS in the rat paw. However, only alpha-humulene significantly reduced the increase in TNF-alpha and IL-1beta levels, paw oedema and the up-regulation of B(1) receptors following treatment with LPS. Both compounds failed to interfere with the activation of the MAP kinases, ERK, p38 and JNK. CONCLUSIONS AND IMPLICATIONS: Both alpha-humulene and trans-caryophyllene inhibit the LPS-induced NF-kappaB activation and neutrophil migration, although only alpha-humulene had the ability to prevent the production of pro-inflammatory cytokines TNF-alpha and IL-1beta and the in vivo up-regulation of kinin B(1) receptors. These data provide additional molecular and functional insights into the beneficial effects of the sesquiterpenes alpha-humulene and trans-caryophyllene isolated from the essential oil of Cordia verbenacea as agents for the management of inflammatory diseases.

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Authors: Medeiros, R., Passos, G. F., Vitor, C. E., Koepp, J., Mazzuco, T. L., Pianowski, L. F., Campos, M. M., & Calixto, J. B.
Affiliations: Universidade Federal de Santa Catarina (BR)
Pontifícia Universidade Católica do Rio Grande do Sul (BR)
ORCID: Medeiros, R
Passos, G F
Mazzuco, T L
Campos, M M
Venue: British Journal of Pharmacology
Publisher: Wiley
Published: 2007-07
Volume: 151
Issue: 5
Pages: 618-627
ISSN: 0007-1188 (ISSN-L)
1476-5381
DOI: 10.1038/sj.bjp.0707270
PMC: PMC2013990
OpenAlex: W1984871487
Cited by: 167
References: 46
Citations by year: 2026: 3 · 2025: 8 · 2024: 7 · 2023: 11 · 2022: 10 · 2021: 12 · 2020: 12 · 2019: 11 · 2018: 11 · 2017: 6 · 2016: 9 · 2015: 16 · 2014: 8 · 2013: 6 · 2012: 6
FWCI: 2.23
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 578 d)
Locations: British Journal of Pharmacology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina
Topics: Physical Sciences › Chemistry › Organic Chemistry › Sesquiterpenes and Asteraceae Studies
Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
Keywords: Cordia verbenacea, α-humulene, β-caryophyllene, sesquiterpenes, essential oils, anti-inflammatory activity, acute inflammation, lipopolysaccharide, paw edema, neutrophil migration, NF-κB, mitogen-activated protein kinase, TNF-α, IL-1β, kinin B1 receptor, inflammatory cytokines
MeSH terms: Polycyclic Sesquiterpenes, Animals, Anti-Inflammatory Agents, Non-Steroidal, Cell Nucleus, Cytosol, Edema, Foot, Lipopolysaccharides, Male, Peroxidase, Neutrophils, Oils, Volatile, Sesquiterpenes, Tumor Necrosis Factor-alpha, Blotting, Western, Up-Regulation, NF-kappa B, Rats, Wistar, Reverse Transcriptase Polymerase Chain Reaction, Neutrophil Infiltration, Mitogen-Activated Protein Kinases, Electrophoretic Mobility Shift Assay, Cordia, Receptor, Bradykinin B1, Rats, Interleukin-1beta

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Effect of two active compounds obtained from the essential oil of Cordia verbenacea on the acute inflammatory responses elicited by LPS in the rat paw

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