The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
GPR55: a new member of the cannabinoid receptor clan?
Open accessAbstract
In this issue of the British Journal of Pharmacology, Ryberg et al. present convincing in vitro evidence that the orphan GPCR, GPR55, is a cannabinoid receptor. GPR55 was activated by a range of plant, synthetic and endogenous cannabinoids and blocked by the non‐psychoactive phytocannabinoid, cannabidiol. Their experiments have revealed several differences between the pharmacology of GPR55 and the established cannabinoid CB 1 and CB 2 receptors. For example, the CB 1 receptor antagonist, AM251, activated GPR55 and the main psychoactive constituent of cannabis, Δ 9‐tetrahydrocannabinol, displayed greater efficacy at GPR55 than at CB 1 or CB 2 receptors. They also compared the distribution of GPR55 and CB 1 mRNA in mouse and report that GPR55 couples to Gα 13, that it is activated by virodhamine, palmitoylethanolamide and oleoylethanolamide, and that virodhamine displays relatively high efficacy as a GPR55 agonist. Still to be identified are the main roles played by GPR55 in health and disease and any potential therapeutic benefits of activating or blocking this receptor. British Journal of Pharmacology (2007) 152, 984–986; doi:10.1038/sj.bjp.0707464; published online 17 September 2007
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Mechoulam, R., Ben-Shabat, S., Hanus, L., Ligumsky, M., Kaminski, N. E., Schatz, A. R., Gopher, A., Almog, S., Martin, B. R., Compton, D. R., et al. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00109-d · Cited by 2,913
Self-citation2-Arachidonoylgylcerol: A Possible Endogenous Cannabinoid Receptor Ligand in Brain
Sugiura, T., Kondo, S., Sukagawa, A., Nakane, S., Shinoda, A., Itoh, K., Yamashita, A., & Waku, K. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2437 · Cited by 2,196
The orphan receptor GPR55 is a novel cannabinoid receptor
Ryberg, E., Larsson, N., Sjögren, S., Hjorth, S., Hermansson, N., Leonova, J., Elebring, T., Nilsson, K., Drmota, T., & Greasley, P. J. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707460 · Cited by 1,568
Cited by
Endocannabinoid-Mediated Control of Synaptic Transmission
Kano, M., Ohno-Shosaku, T., Hashimotodani, Y., Uchigashima, M., & Watanabe, M. (2009) · Physiological Reviews · doi:10.1152/physrev.00019.2008 · Cited by 1,529
Emerging strategies for exploiting cannabinoid receptor agonists as medicines
Pertwee, R. G. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2008.00048.x · Cited by 436
Self-citationCabral, G. A., & Griffin-Thomas, L. (2009) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399409000957 · Cited by 408
Deiana, S., Watanabe, A., Yamasaki, Y., Amada, N., Arthur, M., Fleming, S., Woodcock, H., Dorward, P., Pigliacampo, B., Close, S., et al. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2415-0 · Cited by 398
Iannotti, F. A., Di Marzo, V., & Petrosino, S. (2016) · Progress in Lipid Research · doi:10.1016/j.plipres.2016.02.002 · Cited by 357
Metadata
- Authors
- Pertwee, R. G.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2007-12
- Volume
- 152
- Issue
- 7
- Pages
- 984-986
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W1485798291
- Cited by
- 240
- References
- 3
- FWCI
- 11.75
- Type
- journal article
- Language
- en
- Open access
- bronze
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