Emerging strategies for exploiting cannabinoid receptor agonists as medicines

Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor

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Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

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International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors

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2-Arachidonoylgylcerol: A Possible Endogenous Cannabinoid Receptor Ligand in Brain

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The diverse CB 1 and CB 2 receptor pharmacology of three plant cannabinoids: Δ 9 ‐tetrahydrocannabinol, cannabidiol and Δ 9 ‐tetrahydrocannabivarin

Pertwee, R. G. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707442 · Cited by 1,953 · see citing works

Guide to receptors and channels (GRAC), 5th edition

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The orphan receptor GPR55 is a novel cannabinoid receptor

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Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study

Gaal, L. F. V., Rissanen, A., Scheen, A. J., Ziegler, O., & Rössner, S. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66374-x · Cited by 1,500 · see citing works

Identification and Functional Characterization of Brainstem Cannabinoid CB₂Receptors

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Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia

Després, J.-P., Golay, A., & Sjöström, L. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa044537 · Cited by 1,392 · see citing works

Cannabinoid CB2 receptors: immunohistochemical localization in rat brain

Gong, J.-P., Onaivi, E. S., Ishiguro, H., Liu, Q.-R., Tagliaferro, P. A., Brusco, A., & Uhl, G. R. (2006) · Brain Research · doi:10.1016/j.brainres.2005.11.035 · Cited by 820 · see citing works

Targeting the endocannabinoid system: to enhance or reduce?

Marzo, V. D. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2553 · Cited by 798 · see citing works

Cannabinoid pharmacology: the first 66 years

Pertwee, R. G. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706406 · Cited by 783 · see citing works

Cannabinoid receptors and pain

Pertwee, R. G. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00031-9 · Cited by 741 · see citing works

Cannabinoids: potential anticancer agents

Guzmán, M. (2003) · Nature Reviews. Cancer · doi:10.1038/nrc1188 · Cited by 740 · see citing works

GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current

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Pharmacological Actions of Cannabinoids

Pertwee, R. G. (2005) · Springer eBooks · doi:10.1007/3-540-26573-2_1 · Cited by 600 · see citing works

Do cannabis-based medicinal extracts have general or specific effects on symptoms in multiple sclerosis? A double-blind, randomized, placebo-controlled study on 160 patients

Wade, D. T., Makela, P., Robson, P., House, H., & Bateman, C. (2004) · Multiple Sclerosis Journal · doi:10.1191/1352458504ms1082oa · Cited by 589 · see citing works

Cannabinoid receptors and their ligands

Pertwee, R. G., & Ross, R. A. (2002) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2001.0341 · Cited by 558 · see citing works

Pharmacology of Cannabinoid Receptor Ligands

Pertwee, R. G. (1999) · Current Medicinal Chemistry · doi:10.2174/0929867306666220401124036 · Cited by 530 · see citing works

Guide to Receptors and Channels (GRAC), 3rd edition

Alexander, S. P. H., Mathie, A. A., & Peters, J. A. (2008) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707746 · Cited by 510 · see citing works

COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord

Yiangou, Y., Facer, P., Durrenberger, P., Chessell, I. P., Naylor, A., Bountra, C., Banati, R. R., & Anand, P. (2006) · BMC Neurology · doi:10.1186/1471-2377-6-12 · Cited by 509 · see citing works

Does the cannabinoid dronabinol reduce central pain in multiple sclerosis? Randomised double blind placebo controlled crossover trial

Svendsen, K. B., Jensen, T. S., & Bach, F. W. (2004) · BMJ · doi:10.1136/bmj.38149.566979.ae · Cited by 500 · see citing works

Modulation of the cannabinoid CB 2 receptor in microglial cells in response to inflammatory stimuli

Maresz, K., Carrier, E. J., Ponomarev, E. D., Hillard, C. J., & Dittel, B. N. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03380.x · Cited by 483 · see citing works

Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice

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The endogenous cannabinoid system protects against colonic inflammation

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Identification of GPR55 as a lysophosphatidylinositol receptor

Oka, S., Nakajima, K., Yamashita, A., Kishimoto, S., & Sugiura, T. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.08.078 · Cited by 460 · see citing works

Inverse agonism and neutral antagonism at cannabinoid CB1 receptors

Pertwee, R. G. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.10.025 · Cited by 444 · see citing works

Cannabinoid CB ₂ receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain

Guindon, J., & Hohmann, A. G. (2008) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707531 · Cited by 423 · see citing works

Induction of CB2 receptor expression in the rat spinal cord of neuropathic but not inflammatory chronic pain models

Zhang, J., Hoffert, C., Vu, H. K., Groblewski, T., Ahmad, S., & O'Donnell, D. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02704.x · Cited by 419 · see citing works

Allosteric Modulation of the Cannabinoid CB1 Receptor

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The Endogenous Cannabinoid System Regulates Seizure Frequency and Duration in a Model of Temporal Lobe Epilepsy

Wallace, M. J., Blair, R. E., Falenski, K. W., Martin, B. R., & DeLorenzo, R. J. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.051920 · Cited by 393 · see citing works

The endogenous cannabinoid system protects against colonic inflammation

Massa, F., Marsicano, G., Hermann, H., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419465 · Cited by 387 · see citing works

The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons.

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Analgesic Effect of the Synthetic Cannabinoid CT-3 on Chronic Neuropathic Pain: A Randomized Controlled Trial

Karst, M., Salim, K., Burstein, S., Conrad, I., Hoy, L., & Schneider, U. (2003) · JAMA · doi:10.1001/jama.290.13.1757 · Cited by 340 · see citing works

Blood–Brain Barrier Pathology in Alzheimer's and Parkinson's Disease: Implications for Drug Therapy

Desai, B. S., Monahan, A. J., Carvey, P. M., & Hendey, B. (2007) · Cell Transplantation · doi:10.3727/000000007783464731 · Cited by 339 · see citing works

Cannabinoids and neuroinflammation

Walter, L. M., & Stella, N. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705667 · Cited by 334 · see citing works

Cannabinoids Elicit Antidepressant-Like Behavior and Activate Serotonergic Neurons through the Medial Prefrontal Cortex

Bambico, F. R., Katz, N., Debonnel, G., & Gobbi, G. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1636-07.2007 · Cited by 325 · see citing works

Behavioural and biochemical evidence for interactions between Δ9‐tetrahydrocannabinol and nicotine

Valjent, E., Mitchell, J., Besson, M., Caboche, J., & Maldonado, R. J. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704479 · Cited by 321 · see citing works

Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond

Pertwee, R. G. (2008) · Addiction Biology · doi:10.1111/j.1369-1600.2008.00108.x · Cited by 314 · see citing works

Cannabinoids as Therapeutic Agents

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Synergistic interactions between cannabinoid and opioid analgesics

Cichewicz, D. L. (2004) · Life Sciences · doi:10.1016/j.lfs.2003.09.038 · Cited by 305 · see citing works

Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin

Ständer, S., Schmelz, M., Metze, D., Luger, T. A., & Rukwied, R. (2005) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2005.01.007 · Cited by 300 · see citing works

CB2 receptor-mediated antihyperalgesia: possible direct involvement of neural mechanisms

Beltramo, M., Bernardini, N., Bertorelli, R., Campanella, M., Nicolussi, E., Fredduzzi, S., & Reggiani, A. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04684.x · Cited by 290 · see citing works

Coexpression of the cannabinoid receptor type 1 with dopamine and serotonin receptors in distinct neuronal subpopulations of the adult mouse forebrain

Hermann, H., Marsicano, G., & Lutz, B. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00509-7 · Cited by 290 · see citing works

Cannabinoid CB1 Receptor Antagonists as Promising New Medications for Drug Dependence

Foll, B. L., & Goldberg, S. R. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.077974 · Cited by 290 · see citing works

Adolescent Cannabis Exposure Alters Opiate Intake and Opioid Limbic Neuronal Populations in Adult Rats

Ellgren, M., Spano, S., & Hurd, Y. L. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301127 · Cited by 287 · see citing works

Cannabinoid CB 2 receptors in the gastrointestinal tract: a regulatory system in states of inflammation

Wright, K. L., Duncan, M., & Sharkey, K. A. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707486 · Cited by 269 · see citing works

Efficacy of Dronabinol as an Adjuvant Treatment for Chronic Pain Patients on Opioid Therapy

Narang, S., Gibson, D., Wasan, A. D., Ross, E. L., Michna, E., Nedeljkovic, S. S., & Jamison, R. N. (2008) · The Journal of Pain · doi:10.1016/j.jpain.2007.10.018 · Cited by 257 · see citing works

Effects of Cannabinoids on Neurotransmission

Szabó, B., & Schlicker, E. (2005) · Springer eBooks · doi:10.1007/3-540-26573-2_11 · Cited by 256 · see citing works

Cannabinoid CB1‐receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation

Izzo, A. A., Fezza, F., Capasso, R., Bisogno, T., Pinto, L., Iuvone, T., Esposito, G., Mascolo, N., Marzo, V. D., & Capasso, F. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704293 · Cited by 255 · see citing works

Peripheral nerve injury induces cannabinoid receptor 2 protein expression in rat sensory neurons

Wotherspoon, G., Fox, A., McIntyre, P., Colley, S., Bevan, S., & Winter, J. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.009 · Cited by 251 · see citing works

The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effects

Johns, D. G., Behm, D. J., Walker, D. J., Zhang, A., Shapland, E. M., Daniels, D. A., Riddick, M., Dowell, S. J., Staton, P. C., Green, P., et al. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707419 · Cited by 242 · see citing works

GPR55: a new member of the cannabinoid receptor clan?

Pertwee, R. G. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707464 · Cited by 241 · see citing works

Cannabinoid Receptor as a Novel Target for the Treatment of Prostate Cancer

Sarfaraz, S., Afaq, F., Adhami, V. M., & Mukhtar, H. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3410 · Cited by 241 · see citing works

An open-label pilot study of cannabis-based extracts for bladder dysfunction in advanced multiple sclerosis

BRADY, C. M., Dasgupta, R., Dalton, C. M., Wiseman, O. J., Berkley, K. J., & Fowler, C. J. (2004) · Multiple Sclerosis Journal · doi:10.1191/1352458504ms1063oa · Cited by 240 · see citing works

Endocannabinoids and cannabinoid receptors in ischaemia-reperfusion injury and preconditioning.

Pacher, P., & Haskó, G. (2008) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707582 · Cited by 217 · see citing works

The analgesic effect of oral delta-9-tetrahydrocannabinol (THC), morphine, and a THC-morphine combination in healthy subjects under experimental pain conditions

Naef, M., Curatolo, M., Petersen-Felix, S., Arendt-Nielsen, L., Zbinden, A., & Brenneisen, R. (2003) · Pain · doi:10.1016/s0304-3959(03)00163-5 · Cited by 209 · see citing works

The CB2 cannabinoid agonist AM‐1241 prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset

Shoemaker, J. L., Seely, K. A., Reed, R. L., Crow, J. P., & Prather, P. L. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04346.x · Cited by 208 · see citing works

Site-specific increases in peripheral cannabinoid receptors and their endogenous ligands in a model of neuropathic pain

Mitrirattanakul, S., Ramakul, N., Guerrero, A. V., Matsuka, Y., Ono, T., Iwase, H., Mackie, K., Faull, K. F., & Spigelman, I. (2006) · Pain · doi:10.1016/j.pain.2006.06.016 · Cited by 207 · see citing works

The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids

Pertwee, R. G. (2005) · The AAPS Journal · doi:10.1208/aapsj070364 · Cited by 204 · see citing works

Emerging role of cannabinoids in gastrointestinal and liver diseases: basic and clinical aspects

Izzo, A. A., & Camilleri, M. (2008) · Gut · doi:10.1136/gut.2008.148791 · Cited by 197 · see citing works

Upregulation of spinal cannabinoid-1-receptors following nerve injury enhances the effects of Win 55,212-2 on neuropathic pain behaviors in rats

Lim, G., Sung, B., Ji, R.-R., & Mao, J. (2003) · Pain · doi:10.1016/s0304-3959(03)00242-2 · Cited by 195 · see citing works

Neuropsychobiological Evidence for the Functional Presence and Expression of Cannabinoid CB2 Receptors in the Brain

Onaivi, E. S. (2006) · Neuropsychobiology · doi:10.1159/000100778 · Cited by 187 · see citing works

Cannabinoid Mechanisms of Pain Suppression

Walker, J. M., & Hohmann, A. G. (2005) · Handbook of experimental pharmacology · doi:10.1007/3-540-26573-2_17 · Cited by 177 · see citing works

PSNCBAM‐1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats

Horswill, J. G., Bali, U., Shaban, S. N., Keily, J. F., Jeevaratnam, P., Babbs, A. J., Reynet, C., & In, P. W. K. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707347 · Cited by 175 · see citing works

Agonists of cannabinoid receptor 1 and 2 inhibit experimental colitis induced by oil of mustard and by dextran sulfate sodium

Kimball, E. S., Schneider, C. R., Wallace, N. H., & Hornby, P. J. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00407.2005 · Cited by 173 · see citing works

Actions of cannabinoid receptor ligands on rat cultured sensory neurones: implications for antinociception

Ross, R. A., Coutts, A. A., McFarlane, S. M., Anavi-Goffer, S., Irving, A. J., Pertwee, R. G., MacEwan, D. J., & Scott, R. H. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(00)00135-0 · Cited by 172 · see citing works

Overexpression of cannabinoid receptors CB1 and CB2 correlates with improved prognosis of patients with hepatocellular carcinoma

Xu, X., Liu, Y., Huang, S., Liu, G., Xie, C., Zhou, J., Fan, W., Li, Q., Wang, Q., Zhong, D., et al. (2006) · Cancer Genetics and Cytogenetics · doi:10.1016/j.cancergencyto.2006.06.014 · Cited by 171 · see citing works

Loss of Cannabinoid Receptor 1 Accelerates Intestinal Tumor Growth

Wang, D., Wang, H., Wei, N., Backlund, M. G., Dey, S. K., & DuBois, R. N. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0896 · Cited by 166 · see citing works

Cannabinoid CB 2 Receptor Activation Decreases Cerebral Infarction in a Mouse Focal Ischemia/Reperfusion Model

Zhang, M., Martin, B. R., Adler, M. W., Razdan, R. K., Jallo, J., & Tuma, R. F. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600447 · Cited by 165 · see citing works

Long-term effect of CB1 blockade with rimonabant on cardiometabolic risk factors: two year results from the RIO-Europe Study.

Van Gaal, L. F., Scheen, A. J., Rissanen, A. M., Rössner, S., Hanotin, C., & Ziegler, O. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn076 · Cited by 156 · see citing works

Histamine induced responses are attenuated by a cannabinoid receptor agonist in human skin

Dvorak, M., Watkinson, A., McGlone, F. P., & Rukwied, R. (2003) · Inflammation Research · doi:10.1007/s00011-003-1162-z · Cited by 154 · see citing works

Antinociceptive Synergy between Δ9-Tetrahydrocannabinol and Opioids after Oral Administration

Cichewicz, D. L., & McCarthy, E. A. (2003) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.045575 · Cited by 154 · see citing works

AM1241, a cannabinoid CB2 receptor selective compound, delays disease progression in a mouse model of amyotrophic lateral sclerosis

Kim, K., Moore, D. H., Makriyannis, A., & Abood, M. E. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.05.025 · Cited by 152 · see citing works

The Biosynthesis, Fate and Pharmacological Properties of Endocannabinoids

Marzo, V. D., Bisogno, T., & PETROCELLIS, L. D. (2005) · Handbook of experimental pharmacology · doi:10.1007/3-540-26573-2_5 · Cited by 149 · see citing works

Cannabinoid CB 2 receptors in the enteric nervous system modulate gastrointestinal contractility in lipopolysaccharide-treated rats

Duncan, M., Mouihate, A., Mackie, K., Keenan, C. M., Buckley, N. E., Davison, J. S., Patel, K. D., Pittman, Q. J., & Sharkey, K. A. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90285.2008 · Cited by 145 · see citing works

Dimerization of G protein-coupled receptors: CB1 cannabinoid receptors as an example

Wager‐Miller, J., Westenbroek, R. E., & Mackie, K. (2002) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(02)00151-2 · Cited by 144 · see citing works

Behavioral, pharmacological and molecular characterization of the saphenous nerve partial ligation: a new model of neuropathic pain

Walczak, J.-S., Pichette, V., Leblond, F., Desbiens, K., & Beaulieu, P. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.02.010 · Cited by 133 · see citing works

An endogenous cannabinoid tone attenuates cholera toxin-induced fluid accumulation in mice

Izzo, A. A., Capasso, F., Costagliola, A., Bisogno, T., Marsicano, G., Ligresti, A., Matias, I., Capasso, R., Pinto, L., Borrelli, F., et al. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00892-8 · Cited by 132 · see citing works

The Role of the Cannabinoid CB2 Receptor in Pain Transmission and Therapeutic Potential of Small Molecule CB2 Receptor Agonists

Whiteside, G. T., Lee, G. P., & Valenzano, K. J. (2007) · Current Medicinal Chemistry · doi:10.2174/092986707780363023 · Cited by 132 · see citing works

A comparative analysis of the potential of cannabinoids and ondansetron to suppress cisplatin-induced emesis in the Suncus murinus (house musk shrew)

Kwiatkowska, M., Parker, L., Burton, P., & Mechoulam, R. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1739-9 · Cited by 131 · see citing works

Pain relief with oral cannabinoids in familial Mediterranean fever

Holdcroft, A., Smith, M., Jacklin, A., Hodgson, H. J. F., Smith, B., Newton, M., & Evans, F. J. (1997) · Anaesthesia · doi:10.1111/j.1365-2044.1997.139-az0132.x · Cited by 129 · see citing works

Lack of Analgesia by Oral Standardized Cannabis Extract on Acute Inflammatory Pain and Hyperalgesia in Volunteers

Kraft, B., Frickey, N., Kaufmann, R. M., Reif, M., Frey, R., Gustorff, B., & Kress, H. G. (2008) · Anesthesiology · doi:10.1097/aln.0b013e31817881e1 · Cited by 129 · see citing works

Activation of endocannabinoid transmission induces antidepressant-like effects in rats.

Adamczyk, P., Gołda, A., McCreary, A. C., Filip, M., & Przegaliński, E. (2008) · PubMed · Cited by 123 · see citing works

Spinal Cannabinoid Receptor Type 2 Activation Reduces Hypersensitivity and Spinal Cord Glial Activation after Paw Incision

Romero-Sandoval, A. E., & Eisenach, J. C. (2007) · Anesthesiology · doi:10.1097/01.anes.0000264765.33673.6c · Cited by 122 · see citing works

Biology and therapeutic potential of cannabinoid CB2receptor inverse agonists

Lunn, C. A., Reich, E., Fine, J. S., Lavey, B. J., Kozlowski, J. A., Hipkin, R. W., Lundell, D. J., & Bober, L. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707480 · Cited by 119 · see citing works

In vitropharmacological characterization of AM1241: a protean agonist at the cannabinoid CB2receptor?

Yao, B. B., Mukherjee, S., Fan, Y., Garrison, T. R., Daza, A. V., Grayson, G. K., Hooker, B. A., Dart, M. J., Sullivan, J. P., & Meyer, M. D. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706838 · Cited by 118 · see citing works

Modulation of the balance between cannabinoid CB1 and CB2 receptor activation during cerebral ischemic/reperfusion injury

Zhang, M., Martin, B. R., Adler, M. W., Razdan, R. K., Ganea, D., & Tuma, R. F. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.01.022 · Cited by 116 · see citing works

Anti-inflammatory property of the cannabinoid receptor-2-selective agonist JWH-133 in a rodent model of autoimmune uveoretinitis

Xu, H., Cheng, C. L., Chen, M., Manivannan, A., Cabay, L., Pertwee, R. G., Coutts, A. A., & Forrester, J. V. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0307159 · Cited by 116 · see citing works

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Win 55212-2, a cannabinoid receptor agonist, attenuates leukocyte/endothelial interactions in an experimental autoimmune encephalomyelitis model

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Cannabinoid agonists attenuate capsaicin-induced responses in human skin

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Cannabinoids and Neuroprotection in Basal Ganglia Disorders

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Role of the cannabinoid system in the effects induced by nicotine on anxiety-like behaviour in mice

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Evidence for a novel functional role of cannabinoid CB₂ receptors in the thalamus of neuropathic rats

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Cannabinoids and the Digestive Tract

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Cannabinoid receptors in acute and chronic complications of atherosclerosis

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Behavioral effects of cannabinoids show differential sensitivity to cannabinoid receptor blockade and tolerance development

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Blockade of central cyclooxygenase (COX) pathways enhances the cannabinoid-induced antinociceptive effects on inflammatory temporomandibular joint (TMJ) nociception

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The endocannabinoid system modulates a transient TNF pathway that induces neural stem cell proliferation

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The cannabinoid receptor agonist, WIN 55, 212-2, attenuates tumor-evoked hyperalgesia through peripheral mechanisms

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Contribution of CB1 blockade to the management of high-risk abdominal obesity

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Repeated exposure to Δ9-tetrahydrocannabinol alters heroin-induced locomotor sensitisation and Fos-immunoreactivity

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Reciprocal inhibition of G-protein signaling is induced by CB1 cannabinoid and GABAB receptor interactions in rat hippocampal membranes

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Enhancement of transdermal fentanyl and buprenorphine antinociception by transdermal Δ9-tetrahydrocannabinol

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The serotonin1A receptor agonist 8-OHDPAT reverses Δ9-tetrahydrocannabinol-induced impairment of spatial memory and reduction of acetylcholine release in the dorsal hippocampus in rats

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Direct suppression of autoreactive lymphocytes in the central nervous system via the CB2 receptor

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Co-administration of THC and MDMA (‘Ecstasy’) Synergistically Disrupts Memory in Rats

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