Cited by 418Cannabis and Cannabinoid ResearchPain Mechanisms and TreatmentsAdenosine and Purinergic Signaling

Emerging role of the cannabinoid receptor CB 2 in immune regulation: therapeutic prospects for neuroinflammation

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Cabral, Guy A., Griffin-Thomas, LaToya·2009·Expert Reviews in Molecular Medicine

Abstract

There is now a large body of data indicating that the cannabinoid receptor type 2 (CB 2 ) is linked to a variety of immune events. This functional relevance appears to be most salient in the course of inflammation, a process during which there is an increased number of receptors that are available for activation. Studies aimed at elucidating signal transduction events resulting from CB 2 interaction with its native ligands, and of the role of exogenous cannabinoids in modulating this process, are providing novel insights into the role of CB 2 in maintaining a homeostatic immune balance within the host. Furthermore, these studies suggest that the CB 2 may serve as a selective molecular target for therapeutic manipulation of untoward immune responses, including those associated with a variety of neuropathies that exhibit a hyperinflammatory component.

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Authors
Cabral, G. A., & Griffin-Thomas, L.
Affiliations
Virginia Commonwealth University (US)
Corresponding author
Cabral, Guy A.
Venue
Expert Reviews in Molecular Medicine
Published
2009-01
Volume
11
Pages
e3-e3
ISSN
1462-3994 (ISSN-L)
OpenAlex
W2023366312
Cited by
408
References
190
Citations by year
2026: 25 · 2025: 37 · 2024: 22 · 2023: 24 · 2022: 23 · 2021: 29 · 2020: 34 · 2019: 24 · 2018: 28 · 2017: 37 · 2016: 13 · 2015: 15 · 2014: 22 · 2013: 22 · 2012: 17
FWCI
1.82
Type
journal article
Language
en
Open access
Locations
  • Expert Reviews in Molecular Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • University of Cambridge
  • National Institutes of Health
  • National Institute on Drug Abuse (DA005832, R01DA005832, R01DA029532)
Topics
  • Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
Keywords
CB2 receptor, immune regulation, neuroinflammation, signal transduction, exogenous cannabinoids, immune homeostasis, neuropathy, hyperinflammation, therapeutic target
MeSH terms
Amino Acid Sequence, Animals, Humans, Inflammation, Molecular Sequence Data, Nervous System, Research, Neuroimmunomodulation, Receptor, Cannabinoid, CB2

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