Ubiquitin, TAK1 and IKK: is there a connection?

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IκB kinase β (IKKβ/IKK2/IKBKB)—A key molecule in signaling to the transcription factor NF-κB

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ATM- and NEMO-Dependent ELKS Ubiquitination Coordinates TAK1-Mediated IKK Activation in Response to Genotoxic Stress

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TAK1-dependent Signaling Requires Functional Interaction with TAB2/TAB3

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A newly discovered post-translational modification – the acetylation of serine and threonine residues

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The Drosophila Inhibitor of Apoptosis Protein DIAP2 Functions in Innate Immunity and Is Essential To Resist Gram-Negative Bacterial Infection

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Heat Shock Protein 27 Functions in Inflammatory Gene Expression and Transforming Growth Factor-β-activated Kinase-1 (TAK1)-mediated Signaling

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Phosphorylation and ubiquitination of the IκB kinase complex by two distinct signaling pathways

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Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses

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Lipopolysaccharide-Induced Increase in Intestinal Permeability Is Mediated by TAK-1 Activation of IKK and MLCK/MYLK Gene

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Edible blue-green algae reduce the production of pro-inflammatory cytokines by inhibiting NF-κB pathway in macrophages and splenocytes

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USP18 protects against hepatic steatosis and insulin resistance through its deubiquitinating activity

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TAK1 Regulates Reactive Oxygen Species and Cell Death in Keratinocytes, Which Is Essential for Skin Integrity

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TAK1 Is a Central Mediator of NOD2 Signaling in Epidermal Cells

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Sustained oxidative stress inhibits NF-κB activation partially via inactivating the proteasome

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Transforming Growth Factor-β (TGF-β1) Activates TAK1 via TAB1-mediated Autophosphorylation, Independent of TGF-β Receptor Kinase Activity in Mesangial Cells

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Leishmania donovani Exploits Host Deubiquitinating Enzyme A20, a Negative Regulator of TLR Signaling, To Subvert Host Immune Response

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TAK1 lysine 158 is required for TGF-β-induced TRAF6-mediated Smad-independent IKK/NF-κB and JNK/AP-1 activation

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Retroviral oncoprotein Tax deregulates NF‐κB by activating Tak1 and mediating the physical association of Tak1–IKK

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Glutathione Depletion Down-regulates Tumor Necrosis Factor α-induced NF-κB Activity via IκB Kinase-dependent and -independent Mechanisms

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TAK1-binding Protein 1, TAB1, Mediates Osmotic Stress-induced TAK1 Activation but Is Dispensable for TAK1-mediated Cytokine Signaling

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HIV-1 Vpr stimulates NF-κB and AP-1 signaling by activating TAK1

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Denbinobin inhibits nuclear factor-κB and induces apoptosis via reactive oxygen species generation in human leukemic cells

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Tumor Necrosis Factor-α Augments Matrix Metalloproteinase-9 Production in Skeletal Muscle Cells through the Activation of Transforming Growth Factor-β-activated Kinase 1 (TAK1)-dependent Signaling Pathway

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Human Trim5α has additional activities that are uncoupled from retroviral capsid recognition

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Peli: a family of signal-responsive E3 ubiquitin ligases mediating TLR signaling and T-cell tolerance

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Roles for the ubiquitin–proteasome pathway in protein quality control and signaling in the retina: Implications in the pathogenesis of age-related macular degeneration

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Essential role of TAK1 in regulating mantle cell lymphoma survival

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The Lysosomal Transmembrane Protein 9B Regulates the Activity of Inflammatory Signaling Pathways

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Epithelial transforming growth factor β-activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species

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TAB4 Stimulates TAK1-TAB1 Phosphorylation and Binds Polyubiquitin to Direct Signaling to NF-κB

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TAK1 inhibitor 5Z-7-oxozeaenol sensitizes neuroblastoma to chemotherapy

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TAK1 kinase determines TRAIL sensitivity by modulating reactive oxygen species and cIAP

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Comprehending the complex connection between PKCβ, TAK1, and IKK in BCR signaling

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SIRT7 Regulates Lipopolysaccharide-Induced Inflammatory Injury by Suppressing the NF-κB Signaling Pathway

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NF-κB as a Target for Oncogenic Viruses

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TAK1 ubiquitination regulates doxorubicin-induced NF-κB activation

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NF-κB feedback control of JNK1 activation modulates TRPV1-induced increases in IL-6 and IL-8 release by human corneal epithelial cells.

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Japonicone A Suppresses Growth of Burkitt Lymphoma Cells through Its Effect on NF-κB

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DDX3 Participates in Translational Control of Inflammation Induced by Infections and Injuries

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Compound FLZ inhibits lipopolysaccharide-induced inflammatory effects via down-regulation of the TAK-IKK and TAK-JNK/p38MAPK pathways in RAW264.7 macrophages

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Effect of High-Frequency Resistance Exercise on Adaptive Responses in Skeletal Muscle

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Roles of TRAF6 in CD40 signaling

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TAK1 inhibition-induced RIP1-dependent apoptosis in murine macrophages relies on constitutive TNF-α signaling and ROS production

Wang, J.-S., Wu, D., Huang, D.-Y., & Lin, W. (2015) · Journal of Biomedical Science · doi:10.1186/s12929-015-0182-7 · Cited by 38

Pseudorabies Virus Infection of Epithelial Cells Leads to Persistent but Aberrant Activation of the NF-κB Pathway, Inhibiting Hallmark NF-κB-Induced Proinflammatory Gene Expression

Romero, N., Waesberghe, C. V., & Favoreel, H. W. (2020) · Journal of Virology · doi:10.1128/jvi.00196-20 · Cited by 34

SMYD2‐mediated TRAF2 methylation promotes the NF‐κB signaling pathways in inflammatory diseases

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IL-6 Induction by TNFα and IL-1β in an Osteoblast-Like Cell Line

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Withaferin A disrupts ubiquitin-based NEMO reorganization induced by canonical NF-κB signaling

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HSCARG downregulates NF-κB signaling by interacting with USP7 and inhibiting NEMO ubiquitination

Li, T., Guan, J., Li, S.-Z., Zhang, X., & Zheng, X. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.197 · Cited by 32

Epithelial Cell Death and Inflammation in Skin

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Tubocapsanolide A Inhibits Transforming Growth Factor-β-activating Kinase 1 to Suppress NF-κB-induced CCR7

Pan, M., Chang, H., Wu, Y., Huang, C.-C., & Hung, W.-C. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806223200 · Cited by 31

Contraction-induced changes in TNFα and Akt-mediated signalling are associated with increased myofibrillar protein in rat skeletal muscle

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POPX2 phosphatase regulates apoptosis through the TAK1-IKK-NF-κB pathway

Weng, T., & Koh, C.-G. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.443 · Cited by 29

Phosphorylation and Polyubiquitination of Transforming Growth Factor β-Activated Kinase 1 Are Necessary for Activation of NF-κB by the Kaposi's Sarcoma-Associated Herpesvirus G Protein-Coupled Receptor

Bottero, V., Kerur, N., Sadagopan, S., Patel, K., Sharma-Walia, N., & Chandran, B. (2010) · Journal of Virology · doi:10.1128/jvi.01911-10 · Cited by 29

PGC‐1β suppresses saturated fatty acid‐induced macrophage inflammation by inhibiting TAK1 activation

Chen, H., Liu, Y., Li, D., Song, J., & Xia, M. (2016) · IUBMB Life · doi:10.1002/iub.1470 · Cited by 28

HTLV-1 Tax-mediated TAK1 activation involves TAB2 adapter protein

Yu, Q., Minoda, Y., Yoshida, R., Yoshida, H., Iha, H., Kobayashi, T., Yoshimura, A., & Takaesu, G. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.10.172 · Cited by 28

Role of the Ubiquitin–Proteasome in Protein Quality Control and Signaling

Shang, F., & Taylor, A. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-397863-9.00010-9 · Cited by 29

Resistance exercise and skeletal muscle: protein synthesis, degradation, and controversies

Ji, F., Lee, H. S., & Kim, J.-H. (2025) · European Journal of Applied Physiology · doi:10.1007/s00421-025-05832-z · Cited by 26

Activated Macrophage Survival Is Coordinated by TAK1 Binding Proteins

Mihaly, S. R., Morioka, S., Ninomiya‐Tsuji, J., & Takaesu, G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094982 · Cited by 26

TAK1 inhibitor 5Z-7-oxozeaenol sensitizes cervical cancer to doxorubicin-induced apoptosis

Guan, S., Lu, J., Zhao, Y., Woodfield, S. E., Zhang, H., Xu, X. Y., Yu, Y., Zhao, J., Bieerkehazhi, S., Liang, H., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.16895 · Cited by 25

TAK1 Is Required for Survival of Mouse Fibroblasts Treated with TRAIL, and Does So by NF-κB Dependent Induction of cFLIPL

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Constitutive and Tumor Necrosis Factor-Alpha-Stimulated Activation of Nuclear Factor-KappaB in Immortalized Endometriotic Cells and Their Suppression by Trichostatin A

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Overview of pyroptosis mechanism and in-depth analysis of cardiomyocyte pyroptosis mediated by NF-κB pathway in heart failure

Zhang, Z., Yang, Z., Wang, S., Wang, X., & Mao, J. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117367 · Cited by 22

LncRNA linc00152/NF‐κB feedback loop promotes fibroblast‐like synovial cells inflammation in rheumatoid arthritis via regulating miR‐103a/TAK1 axis and YY1 expression

Zhang, J., Gao, F., & Xie, J. (2021) · Immunity Inflammation and Disease · doi:10.1002/iid3.417 · Cited by 20

A20 Inhibits LPS-Induced Inflammation by Regulating TRAF6 Polyubiquitination in Rainbow Trout

Jang, J. H., Kim, H. J., Jung, I. Y., & Cho, J. H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189801 · Cited by 19

MAP3K7 and GSTZ1 are associated with human longevity: a two-stage case–control study using a multilocus genotyping

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Labdanolic acid methyl ester (LAME) exerts anti-inflammatory effects through inhibition of TAK-1 activation

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Endotoxin tolerance in mast cells, its consequences for IgE-mediated signalling, and the effects of BCL3 deficiency

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MEK-mediated CHPF2 phosphorylation promotes colorectal cancer cell proliferation and metastasis by activating NF-κB signaling

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An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1β signaling pathway

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Inhibition of Inflammatory Responses by Centella asiatica via Suppression of IRAK1-TAK1 in Mouse Macrophages

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Sirtuin 7 Inhibitor Attenuates Colonic Mucosal Immune Activation in Mice—Potential Therapeutic Target in Inflammatory Bowel Disease

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A Moderate Blast Exposure Results in Dysregulated Gene Network Activity Related to Cell Death, Survival, Structure, and Metabolism

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TAK1 (MAP3K7) Signaling Regulates Hematopoietic Stem Cells through TNF-Dependent and -Independent Mechanisms

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TAK1 Inhibitor Enhances the Therapeutic Treatment for Glioblastoma

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DUSP8/TAK1 signaling mediates neuropathic pain through regulating neuroinflammation and neuron death in a spinal nerve ligation (SNL) rat model

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1,3,5-Trihydroxy-4-prenylxanthone represses lipopolysaccharide-induced iNOS expression via impeding posttranslational modification of IRAK-1

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PRKX down-regulates TAK1/IRF7 signaling in the antiviral innate immunity of black carp Mylopharyngodon piceus

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Partners in crime: POPX2 phosphatase and its interacting proteins in cancer

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Ubc13 haploinsufficiency protects against age-related insulin resistance and high-fat diet-induced obesity

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USP13 ameliorates nonalcoholic fatty liver disease through inhibiting the activation of TAK1

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The Emerging Role of OTUB2 in Diseases: From Cell Signaling Pathway to Physiological Function

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Synergistic action of 5Z-7-oxozeaenol and bortezomib in inducing apoptosis of Burkitt lymphoma cell line Daudi

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Ubiquitin-mediated activation of TAK1 and IKK

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Ubiquitination in signaling to and activation of IKK

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Direct activation of protein kinases by unanchored polyubiquitin chains

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Direct Activation of Protein Kinases by Ubiquitin

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TAK1 Lys-158 but not Lys-209 is required for IL-1β-induced Lys63-linked TAK1 polyubiquitination and IKK/NF-κB activation

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