Cited by 1,445Inflammasome and immune disordersImmune Response and InflammationCell death mechanisms and regulation

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

Pétrilli, V, Papin, S, Dostert, C, Mayor, A, Martinon, F, Tschopp, J·2007·Cell Death & Differentiation

Open this paper in CoChat — free account

Abstract

Inflammasomes are Nod-like receptor(NLR)- and caspase-1-containing cytoplasmic multiprotein complexes, which upon their assembly, process and activate the proinflammatory cytokines interleukin (IL)-1beta and IL-18. The inflammasomes harboring the NLR members NALP1, NALP3 and IPAF have been best characterized. While the IPAF inflammasome is activated by bacterial flagellin, activation of the NALP3 inflammasome is triggered not only by several microbial components, but also by a plethora of danger-associated host molecules such as uric acid. How NALP3 senses these chemically unrelated activators is not known. Here, we provide evidence that activation of NALP3, but not of the IPAF inflammasome, is blocked by inhibiting K(+) efflux from cells. Low intracellular K(+) is also a requirement for NALP1 inflammasome activation by lethal toxin of Bacillus anthracis. In vitro, NALP inflammasome assembly and caspase-1 recruitment occurs spontaneously at K(+) concentrations below 90 mM, but is prevented at higher concentrations. Thus, low intracellular K(+) may be the least common trigger of NALP-inflammasome activation.

Integrity signals

Registry

Crossref · 10.1038/sj.cdd.4402195

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The Inflammasome
Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066
Self-citation
Gout-associated uric acid crystals activate the NALP3 inflammasome
Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326
Self-citation
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
Hayashi, F., Smith, K. D., Ozinsky, A., Hawn, T. R., Yi, E. C., Goodlett, D. R., Eng, J. K., Akira, S., Underhill, D. M., & Aderem, A. A. (2001) · Nature · doi:10.1038/35074106 · Cited by 3,605
Cryopyrin activates the inflammasome in response to toxins and ATP
Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
Mariathasan, S., Newton, K., Monack, D. M., Vucic, D., French, D. M., Lee, W. P., Roose-Girma, M., Erickson, S. L., & Dixit, V. M. (2004) · Nature · doi:10.1038/nature02664 · Cited by 1,864
NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder
Agostini, L., Martinon, F., Burns, K., McDermott, M. F., Hawkins, P. N., & Tschopp, J. (2004) · Immunity · doi:10.1016/s1074-7613(04)00046-9 · Cited by 1,768
Self-citation
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3
Kanneganti, T., Özören, N., Body–Malapel, M., Amer, A. O., Park, J., Franchi, L., Whitfield, J. R., Barchet, W., Colonna, M., Vandenabeele, P., et al. (2006) · Nature · doi:10.1038/nature04517 · Cited by 1,149
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages
Franchi, L., Amer, A., Body-Malapel, M., Kanneganti, T.-D., Özören, N., Jagirdar, R., Inohara, N., Vandenabeele, P., Bertin, J., Coyle, A., et al. (2006) · Nature Immunology · doi:10.1038/ni1346 · Cited by 1,131
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf
Miao, E. A., Alpuche-Aranda, C. M., Dors, M., Clark, A. E., Bader, M. W., Miller, S. I., & Aderem, A. (2006) · Nature Immunology · doi:10.1038/ni1344 · Cited by 1,127
NOD-LRR PROTEINS: Role in Host-Microbial Interactions and Inflammatory Disease
Inohara, N., Chamaillard, M., McDonald, C., & Núñez, G. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133347 · Cited by 1,019

Flagged first, then by citations

Show all 38 references

Sorted by citations

Items 801–900 of 1,003

Inflammasome Activation Induced by Perfringolysin O of Clostridium perfringens and Its Involvement in the Progression of Gas Gangrene
Kiyonobu, Y., Ashida, H., Okano, T., Kinoshita-Daitoku, R., Suzuki, S., Ohtani, K., Hamagaki, M., Ikeda, T., & Suzuki, T. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02406 · Cited by 35
To protect or adversely affect? The dichotomous role of the NLRP1 inflammasome in human disease
Tupik, J. D., Nagai-Singer, M. A., & Allen, I. C. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100858 · Cited by 35
Dual Role of Mitophagy in Cardiovascular Diseases
Li, Y., Meng, W., Hou, Y., Li, D., Wang, X., Wu, K., Sun, S., Liu, H., Li, X., Lin, F., et al. (2021) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000001046 · Cited by 33
MiR-223 inhibits hyperosmolarity-induced inflammation through downregulating NLRP3 activation in human corneal epithelial cells and dry eye patients
Ren, Y., Feng, J., Lin, Y., Reinach, P. S., Liu, Y., Xia, X., Ma, X., Chen, W., & Zheng, Q. (2022) · Experimental Eye Research · doi:10.1016/j.exer.2022.109096 · Cited by 35
The Influence of Mitochondrial-DNA-Driven Inflammation Pathways on Macrophage Polarization: A New Perspective for Targeted Immunometabolic Therapy in Cerebral Ischemia-Reperfusion Injury
Yu, S., Fu, J., Wang, J., Zhao, Y., Liu, B., Wei, J., Yan, X., & Su, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010135 · Cited by 34
NEK7: a new target for the treatment of multiple tumors and chronic inflammatory diseases
Wang, J., Chen, S., Liu, M., Zhang, M., & Jia, X. (2022) · Inflammopharmacology · doi:10.1007/s10787-022-01026-7 · Cited by 33
Potassium levels and the risk of all-cause and cardiovascular mortality among patients with cardiovascular diseases: a meta-analysis of cohort studies
Fan, Y., Wu, M., Li, X., Zhao, J., Shi, J., Ding, L., Jiang, H. F., Li, Z., Zhang, W., Ma, T., et al. (2024) · Nutrition Journal · doi:10.1186/s12937-023-00888-z · Cited by 34
Modulation of neuroimmunity by adenosine and its receptors: Metabolism to mental illness
Chiu, G. S., & Freund, G. G. (2014) · Metabolism · doi:10.1016/j.metabol.2014.09.003 · Cited by 37
Uric acid induces caspase-1 activation, IL-1β secretion and P2X7 receptor dependent proliferation in primary human lymphocytes.
Eleftheriadis, T., Pissas, G., Karioti, A., Antoniadi, G., Golfinopoulos, S., Liakopoulos, V., Mamara, A., Speletas, M. G., KOUKOULIS, G. N., & Stefanidis, I. (2013) · Europe PMC (PubMed Central) · Cited by 34
Inhibition of the nucleotide-binding domain, leucine-rich containing family, pyrin-domain containing 3 inflammasome reduces the severity of experimentally induced acute pancreatitis in obese mice
York, J. M., Castellanos, K. J., Cabay, R. J., & Fantuzzi, G. (2014) · Translational research · doi:10.1016/j.trsl.2014.06.012 · Cited by 34
The Innate Immune Response Against Staphylococcus aureus
Bekeredjian‐Ding, I., Stein, C., & Uebele, J. (2015) · Current topics in microbiology and immunology · doi:10.1007/82_2015_5004 · Cited by 38
A whole-genome RNAi screen uncovers a novel role for human potassium channels in cell killing by the parasite Entamoeba histolytica
Marie, C. S., Verkerke, H., Theodorescu, D., & Petri, W. A. (2015) · Scientific Reports · doi:10.1038/srep13613 · Cited by 34
Elevated Systemic Antibodies towards Commensal Gut Microbiota in Autoinflammatory Condition
Manukyan, G. P., Ghazaryan, K. A., Ktsoyan, Z. A., Khachatryan, Z., Arakelova, K. A., Kelly, D., Grant, G., & Aminov, R. I. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003172 · Cited by 34
The trigger for pancreatic disease: NLRP3 inflammasome
Liu, T., Wang, Q., Du, Z., Yin, L., Li, J., Meng, X., & Xue, D. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01550-7 · Cited by 33
Regulation and functions of the NLRP3 inflammasome in RNA virus infection
Yue, Z., Zhang, X., Gu, Y., Liu, Y., Lan, L.-M., Liu, Y., Li, Y., Yang, G., Wan, P., & Chen, X. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1309128 · Cited by 35
Pyroptosis, ferroptosis, and autophagy in spinal cord injury: regulatory mechanisms and therapeutic targets
Zheng, Q., Wang, D., Lin, R., & Xu, W. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00112 · Cited by 34
NLRP3 inflammasome: a novel link between lipoproteins and atherosclerosis
Li, W. L., Hua, L. G., Qu, P., Yan, W. H., Ming, C., Jun, Y. D., Yuan, L. D., & Nan, N. (2016) · Archives of Medical Science · doi:10.5114/aoms.2016.61356 · Cited by 33
Esculentoside A exerts anti-inflammatory activity in microglial cells
Yang, H., Chen, Y., Yu, L., & Xu, Y. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.08.014 · Cited by 34
Tumour viruses and innate immunity
Hopcraft, S. E., & Damania, B. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0267 · Cited by 33
The Role of NLRP3 Inflammasome in Radiation-Induced Cardiovascular Injury
Huang, S., Che, J., Chu, Q., & Zhang, P. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00140 · Cited by 33
Understanding the Role of Inflammasomes in Rheumatoid Arthritis
Makkar, R., Behl, T., BUNGAU, S. G., Kumar, A., & Arora, S. (2020) · Inflammation · doi:10.1007/s10753-020-01301-1 · Cited by 35
The Purinergic P2X7 Receptor-NLRP3 Inflammasome Pathway: A New Target in Alcoholic Liver Disease?
Daré, B. L., Ferron, P., & Gicquel, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042139 · Cited by 35
Senecavirus a 3D Interacts with NLRP3 to Induce IL-1β Production by Activating NF-κB and Ion Channel Signals
Choudhury, S. M., Ma, X., Zeng, Z., Luo, Z., Li, Y., Nian, X., Ma, Y., Shi, Z., Song, R., Zhu, Z., et al. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.02097-21 · Cited by 33
The contribution of ion channels to shaping macrophage behaviour
Selezneva, A. I., Gibb, A. J., & Willis, D. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.970234 · Cited by 32
Apoptotic Cells Induce NF-κB and Inflammasome Negative Signaling
Grau, A., Tabib, A., Grau, I., Reiner, I., & Mevorach, D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122440 · Cited by 34
T-lymphocyte Kv1.3 channel activation triggers the NLRP3 inflammasome signaling pathway in hypertensive patients
Zhu, J., Yang, Y. F., Hu, S.-G., Zhang, Q., Yu, J., & Zhang, Y.-M. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4490 · Cited by 33
The NLRP3 inflammasome: a vital player in inflammation and mediating the anti-inflammatory effect of CBD
Chu, F.-X., Wang, X., Li, B., Xu, L., & Di, B. (2024) · Inflammation Research · doi:10.1007/s00011-023-01831-y · Cited by 33
Inflammasome diversity: exploring novel frontiers in the innate immune response
Yu, G., Choi, Y. K., & Lee, S. (2024) · Trends in Immunology · doi:10.1016/j.it.2024.02.004 · Cited by 32
Unlocking the therapeutic potential of P2X7 receptor: a comprehensive review of its role in neurodegenerative disorders
Liu, X., Li, Y., Huang, L., Kuang, Y., Wu, X., Ma, X., Zhao, B., & Lan, J. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1450704 · Cited by 39
Microparticles and Their Impact on Intestinal Immunity
Becker, H. M., Bertschinger, M. M., & Rogler, G. (2012) · Digestive Diseases · doi:10.1159/000342602 · Cited by 32
Inflammatory responses in the Japanese pufferfish (Takifugu rubripes) head kidney cells stimulated with an inflammasome-inducing agent, nigericin
Bi̇len, S., Biswas, G., Otsuyama, S., Kono, T., Sakai, M., & Hikima, J.-I. (2014) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2014.04.010 · Cited by 32
Sebum, inflammasomes and the skin: current concepts and future perspective
Oyewole, A. O., & Birch‐Machin, M. A. (2015) · Experimental Dermatology · doi:10.1111/exd.12774 · Cited by 33
Geoepidemiology and Immunologic Features of Autoinflammatory Diseases: a Comprehensive Review
Jamilloux, Y., Bélot, A., Magnotti, F., Benezech, S., Gerfaud‐Valentin, M., Bourdonnay, E., Walzer, T., Sève, P., & Henry, T. (2017) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-017-8613-8 · Cited by 33
Artemisia Extract Suppresses NLRP3 and AIM2 Inflammasome Activation by Inhibition of ASC Phosphorylation
Kwak, S.-B., Koppula, S., In, E.-J., Sun, X. Y., Kim, Y.-K., Kim, M.-K., Lee, K., & Kang, T. (2018) · Mediators of Inflammation · doi:10.1155/2018/6054069 · Cited by 32
Selenium Attenuates Staphylococcus aureus Mastitis in Mice by Inhibiting the Activation of the NALP3 Inflammasome and NF-κB/MAPK Pathway
Ma, J.-K., Zhu, S., Guo, Y., Hao, M., Chen, Y., Wang, Y., Yang, M., Chen, J., & Guo, M. (2018) · Biological Trace Element Research · doi:10.1007/s12011-018-1591-8 · Cited by 32
Soluble egg antigen of Schistosoma japonicum induces pyroptosis in hepatic stellate cells by modulating ROS production
Kong, D., Kong, F., Liu, X., Yan, C., Cui, J., Tang, R., & Zheng, K. (2019) · Parasites & Vectors · doi:10.1186/s13071-019-3729-8 · Cited by 32
The NLRP3 inflammasome: a therapeutic target for inflammation-associated cancers
Gouravani, M., Khalili, N., Razi, S., Keshavarz‐Fathi, M., Khalili, N., & Rezaei, N. (2020) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2020.1713755 · Cited by 33
Koumine Suppresses IL-1β Secretion and Attenuates Inflammation Associated With Blocking ROS/NF-κB/NLRP3 Axis in Macrophages
Luo, Y., Xiong, B., Liu, H., Chen, Z., Huang, H., Yu, C., & Yang, J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.622074 · Cited by 32
Inflammasome activation and metabolic disease progression
Li, H., Jin, C., Chen, Y., & Flavell, R. A. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.07.020 · Cited by 32
Inflammasome Activation by Altered Proteostasis
Shin, J. N., Fattah, E. A., Bhattacharya, A., Ko, S., & Eissa, N. T. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.514919 · Cited by 32
Mitochondria–Endoplasmic Reticulum Contact Sites Mediate Innate Immune Responses
Misawa, T., Takahama, M., & Saitoh, T. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-4567-7_14 · Cited by 32
Bacterial RNA Mediates Activation of Caspase-1 and IL-1β Release Independently of TLRs 3, 7, 9 and TRIF but Is Dependent on UNC93B
Eigenbrod, T., Franchi, L., Muñoz-Planillo, R., Kirschning, C. J., Freudenberg, M. A., Núñez, G., & Dalpke, A. H. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103258 · Cited by 30
The Emerging Role of Inflammasomes as Central Mediators in Inflammatory Bladder Pathology
Inouye, B. M., Hughes, F. M., Sexton, S. J., & Purves, J. T. (2018) · Current Urology · doi:10.1159/000447196 · Cited by 34
A high-throughput real-time in vitro assay using mitochondrial targeted roGFP for screening of drugs targeting mitochondria
Chandrasekharan, A., Varadarajan, S. N., Lekshmi, A., Lupitha, S. S., Darvin, P., Chandrasekhar, L., Pillai, P. R., Santhoshkumar, T. R., & Pillai, M. R. (2018) · Redox Biology · doi:10.1016/j.redox.2018.10.013 · Cited by 30
Niclosamide activates the NLRP3 inflammasome by intracellular acidification and mitochondrial inhibition
Tran, U. T., & Kitami, T. (2018) · Communications Biology · doi:10.1038/s42003-018-0244-y · Cited by 31
Purinergic signaling in hepatic disease
Velázquez‐Miranda, E., Díaz‐Muñoz, M., & Vázquez‐Cuevas, F. G. (2019) · Purinergic Signalling · doi:10.1007/s11302-019-09680-3 · Cited by 31
UV-B-Induced Inflammasome Activation Can Be Prevented by Cis-Urocanic Acid in Human Corneal Epithelial Cells
Korhonen, E., Bisevac, J., Hyttinen, J. M. T., Piippo, N., Hytti, M., Kaarniranta, K., Petrovski, G., & Kauppinen, A. (2020) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.61.4.7 · Cited by 31
Activation and Regulation of NLRP3 by Sterile and Infectious Insults
Banerjee, S. K., Chatterjee, A., Gupta, S., & Nagar, A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.896353 · Cited by 31
The Significance of NLRP Inflammasome in Neuropsychiatric Disorders
Shen, Y., Qian, L., Luo, H., Li, X., Ruan, Y., Fan, R., Si, Z., Chen, Y.-P., Li, L., & Liu, Y. (2022) · Brain Sciences · doi:10.3390/brainsci12081057 · Cited by 32
Characterisation of C101248: A novel selective THIK-1 channel inhibitor for the modulation of microglial NLRP3-inflammasome
Ossola, B., Rifat, A., Rowland, A., Hunter, H., Drinkall, S., Bender, C., Hamlischer, M., Teall, M. R., Burley, R., Barker, D. F., et al. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109330 · Cited by 30
NLRP3 inflammasome as therapeutic targets in inflammatory diseases
Prakash, A. V., Park, I.-H., Park, J. W., Bae, J. P., Lee, G. S., & Kang, T. J. (2023) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2023.099 · Cited by 31
Role of NLRP3 and CARD8 in the regulation of TNF-α induced IL-1β release in vascular smooth muscle cells
TANGI, T. N., Elmabsout, A. A., Bengtsson, T., Sirsjö, A., & Fransén, K. (2012) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2012.1026 · Cited by 31
Human pathogenic fungus Trichophyton schoenleinii activates the NLRP3 inflammasome
Li, H., Wu, S., Mao, L., Lei, G., Zhang, L., Lu, A., An, L., Yang, G., Abliz, P., & Meng, G. (2013) · Protein & Cell · doi:10.1007/s13238-013-2127-9 · Cited by 32
Ugonin U stimulates NLRP3 inflammasome activation and enhances inflammasome-mediated pathogen clearance
Chen, C., Yang, C.-H., Tsai, Y., Liaw, C., Chang, W.-Y., & Hwang, T. (2016) · Redox Biology · doi:10.1016/j.redox.2016.12.018 · Cited by 33
Danger of frustrated sensors: Role of Toll-like receptors and NOD-like receptors in aseptic and septic inflammations around total hip replacements
Takagi, M., Takakubo, Y., Pajarinen, J., Naganuma, Y., Oki, H., Maruyama, M., & Goodman, S. B. (2017) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2017.05.004 · Cited by 31
Regulation and Sensing of Inflammasomes and Their Impact on Intestinal Health
Ranson, N., Kunde, D., & Eri, R. D. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112379 · Cited by 30
Nanodevices for the Efficient Codelivery of CRISPR-Cas9 Editing Machinery and an Entrapped Cargo: A Proposal for Dual Anti-Inflammatory Therapy
García‐Fernández, A., Vivo‐Llorca, G., Sancho, M., García-Jareño, A. B., Ramírez‐Jiménez, L., Barber‐Cano, E., Murguía, J. R., Orzáez, M., Sancenón, F., & Martínez‐Máñez, R. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14071495 · Cited by 31
Auranofin Protects against Anthrax Lethal Toxin-Induced Activation of the Nlrp1b Inflammasome
Newman, Z. L., Sirianni, N., Mawhinney, C., Lee, M. S., Leppla, S. H., Moayeri, M., & Johansen, L. M. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00772-10 · Cited by 30
Technical Advance: caspase-1 activation and IL-1β release correlate with the degree of lysosome damage, as illustrated by a novel imaging method to quantify phagolysosome damage
Davis, M. J., & Swanson, J. A. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0310159 · Cited by 30
Hydrogen sulfide exposure induces NLRP3 inflammasome‐dependent IL‐1β and IL‐18 secretion in human mononuclear leukocytes in vitro
Basic, A., Alizadehgharib, S., Dahlén, G., & Dahlgren, U. (2017) · Clinical and Experimental Dental Research · doi:10.1002/cre2.69 · Cited by 30
Guanylate-binding proteins at the crossroad of noncanonical inflammasome activation during bacterial infections
Gomes, M. T. R., Cerqueira, D. M., Guimarães, E. S., Campos, P. C., & Oliveira, S. C. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.4mr0119-013r · Cited by 32
Dengue virus envelope protein domain III induces pro-inflammatory signature and triggers activation of inflammasome
Khan, R. A., Afroz, S., Minhas, G., Battu, S., & Khan, N. (2019) · Cytokine · doi:10.1016/j.cyto.2019.154780 · Cited by 30
Inflammasomes in cancer: Effect of epigenetic and autophagic modulations
Mishra, S. R., Mahapatra, K. K., Behera, B. P., Bhol, C. S., Praharaj, P. P., Panigrahi, D. P., Patra, S., Singh, A., Patil, S., Dhiman, R., et al. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.09.013 · Cited by 31
How Pyroptosis Contributes to Inflammation and Fibroblast-Macrophage Cross-Talk in Rheumatoid Arthritis
Demarco, B., Danielli, S., Fischer, F. A., & Bezbradica, J. S. (2022) · Cells · doi:10.3390/cells11081307 · Cited by 30
Role of NLRP3 inflammasome in systemic sclerosis
Lin, C., Jiang, Z., Cao, L., Zou, H., & Zhu, X. (2022) · Arthritis Research & Therapy · doi:10.1186/s13075-022-02889-5 · Cited by 33
The double sides of NLRP3 inflammasome activation in sepsis
Vigneron, C., Py, B. F., Monneret, G., & Venet, F. (2023) · Clinical Science · doi:10.1042/cs20220556 · Cited by 34
Targeting inflammasomes in rheumatic diseases
So, A. K.-L., Ives, A., Joosten, L. A. B., & Busso, N. (2013) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2013.61 · Cited by 31
Inhibition of the Injectisome and Flagellar Type III Secretion Systems by INP1855 ImpairsPseudomonas aeruginosaPathogenicity and Inflammasome Activation
Anantharajah, A., Faure, E., Buyck, J. M., Sundin, C., Lindmark, T., Mecsas, J. C., Yahr, T. L., Tulkens, P. M., Mingeot‐Leclercq, M., Guery, B. P., et al. (2016) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiw295 · Cited by 30
The Goldilocks Conundrum: NLR Inflammasome Modulation of Gastrointestinal Inflammation during Inflammatory Bowel Disease
Ringel-Scaia, V. M., McDaniel, D. K., & Allen, I. C. (2016) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2017019158 · Cited by 29
Inflammation—The role of ATP in pre‐eclampsia
Fodor, P., White, B., & Khan, R. N. (2019) · Microcirculation · doi:10.1111/micc.12585 · Cited by 30
Early single Aspirin-triggered Lipoxin blocked morphine anti-nociception tolerance through inhibiting NALP1 inflammasome: Involvement of PI3k/Akt signaling pathway
Tian, Y., Liu, M., Mao‐Ying, Q., Liu, H., Wang, Z., Zhang, M., Wang, J., Li, Q., Liu, S., Mi, W., et al. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.06.016 · Cited by 30
Modulation of Microglial Function by ATP-Gated P2X7 Receptors: Studies in Rat, Mice and Human
Tewari, M., Michalski, S. A., & Egan, T. M. (2024) · Cells · doi:10.3390/cells13020161 · Cited by 36
Aging as a loss of morphostatic information: A developmental bioelectricity perspective
Pio‐Lopez, L., & Levin, M. G. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102310 · Cited by 36
Implication of the LRR Domain in the Regulation and Activation of the NLRP3 Inflammasome
Cescato, M., Zhu, Y. Y. J., Corre, L. L., Py, B. F., Georgin‐Lavialle, S., & Rodero, M. P. (2024) · Cells · doi:10.3390/cells13161365 · Cited by 32
Regulation of the β-cell inflammasome and contribution to stress-induced cellular dysfunction and apoptosis
Ghiasi, S. M., Dahllöf, M. S., Osmai, Y., Osmai, M., Jakobsen, K. K., Aivazidis, A., Tyrberg, B., Perruzza, L., Prause, M. C. B., Christensen, D. P., et al. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2018.08.001 · Cited by 30
α-Hemolysin of uropathogenic E. coli regulates NLRP3 inflammasome activation and mitochondrial dysfunction in THP-1 macrophages
Verma, V., Kumar, P., Gupta, S., Yadav, S., Dhanda, R. S., Thorlacius, H., & Yadav, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-69501-1 · Cited by 30
A virulent Bacillus cereus strain from deep-sea cold seep induces pyroptosis in a manner that involves NLRP3 inflammasome, JNK pathway, and lysosomal rupture
Zhao, Y., Jiang, S., Zhang, J., Guan, X., Sun, B.-G., & Sun, L. (2021) · Virulence · doi:10.1080/21505594.2021.1926649 · Cited by 30
Characterization, Antioxidant and Anti-Inflammation Capacities of Fermented Flammulina velutipes Polyphenols
Ma, S., Zhang, H., & Xu, J. (2021) · Molecules · doi:10.3390/molecules26206205 · Cited by 31
Low potassium disrupt intestinal barrier and result in bacterial translocation
Wu, H., Huang, R., Fan, J., Luo, N., & Yang, X. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03499-0 · Cited by 30
Innate Immune Response and Inflammasome Activation During SARS-CoV-2 Infection
Islamuddin, M., Mustfa, S. A., Ullah, S. N. M. N., Omer, U., Kato, K., & Parveen, S. (2022) · Inflammation · doi:10.1007/s10753-022-01651-y · Cited by 31
A critical role for hemolysin in Vibrio fluvialis-induced IL-1β secretion mediated by the NLRP3 inflammasome in macrophages
Song, L., Huang, Y., Zhao, M., Wang, Z., Wang, S., Sun, H., Kan, B., Meng, G., Liang, W., & Ren, Z. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00510 · Cited by 29
K⁺ drops tilt the NLRP3 inflammasome.
Kanneganti, T., & Lamkanfi, M. (2013) · Immunity · doi:10.1016/j.immuni.2013.06.001 · Cited by 25
Enterococcus faecalis Activates Caspase-1 Leading to Increased Interleukin-1 Beta Secretion in Macrophages
Yang, H.-H., Jun, H., Jung, Y.-J., & Choi, B. (2014) · Journal of Endodontics · doi:10.1016/j.joen.2014.06.015 · Cited by 29
Stimulator of IFN genes–mediated DNA‐sensing pathway is suppressed by NLRP3 agonists and regulated by mitofusin 1 and TBC1D15, mitochondrial dynamics mediators
Kwon, D., Park, E., & Kang, S. (2017) · The FASEB Journal · doi:10.1096/fj.201700328r · Cited by 30
Commensal Microbiota Are Required for Systemic Inflammation Triggered by Necrotic Dendritic Cells
Young, J. A., He, T. H., Reizis, B., & Winoto, A. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.04.033 · Cited by 28
Nod-Like Receptors in Host Defence and Disease at the Epidermal Barrier
Danis, J., & Mellett, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094677 · Cited by 28
ML365 inhibits TWIK2 channel to block ATP-induced NLRP3 inflammasome
Wu, X., Lv, J.-Y., Zhang, S., Yi, X., Xu, Z., Zhi, Y., Zhao, B., Pang, J., Yung, K. K. L., Liu, S., et al. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00739-9 · Cited by 29
Clostridium perfringens virulence factors are nonredundant activators of the NLRP3 inflammasome
Mathur, A., Kay, C., Xue, Y., Pandey, A., Lee, J., Jing, W., Tuipulotu, D. E., Pilato, J. L., Feng, S., Ngo, C., et al. (2023) · EMBO Reports · doi:10.15252/embr.202254600 · Cited by 30
Ivermectin-dependent release of IL-1beta in response to ATP by peritoneal macrophages from P2X7-KO mice
Seil, M., Ouaaliti, M. E., Fontanils, U., Gorroño, I., Pochet, S., Moro, G. D., Marino, A., & Dehaye, J. (2010) · Purinergic Signalling · doi:10.1007/s11302-010-9205-8 · Cited by 28
P2X7 Receptor as a Key Player in Oxidative Stress-Driven Cell Fate in Nonalcoholic Steatohepatitis
Chatterjee, S., & Das, S. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/172493 · Cited by 29
Synergism of NOD2 and NLRP3 activators promotes a unique transcriptional profile in murine dendritic cells
Conforti‐Andreoni, C., Beretta, O., Licandro, G., Qian, H. L., Urbano, M., Vitulli, F., Ricciardi‐Castagnoli, P., & Mortellaro, A. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.1009652 · Cited by 28
Ketone body metabolism and the NLRP3 inflammasome in Alzheimer's disease
Shippy, D. C., Evered, A. H., & Ulland, T. K. (2024) · Immunological Reviews · doi:10.1111/imr.13365 · Cited by 33
Selective inhibition of NLRP3 inflammasome by designed peptide originating from ASC
Sušjan, P., Lainšček, D., Strmšek, Ž., Hodnik, V., Anderluh, G., & Hafner‐Bratkovič, I. (2020) · The FASEB Journal · doi:10.1096/fj.201902938rr · Cited by 27
P2X7R orchestrates the progression of murine hepatic fibrosis by making a feedback loop from macrophage to hepatic stellate cells
Jiang, M., Cui, B., Wu, Y., Zhang, Y., Shang, Y., Liu, J., Yang, H., Qiao, C., Zhan, Z., Ye, H., et al. (2020) · Toxicology Letters · doi:10.1016/j.toxlet.2020.07.023 · Cited by 29
Role of interleukin-1 and inflammasomes in oral disease
Murakami, T., Takahata, Y., Hata, K., & Nishimura, R. (2020) · Journal of Oral Biosciences · doi:10.1016/j.job.2020.07.003 · Cited by 30
To inhibit or to boost the ATP/P2RX7 pathway to fight cancer—that is the question
Hreich, S. J. D., Benzaquen, J., Hofman, P. M., & Vouret‐Craviari, V. (2021) · Purinergic Signalling · doi:10.1007/s11302-021-09811-9 · Cited by 27
Macrophage responses to bacterial toxins: a balance between activation and suppression
Keyel, P. A., Heid, M. E., & Salter, R. D. (2011) · Immunologic Research · doi:10.1007/s12026-011-8212-3 · Cited by 27
MCC950 blocks enhanced interleukin-1β production in patients with NLRP3 low penetrance variants
Schuh, E., Groß, C. J., Wagner, D., Schlüter, M., Groß, O., & Kümpfel, T. (2019) · Clinical Immunology · doi:10.1016/j.clim.2019.04.004 · Cited by 27
Monitoring gasdermin pore formation in vitro
Xia, S., Ruan, J., & Wu, H. (2019) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2019.04.024 · Cited by 28
Know your neighbors: microbial recognition at the intestinal barrier and its implications for gut homeostasis and inflammatory bowel disease
Iyer, K., Erkert, L., & Becker, C. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1228283 · Cited by 31

Authors: Pétrilli, V, Papin, S., Dostert, C., Mayor, A., Martinon, F., & Tschopp, J.
Affiliations: University of Lausanne (CH)
Harvard University (US)
Corresponding author: Tschopp, J
ORCID: Pétrilli, V
Papin, S
Martinon, F
Venue: Cell Death & Differentiation
Publisher: Springer Science and Business Media LLC
Published: 2007-06-29
Volume: 14
Issue: 9
Pages: 1583-1589
ISSN: 1350-9047 (ISSN-L)
1476-5403
DOI: 10.1038/sj.cdd.4402195
OpenAlex: W1978274182
Cited by: 1,445
References: 38
Citations by year: 2026: 36 · 2025: 54 · 2024: 62 · 2023: 71 · 2022: 85 · 2021: 78 · 2020: 102 · 2019: 86 · 2018: 73 · 2017: 104 · 2016: 70 · 2015: 79 · 2014: 90 · 2013: 101 · 2012: 93
FWCI: 25.01
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Cell Death and Differentiation (publishedVersion)
PubMed (publishedVersion)
IRIS (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Funders: National Science Foundation
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: NLRP3 inflammasome, potassium efflux, intracellular potassium concentration, caspase-1 activation, inflammasome assembly, NOD-like receptors, damage-associated molecular patterns, uric acid, IL-1β, IL-18
MeSH terms: NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Calcium-Binding Proteins, Carrier Proteins, Cell Line, Humans, Inflammation, Mice, Inbred BALB C, Mice, Inbred C57BL, Potassium, Macrophages, Peritoneal, Caspase 1, Interleukin-18, Apoptosis Regulatory Proteins, Mice, CARD Signaling Adaptor Proteins, Interleukin-1beta

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks