Tschopp, Jürg

The Inflammasome

Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 6,066

A role for mitochondria in nlrp3 inflammasome activation

Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 5,602

Gout-associated uric acid crystals activate the NALP3 inflammasome

Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature

Inflammasome and immune disordersGout, Hyperuricemia, Uric Acid

Cited by 5,326

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

Micheau, O., & Tschopp, J. (2003) · Cell

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 2,738

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

Zhou, R., Tardivel, A., Thorens, B., Choi, I., & Tschopp, J. (2010) · Nature Immunology

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 2,708

The Inflammasomes: Guardians of the Body

Martinon, F., Mayor, A., & Tschopp, J. (2009) · Annual Review of Immunology

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 2,436

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

Meylan, E., Curran, J., Hofmann, K., Moradpour, D., Binder, M., Bartenschlager, R., & Tschopp, J. (2005) · Nature

interferon and immune responsesImmune Response and Inflammation

Cited by 2,401

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

Ghiringhelli, F., Apetoh, L., Tesniere, A., Aymeric, L., Ma, Y., Ortiz, C., Vermaelen, K., Panaretakis, T., Mignot, G., Ullrich, E., et al. (2009) · Nature Medicine

Inflammasome and immune disordersImmunotherapy and Immune Responses

Cited by 1,898

NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder

Agostini, L., Martinon, F., Burns, K., McDermott, M. F., Hawkins, P. N., & Tschopp, J. (2004) · Immunity

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 1,768

Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

Pétrilli, V, Papin, S., Dostert, C., Mayor, A., Martinon, F., & Tschopp, J. (2007) · Cell Death & Differentiation

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 1,445

A pilot study of IL-1 inhibition by anakinra in acute gout

So, A., De Smedt, T., Revaz, S., & Tschopp, J. (2007) · Arthritis Research & Therapy

Gout, Hyperuricemia, Uric AcidInflammasome and immune disorders

Cited by 727

The inflammasome: a danger sensing complex triggering innate immunity

Pétrilli, V., Dostert, C., Muruve, D. A., & Tschopp, J. (2007) · Current Opinion in Immunology

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 700

Identification of Bacterial Muramyl Dipeptide as Activator of the NALP3/Cryopyrin Inflammasome

Martinon, F., Agostini, L., Meylan, E., & Tschopp, J. (2004) · Current Biology

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 579

Inflammasome Components NALP 1 and 3 Show Distinct but Separate Expression Profiles in Human Tissues Suggesting a Site-specific Role in the Inflammatory Response

Kummer, J. A., Broekhuizen, R., Everett, H., Agostini, L., Kuijk, L., Martinon, F., Bruggen, R. V., & Tschopp, J. (2007) · Journal of Histochemistry & Cytochemistry

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 531

Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β

Yazdi, A. S., Guarda, G., Riteau, N., Drexler, S. K., Tardivel, A., Couillin, I., & Tschopp, J. (2010) · Proceedings of the National Academy of Sciences

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 525

Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation

Vince, J. E., Wong, W. W.-L., Gentle, I., Lawlor, K. E., Allam, R., O'Reilly, L., Mason, K., Gross, O., Ma, S., Guarda, G., et al. (2012) · Immunity

Inflammasome and immune disordersCell death mechanisms and regulation

Cited by 491

The Long Form of FLIP Is an Activator of Caspase-8 at the Fas Death-inducing Signaling Complex

Micheau, O., Thome, M., Schneider, P., Holler, N., Tschopp, J., Nicholson, D. W., Briand, C., & Grütter, M. G. (2002) · Journal of Biological Chemistry

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 482

Activation of the IL-1β-Processing Inflammasome Is Involved in Contact Hypersensitivity

Watanabe, H., Gaide, O., Pétrilli, V., Martinon, F., Contassot, E., Roques, S., Kummer, J. A., Tschopp, J., & French, L. E. (2007) · Journal of Investigative Dermatology

Inflammasome and immune disordersContact Dermatitis and Allergies

Cited by 416

Uric Acid Is a Danger Signal Activating NALP3 Inflammasome in Lung Injury Inflammation and Fibrosis

Gasse, P., Riteau, N., Charron, S., Girre, S., Fick, L., Pétrilli, V., Tschopp, J., Lagente, V., Quesniaux, V. F. J., Ryffel, B., et al. (2009) · American Journal of Respiratory and Critical Care Medicine

Inflammasome and immune disordersInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Cited by 410

Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses

Ritter, M., Gross, O., Kays, S., Ruland, J., Nimmerjahn, F., Saijo, S., Tschopp, J., Layland, L. E., & Prazeres da Costa, C. (2010) · Proceedings of the National Academy of Sciences

Inflammasome and immune disordersParasites and Host Interactions

Cited by 243

NALP Inflammasomes: a central role in innate immunity

Martinon, F., Gaide, O., Pétrilli, V., Mayor, A., & Tschopp, J. (2007) · Seminars in Immunopathology

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 218

Protein-based therapeutic approaches targeting death receptors

French, L. E., & Tschopp, J. (2003) · Cell Death & Differentiation

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 102

The role of the inflammasome in nonmyeloid cells

Yazdi, A. S., Drexler, S. K., & Tschopp, J. (2010) · Journal of Clinical Immunology

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 76