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Autophagy promotes necrosis in apoptosis-deficient cells in response to ER stress
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“Disturbance of ER redox state, as a consequence of oxidative stress, alteration of calcium homeostasis, or dysregulated chaperones activity, may result in un/misfolded, or aggregated proteins that will be targeted to degradation pathways or accumulate in cells [47].”
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Metadata
- Authors
- Ullman, E., Fan, Y., Stawowczyk, M., Chen, H.-M., Yue, Z., & Zong, W.-X.
- Affiliations
- Stony Brook University (US)
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Zong, W-X
- Venue
- Cell Death & Differentiation
- Published
- 2007-10-05
- Volume
- 15
- Issue
- 2
- Pages
- 422-425
- ISSN
- 1350-9047 (ISSN-L)
- 1476-5403
- PMC
- PMC3140950
- OpenAlex
- W2060342342
- Cited by
- 161
- References
- 22
- Citations by year
- 2025: 1 · 2024: 5 · 2022: 1 · 2021: 3 · 2020: 4 · 2019: 7 · 2018: 4 · 2017: 6 · 2016: 7 · 2015: 12 · 2014: 16 · 2013: 20 · 2012: 21
- FWCI
- 8.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell Death and Differentiation (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Breast Cancer Research Foundation
- Ministero della Salute
- Istituto Pasteur-Fondazione Cenci Bolognetti
- Stony Brook University
- National Cancer Institute (R01CA129536, K01CA098092)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
- Keywords
- autophagy, necrosis, endoplasmic reticulum stress, unfolded protein response, Bax, Bak, Bcl-xL, Bcl-2 family proteins, ER stress-induced cell death, autophagy inhibition
- MeSH terms
- Animals, Autophagy, Endoplasmic Reticulum, Fibroblasts, Mice, Mutant Strains, Necrosis, Apoptosis, bcl-2 Homologous Antagonist-Killer Protein, bcl-2-Associated X Protein, Mice
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