Predicting risk in space: genetic markers for differential vulnerability to sleep restriction

Goel, Namni; Dinges, David F.

doi:10.1016/j.actaastro.2012.04.002

Cited by 40Sleep and Work-Related FatigueSleep and Wakefulness ResearchSpaceflight effects on biology

Predicting risk in space: genetic markers for differential vulnerability to sleep restriction

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Goel, Namni, Dinges, David F.·2012·Acta Astronautica

DOI 10.1016/j.actaastro.2012.04.002PMC PMC3602842

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Abstract

Several laboratories have found large, highly reliable individual differences in the magnitude of cognitive performance, fatigue and sleepiness, and sleep homeostatic vulnerability to acute total sleep deprivation and to chronic sleep restriction in healthy adults. Such individual differences in neurobehavioral performance are also observed in space flight as a result of sleep loss. The reasons for these stable phenotypic differential vulnerabilities are unknown: such differences are not yet accounted for by demographic factors, IQ or sleep need, and moreover, psychometric scales do not predict those individuals cognitively vulnerable to sleep loss. The stable, trait-like (phenotypic) inter-individual differences observed in response to sleep loss-with intraclass correlation coefficients accounting for 58%-92% of the variance in neurobehavioral measures- point to an underlying genetic component. To this end, we utilized multi-day highly controlled laboratory studies to investigate the role of various common candidate gene variants-each independently-in relation to cumulative neurobehavioral and sleep homeostatic responses to sleep restriction. These data suggest that common genetic variations (polymorphisms) involved in sleep-wake, circadian, and cognitive regulation may serve as markers for prediction of inter-individual differences in sleep homeostatic and neurobehavioral vulnerability to sleep restriction in healthy adults. Identification of genetic predictors of differential vulnerability to sleep restriction-as determined from candidate gene studies-will help identify astronauts most in need of fatigue countermeasures in space flight and inform medical standards for obtaining adequate sleep in space. This review summarizes individual differences in neurobehavioral vulnerability to sleep deprivation and ongoing genetic efforts to identify markers of such differences.

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Data from unrelated individuals indicate that common genetic polymorphisms involved in sleep-wake, circadian, and cognitive regulation may underlie large interindividual differences in neurobehavioral vulnerability to sleep deprivation in healthy adults.
“Indeed, data from unrelated individuals further indicate that common genetic polymorphisms involved in sleep–wake, circadian, and cognitive regulation may underlie these large interindividual differences in neurobehavioral vulnerability to sleep deprivation in healthy adults.164,181,183”
From Circadian rhythms, sleep deprivation, and human performance (2013) · cites this paper as [183]

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Authors: Goel, N., & Dinges, D. F.
Affiliations: University of Pennsylvania (US)
Corresponding author: Goel, Namni
ORCID: Goel, Namni
Dinges, David F.
Venue: Acta Astronautica
Publisher: Elsevier BV
Published: 2012-08
Volume: 77
Pages: 207-213
ISSN: 0094-5765 (ISSN-L)
DOI: 10.1016/j.actaastro.2012.04.002
PMC: PMC3602842
OpenAlex: W1991139187
Cited by: 40
References: 64
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 6 · 2018: 2 · 2017: 3 · 2016: 6 · 2015: 3 · 2014: 5 · 2013: 3
FWCI: 4.71
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Acta Astronautica (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Nursing Research (R01NR004281)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Health Sciences › Medicine › Physiology › Spaceflight effects on biology
Keywords: sleep restriction, sleep deprivation, genetic polymorphism, candidate genes, individual differences, sleep homeostasis, neurobehavioral performance, fatigue, sleepiness, circadian rhythm, spaceflight, astronauts, fatigue countermeasures, genetic markers

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Predicting risk in space: genetic markers for differential vulnerability to sleep restriction

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