Dlx homeobox gene family expression in osteoclasts
Abstract
Skeletal growth and homeostasis require the finely orchestrated secretion of mineralized tissue matrices by highly specialized cells, balanced with their degradation by osteoclasts. Time‐ and site‐specific expression of Dlx and Msx homeobox genes in the cells secreting these matrices have been identified as important elements in the regulation of skeletal morphology. Such specific expression patterns have also been reported in osteoclasts for Msx genes. The aim of the present study was to establish the expression patterns of Dlx genes in osteoclasts and identify their function in regulating skeletal morphology. The expression patterns of all Dlx genes were examined during the whole osteoclastogenesis using different in vitro models. The results revealed that Dlx1 and Dlx2 are the only Dlx family members with a possible function in osteoclastogenesis as well as in mature osteoclasts. Dlx5 and Dlx6 were detected in the cultures but appear to be markers of monocytes and their derivatives. In vivo, Dlx2 expression in osteoclasts was examined using a Dlx2/LacZ transgenic mouse. Dlx2 is expressed in a subpopulation of osteoclasts in association with tooth, brain, nerve, and bone marrow volumetric growths. Altogether the present data suggest a role for Dlx2 in regulation of skeletal morphogenesis via functions within osteoclasts. J. Cell. Physiol. 223:779–787, 2010. © 2010 Wiley‐Liss, Inc.
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A few studies have revealed that homeobox genes, such as Lhx2, Dlx5, and Pax6, affect osteoclast formation.
“A few studies have revealed that homeobox genes, such as Lhx2, Dlx5, and Pax6, affect osteoclast formation44–46”
From Targeting Msx2 as a brake in the fusion fate of osteoclasts and an anabolic therapy in pre-clinical models of osteoporosis (2025) · cites this paper as [45]
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Self-citation
- Authors
- Lézot, F., Thomas, B. L., Blin‐Wakkach, C., Castaneda, B., Bolanos, A., Hotton, D., Sharpe, P. T., Heymann, D., Carles, G. F., Grigoriadis, A. E., & Berdal, A.
- Affiliations
- Inserm (FR)
- King's College London (GB)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Lézot, F.
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2010-03-04
- Volume
- 223
- Issue
- 3
- Pages
- 779-787
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W2153052749
- Cited by
- 24
- References
- 63
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 2 · 2016: 1 · 2015: 1 · 2014: 2
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cellular Physiology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › dental development and anomalies
- Keywords
- osteoclasts, osteoclastogenesis, Dlx2, DLX1, Dlx5, Dlx6, skeletal morphogenesis, bone remodeling, gene expression patterns, monocytes
- MeSH terms
- Tartrate-Resistant Acid Phosphatase, Acid Phosphatase, Animals, beta-Galactosidase, Cell Differentiation, Cell Line, Multigene Family, Isoenzymes, Male, Mandible, Osteoclasts, Osteogenesis, Transcription Factors, Homeodomain Proteins, Gene Expression Regulation, Developmental, Reverse Transcriptase Polymerase Chain Reaction, Matrix Metalloproteinase 9, Gene Expression Profiling, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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