Cited by 92Coenzyme Q10 studies and effectsAntioxidant Activity and Oxidative StressMitochondrial Function and Pathology

Coenzyme Q10: From bench to clinic in aging diseases, a translational review

Gutierrez-Mariscal, Francisco M., Yubero-Serrano, Elena M., Villalba, Jose M., Lopez-Miranda, Jose·2019·Critical Reviews in Food Science and Nutrition

Abstract

Coenzyme Q10 (CoQ10) is a ubiquitous molecule present in all eukaryotic organisms whose principal role in the cell is related to its participation in the electron transport chain in the inner mitochondrial membrane. CoQ10 plays a major role in the control of cell redox status, and both the amount and functionality of this molecule have been related to the regulation of reactive oxygen species generation. Numerous reports can be found discussing the implications of CoQ10 supplementation in human studies and clinical trials related to aging. However, few reviews have made an updating through the translational point of view to integrate both basic and clinical aspects. The aim of this paper is to review our current knowledge from CoQ10 implications at biochemical and physiological level, in order to unravel the molecular mechanisms involved in its application in clinical practice. Although the importance of CoQ10 has been mainly attributed to its role as an agent for energy transduction in mitochondria, new functions for CoQ10 have been described in the recent past years, including anti-inflammatory effects, gene expression regulation and lipid bilayer membranes stabilization, which explain its involvement in aging and age-related diseases such as cardiovascular diseases, renal failure and neurodegenerative diseases.

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Crossref · 10.1080/10408398.2018.1442316

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Authors
Gutierrez-Mariscal, F. M., Yubero-Serrano, E. M., Villalba, J. M., & Lopez-Miranda, J.
Affiliations
  • Instituto de Salud Carlos III (ES)
  • Lipid and Atherosclerosis Unit, Department of Internal Medicine/IMIBIC/Reina Sofia University Hospital/University of Córdoba, Córdoba, Spain; CIBER Fisiología Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain
  • Departamento de Biología Celular, Fisiología e Inmunología, Universidad de Córdoba, Campus de Excelencia Internacional Agroalimentario, ceiA3, Córdoba, Spain
Venue
Critical Reviews in Food Science and Nutrition
Published
2018-03-13
Volume
59
Issue
14
Pages
2240-2257
ISSN
  • 1040-8398 (ISSN-L)
  • 1549-7852
OpenAlex
W2794304138
Cited by
92
References
159
Citations by year
2026: 5 · 2025: 9 · 2024: 11 · 2023: 12 · 2022: 17 · 2021: 11 · 2020: 16 · 2019: 7 · 2018: 3 · 2013: 1
FWCI
0.91
Type
journal article
Language
en
Open access
closed
Locations
  • Critical Reviews in Food Science and Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords
coenzyme Q10, aging, age-related diseases, mitochondrial electron transport chain, reactive oxygen species, redox state, coenzyme Q10 supplementation, anti-inflammatory activity, gene expression regulation, cardiovascular disease, renal failure, neurodegenerative diseases, energy transduction
MeSH terms
Aging, Animals, Cardiovascular Diseases, Humans, Oxidation-Reduction, Ubiquinone, Vitamins, Neurodegenerative Diseases, Models, Animal, Renal Insufficiency, Chronic

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