Coenzyme Q10: From bench to clinic in aging diseases, a translational review
Abstract
Coenzyme Q10 (CoQ10) is a ubiquitous molecule present in all eukaryotic organisms whose principal role in the cell is related to its participation in the electron transport chain in the inner mitochondrial membrane. CoQ10 plays a major role in the control of cell redox status, and both the amount and functionality of this molecule have been related to the regulation of reactive oxygen species generation. Numerous reports can be found discussing the implications of CoQ10 supplementation in human studies and clinical trials related to aging. However, few reviews have made an updating through the translational point of view to integrate both basic and clinical aspects. The aim of this paper is to review our current knowledge from CoQ10 implications at biochemical and physiological level, in order to unravel the molecular mechanisms involved in its application in clinical practice. Although the importance of CoQ10 has been mainly attributed to its role as an agent for energy transduction in mitochondria, new functions for CoQ10 have been described in the recent past years, including anti-inflammatory effects, gene expression regulation and lipid bilayer membranes stabilization, which explain its involvement in aging and age-related diseases such as cardiovascular diseases, renal failure and neurodegenerative diseases.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Cites
Free radicals, metals and antioxidants in oxidative stress-induced cancer
Valko, M., Rhodes, C. J., Moncol, J., Izakovic, M., & Mazur, M. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2005.12.009 · Cited by 6,680 · see citing works
Mitochondrial formation of reactive oxygen species
Turrens, J. F. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049478 · Cited by 5,084 · see citing works
Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis
van Rooij, E., Sutherland, L. B., Thatcher, J. E., DiMaio, J. M., Naseem, R. H., Marshall, W. S., Hill, J. A., & Olson, E. N. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805038105 · Cited by 1,846 · see citing works
The contribution of chronic kidney disease to the global burden of major noncommunicable diseases
Couser, W. G., Remuzzi, G., Mendis, S., & Tonelli, M. A. (2011) · Kidney International · doi:10.1038/ki.2011.368 · Cited by 1,520 · see citing works
Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases
Park, S. J., Ahmad, F., Philp, A., Baar, K., Williams, T., Luo, H., Ke, H., Rehmann, H., Taussig, R., Brown, A. L., et al. (2012) · Cell · doi:10.1016/j.cell.2012.01.017 · Cited by 1,352 · see citing works
Biochemical, physiological and medical aspects of ubiquinone function
Ernster, L., & Dallner, G. (1995) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(95)00028-3 · Cited by 1,232 · see citing works
Metabolism and function of coenzyme Q
Turunen, M., Olsson, J., & Dallner, G. (2004) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2003.11.012 · Cited by 1,026 · see citing works
Effects of Coenzyme Q10 in Early Parkinson Disease: Evidence of Slowing of the Functional Decline
Shults, C. W. (2002) · Archives of Neurology · doi:10.1001/archneur.59.10.1541 · Cited by 984 · see citing works
Mitochondrial role in cell aging
Miquel, J., Economos, A. C., Fleming, J., & Johnson, J. E. (1980) · Experimental Gerontology · doi:10.1016/0531-5565(80)90010-8 · Cited by 937 · see citing works
Biochemical Functions of Coenzyme Q <sub>10</sub>
Crane, F. L. (2001) · Journal of the American College of Nutrition · doi:10.1080/07315724.2001.10719063 · Cited by 869 · see citing works
Hypertension in developing countries
Ibrahim, M. M., & Damasceno, A. A. M. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60861-7 · Cited by 738 · see citing works
Sohal, R. S., Mockett, R. J., & Orr, W. C. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00886-9 · Cited by 593 · see citing works
Isolation of a quinone from beef heart mitochondria
Crane, F. L., Hatefi, Y., Lester, R. L., & Widmer, C. (1957) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(57)90457-2 · Cited by 588 · see citing works
Uribarri, J., Cai, W., Peppa, M., Goodman, S., Ferrucci, L., Striker, G., & Vlassara, H. (2007) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/62.4.427 · Cited by 570 · see citing works
Coenzyme Q10: Absorption, tissue uptake, metabolism and pharmacokinetics
Bhagavan, H. N., & Chopra, R. K. (2006) · Free Radical Research · doi:10.1080/10715760600617843 · Cited by 550 · see citing works
Invited Review: Theories of aging
Weinert, B. T., & Timiras, P. S. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00288.2003 · Cited by 530 · see citing works
The Effect of Coenzyme Q 10 on Morbidity and Mortality in Chronic Heart Failure
Mortensen, S. A., Rosenfeldt, F., Kumar, A., Dolliner, P., Filipiak, K. J., Pella, D., Alehagen, U., Steurer, G., & Littarru, G. P. (2014) · JACC: Heart Failure · doi:10.1016/j.jchf.2014.06.008 · Cited by 488 · see citing works
Nutritional and toxicological aspects of the Maillard browning reaction in foods
O'Brien, J., Morrissey, P. A., & Ames, J. M. (1989) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398909527499 · Cited by 477 · see citing works
Bioenergetic and Antioxidant Properties of Coenzyme Q10: Recent Developments
Littarru, G. P., & Tiano, L. (2007) · Molecular Biotechnology · doi:10.1007/s12033-007-0052-y · Cited by 465 · see citing works
The miR-29 family: genomics, cell biology, and relevance to renal and cardiovascular injury
Kriegel, A. J., Liu, Y., Fang, Y., Ding, X., & Liang, M. (2012) · Physiological Genomics · doi:10.1152/physiolgenomics.00141.2011 · Cited by 461 · see citing works
Coenzyme Q – Biosynthesis and functions
Bentinger, M., Tekle, M., & Dallner, G. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.02.147 · Cited by 429 · see citing works
Lovastatin decreases coenzyme Q levels in humans.
Folkers, K., Langsjoen, P. H., Willis, R. A., Richardson, P. C., Xia, L., Ye, C. Q., & Tamagawa, H. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.22.8931 · Cited by 426 · see citing works
Age‐related changes in the lipid compositions of rat and human tissues
Kalén, A., Appelkvist, E., & Dallner, G. (1989) · Lipids · doi:10.1007/bf02535072 · Cited by 425 · see citing works
Energy metabolism defects in Huntington's disease and effects of coenzyme Q<sub>10</sub>
Koroshetz, W. J., Jenkins, B. G., Rosen, B. R., & Beal, M. F. (1997) · Annals of Neurology · doi:10.1002/ana.410410206 · Cited by 405 · see citing works
Shults, C. W., Haas, R. H., Passov, D., & Beal, M. F. (1997) · Annals of Neurology · doi:10.1002/ana.410420221 · Cited by 326 · see citing works
Gerhart‐Hines, Z., Dominy, J. E., Blättler, S. M., Jedrychowski, M. P., Banks, A. S., Lim, J.-H., Chim, H., Gygi, S. P., & Puigserver, P. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.12.005 · Cited by 323 · see citing works
Flavonoids--food sources and health benefits.
Kozłowska, A., & Szostak-Węgierek, D. E. (2014) · PubMed · Cited by 294 · see citing works
Effect of Coenzyme Q10 on myopathic symptoms in patients treated with statins
Caso, G., Kelly, P., McNurlan, M. A., & Lawson, W. E. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.12.063 · Cited by 286 · see citing works
Functions of coenzyme Q<sub>10</sub> in inflammation and gene expression
Schmelzer, C., Lindner, I., Rimbach, G., Niklowitz, P., Menke, T., & Döring, F. (2008) · BioFactors · doi:10.1002/biof.5520320121 · Cited by 265 · see citing works
The electron transfer flavoprotein: Ubiquinone oxidoreductases
Watmough, N. J., & Frerman, F. E. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.10.007 · Cited by 251 · see citing works
Coenzyme Q10 in health and disease
Overvad, K., Diamant, B., Holm, L., Hølmer, G., Mortensen, S. A., & Stender, S. (1999) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600880 · Cited by 247 · see citing works
Folkers, K., Vadhanavikit, S., & Mortensen, S. A. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.3.901 · Cited by 246 · see citing works
Nutritional Recommendations for Cardiovascular Disease Prevention
Eilat-Adar, S., Sinai, T., Yosefy, C., & Henkin, Y. (2013) · Nutrients · doi:10.3390/nu5093646 · Cited by 236 · see citing works
Coenzyme Q biosynthesis in health and disease
Acosta, M. J., Vázquez-Fonseca, L., Desbats, M. A., Cerqua, C., Zordan, R., Trevisson, E., & Salviati, L. (2016) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2016.03.036 · Cited by 236 · see citing works
Barja, G. (2007) · Rejuvenation Research · doi:10.1089/rej.2006.0516 · Cited by 222 · see citing works
Mitochondrial DNA in Aging and Disease
Wallace, D. C. (1997) · Scientific American · doi:10.1038/scientificamerican0897-40 · Cited by 222 · see citing works
Pharmacotherapy for hypertension in the elderly
Musini, V. M., Tejani, A. M., Bassett, K. L., & Wright, J. M. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000028.pub2 · Cited by 220 · see citing works
Simultaneous Detection of Ubiquinol and Ubiquinone in Human Plasma as a Marker of Oxidative Stress
Yamashita, S., & Yamamoto, Y. (1997) · Analytical Biochemistry · doi:10.1006/abio.1997.2187 · Cited by 220 · see citing works
Roczniki Państwowego Zakładu Higieny
(2018) · Roczniki Państwowego Zakładu Higieny · doi:10.32394/rpzh · Cited by 213 · see citing works
The Mammalian Cytosolic Selenoenzyme Thioredoxin Reductase Reduces Ubiquinone
Xia, L., Nordman, T., Olsson, J. M., Damdimopoulos, A. E., Björkhem‐Bergman, L., Nalvarte, I., Eriksson, L. C., Arnér, E. S. J., Spyrou, G., & Björnstedt, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210456200 · Cited by 209 · see citing works
Coenzyme Q10 supplementation provides mild symptomatic benefit in patients with Parkinson's disease
Müller, T. H., Büttner, T., Gholipour, A.-F., & Kuhn, W. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00185-x · Cited by 203 · see citing works
Coenzyme Q10 improves endothelial dysfunction of the brachial artery in Type II diabetes mellitus
Watts, G. F., Playford, D. A., Croft, K. D., Ward, N. C., Mori, T. A., & Burke, V. (2002) · Diabetologia · doi:10.1007/s00125-001-0760-y · Cited by 193 · see citing works
Uptake of Dietary Coenzyme Q Supplement is Limited in Rats
Zhang, Y., Åberg, F. O., Appelkvist, E., Dallner, G., & Ernster, L. (1995) · Journal of Nutrition · doi:10.1093/jn/125.3.446 · Cited by 192 · see citing works
Himmelfarb, J., & Hakim, R. M. (2003) · Current Opinion in Nephrology & Hypertension · doi:10.1097/00041552-200311000-00004 · Cited by 189 · see citing works
Quinzii, C. M., DiMauro, S., & Hirano, M. (2006) · Neurochemical Research · doi:10.1007/s11064-006-9190-z · Cited by 188 · see citing works
Effect of coenzyme Q10 supplementation on heart failure: a meta-analysis
Fotino, A. D., Thompson‐Paul, A. M., & Bazzano, L. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.040741 · Cited by 185 · see citing works
Alehagen, U., Johansson, P., Björnstedt, M., Rosén, A., & Dahlström, U. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.04.156 · Cited by 175 · see citing works
Reduced Oxidant Stress and Extended Lifespan in Mice Exposed to a Low Glycotoxin Diet
Cai, W., He, C., Zhu, L., Chen, X., Wallenstein, S. R., Striker, G. E., & Vlassara, H. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.061281 · Cited by 175 · see citing works
Coenzyme Q biosynthesis and its role in the respiratory chain structure
Alcázar‐Fabra, M., Navas, P., & Brea‐Calvo, G. (2016) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2016.03.010 · Cited by 173 · see citing works
The role of oxidative and nitrosative stress in accelerated aging and major depressive disorder
Maurya, P. K., Noto, C. D. S., Rizzo, L. B., Rios, A. C., Nunes, S. O. V., Barbosa, D. S., Sethi, S., Zeni‐Graiff, M., Mansur, R. B., Maes, M. H. J., et al. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.08.016 · Cited by 170 · see citing works
Evidence of Oxidant Damage in Huntington's Disease: Translational Strategies Using Antioxidants
Stack, E. C., Matson, W. R., & Ferrante, R. J. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.008 · Cited by 167 · see citing works
Miquel, J. (1998) · Experimental Gerontology · doi:10.1016/s0531-5565(97)00060-0 · Cited by 167 · see citing works
The importance of plasma membrane coenzyme Q in aging and stress responses
Navas, P., Villalba, J. M., & de Cabo, R. (2007) · Mitochondrion · doi:10.1016/j.mito.2007.02.010 · Cited by 156 · see citing works
Self-citationTiano, L., Belardinelli, R., Carnevali, P., Principi, F., Seddaiu, G., & Littarru, G. P. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm267 · Cited by 153 · see citing works
Coenzyme Q10 and Heart Failure
Sharma, A., Fonarow, G. C., Butler, J., Ezekowitz, J. A., & Felker, G. M. (2016) · Circulation Heart Failure · doi:10.1161/circheartfailure.115.002639 · Cited by 150 · see citing works
Li, F., Feng, Y. Y., Chen, G., Qin, L., Chun-ling, F., & Chen, L. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.01.032 · Cited by 145 · see citing works
Gao, L., Mao, Q., Cao, J. J., Wang, Y., Zhou, X., & Li, F. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.10.027 · Cited by 139 · see citing works
Therapeutic use of coenzyme Q 10 and coenzyme Q 10 -related compounds and formulations
Villalba, J. M., Parrado‐Fernández, C., González, M. S., & Alcain, F. J. (2010) · Expert Opinion on Investigational Drugs · doi:10.1517/13543781003727495 · Cited by 134 · see citing works
Self-citationLee, C., Pugh, T. D., Klopp, R. G., Edwards, J. W., Allison, D. B., Weindruch, R. H., & Prolla, T. A. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.01.015 · Cited by 134 · see citing works
Effects of Coenzyme Q10 on Markers of Inflammation: A Systematic Review and Meta-Analysis
Zhai, J., Bo, Y., Lü, Y., Liu, C., & Zhang, L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170172 · Cited by 134 · see citing works
Biomedical and Clinical Aspects of Coenzyme Q
Goodwin, T. W. (1977) · FEBS Letters · doi:10.1016/0014-5793(77)80678-9 · Cited by 132 · see citing works
Baggio, E., Gandini, R., Plancher, A. C., Passeri, M., & Carmosino, G. (1994) · Molecular Aspects of Medicine · doi:10.1016/0098-2997(94)90040-x · Cited by 130 · see citing works
Is coenzyme Q a key factor in aging?
López‐Lluch, G., Rodríguez‐Aguilera, J. C., Santos‐Ocaña, C., & Navas, P. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.02.003 · Cited by 129 · see citing works
Coenzyme Q, oxidative stress and aging
Sohal, R. S., & Forster, M. J. (2007) · Mitochondrion · doi:10.1016/j.mito.2007.03.006 · Cited by 124 · see citing works
Primary and secondary coenzyme Q10 deficiency: the role of therapeutic supplementation
Potgieter, M., Pretorius, E., & Pepper, M. S. (2013) · Nutrition Reviews · doi:10.1111/nure.12011 · Cited by 124 · see citing works
Tian, G., Sawashita, J., Kubo, H., Nishio, S.-Y., Hashimoto, S., Suzuki, N., Yoshimura, H., Tsuruoka, M., Wang, Y., Liu, Y., et al. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5406 · Cited by 123 · see citing works
Plasma Membrane Redox System in the Control of Stress-Induced Apoptosis
Villalba, J. M., & Navas, P. (2000) · Antioxidants and Redox Signaling · doi:10.1089/ars.2000.2.2-213 · Cited by 119 · see citing works
Self-citationCoenzyme Q10 in the diet-daily intake and relative bioavailability
Weber, C., Bysted, A., & Hølmer, G. (1997) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(97)00003-4 · Cited by 117 · see citing works
Farsi, F., Mohammadshahi, M., Alavinejad, P., Rezazadeh, A., Zarei, M., & Engali, K. A. (2015) · Journal of the American College of Nutrition · doi:10.1080/07315724.2015.1021057 · Cited by 116 · see citing works
Xie, L. X., Hsieh, E. J., Watanabe, S., Allan, C. M., Chen, J. Y., Tran, U. C., & Clarke, C. F. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.01.009 · Cited by 116 · see citing works
Oxidative injury in the nervous system
Delanty, N., & Dichter, M. A. (1998) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1998.tb07285.x · Cited by 112 · see citing works
Coenzyme Q10administration and its potential for treatment of neurodegenerative diseases
Beal, M. F. (1999) · BioFactors · doi:10.1002/biof.5520090222 · Cited by 111 · see citing works
Moosmann, B., & Behl, C. (2004) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2004.08.003 · Cited by 110 · see citing works
Forsmark-Andrée, P., Dallner, G., & Ernster, L. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)00076-a · Cited by 109 · see citing works
Xu, Z., Huo, J., Ding, X., Yang, M., Li, L., Dai, J., Hosoe, K., Kubo, H., Mori, M., Higuchi, K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-08899-7 · Cited by 108 · see citing works
Coenzyme Q10: Absorption, Antioxidative Properties, Determinants, and Plasma Levels
Kaikkonen, J., Tuomainen, T., Nyyssönen, K., & Salonen, J. T. (2002) · Free Radical Research · doi:10.1080/10715760290021234 · Cited by 107 · see citing works
Abdollahzad, H., Aghdashi, M. A., Jafarabadi, M. A., & Alipour, B. (2015) · Archives of Medical Research · doi:10.1016/j.arcmed.2015.08.006 · Cited by 105 · see citing works
Tsuneki, H., Sekizaki, N., Suzuki, T., Kobayashi, S., Wada, T., Okamoto, T., Kimura, I., & Sasaoka, T. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.03.006 · Cited by 104 · see citing works
A constituent of the unsaponifiable portion of animal tissue lipids (λmax. 272mμ.)
Festenstein, G. N., Heaton, F. W., Lowe, J. S., & Morton, R. A. (1955) · Biochemical Journal · doi:10.1042/bj0590558 · Cited by 101 · see citing works
A Novel Dialysis Procedure Measuring Free Zn2+ in Bovine Milk and Plasma
Zhang, P., & Allen, J. C. (1995) · Journal of Nutrition · doi:10.1093/jn/125.7.1904 · Cited by 92 · see citing works
Tarry‐Adkins, J. L., Fernandez‐Twinn, D. S., Hargreaves, I. P., Neergheen, V., Aiken, C., Martin‐Gronert, M. S., McConnell, J. M. L., & Ozanne, S. E. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.119834 · Cited by 89 · see citing works
Mitochondrial coenzyme Q content and aging
Lass, A., Kwong, L. K., & Sohal, R. S. (1999) · BioFactors · doi:10.1002/biof.5520090215 · Cited by 87 · see citing works
Yubero‐Serrano, E. M., González-Guardia, L., Rangel-Zúñiga, O. A., Delgado‐Lista, J., Gutierrez-Mariscal, F. M., Pérez‐Martínez, P., Delgado‐Casado, N., Cruz‐Teno, C., Tinahones, F. J., Villalba, J. M., et al. (2011) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr167 · Cited by 86 · see citing works
Self-citationOlivieri, F., Lazzarini, R., Babini, L., Prattichizzo, F., Rippo, M. R., Tiano, L., Di Nuzzo, S., Graciotti, L., Festa, R., Brugè, F., et al. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.05.033 · Cited by 84 · see citing works
Cullen, J. K., Murad, N. A., Yeo, A. J., McKenzie, M., Ward, M. S., Chong, K. L., Schieber, N. L., Parton, R. G., Lim, Y. C., Wolvetang, E. J., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148213 · Cited by 82 · see citing works
Localization and mobility of coenzyme Q in lipid bilayers and membranes
Lenaz, G., Fato, R., Bernardo, S. D., Jarreta, D., Costa, A., Genova, M. L., & Castelli, G. P. (1999) · BioFactors · doi:10.1002/biof.5520090202 · Cited by 81 · see citing works
Estimation of Oxidative Stress Markers in Chronic Kidney Disease
Kuchta, A., Pacanis, A., Kortas‐Stempak, B., Ćwiklińska, A., Ziętkiewicz, M., Renke, M., & Rutkowski, B. (2010) · Kidney & Blood Pressure Research · doi:10.1159/000321508 · Cited by 77 · see citing works
Nonsense mutations in CABC1/ADCK3 cause progressive cerebellar ataxia and atrophy
Gerards, M., van den Bosch, B. J. C., Calis, C., Schoonderwoerd, K., van Engelen, K., Tijssen, M. A. J., de Coo, I. F. M., van der Kooi, A. J., & Smeets, H. J. M. (2010) · Mitochondrion · doi:10.1016/j.mito.2010.05.008 · Cited by 75 · see citing works
Effects of ubiquinone (coenzyme Q10) on myopathy in statin users
Schaars, C. F., & Stalenhoef, A. F. H. (2008) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283168ecd · Cited by 74 · see citing works
Bioactive Nutrients and Nutrigenomics in Age-Related Diseases
Rescigno, T., Micolucci, L., Tecce, M. F., & Capasso, A. (2017) · Molecules · doi:10.3390/molecules22010105 · Cited by 73 · see citing works
Coenzyme Q distribution in HL-60 human cells depends on the endomembrane system
Fernández‐Ayala, D. J. M., Brea‐Calvo, G., López‐Lluch, G., & Navas, P. (2005) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2005.05.010 · Cited by 72 · see citing works
Yeast COQ4 Encodes a Mitochondrial Protein Required for Coenzyme Q Synthesis
Belogrudov, G. I., Lee, P. T., Jonassen, T., Hsu, A. Y., Gin, P., & Clarke, C. F. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2001.2448 · Cited by 69 · see citing works
Decreased Coenzyme Q10 Levels in Multiple System Atrophy Cerebellum
Barca, E., Kleiner, G., Tang, G., Ziosi, M., Tadesse, S., Masliah, E., Louis, E. D., Faust, P. L., Kang, U. J., Torres, J., et al. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlw037 · Cited by 69 · see citing works
Gilmer, L. K., Ansari, M. A., Roberts, K. N., & Scheff, S. W. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.12.011 · Cited by 68 · see citing works
Assessment of coenzyme Q10 absorption using an in vitro digestion-Caco-2 cell model
Bhagavan, H. N., Chopra, R. K., Craft, N. E., Chitchumroonchokchai, C., & Failla, M. L. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.10.007 · Cited by 67 · see citing works
Current state of coenzyme Q10 production and its applications
Jeya, M., Moon, H.-J., Lee, J.-L., Kim, I., & Lee, J.-K. (2009) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-009-2380-2 · Cited by 66 · see citing works
Baba, S. W., Belogrudov, G. I., Lee, J. C., Lee, P. T., Strahan, J. R., Shepherd, J. N., & Clarke, C. F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313712200 · Cited by 65 · see citing works
González-Guardia, L., Yubero-Serrano, E. M., Delgado-Lista, J., Perez-Martinez, P., Garcia-Rios, A., Marin, C., Camargo, A., Delgado-Casado, N., Roche, H. M., Perez-Jimenez, F., et al. (2015) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu098 · Cited by 64 · see citing works
Self-citationYeung, C. K., Billings, F. T., Claessens, A. J., Roshanravan, B., Linke, L., Sundell, M. B., Ahmad, S., Shao, B., Shen, D. D., Ikizler, T. A., et al. (2015) · BMC Nephrology · doi:10.1186/s12882-015-0178-2 · Cited by 63 · see citing works
Nordman, T., Xia, L., Björkhem‐Bergman, L., Damdimopoulos, A. E., Nalvarte, I., Arnér, E. S. J., Spyrou, G., Eriksson, L. C., Björnstedt, M., & Olsson, J. M. (2003) · BioFactors · doi:10.1002/biof.5520180206 · Cited by 62 · see citing works
Navas, P., Fernández‐Ayala, D. J. M., Martín, S. F., López‐Lluch, G., de Cabo, R., Rodríguez‐Aguilera, J. C., & Villalba, J. M. (2002) · Free Radical Research · doi:10.1080/10715760290021207 · Cited by 62 · see citing works
Self-citationRole of plasma membrane coenzyme Q on the regulation of apoptosis
López‐Lluch, G., Barroso, M. P., Martín, S. F., Fernández‐Ayala, D. J. M., Gómez-Dı́az, C., Villalba, J. M., & Navas, P. (1999) · BioFactors · doi:10.1002/biof.5520090212 · Cited by 61 · see citing works
Self-citationCoenzyme Q10 for the treatment of heart failure: a review of the literature
DiNicolantonio, J. J., Bhutani, J., McCarty, M. F., & O’Keefe, J. H. (2015) · Open Heart · doi:10.1136/openhrt-2015-000326 · Cited by 61 · see citing works
Gutierrez-Mariscal, F. M., Pérez‐Martínez, P., Delgado‐Lista, J., Yubero‐Serrano, E. M., Camargo, A., Delgado‐Casado, N., Cruz‐Teno, C., González, M. S., Rodríguez-Cantalejo, F., Castano, J. P., et al. (2011) · AGE · doi:10.1007/s11357-011-9229-1 · Cited by 59 · see citing works
Self-citationAlehagen, U., Lindahl, T. L., Aaseth, J., Svensson, E., & Johansson, P. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137680 · Cited by 59 · see citing works
Young, J. M., Florkowski, C. M., Molyneux, S. L., McEwan, R. G., Frampton, C. M., Nicholls, M. G., Scott, R. S., & George, P. M. (2012) · American Journal of Hypertension · doi:10.1038/ajh.2011.209 · Cited by 59 · see citing works
Improvement in Intestinal Coenzyme Q10 Absorption by Food Intake
Ochiai, A., Itagaki, S., Kurokawa, T., Kobayashi, M., Hirano, T., & Iseki, K. (2007) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.127.1251 · Cited by 57 · see citing works
Yubero‐Serrano, E. M., Delgado‐Casado, N., Delgado‐Lista, J., Pérez‐Martínez, P., Tasset-Cuevas, I., González, M. S., Caballero‐Villarraso, J., García‐Ríos, A., Marı́n, C., Gutierrez-Mariscal, F. M., et al. (2010) · AGE · doi:10.1007/s11357-010-9199-8 · Cited by 54 · see citing works
Self-citationSchmelzer, C., Lorenz, G., Rimbach, G. H., & Döring, F. (2007) · BioFactors · doi:10.1002/biof.5520310308 · Cited by 52 · see citing works
Novel Lipid-Free Nanoformulation for Improving Oral Bioavailability of Coenzyme Q10
Zhou, H., Liu, G., Zhang, J., Sun, N., Duan, M., Yan, Z., & Xia, Q. (2014) · BioMed Research International · doi:10.1155/2014/793879 · Cited by 52 · see citing works
Ubiquinone-10 alters mechanical properties and increases stability of phospholipid membranes
Hernández, V. A., Eriksson, E. K., & Edwards, K. (2015) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2015.05.002 · Cited by 49 · see citing works
Alehagen, U., Johansson, P., Aaseth, J., Alexander, J., & Wågsäter, D. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174880 · Cited by 49 · see citing works
Influence of peroxisome proliferator-activated receptor α on ubiquinone biosynthesis
Turunen, M., Peters, J. M., Gonzalez, F. J., Schedin‐Weiss, S., & Dallner, G. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.3596 · Cited by 48 · see citing works
Munier‐Lehmann, H., Lucas‐Hourani, M., Guillou, S., Helynck, O., Zanghì, G., Noël, A., Tangy, F., Vidalain, P., & Janin, Y. L. (2015) · Journal of Medicinal Chemistry · doi:10.1021/jm501446r · Cited by 48 · see citing works
Oxidative stress, endothelial function and coenzyme Q10
Belardinelli, R., Tiano, L., & Littarru, G. P. (2008) · BioFactors · doi:10.1002/biof.5520320115 · Cited by 48 · see citing works
Plasma Coenzyme Q10 Levels in Patients With Multiple System Atrophy
Mitsui, J., Matsukawa, T., Yasuda, T., Ishiura, H., & Tsuji, S. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.1325 · Cited by 48 · see citing works
Shetty, R. A., Forster, M. J., & Sumien, N. (2013) · AGE · doi:10.1007/s11357-012-9484-9 · Cited by 47 · see citing works
López-Moreno, J., Quintana‐Navarro, G. M., Delgado‐Lista, J., García‐Ríos, A., Alcala-Diaz, J. F., Gómez-Delgado, F., Camargo, A., Pérez‐Martínez, P., Tinahones, F. J., Striker, G. E., et al. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw214 · Cited by 47 · see citing works
Self-citationBiochemical Assessment of Coenzyme Q10 Deficiency
Rodríguez‐Aguilera, J. C., Cortés, A., Fernández‐Ayala, D. J. M., & Navas, P. (2017) · Journal of Clinical Medicine · doi:10.3390/jcm6030027 · Cited by 47 · see citing works
Yubero‐Serrano, E. M., González-Guardia, L., Rangel-Zúñiga, O. A., Delgado‐Casado, N., Delgado‐Lista, J., Pérez‐Martínez, P., García‐Ríos, A., Caballero‐Villarraso, J., Marı́n, C., Gutierrez-Mariscal, F. M., et al. (2011) · AGE · doi:10.1007/s11357-011-9331-4 · Cited by 46 · see citing works
Self-citationCoadministration of Coenzyme Q prevents Rosiglitazone-induced adipogenesis in ob/ob mice
Carmona, M. C., Lefèbvre, P., Lefebvre, B., Galinier, A., Bénani, A., Jeanson, Y., Louche, K., Flajollet, S., Ktorza, A., Dacquet, C., et al. (2009) · International Journal of Obesity · doi:10.1038/ijo.2008.265 · Cited by 46 · see citing works
Prolonged Intake of Coenzyme Q10 Impairs Cognitive Functions in Mice
Sumien, N., Heinrich, K. R., Shetty, R. A., Sohal, R. S., & Forster, M. J. (2009) · The Journal of Nutrition · doi:10.3945/jn.109.110437 · Cited by 46 · see citing works
Rosenfeldt, F., Pepe, S., Ou, R., Mariani, J. A., Rowland, M. A., Nagley, P., & Linnane, A. W. (1999) · BioFactors · doi:10.1002/biof.5520090226 · Cited by 45 · see citing works
Brea‐Calvo, G., Siendones, E., Sánchez-Alcázar, J. A., de Cabo, R., & Navas, P. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005301 · Cited by 45 · see citing works
Serum Levels of Coenzyme Q10 in Patients with Multiple System Atrophy
Kasai, T., Tokuda, T., Ohmichi, T., Ishii, R., Tatebe, H., Nakagawa, M., & Mizuno, T. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147574 · Cited by 44 · see citing works
Coenzyme Q10 Regulates Osteoclast and Osteoblast Differentiation
Moon, H., Ko, W., Jung, M., Kim, J. H., Lee, W., Park, K. W., Heo, J., Bang, J. B., & Kwon, I. K. (2013) · Journal of Food Science · doi:10.1111/1750-3841.12116 · Cited by 42 · see citing works
Shidfar, F., Mohseni, M., Vafa, M., Zarrati, M., Hajimiresmaiel, S. J., & Forushani, A. R. (2015) · International Journal of Preventive Medicine · doi:10.4103/2008-7802.162461 · Cited by 41 · see citing works
Tsai, H., Lin, C.-P., Huang, P.-H., Li, S., Chen, J.-S., Lin, F., Chen, J., & Lin, S. (2015) · Journal of Diabetes Research · doi:10.1155/2016/6384759 · Cited by 40 · see citing works
Ma, D., Stokes, K., Mahngar, K., Domazet-Damjanov, D., Sikorska, M., & Pandey, S. (2014) · Mitochondrion · doi:10.1016/j.mito.2014.07.004 · Cited by 39 · see citing works
Fernández-del-Río, L., Nag, A., Gutiérrez-Casado, E., Ariza, J., Awad, A. M., Joseph, A. I., Kwon, O., Verdin, E., de Cabo, R., Schneider, C. G., et al. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.06.006 · Cited by 38 · see citing works
Self-citationCoenzyme Q10 Decreases TNF-α and IL-2 Secretion by Human Peripheral Blood Mononuclear Cells
Bessler, H., Bergman, M., Blumberger, N., Djaldetti, M., & Salman, H. (2010) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.56.77 · Cited by 36 · see citing works
Polyisoprenoid Epoxides Stimulate the Biosynthesis of Coenzyme Q and Inhibit Cholesterol Synthesis
Bentinger, M., Tekle, M., Brismar, K., Chojnacki, T., Świeżewska, E., & Dallner, G. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710202200 · Cited by 36 · see citing works
Biochemical rationale and experimental data on the antiaging properties of CoQ10 at skin level
Blatt, T., & Littarru, G. P. (2011) · BioFactors · doi:10.1002/biof.169 · Cited by 34 · see citing works
Singh, R. B., Khanna, H. K., & Niaz, M. A. (2000) · Journal of Nutritional & Environmental Medicine · doi:10.1080/13590840020013266 · Cited by 34 · see citing works
Cascajo, M. V., Abdelmohsen, K., Noh, J. H., Fernández‐Ayala, D. J. M., Willers, I. M., Brea‐Calvo, G., López‐Lluch, G., Valenzuela-Villatoro, M., Cuezva, J. M., Gorospe, M., et al. (2015) · RNA Biology · doi:10.1080/15476286.2015.1119366 · Cited by 34 · see citing works
Starace, D., Anna Riccioli, A., D’Alessio, A., Giampietri, C., Petrungaro, S., Galli, R., Filippini, A., Elio Ziparo, A., & Cesaris, P. D. (2004) · The FASEB Journal · doi:10.1096/fj.04-2726fje · Cited by 33 · see citing works
Stimulation of coenzyme Q synthesis
Bentinger, M., Tekle, M., Brismar, K., Chojnacki, T., Świeżewska, E., & Dallner, G. (2008) · BioFactors · doi:10.1002/biof.5520320112 · Cited by 33 · see citing works
Metabolism of coenzyme Q 10 : Biliary and urinary excretion study in guinea pigs
Nakamura, T., Ohno, T., Hamamura, K., & Sato, T. (1999) · BioFactors · doi:10.1002/biof.5520090205 · Cited by 33 · see citing works
Ochoa, J. J., Quiles, J. L., López‐Frías, M., Huertas, J. R., & Mataix, J. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.11.1211 · Cited by 32 · see citing works
Coenzyme Q as an Antiadipogenic Factor
Bour, S., Carmona, M.-C., Galinier, A., Caspar‐Bauguil, S., Gaal, L. V., Staels, B., Pénicaud, L., & Casteilla, L. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3350 · Cited by 31 · see citing works
Alehagen, U., Aaseth, J., & Johansson, P. (2015) · BioFactors · doi:10.1002/biof.1245 · Cited by 31 · see citing works
Resveratrol and its impact on aging and thyroid function.
Duntas, L. H. (2011) · PubMed · doi:10.3275/7926 · Cited by 29 · see citing works
Lopez-Dominguez, J. A., Khraiwesh, H. M., González-Reyes, J. A., López‐Lluch, G., Navas, P., Ramsey, J. J., de Cabo, R., Burón, M. I., & Villalba, J. M. (2012) · AGE · doi:10.1007/s11357-012-9492-9 · Cited by 28 · see citing works
Self-citationCarrasco, J., Anglada, F. J., Campos, J. P., Muntané, J., Requena, M. J., & Padillo, J. (2014) · BJU International · doi:10.1111/bju.12485 · Cited by 26 · see citing works
Coenzyme Q10 redox balance and a free radical scavenger drug
Yamamoto, Y. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.11.026 · Cited by 26 · see citing works
Lippa, S., Colacicco, L., Bondanini, F., Callà, C. A. M., Gozzo, M. L., Ciccariello, M., & Angelitti, A. (2000) · Clinica Chimica Acta · doi:10.1016/s0009-8981(99)00204-1 · Cited by 24 · see citing works
Brain Mitochondrial Dysfunction in Ovariectomized Mice Injected with d-Galactose
Su, Y., Sun, H., Fang, J., Hu, G., & Xiao, M. (2009) · Neurochemical Research · doi:10.1007/s11064-009-0068-8 · Cited by 24 · see citing works
Onur, S., Niklowitz, P., Jacobs, G., Lieb, W., Menke, T., & Döring, F. (2015) · BioFactors · doi:10.1002/biof.1198 · Cited by 24 · see citing works
Rodríguez-Carrizález, A. D., Castellanos‐González, J. A., Martínez‐Romero, E. C., Miller‐Arrevillaga, G., Román-Pintos, L. M., Pacheco-Moisés, F. P., & Miranda‐Díaz, A. G. (2015) · Redox Report · doi:10.1179/1351000215y.0000000032 · Cited by 23 · see citing works
Gutierrez-Mariscal, F. M., Yubero‐Serrano, E. M., Rangel-Zúñiga, O. A., Marı́n, C., García‐Ríos, A., Pérez‐Martínez, P., Delgado‐Lista, J., Malagón, M. M., Tinahones, F. J., Pérez‐Jiménez, F., et al. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt174 · Cited by 21 · see citing works
Self-citationCasado‐Díaz, A., Túnez‐Fiñana, I., Mata-Granados, J. M., Méndez, M. V. R., Dorado, G., Romero-Sánchez, M. C., Navarro-Valverde, C., & Quesada‐Gómez, J. M. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.01.024 · Cited by 21 · see citing works
Chen, C., Liou, S., Chen, C.-C., Chen, W.-C., Hu, F., Wang, I., & Lin, S.-J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.401844 · Cited by 19 · see citing works
Mart�n, S. F., G�mez-D�az, C., Bello, R. I., Navas, P., & Villalba, J. M. (2003) · PROTOPLASMA · doi:10.1007/s00709-002-0070-3 · Cited by 18 · see citing works
Self-citationEfficacy of coenzyme Q10 in mitigating spinal cord injury-induced osteoporosis
ZHANG, X.-X., Qian, K., ZHANG, Y., Wang, Z., Yu, Y., LIU, X.-J., CAO, X.-T., LIAO, Y.-H., & Zhang, D. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3856 · Cited by 16 · see citing works
Effects of various squalene epoxides on coenzyme Q and cholesterol synthesis
Bentinger, M., Kania, M., Danikiewicz, W., Kaczorowska, E., Wójcik, J., Brismar, K., Dallner, G., Chojnacki, T., Świeżewska, E., & Tekle, M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.03.007 · Cited by 15 · see citing works
Gökbel, H., Atalay, H., Okudan, N., Solak, Y., Belviranlı, M., & Türk, S. (2011) · Renal Failure · doi:10.3109/0886022x.2011.589941 · Cited by 15 · see citing works
Vitamin C supplementation for the primary prevention of cardiovascular disease
Flowers, N., Wheelhouse, R., Stranges, S., & Rees, K. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011114 · Cited by 13 · see citing works
Battino, M. A., Svegliati, S., Littarru, G. P., Bompadre, S., Leone, L., Gorini, A., & Villa, R. F. (1997) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(97)00023-x · Cited by 11 · see citing works
Coenzyme Q10 and congestive heart failure; an evolving evidence base
Florkowski, C. M., Molyneux, S. L., & Young, J. M. (2015) · Kardiologia Polska · doi:10.5603/kp.2015.0015 · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Ferroptosis in Parkinson's disease: Molecular mechanisms and therapeutic potential
Ding, X.-S., Gao, L., Han, Z., Eleuteri, S., Shi, W., Shen, Y., Song, Z.-Y., Su, M., Yang, Q., Qu, Y., et al. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102077 · Cited by 199 · see citing works
Gutierrez-Mariscal, F. M., Arenas-de Larriva, A. P., Limia-Perez, L., Romero-Cabrera, J. L., Yubero-Serrano, E. M., & López-Miranda, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217870 · Cited by 190 · see citing works
Self-citationNutraceutical Approach to Non-Alcoholic Fatty Liver Disease (NAFLD): The Available Clinical Evidence
Cicero, A. F. G., Colletti, A., & Bellentani, S. (2018) · Nutrients · doi:10.3390/nu10091153 · Cited by 185 · see citing works
Disorders of Human Coenzyme Q10 Metabolism: An Overview
Hargreaves, I., Heaton, R. A., & Mantle, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186695 · Cited by 182 · see citing works
Bioavailability of Coenzyme Q10: An Overview of the Absorption Process and Subsequent Metabolism
Mantle, D., & Dybring, A. (2020) · Antioxidants · doi:10.3390/antiox9050386 · Cited by 134 · see citing works
de Barcelos, I. P., & Haas, R. (2019) · Biology · doi:10.3390/biology8020028 · Cited by 126 · see citing works
Coenzyme Q10: Clinical Applications in Cardiovascular Diseases
Martelli, A., Testai, L., Colletti, A., & Cicero, A. F. G. (2020) · Antioxidants · doi:10.3390/antiox9040341 · Cited by 121 · see citing works
Coenzyme Q10 supplementation – In ageing and disease
Aaseth, J., Alexander, J., & Alehagen, U. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111521 · Cited by 100 · see citing works
Wei, Y., Zhang, L., Yu, Z., Lin, K., Yang, S., Dai, L., Liu, J., Mao, L., Yuan, F., & Gao, Y. (2019) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2019.03.024 · Cited by 95 · see citing works
Chiu, H., Venkatakrishnan, K., & Wang, C. (2020) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2020.03.008 · Cited by 86 · see citing works
Coenzyme Q10: Clinical Applications beyond Cardiovascular Diseases
Testai, L., Martelli, A., Flori, L., Cicero, A. F. G., & Colletti, A. (2021) · Nutrients · doi:10.3390/nu13051697 · Cited by 82 · see citing works
Coenzyme Q10 and Cardiovascular Diseases
Gutierrez-Mariscal, F. M., de la Cruz, S., Torres-Peña, J. D., Alcala-Diaz, J. F., Yubero‐Serrano, E. M., & López‐Miranda, J. (2021) · Antioxidants · doi:10.3390/antiox10060906 · Cited by 82 · see citing works
Self-citationChen, S., Zhang, Y., Qing, J., Han, Y., McClements, D. J., & Gao, Y. (2020) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2020.105651 · Cited by 78 · see citing works
Coenzyme Q10 for heart failure
Saadi, T. A., Assaf, Y., Farwati, M., Turkmani, K., Al-Mouakeh, A., Shebli, B., Khoja, M. T., Essali, A., & Madmani, M. E. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008684.pub3 · Cited by 62 · see citing works
Sharma, A., Chabloz, S., Lapides, R. A., Roider, E., & Ewald, C. Y. (2023) · Nutrients · doi:10.3390/nu15020445 · Cited by 60 · see citing works
Dludla, P. V., Orlando, P., Silvestri, S., Marcheggiani, F., Cirilli, I., Nyambuya, T. M., Mxinwa, V., Mokgalaboni, K., Nkambule, B. B., Johnson, R., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093247 · Cited by 60 · see citing works
Chen, S., Zhang, Y., Han, Y., McClements, D. J., Liao, W., Mao, L., Yuan, F., & Gao, Y. (2020) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2020.106090 · Cited by 54 · see citing works
Important drug-micronutrient interactions: A selection for clinical practice
Gröber, U., Schmidt, J., & Kisters, K. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1522613 · Cited by 54 · see citing works
Kumari, A., Bhawal, S., Kapila, S., Yadav, H., & Kapila, R. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1825286 · Cited by 52 · see citing works
Fernández-del-Río, L., & Clarke, C. F. (2021) · Metabolites · doi:10.3390/metabo11060385 · Cited by 46 · see citing works
Tsui, K., & Li, C. (2023) · Aging · doi:10.18632/aging.204475 · Cited by 42 · see citing works
Rizzardi, N., Liparulo, I., Antonelli, G., Orsini, F., Riva, A., Bergamini, C., & Fato, R. (2021) · Antioxidants · doi:10.3390/antiox10060927 · Cited by 41 · see citing works
Atherosclerosis and Coenzyme Q10
Suarez-Rivero, J. M., Pastor‐Maldonado, C. J., de la Mata, M., Paz, M. V., Povea-Cabello, S., Álvarez-Córdoba, M., Villalón-García, I., Suárez-Carrillo, A., Talaverón-Rey, M., Munuera-Cabeza, M., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205195 · Cited by 41 · see citing works
Jiang, X., Wu, K., Ye, X., Xie, T., Zhang, P., Blass, B. E., & Bai, R. (2023) · Medicinal Research Reviews · doi:10.1002/med.21939 · Cited by 40 · see citing works
Zhi, R., Cao, K.-F., Zhang, G., Zhu, J., & Xian, G. (2019) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2019.119581 · Cited by 39 · see citing works
Sun, J., Yang, F., Wang, L., Yu, H., Yang, Z., Wei, J., Vasilev, K. A., Zhang, X., Liu, X., & Zhao, Y. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.10.019 · Cited by 39 · see citing works
Atapour‐Mashhad, H., Tayarani‐Najaran, Z., & Golmohammadzadeh, S. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e31429 · Cited by 37 · see citing works
Coenzyme Q10 Supplementation in Fibrosis and Aging
Hargreaves, I. P., & Mantle, D. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-25650-0_6 · Cited by 36 · see citing works
Petrangolini, G., Ronchi, M., Frattini, E., Combarieu, E. D., Allegrini, P., & Riva, A. (2019) · Current Drug Delivery · doi:10.2174/1567201816666190902123147 · Cited by 36 · see citing works
Dai, S., Tian, Z., Zhao, D., Liang, Y. J., Liu, M., Liu, Z., Hou, S., & Yang, Y. (2022) · Antioxidants · doi:10.3390/antiox11071360 · Cited by 35 · see citing works
Molecular mechanisms underlying the renal protective effects of coenzyme Q10 in acute kidney injury
Zhao, S., Wu, W., Liao, J., Zhang, X., Shen, M., Li, X., Qi, L., & Cao, C. (2022) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-022-00361-5 · Cited by 33 · see citing works
Shi, Y., Ye, F., Chen, Y., Hui, Q., & Miao, M. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.127510 · Cited by 32 · see citing works
Fragrant rapeseed oils: A review in production, volatile flavor formation and regulation
Zhang, Y., Zhou, Z.-X., Tan, M., Ye, P.-P., Shi, J.-C., Zhang, H., Chen, Z., Zhou, T.-L., Shu, X.-Q., Cui, F., et al. (2024) · Industrial Crops and Products · doi:10.1016/j.indcrop.2024.118870 · Cited by 30 · see citing works
Okudan, N., Belviranlı, M., & Sezer, T. (2022) · Neurochemical Research · doi:10.1007/s11064-021-03522-8 · Cited by 29 · see citing works
Pagano, G., Pallardó, F. V., Lyakhovich, A., Tiano, L., Fittipaldi, M. R., Toscanesi, M., & Trifuoggi, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197060 · Cited by 27 · see citing works
Alehagen, U., Aaseth, J., Lindahl, T. L., Larsson, A. O., & Alexander, J. (2021) · Nutrients · doi:10.3390/nu13041344 · Cited by 27 · see citing works
Kim, M., Lee, J., & Lee, J. (2024) · Journal of Lipid and Atherosclerosis · doi:10.12997/jla.2024.13.3.306 · Cited by 25 · see citing works
The role of microglia in neurodegenerative diseases: from the perspective of ferroptosis
Liu, Y.-J., Jia, G.-R., Zhang, S.-H., Guo, Y., Ma, X.-Z., Xu, H.-M., & Xie, J.-X. (2025) · Acta Pharmacologica Sinica · doi:10.1038/s41401-025-01560-4 · Cited by 29 · see citing works
Camps, J., Iftimie, S. M., Jiménez-Franco, A., Castro, A., & Joven, J. (2025) · Biomolecules · doi:10.3390/biom15071027 · Cited by 28 · see citing works
Mourad, M. M., Shahin, S. A., El-Ratel, I. T., & Basuini, M. F. E. (2022) · Animals · doi:10.3390/ani12172219 · Cited by 23 · see citing works
miR-612 Enhances RSL3-Induced Ferroptosis of Hepatocellular Carcinoma Cells via Mevalonate Pathway
Xing, K., Bian, X., Shi, D.-M., Dong, S., Zhou, H., Xiao, S., Bai, J., & Wu, W. (2023) · Journal of Hepatocellular Carcinoma · doi:10.2147/jhc.s433332 · Cited by 22 · see citing works
Basuini, M. F. E., Shahin, S. A., Eldenary, M. E., Elshora, S. M., Dawood, M. A. O., & Mourad, M. M. (2022) · Aquaculture Reports · doi:10.1016/j.aqrep.2022.101373 · Cited by 20 · see citing works
New Insights on the Uptake and Trafficking of Coenzyme Q
Guile, M. D., Jain, A., Anderson, K. A., & Clarke, C. F. (2023) · Antioxidants · doi:10.3390/antiox12071391 · Cited by 20 · see citing works
HBM4EU Chromates Study: Urinary Metabolomics Study of Workers Exposed to Hexavalent Chromium
Kozłowska, L., Santonen, T., Duca, R. C., Godderis, L., Jagiełło, K., Janasik, B., Nieuwenhuyse, A. V., Poels, K. L. C., Puzyn, T., Scheepers, P. T. J., et al. (2022) · Metabolites · doi:10.3390/metabo12040362 · Cited by 19 · see citing works
Non-alcoholic fatty liver disease: Dietary and nutraceutical approaches
Cogorno, L., Formisano, E., Vignati, A., Prigione, A., Tramacere, A., Borgarelli, C., Sukkar, S. G., & Pisciotta, L. (2023) · Liver Research · doi:10.1016/j.livres.2023.08.005 · Cited by 19 · see citing works
Ovchinnikov, A. N., Paoli, A., Seleznev, V. V., & Deryugina, A. V. (2022) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2022.2086015 · Cited by 18 · see citing works
Farsi, F., Ebrahimi‐Daryani, N., Golab, F., Akbari, A., Janani, L., Karimi, M. Y., Irandoost, P., Alamdari, N. M., Agah, S., & Vafa, M. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02514-2 · Cited by 18 · see citing works
RetractedCoQ10 Improves Myocardial Damage in Doxorubicin-Induced Heart Failure in C57BL/6 Mice
Pei, Z., Ma, L., Li, Y., Yang, J., Qin, Y., Yao, W., & Li, S. (2022) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2708244 · Cited by 16 · see citing works
Fernández-Del-Río, L., Kelly, M., Contreras, J., Bradley, M. C., James, A. M., Murphy, M., Payne, G., & Clarke, C. (2020) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2020.04.029 · Cited by 14 · see citing works
Fernández-del-Río, L., Soubeyrand, E., Basset, G. J. C., & Clarke, C. F. (2020) · Molecules · doi:10.3390/molecules25132955 · Cited by 14 · see citing works
Regulation of hepatic coenzyme Q biosynthesis by dietary omega-3 polyunsaturated fatty acids
Fernández-del-Río, L., Rodríguez-López, S., Gutiérrez-Casado, E., González-Reyes, J. A., Clarke, C. F., Burón, M. I., & Villalba, J. M. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102061 · Cited by 13 · see citing works
Self-citationChronic Kidney Disease and Coenzyme Q10 Supplementation
Hargreaves, I., Mantle, D., & Milford, D. (2019) · Journal of Kidney Care · doi:10.12968/jokc.2019.4.2.82 · Cited by 12 · see citing works
Villalaı́n, J. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.06.017 · Cited by 11 · see citing works
Oils as a source of bioactive lipids (olive oil, palm oil, fish oil)
Rey, F., Alves, E., Gaspar, L., Conceição, M., & Domingues, M. R. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824043-4.00013-0 · Cited by 13 · see citing works
The Impact of Coenzyme Q10 on Neurodegeneration: a Comprehensive Review
Kadian, M., Sharma, G., Pandita, S., Sharma, K., Shrivasatava, K., Saini, N., & Kumar, A. (2022) · Current Pharmacology Reports · doi:10.1007/s40495-021-00273-6 · Cited by 11 · see citing works
Advancing coenzyme Q10 delivery with plant protein-based nanoparticle-mediated nanosuspensions
Lin, X., Chen, M., Gonzalez, P. R., Danino, D., & Corke, H. (2024) · Food Research International · doi:10.1016/j.foodres.2024.115120 · Cited by 10 · see citing works
Coenzyme Q10 for Diabetes and Cardiovascular Disease: Useful or Useless?
Renke, G., Pereira, M. B., & Renke, A. (2022) · Current Diabetes Reviews · doi:10.2174/1573399818666220429101336 · Cited by 12 · see citing works
Opstad, T. B., Alexander, J., Aaseth, J., Larsson, A. O., Seljeflot, I., & Alehagen, U. (2023) · Antioxidants · doi:10.3390/antiox12030759 · Cited by 11 · see citing works
Yu, L., Chao, C., Li, Q., Ye, S., Lin, J., Zhong, S.-L., Xuan, Q., Xu, K., & Zhao, S. (2022) · Current Drug Delivery · doi:10.2174/1567201819666220630122755 · Cited by 9 · see citing works
Yan, N., Gai, X., Xue, L., Du, Y., Shi, J., & Liu, Y. (2020) · Plants · doi:10.3390/plants9040518 · Cited by 9 · see citing works
Alehagen, U., Aaseth, J., Larsson, A. O., & Alexander, J. (2022) · Cells · doi:10.3390/cells11030509 · Cited by 8 · see citing works
Wu, X., Liang, S., Zhu, X., Wu, X., & Zhan, D. (2020) · PubMed Central · Cited by 8 · see citing works
Cao, S., Yan, H., Tang, W., Zhang, H., & Liu, J. (2023) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-023-00879-4 · Cited by 7 · see citing works
Anti-ageing natural supplements: the main players in promoting healthy lifespan
Izadi, M., Sadri, N., Abdi, A., Zadeh, M. M. R., Jalaei, D., Ghazimoradi, M. M., Shouri, S., & Tahmasebi, S. (2024) · Nutrition Research Reviews · doi:10.1017/s0954422424000301 · Cited by 6 · see citing works
Coenzyme Q nanodisks counteract the effect of statins on C2C12 myotubes
Moschetti, A., Dagda, R. K., & Ryan, R. O. (2021) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2021.102439 · Cited by 5 · see citing works
Histological Effect Of Coq10 On Liver And Buccal Mucosa In Mice
dawood, G., Taqa, G. A., & Alnema, M. M. (2020) · Journal of Applied Veterinary Sciences/Journal of Applied Veterinary Sciences · doi:10.21608/javs.2020.85543 · Cited by 5 · see citing works
Kovacic, S., Habicht, S. D., & Eckert, G. P. (2025) · Journal of Nutritional Science · doi:10.1017/jns.2025.10043 · Cited by 4 · see citing works
“(56,57) Animal-based foods are the main nutritional source of CoQ10.”
Sukri, N. M., Rahim, N. A., Enshasy, H. A. E., Nor, N. F. A., Azelee, N. I. W., Salleh, L. M., Kamari, Z. H., Sujani, S., & Manas, N. H. A. (2025) · Drug Delivery and Translational Research · doi:10.1007/s13346-025-02015-3 · Cited by 4 · see citing works
Amelioration of Phytanic Acid–Induced Neurotoxicity by Nutraceuticals: Mechanistic Insights
Neha, N., Chaudhary, S., Tiwari, P., & Parvez, S. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-03985-0 · Cited by 4 · see citing works
Srivastava, P., Verma, A. K., Arya, J. K., & Rizvi, S. I. (2022) · Biologia Futura · doi:10.1007/s42977-022-00140-5 · Cited by 4 · see citing works
Ahmadimoghaddam, D., Talebi, S. S., Rahmani, A., Zamanirafe, M., Parvaneh, E., Ranjbar, A., Poorolajal, J., & Mehrpooya, M. (2023) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-023-03546-9 · Cited by 4 · see citing works
Azzolin, V. F., Azzolin, V. F., Maia, R. D. S., Mastella, M. H., Sasso, J. S., Barbisan, F., Bitencourt, G. R., Mello, P. A., Ribeiro, E. A. M., Ribeiro, E. E., et al. (2024) · Food and Chemical Toxicology · doi:10.1016/j.fct.2024.114828 · Cited by 4 · see citing works
Ketata, I., & Ellouz, E. (2025) · Advances in Integrative Medicine · doi:10.1016/j.aimed.2025.100478 · Cited by 3 · see citing works
Abdi, S., Qobadighadikolaei, R., Jamali, F., Shahrokhi, M., Dastan, F., & Abbasinazari, M. (2024) · Journal of Cellular & Molecular Anesthesia · doi:10.5812/jcma-145362 · Cited by 3 · see citing works
Coenzyme Q10 for Enhancing Physical Activity and Extending the Human Life Cycle
Bjørklund, G., Semenova, Y. M., Gasmi, A., Indika, N.-L. R., Hrynovets, I., Lysiuk, R., Lenchyk, L. V., Uryr, T., Yeromina, H. О., & Peana, M. (2023) · Current Medicinal Chemistry · doi:10.2174/0929867330666230228103913 · Cited by 3 · see citing works
Yazdi, A., Shirmohammadi, K., Parvaneh, E., Hosseini, S. K., Ranjbar, A., & Mehrpooya, M. (2023) · Pharmaceutical Sciences · doi:10.34172/ps.2023.8 · Cited by 3 · see citing works
Chiarot, A., Minhas, M., de Maat, N. M., Doan, J., Nilsson, M. I., Hettinga, B. P., Faghih, M., Neal, M. S., Nederveen, J. P., & Tarnopolsky, M. A. (2025) · Biomolecules · doi:10.3390/biom15091258 · Cited by 2 · see citing works
Collares, L. F., Messenburger, G. P., Nuñez, F. F., & Pieniz, S. (2026) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2026.2624477 · Cited by 2 · see citing works
Nutraceuticals for Non-alcoholic Fatty Liver Disease
Sönmez, A., Erçin, C. N., Cesur, M., & Doğru, T. (2021) · Contemporary cardiology · doi:10.1007/978-3-030-62632-7_9 · Cited by 2 · see citing works
Therapeutic role of nutraceuticals in the management of brain disorders
Benmelouka, A. Y., Shah, M. A., Saleem, U., Elshanbary, A. A., Meshref, M. M., Shah, G. M., Alsharif, I., Althobaiti, N. A., & Alhasani, R. H. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824356-5.00012-6 · Cited by 2 · see citing works
Hashim, O. A., Numan, I. T., & Mohammed, N. H. (2025) · Toxicology Reports · doi:10.1016/j.toxrep.2025.101942 · Cited by 3 · see citing works
Elevated cellular accumulation of endogenous and exogenous CoQ by altered intracellular trafficking
Wang, Y., & Hekimi, S. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110878 · Cited by 1 · see citing works
Benítez-González, A. M., Stinco, C. M., Brnčić, M., Barba, F. J., & Meléndez‐Martínez, A. J. (2025) · Antioxidants · doi:10.3390/antiox15010043 · Cited by 1 · see citing works
INFLUENCE OF COENZYME Q10 ON HYPERLIPIDEMIA INDUCED IN MICE
Hamad, Z. S., Al-Alsadoon, L. H., Shaban, K. A., & Taqa, G. A. (2022) · Military Medical Science Letters · doi:10.31482/mmsl.2021.043 · Cited by 1 · see citing works
Freye, E. C. K., & Strobel, H. P. (2018) · Natural Products Chemistry & Research · doi:10.4172/2329-6836.1000327
標準予防策の徹底に向けた感染制御スタッフの育成 (特集 職員への対策からはじまる感染予防)
大澤, 栄. (2013) · 看護実践の科学
Zozina, V. I., Kondratenko, S. N., Ших, Е. В., Красных, Л. М., Melnikov, E. S., & Kukes, V. G. (2024) · Pharmacokinetics and Pharmacodynamics · doi:10.37489/2587-7836-2023-4-55-62
Drying of meat, fish, egg, and milk
Mounir, S., Farid, E., Ghandour, A., Sunooj, K. V., Shatta, A., & Allaf, K. S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95602-4.00002-6
Coenzyme Q10 alleviates silicotic fibrosis in rats through the TGF-β1/Smad pathway
Yi, J., Wang, Y., Zhang, H., Yang, X., Xiong, T., Xie, H., Zhan, L., & Zeng, M. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1821205
Zhang, B., Zhu, L., Wan, X., Luo, H., Sagnelli, D., Liu, L., Zhang, H., (81776), G. L., Blennow, A., & Qin, X. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.6879774
Lin, J., Li, J., Wu, Y., Hu, X., Wei, H., Li, M., Hu, X., Luo, Z. Y., Cai, K., & Hu, Y. (2026) · ACS Nano · doi:10.1021/acsnano.6c05740
Kim, S., Noh, S. G., Ji, M., Chen, K., Kuchel, G. A., Al‐Naggar, I. M., & Kwon, O. S. (2026) · GeroScience · doi:10.1007/s11357-026-02515-1
- Authors
- Gutierrez-Mariscal, F. M., Yubero-Serrano, E. M., Villalba, J. M., & Lopez-Miranda, J.
- Affiliations
- Instituto de Salud Carlos III (ES)
- Lipid and Atherosclerosis Unit, Department of Internal Medicine/IMIBIC/Reina Sofia University Hospital/University of Córdoba, Córdoba, Spain; CIBER Fisiología Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain
- Departamento de Biología Celular, Fisiología e Inmunología, Universidad de Córdoba, Campus de Excelencia Internacional Agroalimentario, ceiA3, Córdoba, Spain
- Venue
- Critical Reviews in Food Science and Nutrition
- Publisher
- Informa UK Limited
- Published
- 2018-03-13
- Volume
- 59
- Issue
- 14
- Pages
- 2240-2257
- ISSN
- 1040-8398 (ISSN-L)
- 1549-7852
- OpenAlex
- W2794304138
- Cited by
- 92
- References
- 159
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 11 · 2023: 12 · 2022: 17 · 2021: 11 · 2020: 16 · 2019: 7 · 2018: 3 · 2013: 1
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Reviews in Food Science and Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- coenzyme Q10, aging, age-related diseases, mitochondrial electron transport chain, reactive oxygen species, redox state, coenzyme Q10 supplementation, anti-inflammatory activity, gene expression regulation, cardiovascular disease, renal failure, neurodegenerative diseases, energy transduction
- MeSH terms
- Aging, Animals, Cardiovascular Diseases, Humans, Oxidation-Reduction, Ubiquinone, Vitamins, Neurodegenerative Diseases, Models, Animal, Renal Insufficiency, Chronic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review