The DOI matches its Crossref record; 48 of the 49 references it cites were found in a registry or an index.
Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23
Open accessAbstract
Phosphorylation of the p53 tumor suppressor at Ser20 (murine Ser23) has been proposed to be critical for disrupting p53 interaction with its negative regulator, MDM2, and allowing p53 stabilization. To determine the importance of Ser23 for the function of p53 in vivo, we generated a mouse in which the endogenous p53 locus was targeted to replace Ser23 with alanine. We show that, in mouse embryonic fibroblasts generated from Ser23 mutant mice, Ser23 mutation did not dramatically reduce IR-induced p53 protein stabilization or p53-dependent cell cycle arrest. However, in Ser23 mutant thymocytes and in the developing cerebellum, p53 stabilization following IR was decreased and resistance to apoptosis was observed. Homozygous Ser23 mutant animals had a reduced lifespan, but did not develop thymic lymphomas or sarcomas that are characteristic of p53-/- mice. Instead, Ser23 mutant animals died between 1 and 2 years with tumors that were most commonly of B-cell lineage. These data support an important role for Ser20/23 phosphorylation in p53 stabilization, apoptosis and tumor suppression.
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“Moreover, mouse studies show that blocking p53 phosphorylation at corresponding serine residues only caused modest defects in p53-mediated apoptosis and tumor suppression function [70–73].”
From The p53 orchestra: Mdm2 and Mdmx set the tone (2010) · cites this paper as [71]
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Cites
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MacLaine, N. J., & Hupp, T. (2010) · Molecular biology intelligence unit · doi:10.1007/978-1-4419-8231-5_4 · Cited by 2
The p53-Mdm2 Loop: A Critical Juncture of Stress Response
Levav-Cohen, Y., Goldberg, Z., Alsheich-Bartok, O., Zuckerman, V., Haupt, S., & Haupt, Y. (2010) · Molecular biology intelligence unit · doi:10.1007/978-1-4419-8231-5_5 · Cited by 2
(2018) · Yale University Press eBooks · doi:10.2307/j.ctvqc6gvg.12 · Cited by 2
Lessons on p53 from Mouse Models
Jiang, D., & Attardi, L. D. (2010) · Molecular biology intelligence unit · doi:10.1007/978-1-4419-8231-5_2 · Cited by 1
Chromatin Modifications and Orchestration of Checkpoint Response in Cancer
Nakanishi, M. (2009) · Humana Press eBooks · doi:10.1007/978-1-60761-178-3_6 · Cited by 1
Novel Roles of Replication Protein A Phosphorylation in the Cellular Response to DNA Damage
Serrano, M. A. (2013) · Digital Commons - East Tennessee State University (East Tennessee State University)
Modulation of p53 activities by the prolyl-isomerase PIN1 and the bromodomain protein BRD7
Tocco, F. (2008) · OpenstarTs (Univeristy of Trieste https://www.units.it/)
Negative regulation of gene expression by the tumor suppressor p53
Barsotti, A. M. (2011) · doi:10.7916/d8mg7wkg
p53 and DNA damage checkpoint responses in the human prostate
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Progress in p53 Phosphorylation and Function
Wu, M., & Hu, W. (2015) · Scientia Sinica Vitae · doi:10.1360/n052015-00070 · Cited by 1
Regulation of MDM2 and the p53 Family by the NEDD8 Pathway
Watson, I. R. (2011) · TSpace (University of Toronto)
A Novel Role of the p53 Tumor Suppressor Pathway in Maintaining Glucose Homeostasis
Franck, D.-A., & Tracy, L. (2010) · Digital WPI
The Role of p53 Serine 23 in Insulin Resistance
Nguyen, K. T. (2014) · Digital WPI
Friedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A., & Ellenberger, T. E. (2014) · ASM Press eBooks · doi:10.1128/9781555816704.ch21
Data from Mitochondrially Targeted p53 Has Tumor Suppressor Activities In vivo
Talos, F., Petrenko, O., Mena, P., & Moll, U. M. (2023) · doi:10.1158/0008-5472.c.6495930
Rashid, S. T. A., Dellaire, G., Cuddihy, A. R., Jalali, F., Vaid, M., Coackley, C. L., Folkard, M., Xu, Y., Chen, B. P. C., Chen, D. J., et al. (2023) · doi:10.1158/0008-5472.22364979
Data from Mitochondrially Targeted p53 Has Tumor Suppressor Activities In vivo
Talos, F., Petrenko, O., Mena, P., & Moll, U. M. (2023) · doi:10.1158/0008-5472.c.6495930.v1
Rakotopare, J. (2024) · theses.fr (ABES) · doi:10.70675/cc79cc10zbaf8z4e88za003z8a8d37707576
Mdm2-p53 Signaling in Tissue Homeostasis and the DNA Damage Response: A Dissertation
Gannon, H. (2012) · eScholarship@UMassChan · doi:10.13028/sfjc-xh51
Metadata
- Authors
- MacPherson, D., Kim, J., Kim, T., Rhee, B. K., van Oostrom, C. T., DiTullio, R. A., Venere, M., Halazonetis, T. D., Bronson, R., de Vries, A., Fleming, M., & Jacks, T.
- Affiliations
- Center for Cancer Research (US)
- Sogang University (KR)
- Massachusetts Institute of Technology (US)
- The Wistar Institute (US)
- Tufts University (US)
- Boston Children's Hospital (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Jacks, Tyler
- ORCID
- Venue
- The EMBO Journal
- Published
- 2004-09-02
- Volume
- 23
- Issue
- 18
- Pages
- 3689-3699
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC517606
- OpenAlex
- W2158689768
- Cited by
- 124
- References
- 49
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 2 · 2018: 1 · 2016: 3 · 2015: 4 · 2014: 8 · 2013: 8 · 2012: 6
- FWCI
- 4.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- The EMBO Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Rivm (National Institute for Public Health and the Environment) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- University of Pennsylvania
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Keywords
- p53, MDM2, p53 stabilization, apoptosis resistance, B-cell lymphoma, thymocytes, cerebellar development, tumor suppression, mouse model, ionizing radiation, lifespan
- MeSH terms
- Animals, Cell Cycle, Cells, Cultured, Cerebellum, DNA Damage, Female, Fibroblasts, Homozygote, Infrared Rays, Male, Mice, Inbred C57BL, Phosphorylation, Serine, Thymus Gland, Survival Rate, Tumor Suppressor Protein p53, Lymphoma, B-Cell, Apoptosis, Point Mutation, Mice, Knockout, Mice
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