The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Activation of IKKα target genes depends on recognition of specific κB binding sites by RelB:p52 dimers
Open accessOverview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses
Ghosh, S., May, M. J., & Kopp, E. B. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.225 · Cited by 5,182
Phosphorylation meets ubiquitination: the control of NF-κB activity
Karin, M., & Ben-Neriah, Y. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.621 · Cited by 4,766
Self-citationMissing Pieces in the NF-κB Puzzle
Ghosh, S., & Karin, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00703-1 · Cited by 3,638 · cited 8×
“The classical NF-kB signaling pathway, which is activated by proinflammatory cytokines and pathogen-associated molecu- lar patterns (PAMPs), depends on inducible degradation of specific inhibitors, IkBs, which retain different NF-kB dimers in the cytoplasm (Ghosh and Karin, 2002).”
BackgroundInfluentialSelf-citationFörster, R., Schubel, A., Breitfeld, D., Kremmer, E., Renner-Müller, I., Wolf, E., & Lipp, M. (1999) · Cell · doi:10.1016/s0092-8674(00)80059-8 · Cited by 2,367
Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway
Senftleben, U., Cao, Y., Xiao, G., Greten, F. R., Krähn, G., Bonizzi, G., Chen, Y., Hu, Y., Fong, A., Sun, S.-C., et al. (2001) · Science · doi:10.1126/science.1062677 · Cited by 1,359
Self-citationA chemokine-driven positive feedback loop organizes lymphoid follicles
Ansel, K. M., Ngo, V. N., Hyman, P. L., Luther, S. A., Förster, R., Sedgwick, J. D., Browning, J. L., Lipp, M., & Cyster, J. G. (2000) · Nature · doi:10.1038/35018581 · Cited by 1,278
Severe Liver Degeneration in Mice Lacking the IκB Kinase 2 Gene
Li, Q., Antwerp, D. V., Mercurio, F., Lee, K.-F., & Verma, I. M. (1999) · Science · doi:10.1126/science.284.5412.321 · Cited by 963
The Lymphotoxin-β Receptor Induces Different Patterns of Gene Expression via Two NF-κB Pathways
Dejardin, E., Droin, N. M., Delhase, M., Haas, E., Cao, Y., Makris, C., Li, Z.-W., Karin, M., Ware, C. F., & Green, D. R. (2002) · Immunity · doi:10.1016/s1074-7613(02)00423-5 · Cited by 922
Self-citationNF-κB-Inducing Kinase Regulates the Processing of NF-κB2 p100
Xiao, G., Harhaj, E. W., & Sun, S.-C. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00187-3 · Cited by 834
BAFF-induced NEMO-independent processing of NF-κB2 in maturing B cells
Claudio, E., Brown, K., Park, S., Wang, H., & Siebenlist, U. (2002) · Nature Immunology · doi:10.1038/ni842 · Cited by 693
Cited by
The Nuclear Factor NF- B Pathway in Inflammation
Lawrence, T. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001651 · Cited by 4,898
Shared Principles in NF-κB Signaling
Hayden, M. S., & Ghosh, S. (2008) · Cell · doi:10.1016/j.cell.2008.01.020 · Cited by 4,494
Reactive oxygen species in cancer
Liou, G.-Y., & Storz, P. (2010) · Free Radical Research · doi:10.3109/10715761003667554 · Cited by 3,382
Regulation and Function of NF-κB Transcription Factors in the Immune System
Vallabhapurapu, S., & Karin, M. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132641 · Cited by 2,588
Self-citationNon-canonical NF-κB signaling pathway
Sun, S.-C. (2011) · Cell Research · doi:10.1038/cr.2010.177 · Cited by 1,197
Metadata
- Authors
- Bonizzi, G., Bebien, M., Otero, D. C., Johnson‐Vroom, K. E., Cao, Y., Vu, D., Jegga, A. G., Aronow, B. J., Ghosh, G., Rickert, R. C., & Karin, M.
- Venue
- The EMBO Journal
- Published
- 2004-10-07
- Volume
- 23
- Issue
- 21
- Pages
- 4202-4210
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- OpenAlex
- W2002066494
- Cited by
- 338
- References
- 37
- FWCI
- 8.94
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Activation of IKKα target genes depends on recognition of specific κB binding sites by RelB:p52 dimers. https://app.cochat.ai/papers/10.1038/sj.emboj.7600391
- The paper
- Bonizzi, G., Bebien, M., Otero, D. C., Johnson‐Vroom, K. E., Cao, Y., Vu, D., Jegga, A. G., Aronow, B. J., Ghosh, G., Rickert, R. C., & Karin, M. (2004). Activation of IKKα target genes depends on recognition of specific κB binding sites by RelB:p52 dimers. The EMBO Journal. https://doi.org/10.1038/sj.emboj.7600391
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
