CoChat
Sign Up
Cited by 4,494

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Shared Principles in NF-κB Signaling

Hayden, Matthew S., Ghosh, Sankar·2008·Cell
DOI 10.1016/j.cell.2008.01.020
Open this paper in CoChat — free account

Abstract

The transcription factor NF-kappaB has served as a standard for inducible transcription factors for more than 20 years. The numerous stimuli that activate NF-kappaB, and the large number of genes regulated by NF-kappaB, ensure that this transcription factor is still the subject of intense research. Here, we attempt to synthesize some of the basic principles that have emerged from studies of NF-kappaB, and we aim to generate a more unified view of NF-kappaB regulation.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.cell.2008.01.020

Cites

11 of 11 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 11 references

Research works printed but not linked: 161

  1. Abbott, 2007, Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains, Mol. Cell. Biol., 27, 6012, 10.1128/MCB.00270-07 · DOI
  2. Acharyya, 2007, Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy, J. Clin. Invest., 117, 889, 10.1172/JCI30556 · DOI
  3. Adler, 2007, Motif module map reveals enforcement of aging by continual NF-{kappa}B activity, Genes Dev., 21, 3244, 10.1101/gad.1588507 · DOI · Paper page
  4. Agou, 2004, The trimerization domain of NEMO is comprised of the interacting C-terminal CC2 and LZ coiled-coil subdomains, J. Biol. Chem., 279, 27861, 10.1074/jbc.M314278200 · DOI
  5. Amir, 2004, Mechanism of processing of the NF-kappa B2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCF(beta-TrCP) ubiquitin ligase, Oncogene, 23, 2540, 10.1038/sj.onc.1207366 · DOI
  6. Anest, 2003, A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression, Nature, 423, 659, 10.1038/nature01648 · DOI
  7. Basak, 2007, A fourth IkappaB protein within the NF-kappaB signaling module, Cell, 128, 369, 10.1016/j.cell.2006.12.033 · DOI
  8. Bird, 1997, Activation of nuclear transcription factor NF-kappaB by interleukin-1 is accompanied by casein kinase II-mediated phosphorylation of the p65 subunit, J. Biol. Chem., 272, 32606, 10.1074/jbc.272.51.32606 · DOI
  9. Blonska, 2005, TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation, J. Biol. Chem., 280, 43056, 10.1074/jbc.M507807200 · DOI
  10. Bonizzi, 2004, Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers, EMBO J., 23, 4202, 10.1038/sj.emboj.7600391 · DOI
  11. Bonnard, 2000, Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription, EMBO J., 19, 4976, 10.1093/emboj/19.18.4976 · DOI
  12. Bours, 1993, The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers, Cell, 72, 729, 10.1016/0092-8674(93)90401-B · DOI
  13. Britanova, 2008, In vitro selection of optimal RelB/p52 DNA-binding motifs, Biochem. Biophys. Res. Commun., 365, 583, 10.1016/j.bbrc.2007.10.200 · DOI
  14. Carmody, 2007, Negative regulation of toll-like receptor signaling by NF-kappaB p50 ubiquitination blockade, Science, 317, 675, 10.1126/science.1142953 · DOI
  15. Chen, 2002, TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90, Mol. Cell, 9, 401, 10.1016/S1097-2765(02)00450-1 · DOI
  16. Chen, 2004, Shaping the nuclear action of NF-kappaB, Nat. Rev. Mol. Cell Biol., 5, 392, 10.1038/nrm1368 · DOI
  17. Chen, 2002, Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB, EMBO J., 21, 6539, 10.1093/emboj/cdf660 · DOI · Paper page
  18. Chen, 1996, Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity, Cell, 84, 853, 10.1016/S0092-8674(00)81064-8 · DOI
  19. Cheng, 1998, Functional redundancy of the nuclear factor kappa B inhibitors I kappa B alpha and I kappa B beta, J. Exp. Med., 188, 1055, 10.1084/jem.188.6.1055 · DOI
  20. Cohen, 2001, Processing of p105 is inhibited by docking of p50 active subunits to the ankyrin repeat domain, and inhibition is alleviated by signaling via the carboxyl-terminal phosphorylation/ ubiquitin-ligase binding domain, J. Biol. Chem., 276, 26769, 10.1074/jbc.M102448200 · DOI
  21. Cohen, 2004, Dual effects of IkappaB kinase beta-mediated phosphorylation on p105 fate: SCF(beta-TrCP)-dependent degradation and SCF(beta-TrCP)-independent processing, Mol. Cell. Biol., 24, 475, 10.1128/MCB.24.1.475-486.2004 · DOI
  22. Courtois, 2006, Mutations in the NF-kappaB signaling pathway: implications for human disease, Oncogene, 25, 6831, 10.1038/sj.onc.1209939 · DOI
  23. Cusson-Hermance, 2005, Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation, J. Biol. Chem., 280, 36560, 10.1074/jbc.M506831200 · DOI
  24. De Bosscher, 2006, Cross-talk between nuclear receptors and nuclear factor kappaB, Oncogene, 25, 6868, 10.1038/sj.onc.1209935 · DOI
  25. Delhase, 1999, Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation, Science, 284, 309, 10.1126/science.284.5412.309 · DOI
  26. Deng, 2000, Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain, Cell, 103, 351, 10.1016/S0092-8674(00)00126-4 · DOI · Paper page
  27. Devin, 2000, The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation, Immunity, 12, 419, 10.1016/S1074-7613(00)80194-6 · DOI
  28. Devin, 2001, The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF, Mol. Cell. Biol., 21, 3986, 10.1128/MCB.21.12.3986-3994.2001 · DOI
  29. DiDonato, 1997, A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB, Nature, 388, 548, 10.1038/41493 · DOI · Paper page
  30. Drew, 2007, Inhibitor kappaB kinase beta binding by inhibitor kappaB kinase gamma, Biochemistry, 46, 12482, 10.1021/bi701137a · DOI
  31. Ducut Sigala, 2004, Activation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunit, Science, 304, 1963, 10.1126/science.1098387 · DOI
  32. Duran, 2003, Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation, EMBO J., 22, 3910, 10.1093/emboj/cdg370 · DOI
  33. Ea, 2006, Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO, Mol. Cell, 22, 245, 10.1016/j.molcel.2006.03.026 · DOI
  34. Fong, 2002, S9, a 19 S proteasome subunit interacting with ubiquitinated NF-kappaB2/p100, J. Biol. Chem., 277, 40697, 10.1074/jbc.M205330200 · DOI
  35. Fukushima, 2007, Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses, Proc. Natl. Acad. Sci. USA, 104, 6371, 10.1073/pnas.0700548104 · DOI
  36. Gerondakis, 2006, Unravelling the complexities of the NF-kappaB signalling pathway using mouse knockout and transgenic models, Oncogene, 25, 6781, 10.1038/sj.onc.1209944 · DOI
  37. Goudeau, 2003, IkappaBalpha/IkappaBepsilon deficiency reveals that a critical NF-kappaB dosage is required for lymphocyte survival, Proc. Natl. Acad. Sci. USA, 100, 15800, 10.1073/pnas.2535880100 · DOI
  38. Habelhah, 2004, Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-kappaB, EMBO J., 23, 322, 10.1038/sj.emboj.7600044 · DOI
  39. Hacker, 2006, Regulation and function of IKK and IKK-related kinases, Sci. STKE, 2006, re13, 10.1126/stke.3572006re13 · DOI
  40. Hacker, 2006, Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6, Nature, 439, 204, 10.1038/nature04369 · DOI
  41. Harhaj, 1996, Inhibition of p105 processing by NF-kappaB proteins in transiently transfected cells, Oncogene, 12, 2385
  42. Hasegawa, 2007, A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation, EMBO J.
  43. Hauer, 2005, TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRs, Proc. Natl. Acad. Sci. USA, 102, 2874, 10.1073/pnas.0500187102 · DOI
  44. Hayden, 2004, Signaling to NF-kappaB, Genes Dev., 18, 2195, 10.1101/gad.1228704 · DOI · Paper page
  45. He, 2006, Rescue of TRAF3-null mice by p100 NF-kappa B deficiency, J. Exp. Med., 203, 2413, 10.1084/jem.20061166 · DOI
  46. Hinz, 2007, Signal responsiveness of IkappaB kinases is determined by Cdc37-assisted transient interaction with Hsp90, J. Biol. Chem., 282, 32311, 10.1074/jbc.M705785200 · DOI
  47. Hoberg, 2006, IkappaB kinase alpha-mediated derepression of SMRT potentiates acetylation of RelA/p65 by p300, Mol. Cell. Biol., 26, 457, 10.1128/MCB.26.2.457-471.2006 · DOI
  48. Hoeflich, 2000, Requirement for glycogen synthase kinase-3beta in cell survival and NF- kappaB activation, Nature, 406, 86, 10.1038/35017574 · DOI
  49. Hoffmann, 2002, The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation, Science, 298, 1241, 10.1126/science.1071914 · DOI
  50. Hoffmann, 2003, Genetic analysis of NF-kappaB/Rel transcription factors defines functional specificities, EMBO J., 22, 5530, 10.1093/emboj/cdg534 · DOI
  51. Hoffmann, 2006, Transcriptional regulation via the NF-kappaB signaling module, Oncogene, 25, 6706, 10.1038/sj.onc.1209933 · DOI
  52. Hsu, 1996, TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways, Cell, 84, 299, 10.1016/S0092-8674(00)80984-8 · DOI
  53. Huang, 2007, Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB, Mol. Cell, 26, 75, 10.1016/j.molcel.2007.02.019 · DOI
  54. Hur, 2003, The death domain kinase RIP has an essential role in DNA damage-induced NF-kappa B activation, Genes Dev., 17, 873, 10.1101/gad.1062403 · DOI
  55. Huynh, 2000, Characterization of the recombinant IKK1/IKK2 heterodimer. Mechanisms regulating kinase activity, J. Biol. Chem., 275, 25883, 10.1074/jbc.M000296200 · DOI
  56. Inohara, 2003, NODs: intracellular proteins involved in inflammation and apoptosis, Nat. Rev. Immunol., 3, 371, 10.1038/nri1086 · DOI
  57. Inohara, 2000, An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways, J. Biol. Chem., 275, 27823, 10.1074/jbc.M003415200 · DOI
  58. Ishimaru, 2006, Regulation of naive T cell function by the NF-kappaB2 pathway, Nat. Immunol., 7, 763, 10.1038/ni1351 · DOI
  59. Janssens, 2005, PIDD mediates NF-kappaB activation in response to DNA damage, Cell, 123, 1079, 10.1016/j.cell.2005.09.036 · DOI
  60. Kashatus, 2006, Expression of the Bcl-3 proto-oncogene suppresses p53 activation, Genes Dev., 20, 225, 10.1101/gad.1352206 · DOI
  61. Kearns, 2006, IkappaBepsilon provides negative feedback to control NF-kappaB oscillations, signaling dynamics, and inflammatory gene expression, J. Cell Biol., 173, 659, 10.1083/jcb.200510155 · DOI
  62. Kelliher, 1998, The death domain kinase RIP mediates the TNF-induced NF-kappaB signal, Immunity, 8, 297, 10.1016/S1074-7613(00)80535-X · DOI · Paper page
  63. Khoshnan, 1999, Primary human CD4+ T cells contain heterogeneous I kappa B kinase complexes: role in activation of the IL-2 promoter, J. Immunol., 163, 5444, 10.4049/jimmunol.163.10.5444 · DOI
  64. Kim, 2008, TAK1 Is a central mediator of NOD2 signaling in epidermal cells, J. Biol. Chem., 283, 137, 10.1074/jbc.M704746200 · DOI
  65. Kobayashi, 2001, Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis, EMBO J., 20, 1271, 10.1093/emboj/20.6.1271 · DOI
  66. Krappmann, 2000, The I kappa B kinase (IKK) complex is tripartite and contains IKK gamma but not IKAP as a regular component, J. Biol. Chem., 275, 29779, 10.1074/jbc.M003902200 · DOI
  67. Kray, 2005, Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2A, J. Biol. Chem., 280, 35974, 10.1074/jbc.M506093200 · DOI
  68. Kwak, 2000, Analysis of domains in the IKKalpha and IKKbeta proteins that regulate their kinase activity, J. Biol. Chem., 275, 14752, 10.1074/jbc.M001039200 · DOI
  69. Lamothe, 2007, Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation, J. Biol. Chem., 282, 4102, 10.1074/jbc.M609503200 · DOI
  70. Lawrence, 2005, IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation, Nature, 434, 1138, 10.1038/nature03491 · DOI
  71. Lee, 2004, The kinase activity of Rip1 is not required for tumor necrosis factor-alpha-induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2, J. Biol. Chem., 279, 33185, 10.1074/jbc.M404206200 · DOI
  72. Leung, 2004, One nucleotide in a kappaB site can determine cofactor specificity for NF-kappaB dimers, Cell, 118, 453, 10.1016/j.cell.2004.08.007 · DOI
  73. Li, 2005, Enhanced NF-kappaB activation and cellular function in macrophages lacking IkappaB kinase 1 (IKK1), Proc. Natl. Acad. Sci. USA, 102, 12425, 10.1073/pnas.0505997102 · DOI
  74. Li, 2006, RNAi screen in mouse astrocytes identifies phosphatases that regulate NF-kappaB signaling, Mol. Cell, 24, 497, 10.1016/j.molcel.2006.10.015 · DOI · Paper page
  75. Liang, 2006, beta-TrCP binding and processing of NF-kappaB2/p100 involve its phosphorylation at serines 866 and 870, Cell. Signal., 18, 1309, 10.1016/j.cellsig.2005.10.011 · DOI
  76. Liao, 2004, Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation, J. Biol. Chem., 279, 26243, 10.1074/jbc.M403286200 · DOI
  77. Lin, 1998, Cotranslational biogenesis of NF-kappaB p50 by the 26S proteasome, Cell, 92, 819, 10.1016/S0092-8674(00)81409-9 · DOI
  78. Lin, 2000, Cotranslational dimerization of the Rel homology domain of NF-kappaB1 generates p50-p105 heterodimers and is required for effective p50 production, EMBO J., 19, 4712, 10.1093/emboj/19.17.4712 · DOI
  79. Liu, 2006, Essential role of TAK1 in thymocyte development and activation, Proc. Natl. Acad. Sci. USA, 103, 11677, 10.1073/pnas.0603089103 · DOI
  80. Luo, 2007, Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin, Nature, 446, 690, 10.1038/nature05656 · DOI
  81. Maine, 2007, COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase, EMBO J., 26, 436, 10.1038/sj.emboj.7601489 · DOI
  82. Makris, 2002, The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation, Mol. Cell. Biol., 22, 6573, 10.1128/MCB.22.18.6573-6581.2002 · DOI
  83. Marienfeld, 2006, Dimerization of the I kappa B kinase-binding domain of NEMO is required for tumor necrosis factor alpha-induced NF-kappa B activity, Mol. Cell. Biol., 26, 9209, 10.1128/MCB.00478-06 · DOI
  84. Martin, 2005, Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3, Nat. Immunol., 6, 777, 10.1038/ni1221 · DOI
  85. Massoumi, 2006, Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling, Cell, 125, 665, 10.1016/j.cell.2006.03.041 · DOI
  86. May, 2000, Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex, Science, 289, 1550, 10.1126/science.289.5484.1550 · DOI
  87. May, 2002, Characterization of the Ikappa B-kinase NEMO binding domain, J. Biol. Chem., 277, 45992, 10.1074/jbc.M206494200 · DOI
  88. McCarthy, 1998, RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase, J. Biol. Chem., 273, 16968, 10.1074/jbc.273.27.16968 · DOI
  89. McKenzie, 2000, Functional isoforms of IkappaB kinase alpha (IKKalpha) lacking leucine zipper and helix-loop-helix domains reveal that IKKalpha and IKKbeta have different activation requirements, Mol. Cell. Biol., 20, 2635, 10.1128/MCB.20.8.2635-2649.2000 · DOI
  90. Mercurio, 1997, IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF- kappaB activation, Science, 278, 860, 10.1126/science.278.5339.860 · DOI
  91. Mercurio, 1999, IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex, Mol. Cell. Biol., 19, 1526, 10.1128/MCB.19.2.1526 · DOI
  92. Meylan, 2005, The RIP kinases: crucial integrators of cellular stress, Trends Biochem. Sci., 30, 151, 10.1016/j.tibs.2005.01.003 · DOI
  93. Meylan, 2004, RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation, Nat. Immunol., 5, 503, 10.1038/ni1061 · DOI
  94. Miller, 2001, Complete reconstitution of human IkappaB kinase (IKK) complex in yeast. Assessment of its stoichiometry and the role of IKKgamma on the complex activity in the absence of stimulation, J. Biol. Chem., 276, 36320, 10.1074/jbc.M104051200 · DOI
  95. Moorthy, 2006, The 20S proteasome processes NF-kappaB1 p105 into p50 in a translation-independent manner, EMBO J., 25, 1945, 10.1038/sj.emboj.7601081 · DOI
  96. Motoyama, 2005, Positive and negative regulation of nuclear factor-kappaB-mediated transcription by IkappaB-zeta, an inducible nuclear protein, J. Biol. Chem., 280, 7444, 10.1074/jbc.M412738200 · DOI
  97. Nakagawa, 2002, SOCS-1 participates in negative regulation of LPS responses, Immunity, 17, 677, 10.1016/S1074-7613(02)00449-1 · DOI
  98. Nakano, 1999, Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation, Proc. Natl. Acad. Sci. USA, 96, 9803, 10.1073/pnas.96.17.9803 · DOI
  99. Natoli, 2005, Interactions of NF-kappaB with chromatin: the art of being at the right place at the right time, Nat. Immunol., 6, 439, 10.1038/ni1196 · DOI
  100. Newton, 2004, Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4, Mol. Cell. Biol., 24, 1464, 10.1128/MCB.24.4.1464-1469.2004 · DOI
  101. Oeckinghaus, 2007, Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation, EMBO J., 26, 4634, 10.1038/sj.emboj.7601897 · DOI
  102. Oganesyan, 2006, Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response, Nature, 439, 208, 10.1038/nature04374 · DOI
  103. Palkowitsch, 2008, Phosphorylation of serine 68 in the I{kappa}B kinase (IKK)-binding domain of NEMO interferes with the structure of the IKK complex and tumor necrosis factor-{alpha}-induced NF-{kappa}B activity, J. Biol. Chem., 283, 76, 10.1074/jbc.M708856200 · DOI
  104. Park, 2007, RICK/RIP2 mediates innate immune responses induced through Nod1 and Nod2 but not TLRs, J. Immunol., 178, 2380, 10.4049/jimmunol.178.4.2380 · DOI
  105. Pasparakis, 2006, Dissection of the NF-kappaB signalling cascade in transgenic and knockout mice, Cell Death Differ., 13, 861, 10.1038/sj.cdd.4401870 · DOI
  106. Petersen, 2007, Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis, Cancer Cell, 12, 445, 10.1016/j.ccr.2007.08.029 · DOI
  107. Poyet, 2000, Activation of the Ikappa B kinases by RIP via IKKgamma /NEMO-mediated oligomerization, J. Biol. Chem., 275, 37966, 10.1074/jbc.M006643200 · DOI
  108. Prajapati, 2004, Protein phosphatase 2Cbeta association with the IkappaB kinase complex is involved in regulating NF-kappaB activity, J. Biol. Chem., 279, 1739, 10.1074/jbc.M306273200 · DOI
  109. Qing, 2005, Essential role of IkappaB kinase alpha in the constitutive processing of NF-kappaB2 p100, J. Biol. Chem., 280, 9765, 10.1074/jbc.C400502200 · DOI
  110. Ramirez-Carrozzi, 2006, Selective and antagonistic functions of SWI/SNF and Mi-2beta nucleosome remodeling complexes during an inflammatory response, Genes Dev., 20, 282, 10.1101/gad.1383206 · DOI
  111. Regnier, 1997, Identification and characterization of an IκB kinase, Cell, 90, 373, 10.1016/S0092-8674(00)80344-X · DOI
  112. Rocha, 2003, p53 represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-kappaB subunit with histone deacetylase 1, Mol. Cell. Biol., 23, 4713, 10.1128/MCB.23.13.4713-4727.2003 · DOI
  113. Rothwarf, 1998, IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex, Nature, 395, 297, 10.1038/26261 · DOI
  114. Ruefli-Brasse, 2004, Rip2 participates in Bcl10 signaling and T-cell receptor-mediated NF-kappaB activation, J. Biol. Chem., 279, 1570, 10.1074/jbc.C300460200 · DOI
  115. Saccani, 2001, Two waves of nuclear factor kappaB recruitment to target promoters, J. Exp. Med., 193, 1351, 10.1084/jem.193.12.1351 · DOI
  116. Saccani, 2004, Degradation of promoter-bound p65/RelA is essential for the prompt termination of the nuclear factor kappaB response, J. Exp. Med., 200, 107, 10.1084/jem.20040196 · DOI
  117. Samson, 2004, Combined deficiency in IkappaBalpha and IkappaBepsilon reveals a critical window of NF-kappaB activity in natural killer cell differentiation, Blood, 103, 4573, 10.1182/blood-2003-08-2975 · DOI
  118. Sato, 2005, Essential function for the kinase TAK1 in innate and adaptive immune responses, Nat. Immunol., 6, 1087, 10.1038/ni1255 · DOI
  119. Scheidereit, 2006, IkappaB kinase complexes: gateways to NF-kappaB activation and transcription, Oncogene, 25, 6685, 10.1038/sj.onc.1209934 · DOI
  120. Schmidt-Supprian, 2000, NEMO/IKK gamma-deficient mice model incontinentia pigmenti, Mol. Cell, 5, 981, 10.1016/S1097-2765(00)80263-4 · DOI
  121. Schomer-Miller, 2006, Regulation of IkappaB kinase (IKK) complex by IKKgamma-dependent phosphorylation of the T-loop and C terminus of IKKbeta, J. Biol. Chem., 281, 15268, 10.1074/jbc.M513793200 · DOI
  122. Schreiber, 2006, Coordinated binding of NF-kappaB family members in the response of human cells to lipopolysaccharide, Proc. Natl. Acad. Sci. USA, 103, 5899, 10.1073/pnas.0510996103 · DOI
  123. Schulze-Luehrmann, 2006, Antigen-receptor signaling to nuclear factor kappa B, Immunity, 25, 701, 10.1016/j.immuni.2006.10.010 · DOI
  124. Senftleben, 2001, Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway, Science, 293, 1495, 10.1126/science.1062677 · DOI
  125. Shim, 2005, TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo, Genes Dev., 19, 2668, 10.1101/gad.1360605 · DOI
  126. Simonson, 2007, CYLD: a DUB with many talents, Dev. Cell, 13, 601, 10.1016/j.devcel.2007.10.009 · DOI
  127. Solan, 2002, RelB cellular regulation and transcriptional activity are regulated by p100, J. Biol. Chem., 277, 1405, 10.1074/jbc.M109619200 · DOI
  128. Solt, 2007, Interleukin-1-induced NF-kappaB activation is NEMO-dependent but does not require IKKbeta, J. Biol. Chem., 282, 8724, 10.1074/jbc.M609613200 · DOI
  129. Sun, 2004, The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes, Mol. Cell, 14, 289, 10.1016/S1097-2765(04)00236-9 · DOI
  130. Suyang, 1996, Role of unphosphorylated, newly synthesized I kappa B beta in persistent activation of NF-kappa B, Mol. Cell. Biol., 16, 5444, 10.1128/MCB.16.10.5444 · DOI
  131. Takaesu, 2003, TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway, J. Mol. Biol., 326, 105, 10.1016/S0022-2836(02)01404-3 · DOI
  132. Tang, 2003, Roles for homotypic interactions and transautophosphorylation in IkappaB kinase (IKKbeta) activation, J. Biol. Chem., 278, 38566, 10.1074/jbc.M304374200 · DOI
  133. Tegethoff, 2003, Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation, Mol. Cell. Biol., 23, 2029, 10.1128/MCB.23.6.2029-2041.2003 · DOI
  134. Tergaonkar, 2005, Distinct roles of IkappaB proteins in regulating constitutive NF-kappaB activity, Nat. Cell Biol., 7, 921, 10.1038/ncb1296 · DOI
  135. Thompson, 1995, I kappa B-beta regulates the persistent response in a biphasic activation of NF-kappa B, Cell, 80, 573, 10.1016/0092-8674(95)90511-1 · DOI
  136. Ting, 1996, RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1-initiated apoptosis, EMBO J., 15, 6189, 10.1002/j.1460-2075.1996.tb01007.x · DOI · Paper page
  137. Vermeulen, 2003, Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1), EMBO J., 22, 1313, 10.1093/emboj/cdg139 · DOI
  138. Vince, 2007, IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis, Cell, 131, 682, 10.1016/j.cell.2007.10.037 · DOI
  139. Vivarelli, 2004, RIP links TLR4 to Akt and is essential for cell survival in response to LPS stimulation, J. Exp. Med., 200, 399, 10.1084/jem.20040446 · DOI
  140. Wan, 2006, The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function, Nat. Immunol., 7, 851, 10.1038/ni1355 · DOI
  141. Wan, 2007, Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation, Cell, 131, 927, 10.1016/j.cell.2007.10.009 · DOI
  142. Wang, 2000, Tumor necrosis factor alpha-induced phosphorylation of RelA/p65 on Ser529 is controlled by casein kinase II, J. Biol. Chem., 275, 32592, 10.1074/jbc.M001358200 · DOI
  143. Westerheide, 2001, The putative oncoprotein Bcl-3 induces cyclin D1 to stimulate G(1) transition, Mol. Cell. Biol., 21, 8428, 10.1128/MCB.21.24.8428-8436.2001 · DOI
  144. Windheim, 2008, IL-1 induces the Lys63-linked polyubiquitination of IRAK1 to facilitate NEMO binding and the activation of IKK, Mol. Cell. Biol., 10.1128/MCB.02380-06 · DOI
  145. Woronicz, 1997, IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK, Science, 278, 866, 10.1126/science.278.5339.866 · DOI
  146. Wu, 2003, Differential phosphorylation of the signal-responsive domain of I kappa B alpha and I kappa B beta by I kappa B kinases, J. Biol. Chem., 278, 31980, 10.1074/jbc.M304278200 · DOI
  147. Wu, 2006, Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation, Nat. Cell Biol., 8, 398, 10.1038/ncb1384 · DOI
  148. Xiao, 2004, Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation, J. Biol. Chem., 279, 30099, 10.1074/jbc.M401428200 · DOI
  149. Xiao, 2001, NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100, Mol. Cell, 7, 401, 10.1016/S1097-2765(01)00187-3 · DOI
  150. Yamamoto, 2004, Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta, Nature, 430, 218, 10.1038/nature02738 · DOI · Paper page
  151. Yamamoto, 2006, Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling, Nat. Immunol., 7, 962, 10.1038/ni1367 · DOI
  152. Yamamoto, 2006, Cutting edge: Pivotal function of Ubc13 in thymocyte TCR signaling, J. Immunol., 177, 7520, 10.4049/jimmunol.177.11.7520 · DOI
  153. Yamamoto, 2003, Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression, Nature, 423, 655, 10.1038/nature01576 · DOI
  154. Yamaoka, 1998, Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation, Cell, 93, 1231, 10.1016/S0092-8674(00)81466-X · DOI
  155. Yang, 2007, NOD2 pathway activation by MDP or mycobacterium tuberculosis infection involves the stable polyubiquitination of Rip2, J. Biol. Chem., 282, 36223, 10.1074/jbc.M703079200 · DOI
  156. Yeh, 1997, Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice, Immunity, 7, 715, 10.1016/S1074-7613(00)80391-X · DOI
  157. Zandi, 1997, The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation, Cell, 91, 243, 10.1016/S0092-8674(00)80406-7 · DOI
  158. Zandi, 1998, Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate, Science, 281, 1360, 10.1126/science.281.5381.1360 · DOI
  159. Zhang, 2000, Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation, Immunity, 12, 301, 10.1016/S1074-7613(00)80183-1 · DOI
  160. Zhong, 1998, Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300, Mol. Cell, 1, 661, 10.1016/S1097-2765(00)80066-0 · DOI · Paper page
  161. Zhou, 2004, Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO, Nature, 427, 167, 10.1038/nature02273 · DOI

Cited by

See all 4,494

Metadata

Authors
Hayden, M. S., & Ghosh, S.
Venue
Cell
Publisher
Elsevier BV
Published
2008-02
Volume
132
Issue
3
Pages
344-362
ISSN
0092-8674
DOI
10.1016/j.cell.2008.01.020
Cited by
4,494
References
11
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Shared Principles in NF-κB Signaling. https://app.cochat.ai/papers/10.1016/j.cell.2008.01.020
The paper
Hayden, M. S., & Ghosh, S. (2008). Shared Principles in NF-κB Signaling. Cell. https://doi.org/10.1016/j.cell.2008.01.020