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Cited by 481

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ADAM10 cleavage of N‐cadherin and regulation of cell–cell adhesion and β‐catenin nuclear signalling

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Reiss, Karina, Maretzky, Thorsten, Ludwig, Andreas, Tousseyn, Thomas, de Strooper, Bart, Hartmann, Dieter, Saftig, Paul·2005·The EMBO Journal
DOI 10.1038/sj.emboj.7600548
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Research works printed but not linked: 47

  1. Bixby JL, Zhang R (1990) Purified N‐cadherin is a potent substrate for the rapid induction of neurite outgrowth. J Cell Biol 110: 1253–1260 · DOI · Paper page
  2. Blobel CP (2000) Remarkable roles of proteolysis on and beyond the cell surface. Curr Opin Cell Biol 12: 606–612 · DOI · Paper page
  3. Boterberg T, Bracke M, Bruyneel E, Mareel M (2001) Cell aggregation assays. In Methods in Molecular Medicine, Brooks S, Schumacher U (eds), pp 33–45. Totowa, NJ, USA: Humana Press
  4. Brown JR, Nigh E, Lee RJ, Ye H, Thompson MA, Saudou F, Pestell RG, Greenberg ME (1998) Fos family members induce cell cycle entry by activating cyclin D1. Mol Cell Biol 18: 5609–5619 · DOI · Paper page
  5. Brummelkamp TR, Bernards R, Agami R (2002) A system for stable expression of short interfering RNAs in mammalian cells. Science 296: 550–553 · DOI · Paper page
  6. Fagotto F, Funayama N, Gluck U, Gumbiner BM (1996) Binding to cadherins antagonizes the signaling activity of beta‐catenin during axis formation in Xenopus. J Cell Biol 132: 1105–1114 · DOI · Paper page
  7. Gabbiani G (1981) The myofibroblast: a key cell for wound healing and fibrocontractive diseases. Prog Clin Biol Res 54: 183–194
  8. Gumbiner BM (1996) Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell 84: 345–357 · DOI · Paper page
  9. Gutwein P, Mechtersheimer S, Riedle S, Stoeck A, Gast D, Joumaa S, Zentgraf H, Fogel M, Altevogt DP (2003) ADAM10‐mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles. FASEB J 17: 292–294 · DOI · Paper page
  10. Hartmann D, de Strooper B, Serneels L, Craessaerts K, Herreman A, Annaert W, Umans L, Lubke T, Lena IA, von Figura K, Saftig P (2002) The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha‐secretase activity in fibroblasts. Hum Mol Genet 11: 2615–2624 · DOI · Paper page
  11. Hazan RB, Phillips GR, Qiao RF, Norton L, Aaronson SA (2000) Exogenous expression of N‐cadherin in breast cancer cells induces cell migration, invasion, and metastasis. J Cell Biol 148: 779–790 · DOI · Paper page
  12. He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin PJ, Vogelstein B, Kinzler KW (1998) Identification of c‐MYC as a target of the APC pathway. Science 281: 1509–1512 · DOI · Paper page
  13. Ho AT, Voura EB, Soloway PD, Watson KL, Khokha R (2001) MMP inhibitors augment fibroblast adhesion through stabilization of focal adhesion contacts and up‐regulation of cadherin function. J Biol Chem 276: 40215–40224 · DOI
  14. Hooper NM, Karran EH, Turner AJ (1997) Membrane protein secretases. Biochem J 321 (Part 2): 265–279 · DOI · Paper page
  15. Horiuchi K, Weskamp G, Lum L, Hammes HP, Cai H, Brodie TA, Ludwig T, Chiusaroli R, Baron R, Preissner KT, Manova K, Blobel CP (2003) Potential role for ADAM15 in pathological neovascularization in mice. Mol Cell Biol 23: 5614–5624 · DOI · Paper page
  16. Hundhausen C, Misztela D, Berkhout TA, Broadway N, Saftig P, Reiss K, Hartmann D, Fahrenholz F, Postina R, Matthews V, Kallen KJ, Rose‐John S, Ludwig A (2003) The disintegrin‐like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1‐mediated cell–cell adhesion. Blood 102: 1186–1195 · DOI · Paper page
  17. Huntley GW (2002) Dynamic aspects of cadherin‐mediated adhesion in synapse development and plasticity. Biol Cell 94: 335–344 · DOI
  18. Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SG (2000) Proteomic analysis of NMDA receptor‐adhesion protein signaling complexes. Nat Neurosci 3: 661–669 · DOI · Paper page
  19. Ito K, Okamoto I, Araki N, Kawano Y, Nakao M, Fujiyama S, Tomita K, Mimori T, Saya H (1999) Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E‐cadherin, leading to loss of beta‐catenin from cell–cell contacts. Oncogene 18: 7080–7090 · DOI
  20. Karkkainen I, Rybnikova E, Pelto‐Huikko M, Huovila AP (2000) Metalloprotease‐disintegrin (ADAM) genes are widely and differentially expressed in the adult CNS. Mol Cell Neurosci 15: 547–560 · DOI
  21. Korinek V, Barker N, Morin PJ, van Wichen D, de Weger R, Kinzler KW, Vogelstein B, Clevers H (1997) Constitutive transcriptional activation by a beta‐catenin–Tcf complex in APC−/− colon carcinoma. Science 275: 1784–1787 · DOI · Paper page
  22. Lammich S, Kojro E, Postina R, Gilbert S, Pfeiffer R, Jasionowski M, Haass C, Fahrenholz F (1999) Constitutive and regulated alpha‐secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease. Proc Natl Acad Sci USA 96: 3922–3927 · DOI · Paper page
  23. Li G, Satyamoorthy K, Herlyn M (2001) N‐cadherin‐mediated intercellular interactions promote survival and migration of melanoma cells. Cancer Res 61: 3819–3825
  24. Lichtenthaler SF, Dominguez DI, Westmeyer GG, Reiss K, Haass C, Saftig P, de Strooper B, Seed B (2003) The cell adhesion protein P‐selectin glycoprotein ligand‐1 is a substrate for the aspartyl protease BACE1. J Biol Chem 278: 48713–48719 · DOI · Paper page
  25. Mann B, Gelos M, Siedow A, Hanski ML, Gratchev A, Ilyas M, Bodmer WF, Moyer MP, Riecken EO, Buhr HJ, Hanski C (1999) Target genes of beta‐catenin‐T cell‐factor/lymphoid‐enhancer‐factor signaling in human colorectal carcinomas. Proc Natl Acad Sci USA 96: 1603–1608 · DOI · Paper page
  26. Marambaud P, Shioi J, Serban G, Georgakopoulos A, Sarner S, Nagy V, Baki L, Wen P, Efthimiopoulos S, Shao Z, Wisniewski T, Robakis NK (2002) A presenilin‐1/gamma‐secretase cleavage releases the E‐cadherin intracellular domain and regulates disassembly of adherens junctions. EMBO J 21: 1948–1956 · DOI · Paper page
  27. Marambaud P, Wen PH, Dutt A, Shioi J, Takashima A, Siman R, Robakis NK (2003) A CBP binding transcriptional repressor produced by the PS1/epsilon‐cleavage of N‐cadherin is inhibited by PS1 FAD mutations. Cell 114: 635–645
  28. Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, Vogelstein B, Kinzler KW (1997) Activation of beta‐catenin‐Tcf signaling in colon cancer by mutations in beta‐catenin or APC. Science 275: 1787–1790 · DOI · Paper page
  29. Nakagawa S, Takeichi M (1998) Neural crest emigration from the neural tube depends on regulated cadherin expression. Development 125: 2963–2971 · DOI · Paper page
  30. Nelson WJ, Nusse R (2004) Convergence of Wnt, beta‐catenin, and cadherin pathways. Science 303: 1483–1487 · DOI · Paper page
  31. Paradies NE, Grunwald GB (1993) Purification and characterization of NCAD90, a soluble endogenous form of N‐cadherin, which is generated by proteolysis during retinal development and retains adhesive and neurite‐promoting function. J Neurosci Res 36: 33–45 · DOI
  32. Radice GL, Rayburn H, Matsunami H, Knudsen KA, Takeichi M, Hynes RO (1997) Developmental defects in mouse embryos lacking N‐cadherin. Dev Biol 181: 64–78 · DOI · Paper page
  33. Sadot E, Simcha I, Shtutman M, Ben Ze'ev A, Geiger B (1998) Inhibition of beta‐catenin‐mediated transactivation by cadherin derivatives. Proc Natl Acad Sci USA 95: 15339–15344 · DOI · Paper page
  34. Sahin U, Weskamp G, Kelly K, Zhou HM, Higashiyama S, Peschon J, Hartmann D, Saftig P, Blobel CP (2004) Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands. J Cell Biol 164: 769–779 · DOI · Paper page
  35. Sanson B, White P, Vincent JP (1996) Uncoupling cadherin‐based adhesion from wingless signalling in Drosophila. Nature 383: 627–630 · DOI · Paper page
  36. Schlondorff J, Blobel CP (1999) Metalloprotease‐disintegrins: modular proteins capable of promoting cell–cell interactions and triggering signals by protein‐ectodomain shedding. J Cell Sci 112 (Part 21): 3603–3617 · DOI · Paper page
  37. Seals DF, Courtneidge SA (2003) The ADAMs family of metalloproteases: multidomain proteins with multiple functions. Genes Dev 17: 7–30 · DOI · Paper page
  38. Shtutman M, Zhurinsky J, Simcha I, Albanese C, D'Amico M, Pestell R, Ben Ze'ev A (1999) The cyclin D1 gene is a target of the beta‐catenin/LEF‐1 pathway. Proc Natl Acad Sci USA 96: 5522–5527 · DOI · Paper page
  39. Simcha I, Kirkpatrick C, Sadot E, Shtutman M, Polevoy G, Geiger B, Peifer M, Ben Ze'ev A (2001) Cadherin sequences that inhibit beta‐catenin signaling: a study in yeast and mammalian cells. Mol Biol Cell 12: 1177–1188 · DOI
  40. Takeichi M (1991) Cadherin cell adhesion receptors as a morphogenetic regulator. Science 251: 1451–1455 · DOI · Paper page
  41. Tetsu O, McCormick F (1999) Beta‐catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398: 422–426 · DOI · Paper page
  42. Utton MA, Eickholt B, Howell FV, Wallis J, Doherty P (2001) Soluble N‐cadherin stimulates fibroblast growth factor receptor dependent neurite outgrowth and N‐cadherin and the fibroblast growth factor receptor co‐cluster in cells. J Neurochem 76: 1421–1430 · DOI
  43. Van Hoorde L, Braet K, Mareel M (1999) The N‐cadherin/catenin complex in colon fibroblasts and myofibroblasts. Cell Adhes Commun 7: 139–150 · DOI
  44. Weskamp G, Cai H, Brodie TA, Higashyama S, Manova K, Ludwig T, Blobel CP (2002) Mice lacking the metalloprotease‐disintegrin MDC9 (ADAM9) have no evident major abnormalities during development or adult life. Mol Cell Biol 22: 1537–1544 · DOI · Paper page
  45. Winkel GK, Ferguson JE, Takeichi M, Nuccitelli R (1990) Activation of protein kinase C triggers premature compaction in the four‐cell stage mouse embryo. Dev Biol 138: 1–15 · doi:10.1016/0012-1606(90)90171-e
  46. Yap AS, Brieher WM, Gumbiner BM (1997a) Molecular and functional analysis of cadherin‐based adherens junctions. Annu Rev Cell Dev Biol 13: 119–146 · DOI · Paper page
  47. Yap AS, Brieher WM, Pruschy M, Gumbiner BM (1997b) Lateral clustering of the adhesive ectodomain: a fundamental determinant of cadherin function. Curr Biol 7: 308–315 · DOI · Paper page

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Metadata

Authors
Reiss, K., Maretzky, T., Ludwig, A., Tousseyn, T., de Strooper, B., Hartmann, D., & Saftig, P.
Venue
The EMBO Journal
Publisher
Springer Science and Business Media LLC
Published
2005-02-03
Volume
24
Issue
4
Pages
742-752
ISSN
  • 0261-4189 (ISSN-L)
  • 1460-2075
DOI
10.1038/sj.emboj.7600548
OpenAlex
W2111314225
Cited by
481
References
2
FWCI
11.31
Type
journal article
Language
en
Update notices
erratum (2005-04-21)
Open access
green
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CoChat. (2026). Citation check: ADAM10 cleavage of N‐cadherin and regulation of cell–cell adhesion and β‐catenin nuclear signalling. https://app.cochat.ai/papers/10.1038/sj.emboj.7600548
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Reiss, K., Maretzky, T., Ludwig, A., Tousseyn, T., de Strooper, B., Hartmann, D., & Saftig, P. (2005). ADAM10 cleavage of N‐cadherin and regulation of cell–cell adhesion and β‐catenin nuclear signalling. The EMBO Journal. https://doi.org/10.1038/sj.emboj.7600548

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