The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Cockayne syndrome B protein regulates the transcriptional program after UV irradiation
Open accessAbstract
The phenotype of the human genetic disorder Cockayne syndrome (CS) is not only due to DNA repair defect but also (and perhaps essentially) to a severe transcription initiation defect. After UV irradiation, even undamaged genes are not transcribed in CSB cells. Indeed, neither RNA pol II nor the associated basal transcription factors are recruited to the promoters of the housekeeping genes, around of which histone H4 acetylation is also deficient. Transfection of CSB restores the recruitment process of RNA pol II. On the contrary, the p53-responsive genes do not require CSB and are transcribed in both wild-type and CSB cells upon DNA damage. Altogether, our data highlight the pivotal role of CSB in initiating the transcriptional program of certain genes after UV irradiation, and also may explain some of the complex traits of CS patients.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In living human cells, Proietti-De-Santis et al. [225] have shown that CSB is required during the first phases of RNA pol II transcription initiation.”
From Molecular Mechanisms of Ultraviolet Radiation‐Induced DNA Damage and Repair (2010) · cites this paper as [225]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Molecular mechanism of nucleotide excision repair
de Laat, W. L., Jaspers, N. G. J., & Hoeijmakers, J. H. J. (1999) · Genes & Development · doi:10.1101/gad.13.7.768 · Cited by 1,122
Komarnitsky, P. B., Cho, E., & Buratowski, S. (2000) · Genes & Development · doi:10.1101/gad.824700 · Cited by 1,098
Cockayne syndrome: Review of 140 cases
Nance, M. A., & Berry, S. A. (1992) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320420115 · Cited by 806
Troelstra, C., van Gool, A., de Wit, J., Vermeulen, W., Bootsma, D., & Hoeijmakers, J. H. J. (1992) · Cell · doi:10.1016/0092-8674(92)90390-x · Cited by 729
Acetylation of histone H4 by Esa1 is required for DNA double-strand break repair
Bird, A. W., Yu, D. Y., Pray-Grant, M. G., Qiu, Q., Harmon, K. E., Megee, P. C., Grant, P. A., Smith, M. M., & Christman, M. F. (2002) · Nature · doi:10.1038/nature01035 · Cited by 565
DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy
Lehmann, A. (2003) · Biochimie · doi:10.1016/j.biochi.2003.09.010 · Cited by 518
Henning, K. A., Li, L., Iyer, N., McDaniel, L. D., Reagan, M. S., Legerski, R., Schultz, R. A., Stefanini, M., Lehmann, A. R., Mayne, L. V., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90028-4 · Cited by 507
Mayne, L. V., & Lehmann, A. R. (1982) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(82)90047-1 · Cited by 420
Citterio, E., van den Boom, V., Schnitzler, G. R., Kanaar, R., Bonte, E. J., Kingston, R. E., Hoeijmakers, J. H. J., & Vermeulen, W. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.20.7643-7653.2000 · Cited by 376
Bregman, D. B., Halaban, R., van Gool, A. J., Henning, K. A., Friedberg, E. C., & Warren, S. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11586 · Cited by 331
DNA helicases: Enzymes with essential roles in all aspects of DNA metabolism
Matson, S. W., Bean, D. W., & George, J. W. (1994) · BioEssays · doi:10.1002/bies.950160103 · Cited by 293
Selby, C. P., & Sancar, A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.3.1885 · Cited by 267
A Rad26–Def1 complex coordinates repair and RNA pol II proteolysis in response to DNA damage
Woudstra, E. C., Gilbert, C., Fellows, J., Jansen, L. E. T., Brouwer, J., Erdjument‐Bromage, H., Tempst, P., & Svejstrup, J. Q. (2002) · Nature · doi:10.1038/415929a · Cited by 234
Sarker, A. H., Tsutakawa, S. E., Kostek, S. A., Ng, C., Shin, D. S., Peris, M., Campeau, E., Tainer, J. A., Nogales, E., & Cooper, P. K. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.09.022 · Cited by 224
Somesh, B. P., Reid, J., Liu, W., Søgaard, M., Erdjument‐Bromage, H., Tempst, P., & Svejstrup, J. Q. (2005) · Cell · doi:10.1016/j.cell.2005.04.010 · Cited by 224
CSB Is a Component of RNA Pol I Transcription
Bradsher, J., Auriol, J., Proietti‐De‐Santis, L., Iben, S., Vonesch, J., Grummt, I., & Egly, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00678-0 · Cited by 221
Self-citationNucleosome rearrangement in human chromatin during UV-induced DNA- reapir synthesis.
Smerdon, M. J., & Lieberman, M. W. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.9.4238 · Cited by 210
Dubaele, S., Proietti‐De‐Santis, L., Bienstock, R. J., Keriel, A., Stefanini, M., Houten, B. V., & Egly, J. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00182-5 · Cited by 204
Self-citationRockx, D., Mason, R. S., van Hoffen, A., Barton, M. C., Citterio, E., Bregman, D. B., van Zeeland, A. A., Vrieling, H., & Mullenders, L. H. F. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.180169797 · Cited by 203
Tantin, D. R., Kansal, A., & Carey, M. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.12.6803 · Cited by 202
Reduced RNA polymerase II transcription in intact and permeabilized Cockayne syndrome group B cells
Balajee, A. S., May, A., Dianov, G. L., Friedberg, E. C., & Bohr, V. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4306 · Cited by 177
UV irradiation stimulates histone acetylation and chromatin remodeling at a repressed yeast locus
Yu, Y., Teng, Y., Liu, H., Reed, S. H., & Waters, R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501458102 · Cited by 156
Initiation of DNA repair mediated by a stalled RNA polymerase IIO
Lainé, J., & Egly, J. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7600933 · Cited by 152
Self-citationEnhanced DNA Repair Synthesis in Hyperacetylated Nucleosomes
Ramanathan, B., & Smerdon, M. J. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)60422-3 · Cited by 138
Tornaletti, S., & Pfeifer, G. P. (1995) · Journal of Molecular Biology · doi:10.1006/jmbi.1995.0331 · Cited by 128
The CSB Protein Actively Wraps DNA
Beerens, N., Hoeijmakers, J. H. J., Kanaar, R., Vermeulen, W., & Wyman, C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409147200 · Cited by 119
Cockayne syndrome – a primary defect in DNA repair, transcription, both or neither?
Friedberg, E. C. (1996) · BioEssays · doi:10.1002/bies.950180908 · Cited by 100
Dianov, G. L., Houle, J.-F., Iyer, N., Bohr, V. A., & Friedberg, E. C. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.18.3636 · Cited by 80
The transcriptional response after oxidative stress is defective in Cockayne syndrome group B cells
Kyng, K. J., May, A., Brosh, R. M., Cheng, W., Chen, C., Becker, K. G., & Bohr, V. A. (2003) · Oncogene · doi:10.1038/sj.onc.1206187 · Cited by 69
Transcriptional Activators Stimulate DNA Repair
Frit, P., Kwon, K.-R., Coin, F., Auriol, J., Dubaele, S., Salles, B., & Egly, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00732-3 · Cited by 62
Self-citationChristiansen, M. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg164 · Cited by 51
Tisty, T. D., & Lieberman, M. W. (1978) · Nucleic Acids Research · doi:10.1093/nar/5.9.3261 · Cited by 39
The Sensitivity of RNA Polymerase II in Elongation Complexes to C-terminal Domain Phosphatase
Lehman, A. L., & Dahmus, M. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.20.14923 · Cited by 29
Cited by
Sorted by citations
Molecular Mechanisms of Ultraviolet Radiation‐Induced DNA Damage and Repair
Rastogi, R. P., Richa, Kumar, A., Tyagi, M. B., & Sinha, R. P. (2010) · Journal of Nucleic Acids · doi:10.4061/2010/592980 · Cited by 1,329
“[225] have shown that CSB is required during the first phases of RNA pol II transcription initiation.”
BackgroundDNA repair mechanisms in dividing and non-dividing cells
Iyama, T., & Wilson, D. M. (2013) · DNA Repair · doi:10.1016/j.dnarep.2013.04.015 · Cited by 697
Fousteri, M., & Mullenders, L. H. (2008) · Cell Research · doi:10.1038/cr.2008.6 · Cited by 487
Sunlight damage to cellular DNA: focus on oxidatively generated lesions
Schuch, A. P., Moreno, N. C., Schuch, N. J., Menck, C. F. M., & Garcia, C. C. M. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.01.029 · Cited by 436
Active DNA demethylation by Gadd45 and DNA repair
Niehrs, C., & Schäfer, A. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.01.002 · Cited by 261
Metadata
- Authors
- Proietti‐De‐Santis, L., Drané, P., & Egly, J.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Egly, Jean‐Marc
- Venue
- The EMBO Journal
- Published
- 2006-04-06
- Volume
- 25
- Issue
- 9
- Pages
- 1915-1923
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC1456931
- OpenAlex
- W2070933029
- Cited by
- 163
- References
- 33
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 9 · 2023: 4 · 2022: 7 · 2021: 11 · 2020: 6 · 2019: 5 · 2018: 9 · 2017: 9 · 2016: 5 · 2015: 3 · 2014: 9 · 2013: 18 · 2012: 14
- FWCI
- 3.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- The EMBO Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Institut National de la Santé et de la Recherche Médicale
- Fondation pour la Recherche Médicale
- Ligue Contre le Cancer
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Keywords
- Cockayne syndrome, UV irradiation, transcription initiation, RNA polymerase II recruitment, histone H4 acetylation, DNA damage response, transcriptional programs, DNA repair deficiency
- MeSH terms
- Poly-ADP-Ribose Binding Proteins, Cockayne Syndrome, DNA, DNA Damage, DNA Repair, DNA Helicases, Gene Expression Regulation, Humans, Promoter Regions, Genetic, RNA Polymerase II, Tetrahydrofolate Dehydrogenase, Transcription, Genetic, Ultraviolet Rays, Tumor Suppressor Protein p53, Receptors, Calcitriol, DNA Repair Enzymes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
