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Oxygen-dependent Regulation of Erythropoietin Receptor Turnover and Signaling

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Deficiency of the oxygen sensor PHD1 augments liver regeneration after partial hepatectomy

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William Kaelin, Peter Ratcliffe, and Gregg Semenza receive the 2016 Albert Lasker Basic Medical Research Award

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RSUME inhibits VHL and regulates its tumor suppressor function

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A 25 year perspective on the evolution and advances in an understanding of the biology, evaluation and treatment of kidney cancer

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HIF-2α-dependent induction of miR-29a restrains TH1 activity during T cell dependent colitis

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HIF2 Inhibitor Joins the Kidney Cancer Armamentarium

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Lactate metabolism is essential in early-onset mitochondrial myopathy

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Hypoxic‐ischemic gene expression profile in the isolated variant of biliary atresia

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Increased size of solid organs in patients with Chuvash polycythemia and in mice with altered expression of HIF-1α and HIF-2α

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Pathogenicity of VHL variants in families with non-syndromic von Hippel-Lindau phenotypes: An integrated evaluation of germline and somatic genomic results

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UBE3B promotes breast cancer progression by antagonizing HIF-2α degradation

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Transgenic Models to Understand Hypoxia‐Inducible Factor Function

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Pancreatic HIF2α Stabilization Leads to Chronic Pancreatitis and Predisposes to Mucinous Cystic Neoplasm

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Regulation of hypoxia-inducible factor 2-a is essential for integrity of the glomerular barrier

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Increased expression of transglutaminase 2 drives glycolytic metabolism in renal carcinoma cells

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HIF1α and HIF2α Exert Distinct Nutrient Preferences in Renal Cells

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HIF1 activation safeguards cortical bone formation against impaired oxidative phosphorylation

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Hypoxia-induced factor and its role in liver fibrosis

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Associations between HIFs and tumor immune checkpoints: mechanism and therapy

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Leishmanial lipid suppresses the bacterial endotoxin-induced inflammatory response with attenuation of tissue injury in sepsis

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Influence of hypoxia-dependent factors on the progression of neuroblastoma

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Vascular endothelial growth factor production is induced by histone deacetylase 1 and suppressed by von Hippel-Lindau protein in HaCaT cells

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New cancer targets emerging from studies of the Von Hippel‐Lindau tumor suppressor protein

Kaelin, W. G. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05781.x · Cited by 12

Molecular Biology of Kidney Cancer

Kaelin, W. G. (2015) · Springer eBooks · doi:10.1007/978-3-319-17903-2_3 · Cited by 12

Total loss of VHL gene function impairs neuroendocrine cancer cell fitness due to excessive HIF2α activity

Abu‐Remaileh, M., Persky, N. S., Lee, Y., Root, D. E., & Kaelin, W. G. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2410356121 · Cited by 9

Degradation‐Resistant Hypoxia Inducible Factor‐2α in Murine Osteocytes Promotes a High Bone Mass Phenotype

Mendoza, S. V., Murugesh, D. K., Christiansen, B., Genetos, Z. O., Loots, G. G., Genetos, D. C., & Yellowley, C. E. (2023) · JBMR Plus · doi:10.1002/jbm4.10724 · Cited by 9

Manipulation of the HIF–Vegf pathway rescues methyl tert-butyl ether (MTBE)-induced vascular lesions

Bonventre, J. A., Kung, T. S., White, L. A., & Cooper, K. R. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.10.008 · Cited by 9

Oxygen sensing; a stunningly elegant molecular machinery highjacked in cancer

Claesson, L. (2020) · Upsala Journal of Medical Sciences · doi:10.1080/03009734.2020.1769231 · Cited by 10

Hif-2α programs oxygen chemosensitivity in chromaffin cells

Prange‐Barczynska, M., Jones, H. A., Sugimoto, Y., Cheng, X., Lima, J. D. C. C., Ratnayaka, I., Douglas, G., Buckler, K. J., Ratcliffe, P. J., Keeley, T. P., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci174661 · Cited by 12

Angiotensin II Differentially Regulates Morg1 Expression in Kidney Cells

Bondeva, T., Heinzig, J., Franke, S., & Wolf, G. (2012) · American Journal of Nephrology · doi:10.1159/000337922 · Cited by 8

Modulation of the Physical Properties of 3D Spheroids Derived from Human Scleral Stroma Fibroblasts (HSSFs) with Different Axial Lengths Obtained from Surgical Patients

Katayama, H., Furuhashi, M., Umetsu, A., Hikage, F., Watanabe, M., Ohguro, H., & Ida, Y. (2021) · Current Issues in Molecular Biology · doi:10.3390/cimb43030121 · Cited by 8

Overexpression of HIF-2α in pancreatic β cells does not alter glucose homeostasis

Brunt, J. J., Shi, S. Y., Schroer, S. A., Sivasubramaniyam, T., Cai, E. P., & Woo, M. (2014) · Islets · doi:10.1080/19382014.2015.1006075 · Cited by 8

Review of the Role of Metabolic Factors in Determining the Post-surgical Adhesion and its Therapeutic Implications, with a Focus on Extracellular Matrix and Oxidative Stress

Tavakkoli, M., Khodashahi, R., Aliakbarian, M., Rahimi, H., Ashrafzadeh, K., Ferns, G. A., Khaleghi, E., & Arjmand, M. (2023) · Current Molecular Pharmacology · doi:10.2174/0118761429246636230919122745 · Cited by 7

Skeletal muscle-specific Bambi deletion induces hypertrophy and oxidative switching coupling with adipocyte thermogenesis against metabolic disorders

Yao, X., Mai, X., Tian, Y., Liu, Y., Jin, G., Li, Z., Chen, S., Dai, X., Huang, L., Fan, Z., et al. (2025) · Science China Life Sciences · doi:10.1007/s11427-023-2586-x · Cited by 7

Research Translation and Personalized Medicine

Brugarolas, J. (2012) · Springer eBooks · doi:10.1007/978-1-4614-2400-0_8 · Cited by 7

Hypoxia-Inducible Factor 2α: at the Interface between Oxygen Sensing Systems in Physiology and Pathology

Bishop, T., & Ratcliffe, P. J. (2025) · Physiology · doi:10.1152/physiol.00043.2024 · Cited by 6

Genetic insights into the hypoxia-inducible factor (HIF) pathway

Kiriakidis, S., Esteban, M. A., & Maxwell, P. H. (2007) · Advances in Enzyme Regulation · doi:10.1016/j.advenzreg.2006.12.009 · Cited by 6

HIF‐2α/ARNT complex regulates hair development via induction of p21 Waf1/Cip1 and p27 Kip1

Imamura, Y., Tomita, S., Imanishi, M., Kihira, Y., Ikeda, Y., Ishizawa, K., Tsuchiya, K., & Tamaki, T. (2014) · The FASEB Journal · doi:10.1096/fj.13-244079 · Cited by 6

HIF2 Regulates Intestinal Wnt5a Expression

García, C. J. G., Acevedo-Diaz, A., Kumari, N., Govindaraju, S., Bonilla, M. D. L. C., Lucas, F. A. S., Nguyen, N. D., Jiménez-Sacarello, I., Piwnica-Worms, H. M., Maitra, A., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.769385 · Cited by 5

Osteocytic oxygen sensing: Distinct impacts of VHL and HIF-2alpha on bone integrity

Mendoza, S. V., Wells, K. V., Murugesh, D. K., Hum, N. R., Sebastian, A., Gorman, B. M., Wong, A., Osipov, B., Christiansen, B., Loots, G. G., et al. (2024) · Bone · doi:10.1016/j.bone.2024.117339 · Cited by 5

Stabilization of HIF-2α impacts pancreas growth

Flores‐Martínez, Á., García-Núñez, A., Rojas, A., & Cano, D. A. (2018) · Scientific Reports · doi:10.1038/s41598-018-32054-5 · Cited by 5

Increased HIF-2α activity in the nucleus pulposus causes intervertebral disc degeneration in the aging mouse spine

Johnston, S. N., Tsingas, M., Ain, R., Barve, R. A., & Risbud, M. V. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1360376 · Cited by 5

The multi-dimensional role of intestinal HIFs in liver pathobiology

Ouyang, X., & Mehal, W. Z. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.07.012 · Cited by 4

Portal Hypertension in NASH: Is It Different from Other Aetiologies?

Francque, S., Kwanten, W. J., & van der Graaff, D. (2019) · Current Hepatology Reports · doi:10.1007/s11901-019-00459-z · Cited by 5

Inverse association between lung function and nonalcoholic fatty liver disease: An observational and mendelian randomization study

Zhou, C., Zhang, Y., Ye, Z., Zhang, Y., He, P., Liu, M., Yang, S., Gan, X., Xiang, H., Huang, Y., et al. (2024) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2024.07.007 · Cited by 3

Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein

Cockman, M. E., Masson, N., Mole, D. R., Jaakkola, P., Chang, G.-W., Clifford, S. C., Maher, E. R., Pugh, C. W., Ratcliffe, P. J., & Maxwell, P. H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002740200 · Cited by 1,053

Regulation of HIF prolyl hydroxylases by hypoxia‐inducible factors

Aprelikova, O. N., Chandramouli, G. V. R., Wood, M. J. A., Vasselli, J. R., Riss, J., Maranchie, J. K., Linehan, W. M., & Barrett, J. C. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20067 · Cited by 216

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

Cockman, M., Masson, N., Mole, D., Jaakkola, P., Chang, G., Clifford, S., Maher, E., PUGH, C., Ratcliffe, P., & MAXWELL, P. (2000) · UCL Discovery (University College London) · Cited by 15

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation

Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535

The role of hypoxia inducible factor family members in the development of VHL disease

Rankin, E. B. (2007) · Scholarly Commons (University of Pennsylvania)