Treatment of erythropoietin deficiency in mice with systemically administered siRNA
Open accessAbstract
Anemia linked to a relative deficiency of renal erythropoietin production is a significant cause of morbidity and medical expenditures in the developed world. Recombinant erythropoietin is expensive and has been linked to excess cardiovascular events. Moreover, some patients become refractory to erythropoietin because of increased production of factors such as hepcidin. During fetal life, the liver, rather than the kidney, is the major source of erythropoietin. In the present study, we show that it is feasible to reactivate hepatic erythropoietin production and suppress hepcidin levels using systemically delivered siRNAs targeting the EglN prolyl hydroxylases specifically in the liver, leading to improved RBC production in models of anemia caused by either renal insufficiency or chronic inflammation with enhanced hepcidin production.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Hepatic HIF can be sufficiently stimulated pharmacologically to correct anemia resulting from inadequate EPO production or inflammatory conditions.
“hepatic HIF can be sufficiently stimulated by pharmacologic means to correct anemia that results from inadequate EPO production or from inflammatory conditions. 24, 34”
From Regulation of erythropoiesis by hypoxia-inducible factors (2013) · cites this paper as [34]
Pharmacological inactivation of PHD enzymes with 2OG analogs increases serum EPO levels in animal models and in humans.
“Pharmacological inactivation of PHD enzymes with 2OG analogs increases serum EPO levels in animal models and in humans”
From Regulation of erythropoiesis by hypoxia-inducible factors (2013) · cites this paper as [34]
Pharmacological inactivation of PHD enzymes with 2OG analogs has the potential to benefit patients with anemia that results from inadequate EPO production.
“and has the potential to benefit patients with anemia that results from inadequate EPO production.”
From Regulation of erythropoiesis by hypoxia-inducible factors (2013) · cites this paper as [34]
Genetic or pharmacologic inactivation of all three PHDs is required to produce a strong and sustained erythropoietic response.
“Genetic or pharmacologic inactivation of all three PHDs, however, is required to produce a strong and sustained erythropoietic response.”
From Regulation of erythropoiesis by hypoxia-inducible factors (2013) · cites this paper as [34]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.
Kaelin, W. G., & Ratcliffe, P. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.04.009 · Cited by 3,251 · see citing works
Rational design of cationic lipids for siRNA delivery
Semple, S. C., Akinc, A., Chen, J., Sandhu, A. P., Mui, B. L., Cho, C. K., Sah, D. W. Y., Stebbing, D., Crosley, E. J., Yaworski, E., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1602 · Cited by 1,822 · see citing works
RNAi-mediated gene silencing in non-human primates
Zimmermann, T. S., Lee, A. C. H., Akinc, A., Bramlage, B., Bumcrot, D., Fedoruk, M. N., Harborth, J., Heyes, J. A., Jeffs, L. B., John, M., et al. (2006) · Nature · doi:10.1038/nature04688 · Cited by 1,357 · see citing works
Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms
Akinc, A., Querbes, W., De, S., Qin, J., Frank-Kamenetsky, M., Jayaprakash, K. N., Jayaraman, M., Rajeev, K. G., Cantley, W. L., Dorkin, J. R., et al. (2010) · Molecular Therapy · doi:10.1038/mt.2010.85 · Cited by 1,261 · see citing works
Hypoxia of the Renal Medulla — Its Implications for Disease
Brezis, M., & Rosen, S. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503093321006 · Cited by 1,229 · see citing works
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
Akinc, A., Zumbuehl, A., Goldberg, M. S., Leshchiner, E. S., Busini, V., Hossain, N., Bacallado, S., Nguyen, D. N., Fuller, J. E., Alvarez, R., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1402 · Cited by 1,228 · see citing works
Nicolas, G., Chauvet, C., Viatte, L., Danan, J. L., Bigard, X., Devaux, I., Beaumont, C., Kahn, A., & Vaulont, S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215686 · Cited by 1,214 · see citing works
Oxygen Sensing, Homeostasis, and Disease
Semenza, G. L. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1011165 · Cited by 989 · see citing works
Lipid-like materials for low-dose, in vivo gene silencing
Love, K. T., Mahon, K. P., Levins, C. G., Whitehead, K. A., Querbes, W., Dorkin, J. R., Qin, J., Cantley, W., Qin, L. L., Racie, T., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910603106 · Cited by 969 · see citing works
Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs)
Peyssonnaux, C., Zinkernagel, A. S., Schuepbach, R. A., Rankin, E., Vaulont, S., Haase, V. H., Nizet, V., & Johnson, R. S. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31370 · Cited by 639 · see citing works
Frank-Kamenetsky, M. D., Grefhorst, A., Anderson, N. N., Racie, T., Bramlage, B., Akinc, A., Butler, D., Charissé, K., Dorkin, J. R., Fan, Y., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805434105 · Cited by 635 · see citing works
Secondary analysis of the CHOIR trial epoetin-α dose and achieved hemoglobin outcomes
Szczech, L. A. M., Barnhart, H. X., Inrig, J. K., Reddan, D. N., Sapp, S. K., Califf, R. M., Patel, U. D., & Singh, A. K. (2008) · Kidney International · doi:10.1038/ki.2008.295 · Cited by 527 · see citing works
Suppression of hepcidin during anemia requires erythropoietic activity
Pak, M., Lopez, M. A., Gabayan, V., Ganz, T., & Rivera, S. (2006) · Blood · doi:10.1182/blood-2006-06-028787 · Cited by 472 · see citing works
Hepcidin and disorders of iron metabolism
Ganz, T., & Nemeth, E. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-050109-142444 · Cited by 466 · see citing works
Arthritis in rats after systemic injection of streptococcal cells or cell walls.
Cromartie, W. J., Craddock, J. G., Schwab, J. H., Anderle, S. K., & Yang, C.-H. (1977) · The Journal of Experimental Medicine · doi:10.1084/jem.146.6.1585 · Cited by 438 · see citing works
Vascular tumors in livers with targeted inactivation of the von Hippel–Lindau tumor suppressor
Haase, V. H., Glickman, J. N., Socolovsky, M., & Jaenisch, R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1583 · Cited by 421 · see citing works
Hypoxic regulation of erythropoiesis and iron metabolism
Haase, V. H. (2010) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00174.2010 · Cited by 347 · see citing works
Inhibition of Prolyl Hydroxylases Increases Erythropoietin Production in ESRD
Bernhardt, W. M., Wiesener, M. S., Scigalla, P., Chou, J., Schmieder, R. E., Günzler, V., & Eckardt, K.-U. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010010116 · Cited by 340 · see citing works
Hypoxia-inducible factor 2 regulates hepatic lipid metabolism
Rankin, E. B., Rha, J., Selak, M. A., Unger, T. L., Keith, B., Liu, Q., & Haase, V. H. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00200-09 · Cited by 338 · see citing works
Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis
Silvestri, L., Pagani, A., & Camaschella, C. (2008) · Blood · doi:10.1182/blood-2007-07-100677 · Cited by 311 · see citing works
Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia
Kapitsinou, P. P., Liu, Q., Unger, T. L., Rha, J., Davidoff, O., Keith, B., Epstein, J. A., Moores, S. L., Erickson-Miller, C. L., & Haase, V. H. (2010) · Blood · doi:10.1182/blood-2010-02-270322 · Cited by 307 · see citing works
Safran, M., Kim, W. Y., O'Connell, F., Flippin, L., Günzler, V., Horner, J. W., DePinho, R. A., & Kaelin, W. G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509459103 · Cited by 305 · see citing works
Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure
Minamishima, Y. A., Moslehi, J., Bardeesy, N., Cullen, D., Bronson, R. T., & Kaelin, W. G. (2008) · Blood · doi:10.1182/blood-2007-10-117812 · Cited by 294 · see citing works
Self-citationErythropoiesis-Stimulating Agents — Time for a Reevaluation
Unger, E. F., Thompson, A. M., Blank, M. J., & Temple, R. (2010) · New England Journal of Medicine · doi:10.1056/nejmp0912328 · Cited by 247 · see citing works
Failure to prolyl hydroxylate hypoxia‐inducible factor α phenocopies VHL inactivation in vivo
Kim, W. Y., Safran, M., Buckley, M. R., Ebert, B. L., Glickman, J., Bosenberg, M., Regan, M., & Kaelin, W. G. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601300 · Cited by 235 · see citing works
Ashby, D. R., Gale, D. P., Busbridge, M., Murphy, K. G., Duncan, N. D., Cairns, T. D., Taube, D. H., Bloom, S. R., Tam, F. W. K., Chapman, R., et al. (2010) · Haematologica · doi:10.3324/haematol.2009.013136 · Cited by 191 · see citing works
Qu, A., Taylor, M. J., Xue, X., Matsubara, T., METZGER, D., Chambon, P., Gonzalez, F. J., & Shah, Y. M. (2011) · Hepatology · doi:10.1002/hep.24400 · Cited by 181 · see citing works
The HIF pathway and erythrocytosis
Lee, F. S., & Percy, M. J. (2011) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130321 · Cited by 177 · see citing works
Hsieh, M. M., Linde, N. S., Wynter, A., Metzger, M., Wong, C., Langsetmo, I., Lin, A., Smith, R., Rodgers, G. P., Donahue, R. E., et al. (2007) · Blood · doi:10.1182/blood-2007-02-073254 · Cited by 171 · see citing works
Moslehi, J. J., Minamishima, Y. A., Shi, J., Neuberg, D. S., Charytan, D. M., Padera, R. F., Signoretti, S., Liao, R., & Kaelin, W. G. (2010) · Circulation · doi:10.1161/circulationaha.109.922427 · Cited by 168 · see citing works
Reactivation of hepatic EPO synthesis in mice after PHD loss
Minamishima, Y. A., & Kaelin, W. G. (2010) · Science · doi:10.1126/science.1192811 · Cited by 163 · see citing works
Mastrogiannaki, M., Matak, P., Mathieu, J. R. R., Delga, S., Mayeux, P., Vaulont, S., & Peyssonnaux, C. (2011) · Haematologica · doi:10.3324/haematol.2011.056119 · Cited by 161 · see citing works
A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo
Minamishima, Y. A., Moslehi, J., Padera, R. F., Bronson, R. T., Liao, R., & Kaelin, W. G. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00331-09 · Cited by 161 · see citing works
Self-citationDiagnosis and management of anaemia of chronic disease: current status
Cullis, J. (2011) · British Journal of Haematology · doi:10.1111/j.1365-2141.2011.08741.x · Cited by 144 · see citing works
Safran, M., Kim, W. Y., Kung, A. L., Horner, J. W., Depinho, R. A., & Kaelin, W. G. (2003) · Molecular Imaging · doi:10.1162/153535003322750637 · Cited by 134 · see citing works
Erythropoiesis in Anephric Man *
Nathan, D. G., Schupak, E., Stohlman, F., & Merrill, J. P. (1964) · Journal of Clinical Investigation · doi:10.1172/jci105089 · Cited by 117 · see citing works
Kanbay, M., Perazella, M. A., Kasapoğlu, B., Köroğlu, M., & Covic, A. C. (2009) · Blood Purification · doi:10.1159/000245041 · Cited by 113 · see citing works
Regulation of Type II Transmembrane Serine Proteinase TMPRSS6 by Hypoxia-inducible Factors
Lakhal‐Littleton, S., Schödel, J., Townsend, A., Pugh, C. W., Ratcliffe, P. J., & Mole, D. R. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.173096 · Cited by 113 · see citing works
Volke, M., Gale, D. P., Maegdefrau, U., Schley, G., Klanke, B., Bosserhoff, A.-K., Maxwell, P. H., Eckardt, K.-U., & Warnecke, C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007875 · Cited by 93 · see citing works
Pattern of resistance to erythropoietin-stimulating agents in chronic kidney disease
Bamgbola, O. F. (2011) · Kidney International · doi:10.1038/ki.2011.179 · Cited by 84 · see citing works
Lasocki, S., Millot, S., Andrieu, V., Lettéron, P., Pilard, N., Muzeau, F., Thibaudeau, O., Montravers, P., & Beaumont, C. (2008) · Critical Care Medicine · doi:10.1097/ccm.0b013e31818103b9 · Cited by 83 · see citing works
2-Oxoglutarate-dependent oxygenases control hepcidin gene expression
Braliou, G. G., Falzacappa, M. V. V., Chachami, G., Casanovas, G., Muckenthaler, M. U., & Simos, G. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2007.12.021 · Cited by 67 · see citing works
Effect of age on some properties of mice erythrocytes
Magnani, M., Rossi, L., Stocchi, V., Cucchiarini, L., Piacentini, G., & Fornaini, G. (1988) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(88)90061-9 · Cited by 60 · see citing works
Chuvash polycythemia VHLR200W mutation is associated with down-regulation of hepcidin expression
Gordeuk, V. R., Miasnikova, G. Y., Sergueeva, A. I., Niu, X., Nouraie, M., Okhotin, D. J., Polyakova, L. A., Ammosova, T., Nekhai, S., Ganz, T., et al. (2011) · Blood · doi:10.1182/blood-2011-03-345512 · Cited by 51 · see citing works
Kucejová, B., Sunny, N. E., Nguyen, A. D., Hallac, R. R., Fu, X., Peña‐Llopis, S., Mason, R. P., DeBerardinis, R. J., Xie, X.-J., DeBose‐Boyd, R. A., et al. (2011) · Oncogene · doi:10.1038/onc.2010.587 · Cited by 51 · see citing works
Sartor, R. B., Anderle, S. K., Rifai, N., Goo, D. A. T., Cromartie, W. J., & Schwab, J. H. (1989) · Infection and Immunity · doi:10.1128/iai.57.4.1177-1185.1989 · Cited by 40 · see citing works
Effect of Altitude on Erythropoiesis and Oxygen Affinity in Anaemic Patients on Maintenance Dialysis
Blumberg, A., Keller, H., & Marti, H. (1973) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1973.tb00334.x · Cited by 38 · see citing works
Coccia, M. A., Cooke, K. S., Stoney, G., Pistillo, J., del Castillo, J. M. G., Duryea, D., Tarpley, J. E., & Molineux, G. (2001) · Experimental Hematology · doi:10.1016/s0301-472x(01)00723-8 · Cited by 29 · see citing works
Erythrocyte survival in normal mice and in mice with autoimmune haemolytic anaemia.
Lindsey, E. S., Donaldson, G. W. K., & Woodruff, M. F. A. (1966) · PubMed · Cited by 25 · see citing works
Parfrey, P. S. (2010) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e3283428bc2 · Cited by 23 · see citing works
Flagged first, then by citations
1 of the 51 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Regulation of erythropoiesis by hypoxia-inducible factors
Haase, V. H. (2013) · Blood Reviews · doi:10.1016/j.blre.2012.12.003 · Cited by 787 · see citing works
Anaemia in kidney disease: harnessing hypoxia responses for therapy
Koury, M. J., & Haase, V. H. (2015) · Nature Reviews Nephrology · doi:10.1038/nrneph.2015.82 · Cited by 313 · see citing works
The EGLN-HIF O 2 -Sensing System: Multiple Inputs and Feedbacks
Ivan, M., & Kaelin, W. G. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.06.002 · Cited by 273 · see citing works
Self-citationFraenkel, P. G. (2016) · Medical Clinics of North America · doi:10.1016/j.mcna.2016.09.005 · Cited by 223 · see citing works
Schmidt, P. J., Toudjarska, I., Sendamarai, A. K., Racie, T., Milstein, S., Bettencourt, B. R., Hettinger, J., Bumcrot, D., & Fleming, M. D. (2013) · Blood · doi:10.1182/blood-2012-09-453977 · Cited by 204 · see citing works
Flamme, I., Oehme, F., Ellinghaus, P., Jeske, M., Keldenich, J., & Thuß, U. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111838 · Cited by 170 · see citing works
Joharapurkar, A. A., Pandya, V. B., Patel, V. J., Desai, R. C., & Jain, M. R. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b01686 · Cited by 170 · see citing works
Silencing VDAC1 Expression by siRNA Inhibits Cancer Cell Proliferation and Tumor Growth In Vivo
Arif, T., Vasilkovsky, L., Refaely, Y., Konson, A., & Shoshan‐Barmatz, V. (2014) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2014.9 · Cited by 148 · see citing works
Prolyl 4‐hydroxylases, master regulators of the hypoxia response
Myllyharju, J. (2013) · Acta Physiologica · doi:10.1111/apha.12096 · Cited by 118 · see citing works
Inhibition of fibroblast growth factor 23 (FGF23) signaling rescues renal anemia
Agoro, R., Montagna, A., Goetz, R. M., Aligbe, O., Singh, G. K., Coe, L. M., Mohammadi, M., Rivella, S., & Sitara, D. (2018) · The FASEB Journal · doi:10.1096/fj.201700667r · Cited by 117 · see citing works
Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin
Kobayashi, H., Liu, Q., Binns, T. C., Urrutia, A. A., Davidoff, O., Kapitsinou, P. P., Pfaff, A. S., Olauson, H., Wernerson, A. M., Fogo, A. B., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci83551 · Cited by 104 · see citing works
The VHL Tumor Suppressor Gene: Insights into Oxygen Sensing and Cancer.
Kaelin, W. G. (2017) · Europe PMC (PubMed Central) · Cited by 102 · see citing works
The iron-regulatory hormone hepcidin: A possible therapeutic target?
Rochette, L., Gudjoncik, A., Guénancia, C., Zeller, M., Cottin, Y., & Vergely, C. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.09.004 · Cited by 99 · see citing works
Bogorad, R. L., Yin, H., Zeigerer, A., Nonaka, H., Ruda, V. M., Zerial, M., Anderson, D. G., & Koteliansky, V. (2014) · Nature Communications · doi:10.1038/ncomms4869 · Cited by 85 · see citing works
Understanding anemia of chronic disease
Fraenkel, P. G. (2015) · Hematology · doi:10.1182/asheducation-2015.1.14 · Cited by 83 · see citing works
Speicher, T., Siegenthaler, B., Bogorad, R. L., Ruppert, R., Petzold, T., Padrissa-Altes, S., Bachofner, M., Anderson, D. G., Koteliansky, V., Fässler, R., et al. (2014) · Nature Communications · doi:10.1038/ncomms4862 · Cited by 85 · see citing works
Xiao, T., Liu, B., Lu, J., Li, S., Baiyun, R., Lv, Y., Lü, Q., & Zhang, Z. (2017) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2017.11.010 · Cited by 76 · see citing works
Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes
Tojo, Y., Sekine, H., Hirano, I., Pan, X., Souma, T., Tsujita, T., Kawaguchi, S., Takeda, N., Takeda, K., Fong, G., et al. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00161-15 · Cited by 70 · see citing works
Renal epithelium regulates erythropoiesis via HIF-dependent suppression of erythropoietin
Farsijani, N., Liu, Q., Kobayashi, H., Davidoff, O., Sha, F., Fandrey, J., Ikizler, T. A., O'Connor, P. M., & Haase, V. H. (2016) · Journal of Clinical Investigation · doi:10.1172/jci74997 · Cited by 67 · see citing works
Renal anemia: from incurable to curable
Sato, Y., & Yanagita, M. (2013) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00233.2013 · Cited by 65 · see citing works
Wang, K., Wu, J., Xu, J., Gu, S., Li, Q., Cao, P., Li, M., Zhang, Y., & Zeng, F. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00803 · Cited by 50 · see citing works
Hanudel, M. R., Wong, S. F., Jung, G., Qiao, B., Gabayan, V. R., Zuk, A., & Ganz, T. (2021) · Kidney International · doi:10.1016/j.kint.2021.03.019 · Cited by 36 · see citing works
Duan, L., Takeda, K., & Fong, G. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.12.014 · Cited by 30 · see citing works
Lönnberg, M., Garle, M., Lönnberg, L., & Birgegård, G. (2013) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2013.04.009 · Cited by 29 · see citing works
The Endoplasmic Reticulum Cargo Receptor SURF4 Facilitates Efficient Erythropoietin Secretion
Lin, Z., King, R., Tang, V. T., Myers, G., Balbin-Cuesta, G., Friedman, A. D., McGee, B. M., Desch, K. C., Ozel, A. B., Siemieniak, D. R., et al. (2020) · Molecular and Cellular Biology · doi:10.1128/mcb.00180-20 · Cited by 29 · see citing works
Tadin‐Strapps, M., Robinson, M., LeVoci, L., Andrews, L. E., Yendluri, S., Williams, S., Bartz, S., & Johns, D. G. (2015) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-014-9605-1 · Cited by 23 · see citing works
siRNA Delivery for the treatment of ovarian cancer
Goldberg, M. S. (2013) · Methods · doi:10.1016/j.ymeth.2013.01.007 · Cited by 22 · see citing works
Gene and Cell Doping: The New Frontier - Beyond Myth or Reality
Neuberger, E. W. I., & Simon, P. D. (2017) · Medicine and sport science/Medicine and sport · doi:10.1159/000465456 · Cited by 21 · see citing works
An evaluation of roxadustat for the treatment of anemia associated with chronic kidney disease
Kurata, Y., Tanaka, T., & Nangaku, M. (2021) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2021.1993821 · Cited by 21 · see citing works
Suppression of erythropoiesis by dietary nitrate
Ashmore, T., Fernandez, B. O., Evans, C. E., Huang, Y., Branco‐Price, C., Griffin, J. L., Johnson, R. S., Feelisch, M., & Murray, A. J. (2014) · The FASEB Journal · doi:10.1096/fj.14-263004 · Cited by 20 · see citing works
Smekalova, E. M., Gerashchenko, M. V., O’Connor, P. B. F., Whittaker, C. A., Kauffman, K. J., Fefilova, A. S., Zatsepin, T. S., Bogorad, R. L., Baranov, P. V., Langer, R., et al. (2019) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2019.11.009 · Cited by 17 · see citing works
Histone H3K9 demethylase JMJD1A is a co-activator of erythropoietin expression under hypoxia
Tian, Z., Lv, Y., Shen, Y., Guo, X., & Duan, X. (2019) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2019.01.022 · Cited by 14 · see citing works
PHD1-3 oxygen sensors in vivo—lessons learned from gene deletions
Jucht, A. E., & Scholz, C. C. (2024) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-024-02944-x · Cited by 10 · see citing works
Yamazaki, S., Hirano, I., Kato, K., Yamamoto, M. P., & Suzuki, N. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119075 · Cited by 8 · see citing works
Administration of α-Klotho Does Not Rescue Renal Anemia in Mice
Park, M. Y., Hénaff, C. L., & Sitara, D. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.924915 · Cited by 8 · see citing works
Karsikas, S. (2015) · Cited by 4 · see citing works
Why not the liver instead of the kidney?
Fandrey, J. (2012) · Blood · doi:10.1182/blood-2012-06-433201 · Cited by 4 · see citing works
The Non-Coding RNome Landscape in Erythropoiesis: Pathophysiological Implications
Brisot, E., Metzinger, L., & Meuth, V. M. (2025) · Cells · doi:10.3390/cells14241971 · Cited by 3 · see citing works
About relationship between chronic obstructive pulmonary disease and anemia
Жусина, Ю. Г., Budnevsky, A. V., Феськова, А. А., & Ovsyannikov, Е. S. (2019) · PULMONOLOGIYA · doi:10.18093/0869-0189-2018-28-6-730-735 · Cited by 3 · see citing works
A Single Dose of EGLN1 siRNA Yields Increased Erythropoiesis in Nonhuman Primates
Abrams, M. T., Koser, M. L., Burchard, J., Strapps, W. R., Mehmet, H., Gindy, M. E., Zaller, D. M., Sepp‐Lorenzino, L., & Stickens, D. (2014) · Nucleic Acid Therapeutics · doi:10.1089/nat.2014.0495 · Cited by 2 · see citing works
Nezami-Asl, A., Khoshvaghti, A., Doaee, M., Nikpajouh, A., & Nourmohammadi, A. (2016) · Annals of Military and Health Sciences Research · Cited by 2 · see citing works
Айтбаев, К. А., Murkamilov, I. T., & Fomin, V. V. (2017) · Almanac of Clinical Medicine · doi:10.18786/2072-0505-2017-45-7-565-574 · Cited by 1 · see citing works
Identification of idh1 mutation-related gene signature of glioblastoma multiforme
Zhou, Z. (2014) · Tampere University Institutional Repository (Tampere University)
Schmidt, P. J., Toudjarska, I., Sendamarai, A. K., Racie, T., Milstein, S., Bettencourt, B. R., Hettinger, J. L., Bumcrot, D. A., & Fleming, M. D. (2017)
Small Interfering RNA in Kidney Diseases: Promises and Limitations
Losito, A., & Solano, G. (2024) · Kidney and Dialysis · doi:10.3390/kidneydial5010001
- Authors
- Querbes, W., Bogorad, R. L., Moslehi, J., Wong, J., Chan, A. Y., Bulgakova, E., Kuchimanchi, S., Akinc, A., Fitzgerald, K., Koteliansky, V., & Kaelin, W. G.
- Affiliations
- Alnylam Pharmaceuticals (United States) (US)
- Massachusetts Institute of Technology (US)
- Brigham and Women's Hospital (US)
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2012-08-30
- Volume
- 120
- Issue
- 9
- Pages
- 1916-1922
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC3433093
- OpenAlex
- W2068256856
- Cited by
- 45
- References
- 51
- Citations by year
- 2025: 1 · 2024: 2 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 6 · 2016: 4 · 2015: 5 · 2014: 9 · 2013: 5 · 2012: 2
- FWCI
- 4.47
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- National Cancer Institute (R01CA068490, P50CA101942)
- Topics
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Keywords
- erythropoietin deficiency, siRNA, hepcidin, renal failure, chronic inflammation, anemia, erythropoiesis
- MeSH terms
- Anemia, Animals, Base Sequence, Cells, Cultured, Erythropoiesis, Erythropoietin, Feasibility Studies, Female, Humans, Inflammation, Liver, Male, Mice, Inbred C57BL, Mice, Transgenic, Procollagen-Proline Dioxygenase, Mice, Knockout, Antimicrobial Cationic Peptides, RNA Interference, RNA, Small Interfering, Mice, Renal Insufficiency, Hepcidins, Hypoxia-Inducible Factor-Proline Dioxygenases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
