Changing story of the receptor for phosphatidylserine‐dependent clearance of apoptotic cells
Open accessAbstract
The phosphatidylserine receptor (PSR) was originally described as the putative receptor for phosphatidylserine, which is displayed on the outer membrane leaflet of apoptotic cells as a so-called 'eat me' signal. Since then, contradictory findings about this protein have been published. A common characteristic of all PSR loss-of-function experiments in vertebrates has been neonatal lethality accompanied by severe developmental defects. However, impairment of phagocytosis has only been detected in some of these experiments. Furthermore, several groups have shown that PSR localizes to the nucleus. Structural in silico analysis of PSR indicates that it has a JumonjiC domain, and the molecular features characteristic of Fe(II)-dependent and 2-oxoglutarate-dependent oxygenases. This review summarizes the current status of research on the PSR protein.
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The best characterized bridging molecules are the soluble protein MFG-E8 and the glycolipid-anchored protein Tim-4.
“The best characterized of these are the soluble protein MFG-E8 87,121 and the glycolipid-anchored protein Tim-4 88.”
From Immunogenic and tolerogenic cell death (2009) · cites this paper as [121]
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- Authors
- Wolf, A., Schmitz, C., & Böttger, A.
- Affiliations
- Ludwig-Maximilians-Universität München (DE)
- Corresponding author
- Böttger, Angelika
- Venue
- The EMBO Reports
- Published
- 2007-05-01
- Volume
- 8
- Issue
- 5
- Pages
- 465-469
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- PMC
- PMC1866200
- OpenAlex
- W2168570420
- Cited by
- 31
- References
- 33
- Citations by year
- 2024: 1 · 2023: 1 · 2021: 2 · 2019: 2 · 2018: 1 · 2017: 2 · 2015: 5 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 0.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- EMBO Reports (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- phosphatidylserine receptor, efferocytosis, eat-me signals, phagocytosis, oxygenase, nuclear localization, loss-of-function mutations, neonatal lethality, developmental defects
- MeSH terms
- Amino Acid Sequence, Animals, Humans, Models, Molecular, Molecular Sequence Data, Phagocytosis, Receptors, Cell Surface, Signal Transduction, Sequence Alignment, Apoptosis, Protein Structure, Tertiary
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