Long‐patch DNA repair synthesis during base excision repair in mammalian cells
Open accessAbstract
The base excision repair (BER) process removes base damage such as oxidation, alkylation or abasic sites. Two BER sub-pathways have been characterized using in vitro methods, and have been classified according to the length of the repair patch as either 'short-patch' BER (one nucleotide) or 'long-patch' BER (LP-BER; more than one nucleotide). To investigate the occurrence of LP-BER in vivo, we developed an assay using a plasmid containing a single modified base in the transcribed strand of the enhanced green fluorescent protein (EGFP) gene and a stop codon, based on a single-nucleotide mismatch, at varying distances on the 3' side of the lesion. The reversion of the stop codon occurs after DNA repair synthesis and restores EGFP expression after transfection of mismatch-repair-deficient cells. Repair patches longer than one nucleotide were observed for 55-80% or 80-100% of the plasmids with a mean length of 2-6 or 6-12 nucleotides for 8-oxo-7,8-dihydroguanine or a synthetic abasic site, respectively. These data show the existence of LP-BER in vivo, and emphasize the effect of the type of BER substrate lesion on both the yield and the extent of the LP-BER sub-pathway.
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Sattler et al. made the first attempt to verify long-patch BER in vivo by measuring BER efficiency and a single modified base in a plasmid transfected into mammalian cells.
“On the basis of measuring the BER efficiency and presence of a single modified base in a plasmid molecule transfected into mammalian cells, Sattler et al. [196] made the first attempt to verify the occurrence of LP-BER in vivo.”
From Molecular Mechanisms of Ultraviolet Radiation‐Induced DNA Damage and Repair (2010) · cites this paper as [196]
The Assay principle section describes a single-lesion plasmid transfected into mammalian cells and an EGFP-based assay to test whether LP-BER occurs in vivo. The Introduction says the authors developed this approach, but our copy does not establish that theirs was the first attempt; the assay measured repair-patch outcomes rather than BER efficiency directly. Page numbers are not available in our copy. (LLM, conf=0.82)
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Modelling the impact of cellular variation on flux through base excision DNA repair.
Healing, E. (2019) · Surrey Research Insight Open Access (The University of Surrey) · doi:10.15126/thesis.00850299
Jaffary, S. A. N. R. (2018) · Queensland University of Technology · doi:10.5204/thesis.eprints.119175
Role of DNA damage and repair in chronic eye diseases
Gaisina, G. O., Luchnikova, Y. A., Khrushcheva, A. V., Rufullayeva, L. H., Tagirova, R. R., Mamedli, S. E., Lyashok, M. Y., Smorodova, S. Y., Boriskina, P. A., Vatulin, D. A., et al. (2023) · Clinical Medicine (Russian Journal) · doi:10.30629/0023-2149-2023-101-9-10-474-482
Basic Principles of DNA Repair in Toxicology
Dutta, A., & Dubey, S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00185-6
Shtanov, D. M., Kurgina, T. A., Kutuzov, M. M., Naumenko, K. N., Ukraintsev, A. A., Moor, N. A., & Lavrik, O. I. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.12.705504
Jacobs, B., Ivanov, D., Barraza, I., Faulk, C. D., Booth, C. J., Mattos-Canedo, R., Tian, L., DePietro, K., Uzun, A., Roos, W. P., et al. (2026) · Biomolecules · doi:10.3390/biom16030412
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Shtanov, D. M., Kurgina, T. A., Kutuzov, M. M., Naumenko, K. N., Ukraintsev, A. A., Moor, N. A., & Lavrik, O. I. (2026) · eLife · doi:10.7554/elife.111417.1
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- Authors
- Sattler, U., Frit, P., Salles, B., & Calsou, P.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Salles, Bernard
- Venue
- The EMBO Reports
- Published
- 2003-03-07
- Volume
- 4
- Issue
- 4
- Pages
- 363-367
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- PMC
- PMC1319152
- OpenAlex
- W2099529834
- Cited by
- 89
- References
- 27
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 4 · 2023: 4 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 8 · 2016: 9 · 2015: 2 · 2014: 3 · 2013: 1 · 2012: 1
- FWCI
- 1.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- EMBO Reports (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Association pour la Recherche sur le Cancer
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- long-patch base excision repair, base excision repair, DNA repair synthesis, 8-oxo-7,8-dihydroguanine, abasic sites, single nucleotide mismatch, mismatch repair deficiency, mammalian cells
- MeSH terms
- Animals, Cell Line, Cell Physiological Phenomena, DNA Repair, DNA Replication, Humans, Luminescent Proteins, Mammals, Templates, Genetic, Transfection, Genes, Reporter, Base Pair Mismatch, Green Fluorescent Proteins
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