Nucleosomes regulate base excision repair in chromatin
Open accessAbstract
Chromatin is a significant barrier to many DNA damage response (DDR) factors, such as DNA repair enzymes, that process DNA lesions to reduce mutations and prevent cell death; yet, paradoxically, chromatin also has a critical role in many signaling pathways that regulate the DDR. The primary level of DNA packaging in chromatin is the nucleosome core particle (NCP), consisting of DNA wrapped around an octamer of the core histones H2A, H2B, H3 and H4. Here, we review recent studies characterizing how the packaging of DNA into nucleosomes modulates the activity of the base excision repair (BER) pathway and dictates BER subpathway choice. We also review new evidence indicating that the histone amino-terminal tails coordinately regulate multiple DDR pathways during the repair of alkylation damage in the budding yeast Saccharomyces cerevisiae.
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Nucleosomes regulate DNA repair mechanisms.
“As it is known that nucleosomes regulate DNA repair mechanisms [71,72]”
From DNA Data Storage. (2023) · cites this paper as [71]
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“As it is known that nucleosomes regulate DNA repair mechanisms [71,72], the utilization of eukaryotic organisms, such as Saccharomyces cerevisiae , carrying dChr is one of the promising approaches for DNA data storage.”
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- Authors
- Meas, R., Wyrick, J. J., & Smerdon, M. J.
- Affiliations
- Washington State University (US)
- Corresponding author
- Smerdon, Michael J.
- Venue
- Mutation Research/Reviews in Mutation Research
- Publisher
- Elsevier BV
- Published
- 2019-04
- Volume
- 780
- Pages
- 29-36
- ISSN
- 1383-5742 (ISSN-L)
- PMC
- PMC6684245
- OpenAlex
- W2767401773
- Cited by
- 28
- References
- 87
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 1 · 2023: 4 · 2022: 5 · 2021: 8 · 2020: 4 · 2018: 1
- FWCI
- 0.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Mutation Research/Reviews in Mutation Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (ES002614)
- College of Veterinary Medicine at Washington State University
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Keywords
- nucleosome, base excision repair, chromatin, DNA damage response, nucleosome core particle, histone octamer, alkylation damage, DNA repair enzymes, Saccharomyces cerevisiae, DNA packaging
- MeSH terms
- Animals, Chromatin, DNA, DNA Damage, DNA Repair, Histones, Humans, Nucleosomes, Saccharomyces cerevisiae, Signal Transduction
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