Cited by 28DNA Repair MechanismsGenomics and Chromatin DynamicsNuclear Structure and Function

Nucleosomes regulate base excision repair in chromatin

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Meas, Rithy, Wyrick, John J., Smerdon, Michael J.·2019·Mutation Research/Reviews in Mutation Research

Abstract

Chromatin is a significant barrier to many DNA damage response (DDR) factors, such as DNA repair enzymes, that process DNA lesions to reduce mutations and prevent cell death; yet, paradoxically, chromatin also has a critical role in many signaling pathways that regulate the DDR. The primary level of DNA packaging in chromatin is the nucleosome core particle (NCP), consisting of DNA wrapped around an octamer of the core histones H2A, H2B, H3 and H4. Here, we review recent studies characterizing how the packaging of DNA into nucleosomes modulates the activity of the base excision repair (BER) pathway and dictates BER subpathway choice. We also review new evidence indicating that the histone amino-terminal tails coordinately regulate multiple DDR pathways during the repair of alkylation damage in the budding yeast Saccharomyces cerevisiae.

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Crossref · 10.1016/j.mrrev.2017.10.002

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  • Nucleosomes regulate DNA repair mechanisms.

    “As it is known that nucleosomes regulate DNA repair mechanisms [71,72]”

    From DNA Data Storage. (2023) · cites this paper as [71]

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Authors
Meas, R., Wyrick, J. J., & Smerdon, M. J.
Affiliations
Washington State University (US)
Corresponding author
Smerdon, Michael J.
Venue
Mutation Research/Reviews in Mutation Research
Publisher
Elsevier BV
Published
2019-04
Volume
780
Pages
29-36
ISSN
1383-5742 (ISSN-L)
OpenAlex
W2767401773
Cited by
28
References
87
Citations by year
2026: 1 · 2025: 4 · 2024: 1 · 2023: 4 · 2022: 5 · 2021: 8 · 2020: 4 · 2018: 1
FWCI
0.13
Type
journal article
Language
en
Open access
Locations
  • Mutation Research/Reviews in Mutation Research (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • NIH (ES002614)
  • College of Veterinary Medicine at Washington State University
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Keywords
nucleosome, base excision repair, chromatin, DNA damage response, nucleosome core particle, histone octamer, alkylation damage, DNA repair enzymes, Saccharomyces cerevisiae, DNA packaging
MeSH terms
Animals, Chromatin, DNA, DNA Damage, DNA Repair, Histones, Humans, Nucleosomes, Saccharomyces cerevisiae, Signal Transduction

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