The MRN complex: coordinating and mediating the response to broken chromosomes
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Items 101–200 of 289
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- Stalled Replication Induces p53 Accumulation through Distinct Mechanisms from DNA Damage Checkpoint PathwaysChui Chui Ho, Wai Yi Siu, Anita W.S. Lau, Wan Mui Chan, Talha Arooz, Randy Y.C. Poon · 2006 · Cancer Research
- Large-Scale Proteomics Data Reveal Integrated Prognosis-Related Protein Signatures and Role of SMAD4 and RAD50 in Prognosis and Immune Infiltrations of Prostate Cancer MicroenvironmentAihetaimujiang Anwaier, Shuxuan Zhu, Xi Tian, Wenhao Xu, Yue Wang, Maierdan Palihati, Wei-Yue Wang, Guohai Shi, Yuanyuan Qu, Hai‐Liang Zhang et al. · 2022 · Phenomics
- Rad50 Is Not Essential for the Mre11-Dependent Repair of DNA Double-Strand Breaks inHalobacteriumsp. Strain NRC-1Adrienne Kish, Jocelyne DiRuggiero · 2008 · Journal of Bacteriology
- Some mutations in the xeroderma pigmentosum D gene may lead to moderate but significant radiosensitivity associated with a delayed radiation-induced ATM nuclear localizationMélanie L. Ferlazzo, Élise Berthel, Adeline Granzotto, Clément Devic, Laurène Sonzogni, Jean-Thomas Bachelet, Sandrine Pereira, Michel Bourguignon, Alain R. Sarasin, Mauro Mezzina et al. · 2019 · International Journal of Radiation Biology
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- TIS21/BTG2/PC3 accelerates the repair of DNA double strand breaks by enhancing Mre11 methylation and blocking damage signal transfer to the Chk2T68–p53S20 pathwayKyu-Sung Choi, Ji Yeon Kim, Seo-Kyung Lim, Yong Won Choi, Young Hwa Kim, So Young Kang, Tae Jun Park, In Kyoung Lim · 2012 · DNA repair
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- Structure of a Second BRCT Domain Identified in the Nijmegen Breakage Syndrome Protein Nbs1 and its Function in an MDC1-Dependent Localization of Nbs1 to DNA Damage SitesChao Xu, Liming Wu, Gaofeng Cui, Maria Victoria Botuyan, Junjie Chen, Georges Mer · 2008 · Journal of Molecular Biology
- The Repression Domain of the E1B 55-Kilodalton Protein Participates in Countering Interferon-Induced Inhibition of Adenovirus ReplicationJasdave S. Chahal, Courtney Gallagher, Caroline J. DeHart, Sarah Jane Flint · 2013 · Journal of Virology
- Elevated MRE11 expression associated with progression and poor outcome in prostate cancerJun Wang, Wenhao Xu, Wei Yu, Yao Zhu, Xiao-Jian Qin, Hai‐Liang Zhang, Dingwei Ye · 2019 · Journal of Cancer
- Factors affecting the radiation response in glioblastomaRadhika Aiyappa‐Maudsley, Anthony J. Chalmers, Jason Luke Parsons · 2022 · Neuro-Oncology Advances
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- Investigation of the Functional Link between ATM and NBS1 in the DNA Damage Response in the Mouse CerebellumInbal Dar, Galit Yosha, Ronen Elfassy, Ronit Galron, Zhao‐Qi Wang, Yosef Shiloh, Ari Barzilai · 2011 · Journal of Biological Chemistry
- 50-Hertz Electromagnetic Fields Induce gammaH2AX Foci Formation in Mouse Preimplantation Embryos In Vitro1Qiong Luo, Jun Jie Yang, Qunli Zeng, Xiaoming Zhu, Yuli Qian, Hefeng Huang · 2006 · Biology of Reproduction
- IDN2 Interacts with RPA and Facilitates DNA Double-Strand Break Repair by Homologous Recombination in ArabidopsisMingming Liu, Zhaoqing Ba, Pedro Costa‐Nunes, Wei Wei, Lanxia Li, Fansi Kong, Yan Li, Jijie Chai, Olga Pontes, Yijun Qi · 2017 · The Plant Cell
- ATM and ATR Activation Through Crosstalk Between DNA Damage Response PathwaysElizabeth A. Fedak, Frederick R. Adler, Lisa M. Abegglen, Joshua David Schiffman · 2021 · Bulletin of Mathematical Biology
- TACC3 deregulates the DNA damage response and confers sensitivity to radiation and PARP inhibitionGeun‐Hyoung Ha, J-L Kim, A Petersson, Sang Ho Oh, Mitchell F. Denning, T Patel, E-K Breuer · 2014 · Oncogene
- Importance of Germline and Somatic Alterations in Human MRE11, RAD50, and NBN Genes Coding for MRN ComplexBarbora Otahalova, Zuzana Volkova, Jana Soukupová, Petra Kleiblová, Markéta Janatová, Michal Vočka, Libor Macůrek, Zdeněk Kleibl · 2023 · International Journal of Molecular Sciences
- A central role of TRAX in the ATM-mediated DNA repairJ-Y Wang, S-Y Chen, C-N Sun, T Chien, Yijuang Chern · 2015 · Oncogene
- PARP Inhibitors in Epithelial Ovarian Cancer: State of Art and Perspectives of Clinical Research.Angiolo Gadducci, Maria Elena Guerrieri · 2016 · PubMed
- Tumour-suppressor function in the nervous systemSuzanne J. Baker, Peter J. McKinnon · 2004 · Nature reviews. Cancer
- Bioactive steroidal glycosides from the marine sponge Erylus lendenfeldiJoel S. Sandler, Susan L. Forsburg, D. John Faulkner · 2005 · Tetrahedron
- Targeting DNA Repair through Podophyllotoxin and Rutin Formulation in Hematopoietic Radioprotection: An in Silico, in Vitro, and in Vivo StudyM.H. Yashavarddhan, Sandeep Kumar Shukla, Pankaj Chaudhary, Nitya Nand Srivastava, Jayadev Joshi, Mrutyunjay Suar, Manju Lata Gupta · 2017 · Frontiers in Pharmacology
- Genome Stability of Arabidopsis atm, ku80 and rad51b Mutants: Somatic and Transgenerational Responses to StressYouli Yao, Andriy Bilichak, Viktor Titov, Andrey Golubov, Igor Kovalchuk · 2013 · Plant and Cell Physiology
- Double-strand breaks trigger MRX- and Mec1-dependent, but Tel1-independent, checkpoint activationMuriel Grenon, Christine P. Magill, Noel Francis Lowndes, Stephen P. Jackson · 2006 · FEMS Yeast Research
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- ID3 promotes homologous recombination via non-transcriptional and transcriptional mechanisms and its loss confers sensitivity to PARP inhibitionAli Bakr, Joschka Hey, Gianluca Sigismondo, Chun-Shan Liu, Ahmed Sadik, Ashish Goyal, Alice Cross, Ramya Lakshmana Iyer, Patrick Müller, Max Trauernicht et al. · 2021 · Nucleic Acids Research
- Regulation of nuclear DNA damage response by mitochondrial morphofunctional pathwayNguyen Thi Kim Oanh, Ho‐Soo Lee, Yong‐Hyun Kim, Sunwoo Min, Yeon‐Ji Park, June Heo, Yong‐Yea Park, Wonchung Lim, Hyeseong Cho · 2022 · Nucleic Acids Research
- Enhanced radiation-mediated cell killing of human cervical cancer cells by small interference RNA silencing of ataxia telangiectasia-mutated proteinWenhao Li, W. JIAN, XU Xiao-ping, L. YINGFENG, X. TAO, X. XIAOYAN · 2006 · International Journal of Gynecological Cancer
- Genetic polymorphisms in homologous recombination repair genes in healthy Slovenian population and their influence on DNA damageKatja Goričar, Nina Erčulj, Maja Zadel, Vita Dolžan · 2012 · Radiology and Oncology
- Interactions between miRNAs and Double-Strand Breaks DNA Repair Genes, Pursuing a Fine-Tuning of RepairRicardo I. Peraza-Vega, Mahara Valverde, Emilio Rojas · 2022 · International Journal of Molecular Sciences
- The effects of 41°C hyperthermia on the DNA repair protein, MRE11, correlate with radiosensitization in four human tumor cell linesM. Xu, Robert J. Myerson, Y. Xia, T. Whitehead, Eduardo G. Moros, William L. Straube, Joseph L. Roti Roti · 2007 · International Journal of Hyperthermia
- Systems Modelling of NHEJ Reveals the Importance of Redox Regulation of Ku70/80 in the Dynamics of DNA Damage FociDavid Dolan, Glyn Nelson, Anže Županič, Graham R. Smith, Daryl P. Shanley · 2013 · PLoS ONE
- A Comprehensive Analysis of Alterations in DNA Damage Repair Pathways Reveals a Potential Way to Enhance the Radio-Sensitivity of Esophageal Squamous Cell CancerGuangchao Wang, Shichao Guo, Weimin Zhang, Zhangfu Li, Jiancheng Xu, Dan Li, Yan Wang, Qimin Zhan · 2020 · Frontiers in Oncology
- Acetylation of Lysine 382 and Phosphorylation of Serine 392 in p53 Modulate the Interaction between p53 and MDC1 In VitroOr David Shahar, Ronen Gabizon, Oren Feine, Raphael Alhadeff, Assaf Ganoth, Liron Argaman, Elee Shimshoni, Assaf Friedler, Michal Goldberg · 2013 · PLoS ONE
- Targeting of DNA Damage Signaling Pathway Induced Senescence and Reduced Migration of Cancer cellsRan Gao, Rumani Singh, Zeenia Kaul, Sunil C. Kaul, Renu Wadhwa · 2014 · The Journals of Gerontology Series A
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- Malfunctioning DNA Damage Response (DDR) Leads to the Degeneration of Nigro-Striatal Pathway in Mouse BrainMichal Kirshner, Ronit Galron, Dan Frenkel, Gil Mandelbaum, Yosef Shiloh, Zhao‐Qi Wang, Ari Barzilai · 2011 · Journal of Molecular Neuroscience
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- S-phase-coupled apoptosis in tumor suppressionYong–Jig Cho, Peng Liang · 2011 · Cellular and Molecular Life Sciences
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- Modes of action of the archaeal Mre11/Rad50 DNA-repair complex revealed by fast-scan atomic force microscopyEkaterina Zabolotnaya, Ioanna Mela, Mark J. Williamson, Sian Bray, Siu Kei Yau, Dimitra Papatziamou, John Michael Edwardson, Nicholas P. Robinson, Robert M. Henderson · 2020 · Proceedings of the National Academy of Sciences
- Astrocyte Dysfunction Associated with Cerebellar Attrition in a Nijmegen Breakage Syndrome Animal ModelRonit Galron, Ralph Gruber, Veronica Lifshitz, Haizhen Lu, Michal Kirshner, Natali Ziv, Zhao‐Qi Wang, Yosef Shiloh, Ari Barzilai, Dan Frenkel · 2011 · Journal of Molecular Neuroscience
- Mutation Spectra of the MRN (MRE11, RAD50, NBS1/NBN) Break Sensor in Cancer CellsMatthew T. McPherson, Ashton S. Holub, Aman Y. Husbands, Ruben C. Petreaca · 2020 · Cancers
- Timely Synthesis of the Adenovirus Type 5 E1B 55-Kilodalton Protein Is Required for Efficient Genome Replication in Normal Human CellsJasdave S. Chahal, Sarah Jane Flint · 2012 · Journal of Virology
- Overview of DNA repair pathways, current targets, and clinical trials bench to clinicMark R. Kelley, Melissa L. Fishel · 2016 · Elsevier eBooks
- In search of drug treatment for genetic defects in the DNA damage response: the example of ataxia-telangiectasiaYosef Shiloh, Yair Andegeko, Ilan Tsarfaty · 2004 · Seminars in Cancer Biology
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- Differential DNA Damage Response of Peripheral Blood Lymphocyte PopulationsKerstin Felgentreff, Catharina Schuetz, Ulrich Baumann, Christian Klemann, Dorothee Viemann, Simona Ursu, Eva‐Maria Jacobsen, Klaus‐Michael Debatin, Ansgar Schulz, Manfred Hoenig et al. · 2021 · Frontiers in Immunology
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- Enhanced radiation response through directed molecular targeting approachesSpencer James Collis, Theodore L. DeWeese · 2004 · Cancer and Metastasis Reviews
- Coordination and Processing of DNA Ends During Double-Strand Break Repair: The Role of the Bacteriophage T4 Mre11/Rad50 (MR) ComplexJoshua Richard Almond, Bradley A. Stohr, Anil K. Panigrahi, Dustin W. Albrecht, Scott William Nelson, Kenneth N. Kreuzer · 2013 · Genetics
- Calcium influx-mediated translocation ofm-calpain induces Ku80 cleavage and enhances the Ku80-related DNA repair pathwayKyung Hye Baek, Han Vit Yu, Eosu Kim, Younghwa Na, Youngjoo Kwon · 2016 · Oncotarget
- The characterization of γH2AX and p53 as biomarkers of genotoxic stress in a rainbow trout (Oncorhynchus mykiss) brain cell lineMark E. Hamilton, Niels C. Bols, Bernard P. Duncker · 2018 · Chemosphere
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- Construction of a DNA damage repair gene signature for predicting prognosis and immune response in breast cancerYi‐Ming Chang, Zhiyuan Huang, Hong Quan, Hui Li, Shuo Yang, Yifei Song, Jian Wang, Jian Yuan, Chenming Wu · 2023 · Frontiers in Oncology
- Characterization of the gene Mre11 and evidence of silencing after polyploidization in TriticumAlfredo de Bustos, Ruth Pérez, N. Jouve · 2007 · Theoretical and Applied Genetics
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- In silico analysis on the functional and structural impact of Rad50 mutations involved in DNA strand break repairJuwairiah Remali, Wan Mohd Aizat, Chyan Leong Ng, Yi Chieh Lim, Zeti‐Azura Mohamed‐Hussein, Shazrul Fazry · 2020 · PeerJ
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- Modification in the Expression of MRE11/RAD50/NBS1 Complex in Low dose Irradiated Human LymphocytesSompal Singh, Madhu Bala, Raj Kumar, Anil Kumar, SC Dhiman · 2009 · Dose-Response
- MR (Mre11-Rad50) complex in Giardia duodenalis: In vitro characterization and its response upon DNA damageAntonio Sandoval-Cabrera, Ana L. Zarzosa-Álvarez, Rosa María Martínez-Miguel, Rosa María Bermúdez‐Cruz · 2015 · Biochimie
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- The Aspergillus nidulans sldIRAD50 gene interacts with bimEAPC1, a homologue of an anaphase‐promoting complex subunitIran Malavazi, Joel Fernandes Lima, Márcia Regina von Zeska Kress, Vladimir P. Efimov, Maria Helena S. Goldman, Gustavo Henrique Goldman · 2005 · Molecular Microbiology
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