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ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks

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The MRE11 complex: at the crossroads of DNA repair and checkpoint signalling

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ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

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DNA damage-induced G2–M checkpoint activation by histone H2AX and 53BP1

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Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damagePreprint

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53BP1, a Mediator of the DNA Damage Checkpoint

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The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair

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Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

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Adenovirus oncoproteins inactivate the Mre11–Rad50–NBS1 DNA repair complex

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Structural Biochemistry and Interaction Architecture of the DNA Double-Strand Break Repair Mre11 Nuclease and Rad50-ATPase

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Human Rad50/Mre11 Is a Flexible Complex that Can Tether DNA Ends

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MDC1 is required for the intra-S-phase DNA damage checkpoint

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SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpointPreprint

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hMre11 and hRad50 Nuclear Foci Are Induced During the Normal Cellular Response to DNA Double-Strand Breaks †

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ATM-dependent phosphorylation of nibrin in response to radiation exposure

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The Nuclease Activity of Mre11 Is Required for Meiosis but Not for Mating Type Switching, End Joining, or Telomere Maintenance

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The Mre11 Complex Is Required for Repair of Hairpin-Capped Double-Strand Breaks and Prevention of Chromosome Rearrangements

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Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation

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The DNA damage-dependent intra–S phase checkpoint is regulated by parallel pathways

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DNA Damage-Dependent Nuclear Dynamics of the Mre11 Complex

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Characterization of Double-Strand Break-Induced Recombination: Homology Requirements and Single-Stranded DNA Formation

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Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice

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Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells

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The ABCs of SMC proteins: two-armed ATPases for chromosome condensation, cohesion, and repairPreprint

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A subset of ATM‐ and ATR‐dependent phosphorylation events requires the BRCA1 protein

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Yeast histone 2A serine 129 is essential for the efficient repair of checkpoint‐blind DNA damage

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Cancer predisposition and hematopoietic failure in <i> Rad50 ^S/S </i> mice

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Chk2 Activation Dependence on Nbs1 after DNA Damage

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Characterization of double-strand break-induced recombination: homology requirements and single-stranded DNA formation.

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DNA replication-dependent nuclear dynamics of the Mre11 complex.

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Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair

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DNA Double-Strand Break Repair by Homologous Recombination

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Mediator of DNA Damage Checkpoint Protein 1 Regulates BRCA1 Localization and Phosphorylation in DNA Damage Checkpoint Control

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The BRCT domain of the S. cerevisiae checkpoint protein Rad9 mediates a Rad9–Rad9 interaction after DNA damage

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DNA end-binding specificity of human Rad50/Mre11 is influenced by ATP

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Editorial

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Non-homologous end joining as a mechanism of DNA repair

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Doxorubicin—An Agent with Multiple Mechanisms of Anticancer Activity

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DNA damage responses to oxidative stress

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Postreplicative Recruitment of Cohesin to Double-Strand Breaks Is Required for DNA Repair

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PTIP Associates with MLL3- and MLL4-containing Histone H3 Lysine 4 Methyltransferase Complex

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Metabolic regulation of homologous recombination repair by MRE11 lactylation

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DNA damage-induced activation of ATM and ATM-dependent signaling pathways

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Mdc1 couples DNA double‐strand break recognition by Nbs1 with its H2AX‐dependent chromatin retention

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ATM and ataxia telangiectasia

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G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer

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Comparative genomics of the FtsK-HerA superfamily of pumping ATPases: implications for the origins of chromosome segregation, cell division and viral capsid packaging

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DNA Strand Break Repair and Human Genetic Disease

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ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks

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The DNA Damage Checkpoint Response Requires Histone H2B Ubiquitination by Rad6-Bre1 and H3 Methylation by Dot1

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Classical and Alternative End-Joining Pathways for Repair of Lymphocyte-Specific and General DNA Double-Strand Breaks

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Human RAD50 Deficiency in a Nijmegen Breakage Syndrome-like Disorder

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MRE11-RAD50-NBS1 complex alterations and DNA damage response: implications for cancer treatment

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Nucleoside analogs: molecular mechanisms signaling cell death

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Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress

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Applying Synthetic Lethality for the Selective Targeting of Cancer

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Two-step activation of ATM by DNA and the Mre11–Rad50–Nbs1 complex

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Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint controlPreprint

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Mre11–Rad50–Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks

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Ionizing Radiation–dependent γ-H2AX Focus Formation Requires Ataxia Telangiectasia Mutated and Ataxia Telangiectasia Mutated and Rad3-related

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The DNA damage response pathways: at the crossroad of protein modifications

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DNA Repair: The Importance of Phosphorylating Histone H2AX

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Live cell microscopy analysis of radiation-induced DNA double-strand break motion

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CRISPR/Cas9 cleavages in budding yeast reveal templated insertions and strand-specific insertion/deletion profiles

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Non-homologous end-joining factors ofSaccharomyces cerevisiae

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Evidence That the ATR/Chk1 Pathway Maintains Normal Replication Fork Progression during Unperturbed S Phase

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Orchestration of chromatin-based processes: mind the TRRAP

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ATM-Dependent Phosphorylation of All Three Members of the MRN Complex: From Sensor to Adaptor

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Studying DNA Double-Strand Break Repair: An Ever-Growing Toolbox

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BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer

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Radiation-Induced DNA Damage in Operators Performing Endovascular Aortic Repair

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Ubiquitin-binding domains and their role in the DNA damage response

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Identification and functional consequences of a novel MRE11 mutation affecting 10 Saudi Arabian patients with the ataxia telangiectasia-like disorder

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The Role of Mechanistic Factors in Promoting Chromosomal Translocations Found in Lymphoid and Other Cancers

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Sensing core histone phosphorylation — A matter of perfect timing

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The Functions of Budding Yeast Sae2 in the DNA Damage Response Require Mec1- and Tel1-Dependent Phosphorylation

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Cohesin and DNA damage repair

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DNA Double Strand Break Repair: A Radiation Perspective

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ATM Protein-dependent Phosphorylation of Rad50 Protein Regulates DNA Repair and Cell Cycle Control

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Srs2 and Sgs1 DNA Helicases Associate with Mre11 in Different Subcomplexes following Checkpoint Activation and CDK1-Mediated Srs2 Phosphorylation

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A Role for Homologous Recombination and Abnormal Cell-Cycle Progression in Radioresistance of Glioma-Initiating Cells

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Late S Phase-Specific Recruitment of Mre11 Complex Triggers Hierarchical Assembly of Telomere Replication Proteins in Saccharomyces cerevisiae

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Delineation of the Role of the Mre11 Complex in Class Switch Recombination

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Processing of recombinant AAV genomes occurs in specific nuclear structures that overlap with foci of DNA-damage-response proteins

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DNA Cross-Link Repair Protein SNM1A Interacts with PIAS1 in Nuclear Focus Formation

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Ataxia-Telangiectasia and Related Diseases

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ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining

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Terminal differentiation of cardiac and skeletal myocytes induces permissivity to AAV transduction by relieving inhibition imposed by DNA damage response proteins

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Off-Target Analysis in Gene Editing and Applications for Clinical Translation of CRISPR/Cas9 in HIV-1 Therapy

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Overexpression of the MRE11-RAD50-NBS1 (MRN) complex in rectal cancer correlates with poor response to neoadjuvant radiotherapy and prognosis

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A telomeric repeat sequence adjacent to a DNA double-stranded break produces an anticheckpointPreprint

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Human TopBP1 Ensures Genome Integrity during Normal S Phase

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The human VRK1 chromatin kinase in cancer biology

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Copper enhances genotoxic drug resistance via ATOX1 activated DNA damage repair

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ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1

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Cell Cycle-dependent Regulation of a Human DNA Helicase That Localizes in DNA Damage Foci

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SPIKE – a database, visualization and analysis tool of cellular signaling pathways

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The S phase checkpoint: When the crowd meets at the fork

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The MRE11-RAD50-NBS1 complex accelerates somatic hypermutation and gene conversion of immunoglobulin variable regions

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Bocavirus Infection Induces a DNA Damage Response That Facilitates Viral DNA Replication and Mediates Cell Death

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Redox-sensitive signaling in inflammatory T cells and in autoimmune disease

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ATM-NF-κB Connection as a Target for Tumor Radiosensitization

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The radiobiology of HPV-positive and HPV-negative head and neck squamous cell carcinoma

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RAD50 and NBS1 form a stable complex functional in DNA binding and tethering

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Evaluation of RAD50 in familial breast cancer predisposition

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A Mutant Allele ofMRE11Found in Mismatch Repair-deficient Tumor Cells Suppresses the Cellular Response to DNA Replication Fork Stress in a Dominant Negative Manner

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Epstein–Barr Virus Hijacks DNA Damage Response Transducers to Orchestrate Its Life Cycle

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Detection of a tandem BRCT in Nbs1 and Xrs2 with functional implications in the DNA damage response

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Differential Arrangements of Conserved Building Blocks among Homologs of the Rad50/Mre11 DNA Repair Protein Complex

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The Luminal Progenitor Compartment of the Normal Human Mammary Gland Constitutes a Unique Site of Telomere Dysfunction

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A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans : Major Findings, Functional and Mechanistic Insight and Challenges

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Epigenetic Telomere Protection by Drosophila DNA Damage Response Pathways

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The human set and transposase domain protein Metnase interacts with DNA Ligase IV and enhances the efficiency and accuracy of non-homologous end-joining

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Can corruption of chromosome cohesion create a conduit to cancer?

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Structural and Functional Characterization of an SMC-like Protein RecN: New Insights into Double-Strand Break Repair

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PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin

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The importance of making ends meet: Mutations in genes and altered expression of proteins of the MRN complex and cancer

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Hepatitis B virus pre‐ S2 mutant large surface protein inhibits DNA double‐strand break repair and leads to genome instability in hepatocarcinogenesis

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The FANC/BRCA Pathway Releases Replication Blockades by Eliminating DNA Interstrand Cross-Links

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Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair

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Early Events in the DNA Damage Response

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Mechanisms of clastogen-induced chromosomal aberrations: A critical review and description of a model based on failures of tethering of DNA strand ends to strand-breaking enzymes

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Mre11–Rad50–Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin templateThis paper is one of a selection of papers published in this Special Issue, entitled 28th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal's usual peer review process.

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The MRN complex

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The MRE11–RAD50–NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair

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Signalling around DNA breaks – new tricks for old dogs!

Smerdon, S. J. (2017) · Acta Crystallographica Section A Foundations and Advances · doi:10.1107/s2053273317087447

MRN and the race to the break

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