The MRN complex: coordinating and mediating the response to broken chromosomes

van den Bosch, Michael, Bree, Ronan T, Lowndes, Noel F·2003·The EMBO Reports
DOI 10.1038/sj.embor.embor925

Cited by (289)

Items 201–289 of 289

  1. Role of the Molecular Chaperones Hsp70 and Hsp90 in the DNA Damage Response
    Laura E. Knighton, Andrew W. Truman · 2019 · Heat shock proteins
  2. A Potential Link between Alternative Splicing of theNBS1Gene and DNA Damage/Environmental Stress
    Ken Takai, Shuichi Sakamoto, Tatsunori Sakai, Jun‐ichirou Yasunaga, Kenshi Komatsu, Masao Matsuoka · 2008 · Radiation Research
  3. Identification and characterization of a novel nuclear structure containing members of the homologous recombination and DNA damage response pathways
    Megan L. Sierant, Scott K. Davey · 2018 · Cancer Genetics
  4. Enhanced oncolytic adenoviral production by downregulation of death-domain associated protein and overexpression of precursor terminal protein
    Ji-Hyun Lee, Geun-Hyeok Oh, Jeong Ae Hong, Soojin Choi, Hye Jin Choi, Jae Jin Song · 2021 · Scientific Reports
  5. Elevated 2-oxoglutarate antagonizes DNA damage responses in cholangiocarcinoma chemotherapy through regulating aspartate beta-hydroxylase
    Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Y. Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller et al. · 2023 · Cancer Letters
  6. Regulation of DNA damage repair and lipid uptake by CX3CR1 in epithelial ovarian carcinoma
    Jia Xie, Hilal Gurler Main, Joelle Sacks Suarez, Goda G. Muralidhar, Maria V. Barbolina · 2018 · Oncogenesis
  7. Molecular mechanism of high glucose-induced mitochondrial DNA damage in retinal ganglion cells
    Jinzi Zhou, Fenghua Chen, Aimin Yan, Xiaobo Xia · 2024 · Cellular and Molecular Biology
  8. Melanoma Cells from Different Patients Differ in Their Sensitivity to Alpha Radiation-Mediated Killing, Sensitivity Which Correlates with Cell Nuclei Area and Double Strand Breaks
    O. Levy, Anat Altaras, Lior Binyamini, Orit Sagi‐Assif, Sivan Izraely, Tomer Cooks, Oren Kobiler, Motti Gerlic, I. Kelson, Isaac P. Witz et al. · 2024 · Cancers
  9. Repair of DNA Double-Strand Breaks
    Martin Falk, Emílie Lukášová, Stanislav Kozubek · 2011 · Biological and medical physics series
  10. Identification of ATM-dependent long non-coding RNAs induced in response to DNA damage
    Marta Podralska, Marcin Piotr Sajek, Antonina Bielicka, Magdalena Żurawek, Iwona Ziółkowska‐Suchanek, Katarzyna Iżykowska, Tomasz Kolenda, Marta Kazimierska, Marta Elżbieta Kasprzyk, Weronika Sura et al. · 2024 · DNA repair
  11. RAD50 Loss of Function Variants in the Zinc Hook Domain Associated with Higher Risk of Familial Esophageal Squamous Cell Carcinoma
    Josephine Mun Yee Ko, Shiu Yeung Lam, Lvwen Ning, Annie Wai Yeeng Chai, Lisa Chan Lei, Sheyne S. A. Choi, Carissa Wing-Yan Wong, Maria Li Lung · 2021 · Cancers
  12. Second in Molecular Medicine Review Series
    Peter J. McKinnon · 2004
  13. Molecular and Biological Characteristics of Stroma and Tumor Cells in Colorectal Cancer
    Jingfang Gao · 2008 · KTH Publication Database DiVA (KTH Royal Institute of Technology)
  14. OT-Curtains: an approach for studying protein interactions with DNA ends using optical tweezers and confocal fluorescence microscopy
    Sara de Bragança, Clara Aicart-Ramos, Ángel Rivera-Calzada, Raquel Arribas-Bosacoma, Mark Simon Dillingham, Óscar Llorca, Fernando Moreno‐Herrero · 2026 · Nucleic Acids Research
  15. CRISPR Screening Identifies SMARCAL1 and MRN as Modulators of WRN Dependency in MSI-H Colorectal Cancer
    Tiantian Ma, Jibo Wu, Siting Li, Junjie Chen · 2026 · Cancer Research
  16. The Identification of BRCA1 and BRCA2 Mutation Carriers Using Functional Genomic Assays
    Claire S. Michel · 2009 · QSpace (Queen's University Library)
  17. PRMT5 genetic interactions with DNA double strand break repair genes
    Hunter J. Bliss, Juliana Tron, Wesley A. Bush, Renee A. Bouley, Ruben C. Petreaca · 2025 · PLoS ONE
  18. WDFY2 promotes MRN complex formation required for homologous recombination-mediated DNA repair
    Ya-Fei Lu, Huangqi Tang, Longjiang Di, Yerkezhan Yerkinkazhina, Jiajie Su, Ming Tang, Jinqin Qian, Rongsheng Zeng, Yuxin Shu, Xingkai He et al. · 2025 · Cell Reports
  19. Thermal Modulation of Radiation-Induced DNA Damage Responses
    Joseph L. Roti Roti, Robert P. Vanderwaal, Andrei Laszlo · 2011 · Springer eBooks
  20. Targeted next-generation sequencing of 21 candidate genes in hereditary ovarian cancer patients from the Republic of Bashkortostan
    Darya S. Prokofyeva, Elvira Mingazheva, Yana V. Valova, Dina Sakaeva, Фаисханова Рания Разяповна, А.К. Нургалиева, Р. Р. Валиев, Natalia Viktorovna Bogdanova, Thilo Dörk, Э. К. Хуснутдинова · 2023 · Journal of Ovarian Research
  21. MRE11 as a plausible biomarker and prognostic bioindicator for head and neck squamous cell carcinoma
    Zhengrui Li, Yuhan Zhang, Xufeng Huang, Divya Gopinath · 2024 · Journal of Stomatology Oral and Maxillofacial Surgery
  22. Damage and Replication Stress Responses
    Haiying Wang, Ping Shen, Wei‐Guo Zhu · 2011 · InTech eBooks
  23. Fait nouveau : la méthylation des arginines joue un rôle dans la réparation de l’ADN
    François‐Michel Boisvert, Ugo Déry, Jean‐Yves Masson, Stéphane Richard · 2005 · médecine/sciences
  24. ATM, RAD50 and p53 in breast cancer
    Johanna Tommiska · 2008 · Työväentutkimus Vuosikirja
  25. Relationship between DNA damage response and telomere maintenance
    Maryam Ojani · 2012 · Brunel University Research Archive (BURA) (Brunel University London)
  26. Loss of cyclin A2 in murine colonic epithelial cells disrupts colon homeostasis by triggering DNA damage and dysplasia and high cyclin A2 expression is a good-prognosis factor in patients with colorectal cancer
    Yuchen Guo, Monica Gabola, Rossano Lattanzio, Conception Paul, Valérie Pinet, Ruizhi Tang, Hulya Tulari, Julie Bremond, Chloé Maurizy, Quentin Da Costa et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  27. Regulation of DNA damage response by trimeric G-protein Signaling
    Amer Ali Abd El‐Hafeez, Nina N. Sun, Anirban Chakraborty, Jason Ear, Suchismita Roy, Pranavi Chamarthi, Navin Rajapakse, Soumita Das, Kathryn E. Luker, Tapas K. Hazra et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  28. Analiza molekularna kompleksu genów MRE11/RAD50/NBS1 w rodzinach z agregacją zachorowań na raki piersi i/lub jajnika
    Ewelina Antoszewska · 2021
  29. A Regulatory Role for ATM in Suppression of Mre11-Dependent DNA Degradation and Microhomology-Mediated End Joining
    Elias A. Rahal · 2009 · UA Campus Repository (The University of Arizona)
  30. Molecular Mechanisms of Radiation-Induced Second Cancers
    Carsten Herskind, Frederik K. Wenz · 2009 · World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany
  31. Characterising the role of the Cajal Body during a productive adenovirus infection
    Laura White · 2012 · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
  32. DNA double-strand break repair in vivo assessed by g-H2AX [gamma-H2AX] foci analysis in brain and lung tissue of repair-proficient and -deficient mouse strains
    Xiaorong Dong · 2007 · Publications of the UdS (Saarland University)
  33. Replication fork stability in mammalian cells
    Ingegerd Elvers · 2011 · KTH Publication Database DiVA (KTH Royal Institute of Technology)
  34. The Rad9-Rad1-Hus1 complex and Bif-1 regulate multiple mechanisms that affect sensitivity to DNA damage
    Cheryl L. Meyerkord · 2009 · Digital Commons - University of South Florida (University of South Florida)
  35. A role for topoisomerase II alpha in chromosome damage in human cell lines
    Samantha Y.A. Terry · 2010 · St Andrews Research Repository (St Andrews Research Repository)
  36. ATM Mediated Signaling Defends the Integrity of the Genome
    Martin Francis Lavin, Magtouf Hnaidi Gatei, P. Chen, Amanda Wraith Kijas, Sergei Kozlov · 2010 · Elsevier eBooks
  37. Caracterização funcional de diferentes componentes das vias metabólicas de resposta ao dano DNA no fungo filamentoso 'Aspergillus nidulan'
    Iran Malavazi · 2007 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
  38. SEARCHING FOR RADIOSENSITIZERS: DEVELOPMENT OF A NOVEL ASSAY AND HIGH-THROUGHPUT SCREENING
    David R. Katz · 2008 · TSpace (University of Toronto)
  39. Functions of the MRE11-RAD50-NBS1 complex in DNA double strand break repair
    Swetlana Konkow · 2012 · DuEPublico (University of Duisburg-Essen)
  40. Interplay between ATM and ATR for the regulation of cellular responses to DNA damage
    Xiaoxiang Fan · 2010 · DuEPublico (University of Duisburg-Essen)
  41. p53 and DNA damage checkpoint responses in the human prostate
    Taija af Hällström · 2007
  42. Structural maintenance of chromsomes : A complex tale of genomic integrity
    Hanna Betts Lindroos · 2009 · Figshare
  43. HUMAN CHROMOSOMAL ABERRATIONS CAUSED BY ELECTROMAGNITIC FIELD
    Rafid Abdul-Wahid · 2009 · Iraqi Journal of Science
  44. Joana Raquel Faria da Silva PERFIL TRANSCRIPTÓMICO E GENÉTICO DO CANCRO DA PRÓSTATA
    Avaliação Da Expressão Dos Genes · 2010
  45. Homologous Recombination Repair Polymorphisms, Cancer Susceptibility and Treatment Outcome
    Katja Goričar, Vita Dolžan · 2015 · InTech eBooks
  46. Nuclear Architecture: Topology and Function of Chromatin- and Non-Chromatin Nuclear Domains
    Satoshi Tashiro, Marion Cremer, Irina V. Solovei, Thomas Cremer · 2007 · Springer eBooks
  47. LIM Protein Ajuba Participates in the Repression of ATR-Mediated DNA Damage Response in Human Cells
    Sampada Kalan · 2016 · CUNY Academic Works (City University of New York)
  48. Distribution and dynamics of charged particle-induced DNA double-strand breaks
    J. Splinter · 2010 · GSI Repository (German Federal Government)
  49. Telomere dynamics and telomerase-independent cell survival in Arabidopsis thaliana
    J. Matthew Watson · 2009 · OakTrust (Texas A&M University Libraries)
  50. DNA Damage Response to Lesions Involving Both Strands of the Double-helix
    Mukherjee, Sushmita · 2019 · Carolina Digital Repository (University of North Carolina at Chapel Hill)
  51. Molecular dissection of telomere dysfunction and analysis of G-overhangs in Arabidopsis thaliana
    Michelle L. Heacock · 2009 · OakTrust (Texas A&M University Libraries)
  52. Defining a role for TPX2 in the nucleus – Regulation of the DNA damage response
    Gernot Neumayer · 2013 · Libraries and Cultural Resources (University of Calgary)
  53. Coping with DNA Damage and Replication Stress
    Helle D. Ulrich · 2009 · Royal Society of Chemistry eBooks
  54. THE ROLE OF NBS1 IN THE INSULIN-LIKE GROWTH FACTOR-1 SIGNALING
    Dissertation der Fakultät, Für Biologie · 2008
  55. Analysis of the Genetic Requirements for Rad51-Mediated 3’ Polymerization during DNA Repair by Homologous Recombination
    Maureen M. Mundia · 2016 · The Atrium (University of Guelph)
  56. Interaction of the Mre11/Rad50/Nbs1 (MRN) complex and replication protein A (RPA) in response to DNA damage.
    Jacob G. Robison · 2005 · OhioLink ETD Center (Ohio Library and Information Network)
  57. Characterization of p53 in rainbow trout cell lines
    Michelle Liu · 2010 · UWSpace (University of Waterloo)
  58. Molecular mechanisms of anti-proliferative effects of the Traditional Chinese Medicinal compound Rocaglamide A on cancers
    Jennifer Neumann · 2012 · heiDOK (Heidelberg University)
  59. The effect of UVA irradiation on the DNA damage response in a human keratinocyte cell line
    Matthew Eastham · 2016 · Lancaster EPrints (Lancaster University)
  60. C9orf72 expansions disrupt ATM-mediated DNA repair
    Callum Walker · 2018 · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
  61. Novel Pathways Linking Mammalian Septins and the DNA Damage Response
    Timothy M. Errington · 2013
  62. The role of melanocyte senescence in skin ageing
    Stella G. Victorelli · 2018
  63. Peer Review #2 of "In silico analysis on the functional and structural impact of Rad50 mutations involved in DNA strand break repair (v0.1)"
    2020 · PeerJ
  64. Characterization of NEK10 Tyrosine Kinase Activity in the Cellular Response to DNA Damage
    Nasir Haider · 2018 · TSpace (University of Toronto)
  65. Analysis of the role of CIZ1 in regulation of DNA replication
    Tollitt, James · 2021 · Lancaster EPrints (Lancaster University)
  66. Role of Histone Metabolism and Chromatin Structure in DNA Repair
    Vijayalakshmi Kari · 2014 · eDiss (Georg-August-Universität Göttingen)
  67. Envolvimento do dano ao DNA e estresse oxidativo no transtorno bipolar e no uso de metilfenidato
    Ana C. Andreazza · 2008 · Americanae (AECID Library)
  68. Faculty Opinions recommendation of A telomeric repeat sequence adjacent to a DNA double-stranded break produces an anticheckpoint.
    Stephen P. Jackson · 2005 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  69. RAD50 loss of function variants in the zinc hook domain associated with higher risk of familial esophageal squamous cell carcinoma
    Josephine Mun Yee Ko, Maria Li Lung, Shiu Yeung Lam, Lvwen Ning, Annie Wai Yeeng Chai, Lisa Chan Lei, Sheyne S. A. Choi · 2021 · International Electronic Conference on Cancers (IECC)
  70. Identification of novel mediators of efficient non-homologous end joining in the yeast Saccharomyces cerevisiae
    Matthew Jessulat · 2011 · Carleton University's Institutional Repository (MacOdrum Library, Carleton University)
  71. Novel Pathways Linking Mammalian Septins and the DNA Damage Response
    Timothy M. Errington · 2016 · OSF Preprints (OSF Preprints)
  72. Peer Review #1 of "In silico analysis on the functional and structural impact of Rad50 mutations involved in DNA strand break repair (v0.3)"
    2020 · PeerJ
  73. Implicación de las quinasas humanas VRK1 y VRK2 en las rutas de respuesta a daño genético y apoptosis
    Diana M. Monsalve · 2014 · Gredos (University of Salamanca)
  74. Peer Review #1 of "In silico analysis on the functional and structural impact of Rad50 mutations involved in DNA strand break repair (v0.2)"
    2020 · PeerJ
  75. Peer Review #3 of "In silico analysis on the functional and structural impact of Rad50 mutations involved in DNA strand break repair (v0.2)"
    2020 · PeerJ
  76. Peer Review #1 of "In silico analysis on the functional and structural impact of Rad50 mutations involved in DNA strand break repair (v0.4)"
    2020 · PeerJ
  77. Peer Review #1 of "In silico analysis on the functional and structural impact of Rad50 mutations involved in DNA strand break repair (v0.1)"
    2020 · PeerJ
  78. Data from Role of histone deacetylase inhibitor-induced reactive oxygen species and DNA damage in LAQ-824/fludarabine antileukemic interactions
    Roberto R. Rosato, Jorge A. Almenara, Sonia C. Maggio, Stefanie Coe, Peter Wisdom Atadja, Paul Dent, Steven Grant · 2023
  79. Comparison of cellular responses to ionizing radiation in keratinocytes isolated from healthy donors and type II diabetes patients
    Hae Jin Lee, Hyuntaik Im, Hae‐June Lee, Hyunggee Kim, Jae Youn Yi · 2023 · International Journal of Radiation Biology
  80. Translationally Controlled Tumor Protein (TCTP) and Growth Regulation in the Drosophila Model
    Kwang‐Wook Choi, Sung-Tae Hong · 2025 · Advances in experimental medicine and biology
  81. Surviving Ionizing Radiation: General Stress Response and Mechanisms for the Prevention and Repair of DNA Damage in Halobacterium sp. str. NRC-1
    Adrienne Kish · 2007 · University Libraries (University of Maryland)
  82. Additional file 1 of Targeted next-generation sequencing of 21 candidate genes in hereditary ovarian cancer patients from the Republic of Bashkortostan
    Prokofyeva, D. S., Mingazheva, E. T., Valova, Ya. V., Sakaeva, D. D., Faishanova, R. R., Nurgalieva, A. Kh., Р. Р. Валиев, Bogdanova, N., Dörk, T., Khusnutdinova, E. K. · 2024 · Figshare
  83. Déterminants génétiques de la réparation d'ADN et du métabolisme des monocarbones : approche gènes candidats et études d'association avec le risque de carcinome hépatocellulaire et le cancer du poumon
    Patrice Hodonou Avogbe · 2012 · theses.fr (ABES)
  84. Comprendre et perturber le choix de la voie de réparation des cassures double brin de l'ADN pour augmenter l'efficacité et la sélectivité des agents anticancéreux génotoxiques
    Pauline Chanut · 2017 · theses.fr (ABES)
  85. Rôle de Ku70/80 dans le recrutement des facteurs du NHEJ portant un motif de fixation à Ku
    Clement Nemoz · 2017 · theses.fr (ABES)
  86. The Impact of DNA Damage on Epithelial Cell Maintenance of the Lung
    Lidza Kalifa, Michael A. O’Reilly · 2014 · Respiratory medicine
  87. A systems biology approach to DNA damage repair
    David Dolan · 2013
  88. The Role of Cohesin Associated Factors, Pds5,Scc3, and Wpl1 during Cohesion Establishmentand Maintenance in Budding Yeast
    Irina A. Kulemzina · 2012
  89. Prédiction structurale et ingénierie des assemblages macromoléculaires par bioinformatique
    Hocine Madaoui · 2007 · HAL