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An IL-13 promoter polymorphism associated with increased risk of allergic asthma
Abstract
IL-13 plays a crucial role in the development of allergic asthma by several mechanisms, including induction of IgE antibodies, airway eosinophilia and hyper-reactivity. We previously established a deregulated production of IL-13 by T cells from allergic asthma patients. In this report we describe the identification of a novel IL-13 promoter polymorphism (C to T exchange) at position -1055. The IL-13 -1055 TT genotype is associated with allergic asthma (P = 0.002), altered regulation of IL-13 production (P < 0.002), and increased binding of nuclear proteins to this region. We postulate that the presence of this polymorphism predisposes to the development of allergic asthma.
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“Resistance to Schistosoma haematobium was associated with the IL13-1055T/T genotype, 62 which has also been implicated in asthma exacerbations.63”
From Global issues in allergy and immunology: Parasitic infections and allergy (2017) · cites this paper as [63]
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Global issues in allergy and immunology: Parasitic infections and allergy
Cruz, A. A., Cooper, P. J., Figueiredo, C. A., Alcantara-Neves, N. M., Rodrigues, L. C., & Barreto, M. L. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.09.005 · Cited by 82
Lupiañez, C. B., Canet, L. M., Carvalho, A., Alcazar-Fuoli, L., Springer, J., Lackner, M., Segura-Catena, J., Comino, A., Olmedo, C., Ríos, R., et al. (2016) · Infection and Immunity · doi:10.1128/iai.01359-15 · Cited by 42
Metadata
- Authors
- van der Pouw Kraan, T., van Veen, A., Boeije, L., van Tuyl, S., de Groot, E., Stapel, S., Bakker, A., Verweij, C., Aarden, L., & van der Zee, J.
- Venue
- Genes & Immunity
- Published
- 1999-09-01
- Volume
- 1
- Issue
- 1
- Pages
- 61-65
- ISSN
- 1466-4879
- 1476-5470
- Cited by
- 228
- References
- 0
- Language
- en
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