Cited by 106Virus-based gene therapy researchRNA Interference and Gene DeliveryRetinal Development and Disorders

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Immune responses limit adenovirally mediated gene expression in the adult mouse eye

Reichel, MB, Ali, RR, Thrasher, AJ, Hunt, DM, Bhattacharya, SS, Baker, D·1998·Gene Therapy

Open this paper in CoChat — free account

Abstract

In order to investigate the immunological consequences of gene transfer to the eye using viral vectors, adenovirus carrying a lacZ reporter gene (AV.LacZ) was injected either subretinally, subconjunctivally or into the anterior chamber of three groups of adult mice: immunocompetent or transiently immunosuppressed BALB/c mice and congenic immunodeficient nude mice. Adenovirally mediated lacZ expression persisted for approximately 3 weeks following injection of the vector into the anterior chamber, retina or extra ocular tissues of the conjuctiva of BALB/c mice. It appears that T cell-mediated immune responses limit the duration of AV-mediated ocular gene expression in adult mice since lacZ gene expression was detected for at least 15 weeks in T cell-deficient BALB/c nude mice, although the level of transgene expression decreased with time. Since intra-ocular AV-mediated gene expression was not significantly longer than extra-ocular expression, it appears that the eye is not normally immune-privileged with respect to viral vectors. Inflammatory cells were detected in the vitreous after anterior chamber injection and in the retina after subretinal injection of adenovirus. The presence of both CD4+ and CD8+ T cells was established by immunophenotyping. Reinjection of BALB/c mice resulted in rapid decline in reporter gene expression, but successful readministration was possible in the case of immunodeficient nude mice. However, after transient depletion of T cells, achieved by intraperitoneal injection of both CD8- and CD4-specific antibodies, the duration of expression in BALB/c mice was longer in the eye (at least 12 weeks, again with decrease in level over time), than in extra-ocular tissues (8 weeks) provided the animal was not reinjected with virus raising the possibility of partial ocular immune-privilege after transient immunosuppression.

Integrity signals

Registry

Crossref · 10.1038/sj.gt.3300691

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cellular immune reactivity within the CNS
Wekerle, H., Linington, C., Lassmann, H., & Meyermann, R. (1986) · Trends in Neurosciences · doi:10.1016/0166-2236(86)90077-9 · Cited by 774
Manipulation of Adenovirus Vectors
Graham, F. L., & PREVEC, L. (2003) · Humana Press eBooks · doi:10.1385/0-89603-178-0:109 · Cited by 748
A "humanized" green fluorescent protein cDNA adapted for high-level expression in mammalian cells
Zolotukhin, S., Potter, M., Hauswirth, W. W., Guy, J., & Muzyczka, N. (1996) · Journal of Virology · doi:10.1128/jvi.70.7.4646-4654.1996 · Cited by 609
Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long-term expression.
Dai, Y., Schwarz, E. M., Gu, D., Zhang, W., Sarvetnick, N., & Verma, I. M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.5.1401 · Cited by 590
Monoclonal antibodies to promote marrow engraftment and tissue graft tolerance
Cobbold, S. P., Martín, G., QIN, S., & Waldmann, H. (1986) · Nature · doi:10.1038/323164a0 · Cited by 335
Photoreceptor cell rescue in retinal degeneration (rd) mice by in vivo gene therapy
Bennett, J., Tanabe, T., Sun, D., Zeng, Y., Kjeldbye, H., Gouras, P., & Maguire, A. M. (1996) · Nature Medicine · doi:10.1038/nm0696-649 · Cited by 316
Adenovirus gene transfer causes inflammation in the brain
Byrnes, A. P., Rusby, J. E., Wood, M. J. A., & Charlton, H. M. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00068-t · Cited by 276
Immune Privilege and Immune Regulation in the Eye
Niederkorn, J. Y. (1990) · Advances in immunology · doi:10.1016/s0065-2776(08)60755-5 · Cited by 266
Gene transfer into the mouse retina mediated by an adeno-associated viral vector
Ali, R. R. (1996) · Human Molecular Genetics · doi:10.1093/hmg/5.5.591 · Cited by 258
Self-citation
Recombinant IL–12 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung
Yang, Y., Trinchieri, G., & Wilson, J. M. (1995) · Nature Medicine · doi:10.1038/nm0995-890 · Cited by 243

Show all 34 references

Sorted by citations

Pharmaceutical development of AAV-based gene therapy products for the eye
Rodrigues, G. A., Shalaev, E., Karami, T. K., Cunningham, J., Slater, N. K. H., & Rivers, H. M. (2019) · Pharmaceutical Research · doi:10.1007/s11095-018-2554-7 · Cited by 213
In Vivo Gene Transfer to the Mouse Eye Using an HIV-Based Lentiviral Vector; Efficient Long-Term Transduction of Corneal Endothelium and Retinal Pigment Epithelium
Bainbridge, J., Stephens, C., Parsley, K., Demaison, C., Halfyard, A., Thrasher, A., & Ali, R. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301574 · Cited by 197
Self-citation
Vector platforms for gene therapy of inherited retinopathies
Trapani, I., Puppo, A., & Auricchio, A. (2014) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2014.08.001 · Cited by 191
Inhibition of retinal neovascularisation by gene transfer of soluble VEGF receptor sFlt-1
Bainbridge, J. W., Mistry, A., de Alwis, M., Paleolog, E. M., Baker, A. H., Thrasher, A. J., & Ali, R. R. (2002) · Gene Therapy · doi:10.1038/sj.gt.3301680 · Cited by 155
Self-citation
AAV-Mediated gene transfer slows photoreceptor loss in the RCS rat model of retinitis pigmentosa
Smith, A. J., Schlichtenbrede, F. C., Tschernutter, M., Bainbridge, J. W., Thrasher, A. J., & Ali, R. R. (2003) · Molecular Therapy · doi:10.1016/s1525-0016(03)00144-8 · Cited by 141
Self-citation
Cell Transplantation as a Treatment for Retinal Disease
Lund, R. D., Kwan, A., Keegan, D., Sauvé, Y., Coffey, P. J., & Lawrence, J. M. (2001) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(01)00003-9 · Cited by 132
Immune response following intraocular delivery of recombinant viral vectors
Bennett, J. (2003) · Gene Therapy · doi:10.1038/sj.gt.3302030 · Cited by 111
Let There Be Light: Gene and Cell Therapy for Blindness
Dalkara, D., Goureau, O., Marazova, K., & Sahel, J. (2016) · Human Gene Therapy · doi:10.1089/hum.2015.147 · Cited by 141
Long-term preservation of retinal function in the RCS rat model of retinitis pigmentosa following lentivirus-mediated gene therapy
Tschernutter, M., Schlichtenbrede, F. C., Howe, S. J., Balaggan, K. S., Munro, P., Bainbridge, J. W., Thrasher, A. J., Smith, A. J., & Ali, R. R. (2005) · Gene Therapy · doi:10.1038/sj.gt.3302460 · Cited by 132
Self-citation
Gene replacement therapy in the retinal degeneration slow (rds)mouse: the effect on retinal degeneration following partial transduction of the retina
Sarra, G. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.21.2353 · Cited by 127
Clinical applications of retinal gene therapy
Lipinski, D. M., Thake, M., & MacLaren, R. E. (2012) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2012.09.001 · Cited by 123
AAV-mediated gene therapy for retinal disorders: from mouse to man
Buch, P. K., Bainbridge, J. W., & Ali, R. R. (2008) · Gene Therapy · doi:10.1038/gt.2008.66 · Cited by 124
Self-citation
Adenovirus-Mediated Expression of Ciliary Neurotrophic Factor (CNTF) Rescues Axotomized Rat Retinal Ganglion Cells But Does Not Support Axonal Regeneration in Vivo
Weise, J., Isenmann, S., Klöcker, N., Kügler, S., Hirsch, S., Gravel, C., & Bähr, M. (2000) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0285 · Cited by 118
Intravitreal injection of adeno-associated viral vectors results in the transduction of different types of retinal neurons in neonatal and adult rats: A comparison with lentiviral vectors
Harvey, A. R., Kamphuis, W., Eggers, R., Symons, N. A., Blits, B., Niclou, S., Boer, G. J., & Verhaagen, J. (2002) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2002.1168 · Cited by 114
Gene therapy and transplantation in CNS repair: The visual system
Harvey, A. R., Hu, Y. J., Leaver, S. G., Mellough, C., Park, K. K., Verhaagen, J., Plant, G. W., & Cui, Q. (2006) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2006.07.002 · Cited by 110
Different Therapeutic Outcomes in Experimental Allergic Encephalomyelitis Dependant Upon the Mode of Delivery of IL-10: A Comparison of the Effects of Protein, Adenoviral or Retroviral IL-10 Delivery into the Central Nervous System
Croxford, J. L., Feldmann, M., Chernajovsky, Y., & Baker, D. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.6.4124 · Cited by 98
Self-citation
Modulating conjunctival wound healing
Cordeiro, M. F., Chang, L., Lim, K. S., Daniels, J. T., Pleass, R. D., Siriwardena, D., & Khaw, P. T. (2000) · Eye · doi:10.1038/eye.2000.141 · Cited by 93
Gene therapy for retinal ganglion cell neuroprotection in glaucoma
Wilson, A. M., & Polo, A. D. (2011) · Gene Therapy · doi:10.1038/gt.2011.142 · Cited by 81
Corneal gene therapy
Klausner, E. A., Peer, D., Chapman, R. L., Multack, R. F., & Andurkar, S. V. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.05.041 · Cited by 80
Effect of GDNF gene transfer into axotomized retinal ganglion cells using in vivo electroporation with a contact lens-type electrode
Ishikawa, H., Takano, M., Matsumoto, N., Sawada, H., Ide, C., Mimura, O., & Dezawa, M. (2004) · Gene Therapy · doi:10.1038/sj.gt.3302277 · Cited by 78
Advances in gene therapy technologies to treat retinitis pigmentosa
Petrs‐Silva, H., & Linden, R. (2013) · Clinical ophthalmology · doi:10.2147/opth.s38041 · Cited by 81
Ocular gene therapy: current progress and future prospects
Colella, P., Cotugno, G., & Auricchio, A. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2008.11.003 · Cited by 72
A Deviant Immune Response to Viral Proteins and Transgene Product Is Generated on Subretinal Administration of Adenovirus and Adeno-associated Virus
Anand, V., Duffy, B., Yang, Z., Dejneka, N. S., Maguire, A. M., & Bennett, J. (2002) · Molecular Therapy · doi:10.1006/mthe.2002.0525 · Cited by 69
Inhibition of Corneal Neovascularization by Recombinant Adenovirus Mediated Antisense VEGF RNA
Lai, C., Spilsbury, K., Brankov, M., Zaknich, T., & Rakoczy, P. E. (2002) · Experimental Eye Research · doi:10.1006/exer.2002.2075 · Cited by 64
In vivo gene transfection via intravitreal injection of cationic liposome/plasmid DNA complexes in rabbits
Kawakami, S., Harada, A., Sakanaka, K., Nishida, K., Nakamura, J., Sakaeda, T., Ichikawa, N., Nakashima, M., & Sasaki, H. (2004) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2004.03.013 · Cited by 58
Gene supplementation therapy for recessive forms of inherited retinal dystrophies
Smith, A. J., Bainbridge, J. W., & Ali, R. R. (2011) · Gene Therapy · doi:10.1038/gt.2011.161 · Cited by 60
Self-citation
A novel bubble liposome and ultrasound-mediated gene transfer to ocular surface: RC-1 cells in vitro and conjunctiva in vivo
Yamashita, T., Sonoda, S., Suzuki, R., Arimura, N., Tachibana, K., Maruyama, K., & Sakamoto, T. (2007) · Experimental Eye Research · doi:10.1016/j.exer.2007.08.006 · Cited by 54
Retinal transplantation: progress and problems in clinical application
Lund, R. D., Ono, S. J., Keegan, D., & Lawrence, J. M. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0103041 · Cited by 54
Tetracycline-Inducible Viral Interleukin-10 Intraocular Gene Transfer, Using Adeno-Associated Virus in Experimental Autoimmune Uveoretinitis
Smith, J. R., Verwaerde, C., Rolling, F., Naud, M., Delanoye, A., Thillaye-Goldenberg, B., Apparailly, F., & de Kozak, Y. (2005) · Human Gene Therapy · doi:10.1089/hum.2005.16.1037 · Cited by 53
Immune responses to gene editing by viral and non-viral delivery vectors used in retinal gene therapy
Ren, D., Fisson, S., Dalkara, D., & Ail, D. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14091973 · Cited by 52
Marked inhibition of retinal neovascularization in rats following soluble‐flt‐1 gene transfer
Rota, R., Riccioni, T., Zaccarini, M., Lamartina, S., Gallo, A. D., Fusco, A., Kovesdi, I., Balestrazzi, E., ABENI, D. D., Ali, R. R., et al. (2004) · The Journal of Gene Medicine · doi:10.1002/jgm.586 · Cited by 52
Self-citation
Adeno-associated and Herpes Simplex Viruses as Vectors for Gene Transfer to the Corneal Endothelium
Hudde, T., Rayner, S. A., de Alwis, M., Thrasher, A. J., Smith, J., Coffin, R. S., George, A. J. T., & Larkin, F. (2000) · Cornea · doi:10.1097/00003226-200005000-00022 · Cited by 51
Self-citation
Gene Therapy of Inherited Retinopathies: A Long and Successful Road from Viral Vectors to Patients
Colella, P., & Auricchio, A. (2012) · Human Gene Therapy · doi:10.1089/hum.2012.123 · Cited by 54
Retinal cell type expression specificity of HIV-1-derived gene transfer vectors upon subretinal injection in the adult rat: influence of pseudotyping and promoter
Bemelmans, A., Bonnel, S., Houhou, L., Dufour, N., Nandrot, E. F., Helmlinger, D., Sarkis, C., Abitbol, M. M., & Mallet, J. J. (2005) · The Journal of Gene Medicine · doi:10.1002/jgm.788 · Cited by 50
Post-pegylated lipoplexes are promising vehicles for gene delivery in RPE cells
Peeters, L., Sanders, N. N., Jones, A. T., Demeester, J., & Smedt, S. C. D. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.05.033 · Cited by 50
Gene therapy for ocular angiogenesis
Bainbridge, J. W., Mistry, A., Thrasher, A. J., & Ali, R. R. (2003) · Clinical Science · doi:10.1042/cs20020314 · Cited by 50
Self-citation
Gene transfer mediated by recombinant baculovirus into mouse eye.
Haeseleer, F., Imanishi, Y., Saperstein, D. A., & Palczewski, K. (2001) · PubMed · Cited by 50
Long-term transgene expression in the RPE after gene transfer with a high-capacity adenoviral vector.
Kreppel, F., Luther, T. T., Semkova, I., Schraermeyer, U., & Kochanek, S. (2002) · PubMed · Cited by 46
Ocular delivery of CRISPR/Cas genome editing components for treatment of eye diseases
Yu, W., & Wu, Z. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.011 · Cited by 48
Transscleral-RPE Permeability of PEDF and Ovalbumin Proteins: Implications for Subconjunctival Protein Delivery
Amaral, J., Fariss, R. N., Campos, M. M., Robison, W. G., Kim, H., Lutz, R., & Becerra, S. P. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-0492 · Cited by 43
Barriers for retinal gene therapy: separating fact from fiction.
Kumar-Singh, R. (2008) · Vision Research · doi:10.1016/j.visres.2008.05.005 · Cited by 43
Ribozyme uses in retinal gene therapy
Hauswirth, W. W., & Lewin, A. S. (2000) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(00)00007-0 · Cited by 39
Development of a Novel Helper-Dependent Adenovirus-Epstein-Barr Virus Hybrid System for the Stable Transformation of Mammalian Cells
Dorigo, O., Gil, J. S., Gallaher, S. D., Tan, B. T., Castro, M. G., Lowenstein, P. R., Calos, M. P., & Berk, A. J. (2004) · Journal of Virology · doi:10.1128/jvi.78.12.6556-6566.2004 · Cited by 38
Molecular therapy in ocular wound healing
Cordeiro, M. F., Schultz, G., Ali, R. R., Bhattacharya, S. S., & Khaw, P. T. (1999) · British Journal of Ophthalmology · doi:10.1136/bjo.83.11.1219 · Cited by 36
Self-citation
Delivery of anti-angiogenic molecular therapies for retinal disease
Anderson, O. A., Bainbridge, J. W., & Shima, D. T. (2010) · Drug Discovery Today · doi:10.1016/j.drudis.2010.02.004 · Cited by 34
Gene Therapy for Inherited Retinal Degeneration
Arbabi, A., Liu, A., & Ameri, H. (2019) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2018.0087 · Cited by 30
Simian Immunodeficiency Virus-Based Lentivirus Vector for Retinal Gene Transfer: A Preclinical Safety Study in Adult Rats
Ikeda, Y., Goto, Y., Yonemitsu, Y., Miyazaki, M., Sakamoto, T., Ishibashi, T., Tabata, T., Ueda, Y., Hasegawa, M., Tobimatsu, S., et al. (2003) · Gene Therapy · doi:10.1038/sj.gt.3301973 · Cited by 30
Recombinant Sendai Virus-mediated Gene Transfer into Adult Rat Retinal Tissue: Efficient Gene Transfer by Brief Exposure
Ikeda, Y., Yonemitsu, Y., Sakamoto, T., Ishibashi, T., Ueno, H., Kato, A., Nagai, Y., Fukumura, M., Inomata, H., Hasegawa, M., et al. (2002) · Experimental Eye Research · doi:10.1006/exer.2002.1177 · Cited by 29
Sustained expression after nonviral ocular gene transfer using mammalian promoters
Kachi, S., Esumi, N., Zack, D. J., & Campochiaro, P. A. (2006) · Gene Therapy · doi:10.1038/sj.gt.3302700 · Cited by 30
Co-injection of adenovirus expressing CTLA4-Ig prolongs adenovirally mediated lacZ reporter gene expression in the mouse retina
Ali, R. R., Reichel, M., Byrnes, A. P., Stephens, C., Thrasher, A. J., Baker, D., Hunt, D. M., & Bhattacharya, S. S. (1998) · Gene Therapy · doi:10.1038/sj.gt.3300761 · Cited by 28
Self-citation
Non-Primate Lentiviral Vectors and Their Applications in Gene Therapy for Ocular Disorders
Cavalieri, V., Baiamonte, E., & Iacono, M. L. (2018) · Viruses · doi:10.3390/v10060316 · Cited by 29
Long-Lasting Secretion of Transgene Product from Differentiated and Filter-Grown Retinal Pigment Epithelial Cells After Nonviral Gene Transfer
Mannermaa, E., Rönkkö, S., Ruponen, M., Reinisalo, M., & Urtti, A. O. (2005) · Current Eye Research · doi:10.1080/02713680590934058 · Cited by 28
Feline immunodeficiency virus vectors. Gene transfer to mouse retina following intravitreal injection
Derksen, T. A., Sauter, S. L., & Davidson, B. L. (2002) · The Journal of Gene Medicine · doi:10.1002/jgm.267 · Cited by 28
Gene Therapy for Genetic and Acquired Retinal Diseases
Chaum, E., & Hatton, M. P. (2002) · Survey of Ophthalmology · doi:10.1016/s0039-6257(02)00336-3 · Cited by 28
The possibility of gene therapy for the treatment of choroidal neovascularization
Murata, T. (2000) · Ophthalmology · doi:10.1016/s0161-6420(00)00147-0 · Cited by 26
Inhibition of Experimental Autoimmune Anterior Uveitis by Adenovirus-Mediated Transfer of the Interleukin-10 Gene
Fang, I., Lin, C., Yang, C., Chiang, B., Yang, C., Chau, L., & Chen, M. (2005) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2005.21.420 · Cited by 25
Viral-vector-delivered anti-angiogenic therapies to the eye
Koponen, S., Kokki, E., Kinnunen, K., & Ylä-Herttuala, S. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13020219 · Cited by 24
Educational paper
Sundaram, V., Moore, A. T., Ali, R. R., & Bainbridge, J. W. (2011) · European Journal of Pediatrics · doi:10.1007/s00431-011-1615-2 · Cited by 24
Self-citation
Strain-dependent anterior segment neovascularization following intravitreal gene transfer of basic fibroblast growth factor (bFGF)
Gupta, A. R., Dejneka, N. S., D’Amato, R. J., Yang, Z., Syed, N. A., Maguire, A. M., & Bennett, J. (2001) · The Journal of Gene Medicine · doi:10.1002/1521-2254(200105/06)3:3 · Cited by 17
Gene therapy for retinal and choroidal diseases
Campochiaro, P. A. (2002) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2.5.537 · Cited by 23
Uptake Dynamics and Retinal Tolerance of Phosphorothioate Oligonucleotide and Its Direct Delivery into the Site of Choroidal Neovascularization Through Subretinal Administration in the Rat
Shen, W.-Y., & Rakoczy, P. E. (2001) · Antisense and Nucleic Acid Drug Development · doi:10.1089/108729001317022250 · Cited by 20
Combined Effect of Cyclosporine and Sirolimus on Improving the Longevity of Recombinant Adenovirus–Mediated Transgene Expression in the Retina
Shen, W. (2001) · Archives of Ophthalmology · doi:10.1001/archopht.119.7.1033 · Cited by 20
CRISPR Systems Suitable for Single AAV Vector Delivery
Stevanovic, M., Piotter, E., McClements, M. E., & MacLaren, R. E. (2021) · Current Gene Therapy · doi:10.2174/1566523221666211006120355 · Cited by 19
Inhibition of experimental autoimmune uveitis by intravitreal AAV-Equine-IL10 gene therapy
Crabtree, E. E., Uribe, K., Smith, S. M., Roberts, D. M., Salmon, J. H., Bower, J. J., Song, L., Bastola, P., Hirsch, M. L., & Gilger, B. C. (2022) · PLoS ONE · doi:10.1371/journal.pone.0270972 · Cited by 19
Gene Therapy Using Stem CellsPreprint
Burnight, E. R., Wiley, L. A., Mullins, R. F., Stone, E. M., & Tucker, B. A. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a017434 · Cited by 20
Gene targeting to the retina
Sakamoto, T., Ikeda, Y., & Yonemitsu, Y. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00191-0 · Cited by 18
Commentary: An Aye for Eye Gene Therapy
Bennett, J. (2006) · Human Gene Therapy · doi:10.1089/hum.2006.17.177 · Cited by 18
Quantitative model demonstrating that recombinant adeno‐associated virus and green fluorescent protein are non‐toxic to the rat retina
Daniels, D. M., Shen, W., Constable, I. J., & Rakoczy, P. E. (2003) · Clinical and Experimental Ophthalmology · doi:10.1046/j.1442-9071.2003.00693.x · Cited by 17
An immune response after intraocular administration of an adenoviral vector containing a beta galactosidase reporter gene slows retinal degeneration in the rd mouse
Reichel, M. B. (2001) · British Journal of Ophthalmology · doi:10.1136/bjo.85.3.341 · Cited by 17
Self-citation
Absence of PKR Attenuates the Anti-HSV-1 Activity of an Adenoviral Vector Expressing Murine IFN- β
Al-Khatib, K., Williams, B. R. G., Silverman, R. H., Halford, W. P., & Carr, D. J. J. (2002) · Journal of Interferon & Cytokine Research · doi:10.1089/107999002760274872 · Cited by 16
Gene therapy in immune-mediated diseases of the eye
Pleyer, U. (2003) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(02)00046-0 · Cited by 16
Down-regulation of inducible co-stimulator (ICOS) by intravitreal injection of small interfering RNA (siRNA) plasmid suppresses ongoing experimental autoimmune uveoretinitis in rats
Hou, Y., Lin, X., Fu, S., Zhang, X., Liu, J., Liu, H., Lv, B., & Cui, H. Z. (2009) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-008-1023-0 · Cited by 15
Acute Toxicity Study of a Simian Immunodeficiency Virus-Based Lentiviral Vector for Retinal Gene Transfer in Nonhuman Primates
Ikeda, Y., Yonemitsu, Y., Miyazaki, M., Kohno, R.-I., Murakami, Y., Murata, T., Goto, Y., Tabata, T., Ueda, Y., Ono, F., et al. (2009) · Human Gene Therapy · doi:10.1089/hum.2009.048 · Cited by 15
Gene therapy for ocular neovascularization: a cure in sight
Reich, S. J., & Bennett, J. (2003) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(03)00043-1 · Cited by 15
Prospects for gene therapy of inherited retinal disease
Bainbridge, J. W. (2009) · Eye · doi:10.1038/eye.2008.412 · Cited by 12
Ex vivo adenovirus mediated gene transfection of human conjunctival epithelium
Shen, J. (2001) · British Journal of Ophthalmology · doi:10.1136/bjo.85.7.861 · Cited by 12
Remote Adenoviral Gene Delivery to the Spinal Cord: Contralateral Delivery and Reinjection
Turner, D. E., Noordmans, A. J., Feldman, E. L., & Boulis, N. M. (2001) · Neurosurgery · doi:10.1097/00006123-200106000-00026 · Cited by 12
Conotoxins and their potential pharmaceutical applications
Adams, D. J., Alewood, P. F., Craik, D. J., Drinkwater, R. D., & Lewis, R. J. (1999) · Drug Development Research · doi:10.1002/(sici)1098-2299(199903/04)46:3/4 · Cited by 104
T cell responses in experimental viral retinitis: Mechanisms, peculiarities and implications for gene therapy with viral vectors
Zinkernagel, M. S., McMenamin, P. G., Forrester, J. V., & Degli‐Esposti, M. A. (2011) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2011.04.001 · Cited by 11
La conception de vecteurs adaptés à la thérapie génique oculaire
Khabou, H., & Dalkara, D. (2015) · médecine/sciences · doi:10.1051/medsci/20153105015 · Cited by 11
Lentiviral Vectors Containing a Retinal Pigment Epithelium Specific Promoter for Leber Congenital Amaurosis Gene Therapy
Bemelmans, A., Kostic, C., Hornfeld, D., Jaquet, M., Crippa, S. V., Hauswirth, W. W., Lem, J., Wang, Z., Schorderet, D. F., Munier, F. L., et al. (2006) · Advances in experimental medicine and biology · doi:10.1007/0-387-32442-9_35 · Cited by 10
Adenoviral capsid modulates secretory compartment organization and function in acinar epithelial cells from rabbit lacrimal gland
Wang, Y., Xie, J., Yarber, F., Mazurek, C., Trousdale, M. D., Medina‐Kauwe, L. K., Kasahara, N., & Hamm‐Alvarez, S. F. (2004) · Gene Therapy · doi:10.1038/sj.gt.3302247 · Cited by 10
Preferential adenovirus-mediated transduction of cells at the sites of laser photocoagulation in the rat eye
Lai, C., Shen, W., Constable, I. J., & Rakoczy, P. E. (1999) · Current Eye Research · doi:10.1076/ceyr.19.5.411.5288 · Cited by 9
In vivo gene transfer into choroidal neovascularization by the HVJ liposome method
Otsuji, T., Ogata, N., Takahashi, K. A., Matsushima, M., Uyama, M., & Kaneda, Y. (2000) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s004170050032 · Cited by 7
Immunosuppression by IL-10-transfected human retinal pigment epithelial cells in vitro
Enzmann, V., Hollborn, M., Poschinger, K., Wiedemann, P., & Kohen, L. (2001) · Current Eye Research · doi:10.1076/ceyr.23.2.98.5474 · Cited by 5
Periocular Triamcinolone Enhances Intraocular Gene Expression after Delivery by Adenovirus
Park, C. Y., Chuck, R. S. H., Cano, M., Yew, M., Nguyen, V. Q., Parker, J., Mori, K., & Gehlbach, P. L. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-0619 · Cited by 4
Vascular Endothelial Growth Factors In Eye Diseases Pathophysiology and New Therapeutic Strategies for Retinal and Choroideal Angiogenesis
Kinnunen, K. (2009) · Cited by 3
Gene Therapy in Age-related Macular Degeneration
Zhou, H. W., & Kim, L. A. (2025) · International Ophthalmology Clinics · doi:10.1097/iio.0000000000000567 · Cited by 2
Viral Transgene Expression Delivered by Repeat Intraocular Adenoviral Vector Injection: in Vivo Live Imaging Study
Gehlbach, P. L., Chuck, R. S. H., Park, C., & Park, C. Y. (2012) · Molecular Imaging · doi:10.2310/7290.2011.00053 · Cited by 1
Gene therapy for Stargardt and other ABCA4-related diseases: lessons from RPE65-LCA trials
Silva, N. F. A. (2010) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · Cited by 1
Injection of vitreous body to the Joint Space may be an Alternative Treatment for Degenerative Joint Disorders, New Idea
Mosallaei, M. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2006.08.003 · Cited by 1
The Healing Effect of Vitreous Body on Repair of Cartilage Defects of Knee Joint in Dog as an Animal Model
Mehryar, M., Mosallaei, M., Ashraf, H., Rezasadeh, S., Azarpira, N., Tanideh, N., & Mehrabani, D. (2009) · Iranian Red Crescent Medical Journal · Cited by 1
DEVELOPMENT OF RAT MODELS FOR CHOROIDAL NEOVASCULARISATION (CNV) A Comparison between Laser and Recombinant Adenovirus Induced CNV
Rakoczy, E. P., Shen, W., Spilsbury, K., Yu, M., Lai, M. C., Barry, C. J., & Constable, I. J. (1999) · Cited by 1
Remote Adenoviral Gene Delivery to the Spinal Cord: Contralateral Delivery and Reinjection
Turner, D. E., Noordmans, A. J., Feldman, E. L., & Boulis, N. M. (2001) · Neurosurgery · doi:10.1227/00006123-200106000-00026 · Cited by 1
Novel Methods to Eliminate the Immune Response to Adenovirus Gene Therapy
Zhang, H., Hsu, H., & Mountz, J. D. (2002) · Elsevier eBooks · doi:10.1016/b978-012199504-1/50015-8 · Cited by 1
Development Of Rat Models For Choroidal Neovascularisation (CNV)
Rakoczy, P. E., Shen, W., Spilsbury, K., Yu, M., Lai, M. C., Barry, C. J., & Constable, I. J. (2007) · Springer eBooks · doi:10.1007/978-0-585-33172-0_36
EFFICIENT TRANSDUCTION AND TARGETED EXPRESSION OF LENTIVIRAL VECTOR TRANSGENES IN THE DEVELOPING RETINA
Coleman, J. E. (2003)
EUROPEAN SCHOOL OF MOLECULAR MEDICINE
Napoli, S. D. (2010)
Anti-Angiogenic Gene Therapy: Basic Science and Challenges for Translation into the Clinic
Lange, C., & Bainbridge, J. W. (2016) · Essentials in ophthalmology/Essentials ophthalmology · doi:10.1007/978-3-319-24097-8_11
New Experimental Therapeutic Approaches for Degenerative Diseases of the Retina
Tombran‐Tink, J. (2021) · Routledge eBooks · doi:10.4324/9781003113423-23

Authors: Reichel, M., Ali, R., Thrasher, A., Hunt, D., Bhattacharya, S., & Baker, D.
Affiliations: University College London (GB)
ORCID: Baker, D
Venue: Gene Therapy
Publisher: Springer Science and Business Media LLC
Published: 1998-08-01
Volume: 5
Issue: 8
Pages: 1038-1046
ISSN: 0969-7128 (ISSN-L)
1476-5462
DOI: 10.1038/sj.gt.3300691
OpenAlex: W2047633827
Cited by: 106
References: 34
Citations by year: 2026: 1 · 2025: 1 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 2 · 2016: 3 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 4
FWCI: 4.76
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Gene Therapy (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
Keywords: adenoviral vector, immune privilege, T cell immunity, subretinal injection, anterior chamber injection, subconjunctival injection, nude mice, immunodeficient mice, transient immunosuppression, CD4+ T cells, CD8+ T cells, vitreous inflammation, ocular immunology
MeSH terms: Adenoviridae, Animals, Anterior Chamber, Antibodies, Antibodies, Viral, beta-Galactosidase, Blood-Retinal Barrier, Conjunctiva, Eye, Genetic Vectors, Immunosuppression Therapy, Injections, Retina, T-Lymphocytes, Time Factors, Transfection, Genetic Therapy, Gene Expression, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Immune responses limit adenovirally mediated gene expression in the adult mouse eye

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks