The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.
Life and death in the granuloma: immunopathology of tuberculosis
Abstract
During tuberculosis (TB) infection, the granuloma provides the microenvironment in which antigen‐specific T cells colocate with and activate infected macrophages to inhibit the growth of Mycobacterium tuberculosis. Although the granuloma is the site for mycobacterial killing, virulent mycobacteria have developed a variety of mechanisms to resist this macrophage‐mediated killing. These surviving mycobacteria become dormant, however, if host cellular immunity or the signals maintaining granuloma structure wane, or if mycobacteria resume replication, leading to reactivation of TB. This balance of life and death applies not only to the mycobacterium but also to the host macrophages that may undergo apoptosis or necrosis, leading to the characteristic caseous necrosis within the granuloma, and the potential spread of TB infection. The immunological factors controlling the development and maintenance of the granuloma will be reviewed.
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Cites
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Cited by
Mycobacterium tuberculosis and the Macrophage: Maintaining a Balance
Pieters, J. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.05.006 · Cited by 503
Expansion and function of Foxp3-expressing T regulatory cells during tuberculosis
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Macrophage and T Cell Dynamics during the Development and Disintegration of Mycobacterial Granulomas
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Macrophages in tuberculosis: friend or foe
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Interactions of the Human Pathogenic Brucella Species with Their Hosts
Atluri, V. L., Xavier, M. N., de Jong, M. F., den Hartigh, A. B., & Tsolis, R. M. (2011) · Annual Review of Microbiology · doi:10.1146/annurev-micro-090110-102905 · Cited by 295
Metadata
- Authors
- Saunders, B. M., & Britton, W. J.
- Venue
- Immunology & Cell Biology
- Publisher
- Wiley
- Published
- 2007-01-09
- Volume
- 85
- Issue
- 2
- Pages
- 103-111
- ISSN
- 0004-945X (ISSN-L)
- 0818-9641
- 1440-1711
- OpenAlex
- W2064521374
- Cited by
- 340
- References
- 103
- FWCI
- 19.00
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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