The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Expansion and function of Foxp3-expressing T regulatory cells during tuberculosis
Open accessAbstract
Mycobacterium tuberculosis (Mtb) frequently establishes persistent infections that may be facilitated by mechanisms that dampen immunity. T regulatory (T reg) cells, a subset of CD4+ T cells that are essential for preventing autoimmunity, can also suppress antimicrobial immune responses. We use Foxp3-GFP mice to track the activity of T reg cells after aerosol infection with Mtb. We report that during tuberculosis, T reg cells proliferate in the pulmonary lymph nodes (pLNs), change their cell surface phenotype, and accumulate in the pLNs and lung at a rate parallel to the accumulation of effector T cells. In the Mtb-infected lung, T reg cells accumulate in high numbers in all sites where CD4+ T cells are found, including perivascular/peribronchiolar regions and within lymphoid aggregates of granulomas. To determine the role of T reg cells in the immune response to tuberculosis, we generated mixed bone marrow chimeric mice in which all cells capable of expressing Foxp3 expressed Thy1.1. When T reg cells were depleted by administration of anti-Thy1.1 before aerosol infection with Mtb, we observed ∼1 log less of colony-forming units of Mtb in the lungs. Thus, after aerosol infection, T reg cells proliferate and accumulate at sites of infection, and have the capacity to suppress immune responses that contribute to the control of Mtb.
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Cites
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
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Self-citationThe Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer
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Restoring function in exhausted CD8 T cells during chronic viral infection
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Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3
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Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
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Self-citationCD4+CD25+ regulatory T cells control Leishmania major persistence and immunity
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Cited by
Koch, M. A., Tucker-Heard, G., Perdue, N. R., Killebrew, J. R., Urdahl, K. B., & Campbell, D. J. (2009) · Nature Immunology · doi:10.1038/ni.1731 · Cited by 1,258
Self-citationCell-Mediated Immune Responses in Tuberculosis
Cooper, A. M. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132703 · Cited by 1,162
Grainger, J. R., Smith, K. A., Hewitson, J. P., McSorley, H. J., Harcus, Y., Filbey, K. J., Finney, C. A. M., Greenwood, E. J. D., Knox, D. P., Wilson, M. S., et al. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20101074 · Cited by 469
Self-citationIntracellular Pathogens: Host Immunity and Microbial Persistence Strategies
Thakur, A., Mikkelsen, H., & Jungersen, G. (2019) · Journal of Immunology Research · doi:10.1155/2019/1356540 · Cited by 396
The role of cytokines in the initiation, expansion, and control of cellular immunity to tuberculosis
Cooper, A. M., & Khader, S. A. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00702.x · Cited by 353
Metadata
- Authors
- Scott-Browne, J. P., Shafiani, S., Tucker-Heard, G., Ishida-Tsubota, K., Fontenot, J. D., Rudensky, A. Y., Bevan, M. J., & Urdahl, K. B.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2007-08-20
- Volume
- 204
- Issue
- 9
- Pages
- 2159-2169
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2097509788
- Cited by
- 403
- References
- 56
- FWCI
- 22.14
- Type
- journal article
- Language
- en
- Open access
- bronze
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