The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Normal proportion and expression of maturation markers in migratory dendritic cells in the absence of germs or Toll-like receptor signaling
Abstract
Dendritic cells (DCs) play major roles in immunosurveillance. In peripheral tissues, 'immature' DCs are dedicated to capturing antigens. Detection of pathogens through Toll-like receptors (TLRs) triggers DC migration to the lymph nodes (LNs), where they acquire a 'mature' phenotype specialized at presenting antigens. However, DCs migrate from tissues and mature even in the absence of overt infections. This has been attributed to detection of commensal flora in the skin, the gut or other peripheral tissues in the steady state. To test this assumption, we have analyzed the DCs contained in the lymphoid organs of germ-free mice and of mice lacking the TLR adapter molecules, MyD88 and TRIF. We show that the proportion and expression of maturation markers in DC immigrants in the LNs of these mice are similar to those in normal mice. These results suggest that DC migration from tissues, followed by their phenotypic maturation, is regulated in the steady state by an inherent program of DC differentiation or by the release of low levels of inflammatory signals from normal tissues.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Of note, we did not observe differences in DC proportions in the spleen, tumor-draining or inguinal lymph nodes from SPF and GF mice that were either naive or tumor-bearing (Figures S2D and S2E), agreeing with previous reports (Ganal et al., 2012; Wilson et al., 2008).”
From Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment (2021) · cites this paper as Wilson et al., 2008
Citations
Cites
Akira, S., & Takeda, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1391 · Cited by 8,312
Toll-like receptor control of the adaptive immune responses
Iwasaki, A., & Medzhitov, R. M. (2004) · Nature Immunology · doi:10.1038/ni1112 · Cited by 4,166
Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway
Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda, K., et al. (2003) · Science · doi:10.1126/science.1087262 · Cited by 3,286
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.
Adachi, O., Kawai, T., Takeda, K., Matsumoto, M., Tsutsui, H., Sakagami, M., Nakanishi, K., & Akira, S. (1998) · Immunity · doi:10.1016/s1074-7613(00)80596-8 · Cited by 2,358
Dendritic cells in a mature age
Sousa, C. R. E. (2006) · Nature reviews. Immunology · doi:10.1038/nri1845 · Cited by 1,197
Huang, F., Platt, N., Wykes, M., Major, J. R., Powell, T. J., Jenkins, C. D., & MacPherson, G. G. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.3.435 · Cited by 902
Toll-dependent selection of microbial antigens for presentation by dendritic cells
Blander, J. M., & Medzhitov, R. M. (2006) · Nature · doi:10.1038/nature04596 · Cited by 841
CD4 and CD8 Expression by Dendritic Cell Subtypes in Mouse Thymus and Spleen
Vremec, D., Pooley, J. L., Hochrein, H., Wu, L., & Shortman, K. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.6.2978 · Cited by 805
Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo.
Smedt, T. D., Pajak, B., Muraille, É., Lespagnard, L., Heinen, E., BAETSELIER, P. D., Urbain, J., Léo, O., & Moser, M. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.4.1413 · Cited by 755
Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo
Villadangos, J. A., & Schnorrer, P. (2007) · Nature reviews. Immunology · doi:10.1038/nri2103 · Cited by 737
Cited by
Sorted by citations
Compartmentalized Control of Skin Immunity by Resident Commensals
Naik, S., Bouladoux, N., Wilhelm, C., Molloy, M. J., Salcedo, R., Kastenmuller, W., Deming, C., Quinones, M., Koo, L., Conlan, S., et al. (2012) · Science · doi:10.1126/science.1225152 · Cited by 1,092
Dendritic cells in intestinal immune regulation
Coombes, J. L., & Powrie, F. M. (2008) · Nature reviews. Immunology · doi:10.1038/nri2335 · Cited by 821
Homeostasis and Inflammation in the Intestine
Garrett, W. S., Gordon, J. I., & Glimcher, L. H. (2010) · Cell · doi:10.1016/j.cell.2010.01.023 · Cited by 822
Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment
Lam, K. C., Araya, R. E., Huang, A., Chen, Q., Di Modica, M., Rodrigues, R. R., Lopès, A., Johnson, S. B., Schwarz, B., Bohrnsen, E., et al. (2021) · Cell · doi:10.1016/j.cell.2021.09.019 · Cited by 604
Antigen-presentation properties of plasmacytoid dendritic cells.
Villadangos, J., & Young, L. J. (2008) · Immunity · doi:10.1016/j.immuni.2008.09.002 · Cited by 577
Metadata
- Authors
- Wilson, N. S., Young, L. J., Kupresanin, F., Naik, S. H., Vremec, D., Heath, W. R., Akira, S., Shortman, K., Boyle, J., Maraskovsky, E., Belz, G. T., & Villadangos, J. A.
- Affiliations
- Genentech (US)
- Walter and Eliza Hall Institute of Medical Research (AU)
- Research Institute for Microbial Diseases, The University of Osaka (JP)
- CSL (Australia) (AU)
- The Walter and Eliza Hall Institute of Medical Research Parkville Victoria Australia
- Corresponding author
- Belz, Gabrielle T
- ORCID
- Venue
- Immunology & Cell Biology
- Publisher
- Wiley
- Published
- 2007-11-20
- Volume
- 86
- Issue
- 2
- Pages
- 200-205
- ISSN
- 0004-945X (ISSN-L)
- 0818-9641
- 1440-1711
- OpenAlex
- W1969532079
- Cited by
- 102
- References
- 38
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 6 · 2017: 10 · 2016: 5 · 2015: 8 · 2014: 7 · 2013: 9 · 2012: 8
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Immunology and Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health and Medical Research Council of Australia
- University of Melbourne Research Scholarship
- Leukemia and Lymphoma Society Scholarship
- Wellcome Trust Senior Overseas Fellowship
- Howard Hughes Medical Institute International Fellowships
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- dendritic cells, dendritic cell migration, dendritic cell maturation, Toll-like receptors, MyD88, TRIF, germ-free mice, lymph nodes, steady-state immunity, commensal microbiota, inflammatory signals
- MeSH terms
- Animals, Bacteria, Cell Movement, Dendritic Cells, Germ-Free Life, Mice, Inbred C57BL, Signal Transduction, Adaptor Proteins, Vesicular Transport, Toll-Like Receptors, Mice, Myeloid Differentiation Factor 88
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
