Akira, Shizuo

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

Kawai, T., & Akira, S. (2010) · Nature Immunology

Immune Response and InflammationInflammasome and immune disorders

Cited by 9,304

Pattern Recognition Receptors and Inflammation

Takeuchi, O., & Akira, S. (2010) · Cell

Immune Response and InflammationInflammasome and immune disorders

Cited by 8,895

Toll-like receptor signalling

Akira, S., & Takeda, K. (2004) · Nature reviews. Immunology

Immune Response and InflammationInflammasome and immune disorders

Cited by 8,312

A Toll-like receptor recognizes bacterial DNA

Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature

Immune Response and InflammationImmunotherapy and Immune Responses

Cited by 6,491

Toll-Like Receptors

Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology

Immune Response and InflammationInvertebrate Immune Response Mechanisms

Cited by 6,143

Toll-like receptors: critical proteins linking innate and acquired immunity

Akira, S., Takeda, K., & Kaisho, T. (2001) · Nature Immunology

Immune Response and InflammationInflammasome and immune disorders

Cited by 4,777

Guidelines for the use and interpretation of assays for monitoring autophagy

Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., et al. (2012) · Autophagy

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

Cited by 3,996

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

Heil, F., Hemmi, H., Hochrein, H., Ampenberger, F., Kirschning, C., Akira, S., Lipford, G., Wagner, H., & Bauer, S. (2004) · Science

Immune Response and InflammationImmunotherapy and Immune Responses

Cited by 3,947

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

Kato, H., Takeuchi, O., Sato, S., Yoneyama, M., Yamamoto, M., Matsui, K., Uematsu, S., Jung, A., Kawai, T., Ishii, K. J., et al. (2006) · Nature

interferon and immune responsesImmune Response and Inflammation

Cited by 3,888

Toll-like receptors and their crosstalk with other innate receptors in infection and immunity

Kawai, T., & Akira, S. (2011) · Immunity

Immune Response and InflammationInflammasome and immune disorders

Cited by 3,658

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., & Reis e Sousa, C. (2004) · Science

Immune Response and Inflammationinterferon and immune responses

Cited by 3,444

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product

Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K., & Akira, S. (1999) · The Journal of Immunology

Immune Response and InflammationInflammasome and immune disorders

Cited by 3,374

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

Kawai, T., Takahashi, K., Sato, S., Coban, C., Kumar, H., Kato, H., Ishii, K. J., Takeuchi, O., & Akira, S. (2005) · Nature Immunology

interferon and immune responsesImmune Response and Inflammation

Cited by 2,562

5'-Triphosphate RNA Is the Ligand for RIG-I

Hornung, V., Ellegast, J., Kim, S., Brzózka, K., Jung, A., Kato, H., Poeck, H., Akira, S., Conzelmann, K.-K., Schlee, M., et al. (2006) · Science

interferon and immune responsesImmune Response and Inflammation

Cited by 2,474

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

Karikó, K., Muramatsu, H., Welsh, F. A., Ludwig, J., Kato, H., Akira, S., & Weissman, D. (2008) · Molecular Therapy

RNA Interference and Gene DeliveryRNA and protein synthesis mechanisms

Cited by 1,930

Autophagy in infection, inflammation and immunity

Deretic, V., Saitoh, T., & Akira, S. (2013) · Nature Reviews Immunology

Autophagy in Disease and TherapyImmune Response and Inflammation

Cited by 1,919

Innate immune recognition of viral infection

Kawai, T., & Akira, S. (2006) · Nature Immunology

Immune Response and Inflammationinterferon and immune responses

Cited by 1,899

Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron

Flo, T. H., Smith, K. D., Sato, S., Rodriguez, D. J., Holmes, M. A., Strong, R. K., Akira, S., & Aderem, A. (2004) · Nature

Iron Metabolism and DisordersImmune Response and Inflammation

Cited by 1,877

Essential role of Stat6 in IL-4 signalling

Takeda, K., Tanaka, T., Shi, W., Matsumoto, M., Minami, M., Kashiwamura, S.-I., Nakanishi, K., Yoshida, N., Kishimoto, T., & Akira, S. (1996) · Nature

Cytokine Signaling Pathways and InteractionsT-cell and B-cell Immunology

Cited by 1,557

Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

Sato, K., Suematsu, A., Okamoto, K., Yamaguchi, A., Morishita, Y., Kadono, Y., Tanaka, S., Kodama, T., Akira, S., Iwakura, Y., et al. (2006) · The Journal of Experimental Medicine

Bone Metabolism and DiseasesPsoriasis: Treatment and Pathogenesis

Cited by 1,554

Cell Type-Specific Involvement of RIG-I in Antiviral Response

Kato, H., Sato, S., Yoneyama, M., Yamamoto, M., Uematsu, S., Matsui, K., Tsujimura, T., Takeda, K., Fujita, T., Takeuchi, O., et al. (2005) · Immunity

interferon and immune responsesImmune Response and Inflammation

Cited by 1,368

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

Imai, Y., Kuba, K., Neely, G. G., Yaghubian-Malhami, R., Perkmann, T., van Loo, G., Ermolaeva, M., Veldhuizen, R., Leung, Y. H. C., Wang, H., et al. (2008) · Cell

Immune Response and InflammationRespiratory Support and Mechanisms

Cited by 1,356

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

Takeda, K., Noguchi, K., Shi, W., Tanaka, T., Matsumoto, M., Yoshida, N., Kishimoto, T., & Akira, S. (1997) · Proceedings of the National Academy of Sciences

Cytokine Signaling Pathways and InteractionsDevelopmental Biology and Gene Regulation

Cited by 1,323

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

Matsunaga, K., Saitoh, T., Tabata, K., Omori, H., Satoh, T., Kurotori, N., Maejima, I., Shirahama-Noda, K., Ichimura, T., Isobe, T., et al. (2009) · Nature Cell Biology

Autophagy in Disease and TherapyCellular transport and secretion

Cited by 1,235