The DOI matches its Crossref record; 30 of the 31 references it cites were found in a registry or an index.
Energy intake and appetite are suppressed by glucagon-like peptide-1 (GLP-1) in obese men.
Abstract
Background Peripheral administration of glucagon-like peptide-1 (GLP-1) for four hours, to normal weight and obese humans, decreases food intake and suppresses appetite.Objective The aim of this study was to assess the effect of an eight hour infusion of GLP-1 on appetite and energy intake at lunch and dinner in obese subjects.Design Randomised, blinded cross-over design with intravenous infusion of GLP-1 (0.75 pmol x kg(-1) min(-1)) or saline.Subjects Eight obese (body mass index, BMI, 45.5 +/- 2.3 kg/m2) male subjects.Measurements Ad libitum energy intake at lunch (12.00 h) and dinner (16.00 h) after an energy fixed breakfast (2.4 MJ) at 08.00 h. Appetite sensations using visual analogue scales, (VAS) immediately before and after meals and hourly in-between. Blood samples for the analysis of glucose, insulin, C-peptide, GLP-1 and peptide YY. Gastric emptying after breakfast and lunch using a paracetamol absorption technique.Results Hunger ratings were significantly lower with GLP-1 infusion. The summed ad libitum energy intake at lunch and dinner was reduced by 1.7 +/- 0.5 MJ (21 +/- 6%) by GLP-1 infusion (P = 0.01). Gastric emptying was delayed by GLP-1 infusion, and plasma glucose concentrations decreased (baseline: 6.6 +/- 0.35 mmol/L; nadir: 5.3 +/- 0.15 mmol/L). No nausea was recorded during GLP-1 infusion.Conclusions Our results demonstrate that GLP-1 decreases feelings of hunger and reduces energy intake in obese humans. One possible mechanism for this finding might be an increased satiety primarily mediated by gastric vagal afferent signals.
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“These agents promote glucose-dependent insulin secretion, suppress glucagon release, and delay gastric emptying,29 thereby attenuating postprandial glucose excursions.30”
From Metabolic rebound after GLP-1 receptor agonist discontinuation: a systematic review and meta-analysis (2025) · cites this paper as [29]
Citations
Cites
A role for glucagon-like peptide-1 in the central regulation of feeding
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Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans.
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Truncated GLP-1 (proglucagon 78?107-amide) inhibits gastric and pancreatic functions in man
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Self-citationHamster preproglucagon contains the sequence of glucagon and two related peptides
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Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats
Tang-Christensen, M., Larsen, P. J., Goke, R., Fink-Jensen, A., Jessop, D. S., Moller, M., & Sheikh, S. P. (1996) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1996.271.4.r848 · Cited by 597
Attenuated GLP-1 secretion in obesity: cause or consequence
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The Physiology of Glucagon-like Peptide 1
Holst, J. J. (2007) · Physiological Reviews · doi:10.1152/physrev.00034.2006 · Cited by 3,371
Self-citationGastrointestinal regulation of food intake
Cummings, D. E., & Overduin, J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30227 · Cited by 1,216
Astrup, A., Rössner, S., Van Gaal, L., Rissanen, A., Niskanen, L., Al Hakim, M., Madsen, J., Rasmussen, M. F., & Lean, M. E. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61375-1 · Cited by 1,163
Self-citationKieffer, T. J., & Habener, J. F. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.6.0385 · Cited by 1,062
The role of incretins in glucose homeostasis and diabetes treatment
Kim, W., & Egan, J. M. (2008) · Pharmacological Reviews · doi:10.1124/pr.108.000604 · Cited by 824
“These effects of GLP-1 are observed in lean and obese as well as diabetic humans (Flint et al., 1998; Näslund et al., 1999; Verdich et al., 2001; Zander et al., 2002).”
Background
Metadata
- Authors
- Näslund, E., Barkeling, B., King, N., Gutniak, M., Blundell, J., Holst, J., Rössner, S., & Hellström, P.
- Affiliations
- Danderyds sjukhus (SE)
- University of Leeds (GB)
- ORCID
- Venue
- International Journal of Obesity
- Published
- 1999-03
- Volume
- 23
- Issue
- 3
- Pages
- 304-311
- ISSN
- 0307-0565 (ISSN-L)
- 1476-5497
- OpenAlex
- W2005334239
- Cited by
- 468
- References
- 31
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 10 · 2023: 12 · 2022: 7 · 2021: 10 · 2020: 10 · 2019: 7 · 2018: 12 · 2017: 12 · 2016: 17 · 2015: 22 · 2014: 18 · 2013: 26 · 2012: 25
- FWCI
- 4.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- International Journal of Obesity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
- Keywords
- glucagon-like peptide-1, appetite, energy intake, obesity, hunger, gastric emptying, satiety, peptide YY, insulin, glucose, intravenous infusion
- MeSH terms
- Adult, Appetite, Blood Glucose, C-Peptide, Energy Intake, Double-Blind Method, Eating, Gastric Emptying, Glucagon, Humans, Hunger, Infusions, Intravenous, Insulin, Male, Obesity, Peptide Fragments, Protein Precursors, Body Mass Index, Cross-Over Studies, Peptide YY, Glucagon-Like Peptide 1
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