Body morphology differentially predicts coronary calcium
Abstract
Objective To test the hypothesis that three measures of body morphology would be differentially correlated with and predictive of coronary artery calcification.Design Cross-sectional analytic study of body mass index (BMI), central adiposity ('visceral fat') and total body percent fat.Subjects In a total of 3028 healthy, free living men and women (mean age and BMI: 56.7 and 27.0, respectively).Measurements Coronary calcification and visceral fat (VF) content was measured using electron beam computed tomography while percent body fat (BF) was determined using bioimpedence.Results In men, the median coronary calcium score increased from 6.7 for a BMI < or =24 to 30.9 for a BMI > or =30; from 3.6 to 46.4 between the first and fourth quartile of VF; and from 1 to 97.6 for the same in BF. There were no significant increases in calcium scores in women for any of these indices. There were also no significant age-adjusted correlations between BMI, BF and VF with the extent of coronary calcium in either gender. On multivariable logistic regression analysis, men with a BMI in the third and fourth quartiles had 1.64 and 2.01 times increase in risk, respectively, for the presence of any coronary calcium compared to those in the first quartile (P< or =0.01 for both) while men in the highest quartile for VF had a 63% increase in this same risk (P=0.04). For women, a BMI in the fourth quartile was associated with a 68% increase in risk for the presence of any coronary calcium (P=0.01).Conclusion BMI is a significant predictor of coronary calcium. In men, central adiposity is also an independent predictor. These findings lend further support to weight control for coronary disease prevention.
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Obesity, especially abdominal obesity, is a well-defined risk factor for the development of atherosclerotic coronary artery disease.
“Suffice it to say that obesity, especially abdominal obesity, is a well-defined risk factor for the development of atherosclerotic coronary artery disease (12, 188, 241).”
From Cardiac remodeling in obesity (2008) · cites this paper as [12]
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BackgroundThe epidemiology of abdominal aortic diameter
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BackgroundThe associations between visceral fat and calcified atherosclerosis are stronger in women than men
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“To date, the overwhelming majority of studies that examined the relationship between CAC and body size was performed in homogeneous populations of middle aged Caucasians without known coronary artery disease.(31) –36 These studies, almost always performed using CT scanning, generally reported a positive association be…”
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“Previous studies have determined strong correlation between central obesity and coronary and abdominal aortic calcium plaques.(10,11) The present study aimed to investigate effect of subcutaneous fat volume (SFV) and abdominal visceral fat volume (VFV) on aortic atherosclerosis (AA) via multislice CT (MSCT).”
BackgroundResting Heart Rate and Coronary Artery Calcium in Postmenopausal Women
Allison, M., Manson, J. E., Aragaki, A. K., Eaton, C. B., Hsai, J., Phillips, L., Kuller, L. H., & Trevisan, M. (2011) · Journal of Women s Health · doi:10.1089/jwh.2010.2475 · Cited by 7 · see citing works
“Higher BMI has also been associated with a significantly increased odds for having CAC.(34) Because it seems more physiologically plausible that smoking and increased body mass result in a higher RHR (instead of vice-versa), and both of these variables were significantly associated with CAC in our study population, Ta…”
Self-citationAltintas, S., van Workum, S., Kok, M., Joosen, I. A., Versteylen, M. O., Nelemans, P. J., Wildberger, J. E., Crijns, H. J. G. M., Das, M., & Kietselaer, B. (2022) · Obesity Science & Practice · doi:10.1002/osp4.636 · Cited by 5 · see citing works
“From December 2007 until June 2010, a 64‐slice multi‐detector CT‐scanner (Brilliance 64; Philips Healthcare, Best, The Netherlands; n = 1.735) was used to measure CAC.”
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Impact of obesity on aortic root calcification and coronary calcification using multi-detector CT
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“19 There were several limitations in our study.”
Assessment of Health Status by BMI and BP among Adult Men from Punjab, India
Singh, A., Singh, S. P., & Kaur, A. (2011) · Journal of Life Sciences · doi:10.1080/09751270.2011.11885171 · Cited by 1 · see citing works
“Body morphology indices are independently related with increased risk of developing coronary artery calcification (CAC) while showing significant prediction of coronary calcium (Allison and Wright 2004).”
BackgroundAnthropometric Measurements, Adipokines and Abdominal Aortic Calcification
Parr, A. F., & Golledge, J. (2012) · Springer eBooks · doi:10.1007/978-1-4419-1788-1_133 · Cited by 1 · see citing works
Atherosclerosis Burden in Patients with Acute Chest Pain: Obesity Paradox
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“In contrast to several prior CT-based studies which demonstrated positive relationship between BMI and CAC score [22–28], our study found that increased BMI was associated with lower CAC.”
ResultObesity and Cardiac Dysfunction
Sweeney, G., Litwin, S. E., & Abel, E. D. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1607-5_14
Salam, Y. M., Guileyardo, J. M., & Roberts, W. C. (2020) · Baylor University Medical Center Proceedings · doi:10.1080/08998280.2020.1847948
Nagano, F. E. Z., de Almeida, C. C. P., Magalhães, T. A., Cerci, R., Fernandes-Silva, M. M., & Júnior, E. L. (2022) · Research Society and Development · doi:10.33448/rsd-v11i5.28190
“No significance was established for biochemical predictors in any of the analyses conducted which are partially or integrally after other findings (Choi et al., 2010; Allison & Wright, 2004).”
ResultNon-Invasive Measurement of Coronary Atherosclerosis
den Dunnen, W. F. A., Suurmeijer, A. J. H., Vliegenthart, R., Herzog, C., Groen, J. M., Greuter, M. J. W., Oudkerk, M., Schmermund, A., Möhlenkamp, S., Erbel, R., et al. (2009) · Medical radiology · doi:10.1007/978-3-540-32984-8_4
- Authors
- Allison, M. A., & Michael Wright, C.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Allison, M A
- ORCID
- Allison, M A
- Venue
- International Journal of Obesity
- Published
- 2004-01-13
- Volume
- 28
- Issue
- 3
- Pages
- 396-401
- ISSN
- 0307-0565 (ISSN-L)
- 1476-5497
- OpenAlex
- W1979163812
- Cited by
- 30
- References
- 32
- Citations by year
- 2022: 3 · 2020: 1 · 2014: 3 · 2013: 2 · 2012: 3
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- International Journal of Obesity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- National Institutes of Health
- University of California, San Diego
- National Center for Research Resources (M-01RR00827, M01RR000827)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- coronary artery calcification, body morphology, body mass index, abdominal obesity, visceral fat, body fat percentage, sex differences, coronary artery calcium score, weight management, coronary heart disease prevention
- MeSH terms
- Adipose Tissue, Adult, Aged, Body Composition, Calcinosis, Coronary Disease, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Obesity, Risk Factors, Body Mass Index, Logistic Models
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