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Obese men respond to cognitive but not to catabolic brain insulin signaling
Abstract
Context and objective Insulin acts in the brain to reduce food intake and body weight and is considered a major adiposity signal in energy homeostasis. In normal-weight men, intranasal insulin administration reduces body fat and improves declarative memory. The present experiments aimed to generalize these findings to obese patients, with a view to evaluate the therapeutic potential of the compound.Design, subjects and measurements Insulin and placebo, respectively, were intranasally administered four times a day (amounting to 160 IU day(-1)) over 8 weeks to two groups of 15 obese men each.Results Contrasting with the catabolic effects in normal-weight men, insulin treatment did not induce any significant reduction of body weight (P>0.50) and body fat (P>0.44) in the obese subjects. However, in accordance with the effects in normal-weight men, declarative memory and mood were improved (P<0.05) and hypothalamic-pituitary-adrenal axis activity as assessed by circulating ACTH (P<0.01) and cortisol levels (P<0.04) was reduced.Conclusions Our results indicate that in obese men, intranasal insulin is functionally active in the central nervous system but fails to affect the neuronal networks critically involved in body weight regulation. We conclude that obesity in men is associated with central nervous resistance to the adiposity signal insulin. This defect likely contributes to the persistence of obesity in spite of elevated levels of circulating insulin in obese patients.
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“8-week administration of IN insulin failed to affect body weight and fat mass in obese individuals.”
From Intranasal insulin (2021) · cites this paper as [87]
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“Signs of reduced hypothalamic-pituitary-adrenal (HPA) axis activity as a result of IN insulin were, however, also observed in human participants under resting conditions after 8 weeks of daily administration.”
From Intranasal insulin (2021) · cites this paper as [87]
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“This finding was later replicated in obese men.87”
From Intranasal insulin (2021) · cites this paper as [87]
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“The 8-week paradigm of IN insulin administration described above improved rated mood in normal-weight,38 as well as obese participants.87”
From Intranasal insulin (2021) · cites this paper as [87]
Citations
Cites
Brain corticosteroid receptor balance in health and disease
de Kloet, E. R., Vreugdenhil, E., Oitzl, M. S., & Joëls, M. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0331 · Cited by 2,614
JACOBSON, L., & SAPOLSKY, R. (1991) · Endocrine Reviews · doi:10.1210/edrv-12-2-118 · Cited by 1,739
Sniffing neuropeptides: A transnasal approach to the human brain
Born, J., Lange, T., Kern, W., McGregor, G. P., Bickel, U., & Fehm, H. L. (2002) · Nature Neuroscience · doi:10.1038/nn0602-849 · Cited by 1,356
Self-citationStructure and function of declarative and nondeclarative memory systems
Squire, L. R., & Zola, S. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13515 · Cited by 1,327
Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons
Woods, S. C., Lotter, E. C., McKay, L. D., & Porte, D. (1979) · Nature · doi:10.1038/282503a0 · Cited by 1,114
The stroop color-word test: A review
Jensen, A. R., & Rohwer, W. D. (1966) · Acta Psychologica · doi:10.1016/0001-6918(66)90004-7 · Cited by 958
Thorne, R. G., Pronk, G. J., Padmanabhan, V., & Frey, W. H. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.05.029 · Cited by 958
Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity
El-Haschimi, K., Pierroz, D. D., Hileman, S. M., Bjørbæk, C., & Flier, J. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9842 · Cited by 887
Epidemiologic and economic consequences of the global epidemics of obesity and diabetes
Yach, D., Stückler, D., & Brownell, K. D. (2006) · Nature Medicine · doi:10.1038/nm0106-62 · Cited by 856
Diabetes, Obesity, and the Brain
Schwartz, M. W., & Porte, D. (2005) · Science · doi:10.1126/science.1104344 · Cited by 841
Flagged first, then by citations
Research works printed but not linked: 1
- Janke W, Debus G . Die Eigenschaftswörterliste (EWL). Hogrefe: Göttingen, 1978.
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Items 101–165 of 165
Clinical trials of intranasal delivery for treating neurological disorders – a critical review
Liu, X. (2011) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2011.633508 · Cited by 24
Furigo, I. C., & Dearden, L. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1078955 · Cited by 20
Derkach, K. V., Ivantsov, A. O., Chistyakova, O. V., Sukhov, I. B., Buzanakov, D. M., Kulikova, A. A., & Shpakov, A. O. (2017) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-017-3762-6 · Cited by 21
Thienel, M., Wilhelm, I., Benedict, C., Born, J., & Hallschmid, M. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.03.006 · Cited by 20
Self-citationPaul, E. R., Östman, L., Heilig, M. A., Mayberg, H. S., & Hamilton, J. P. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02466-7 · Cited by 17
Estrogen and insulin transport through the blood-brain barrier
May-Zhang, A. A., Bedel, N. D., Shen, L., Woods, S. C., & Liu, M. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.05.019 · Cited by 18
Scherer, T., Wolf, P. S., Smajis, S., Gaggini, M., Hackl, M. T., Gastaldelli, A., Klimek, P., Einwallner, E., Marculescu, R., Luger, A., et al. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-3623 · Cited by 17
Torabi, N., Noursadeghi, E., Shayanfar, F., Nazari, M., Fahanik‐Babaei, J., Saghiri, R., Khodagholi, F., & Eliassi, A. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166075 · Cited by 15
A meal enriched in saturated fat acutely impairs cognitive performance in obese men
Ruegsegger, G. N., Rappaport, C. I., Hill, J. J., Jochum, K. A., Challeen, E. S., & Roth, M. C. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113664 · Cited by 13
Metabolic neuroimaging of the brain in diabetes mellitus and hypoglycaemia
Cheah, Y. S., & Amiel, S. A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.97 · Cited by 13
Hypothalamic insulin signalling as a nexus regulating mood and metabolism
Rawlinson, S., & Andrews, Z. B. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12939 · Cited by 12
Yanagita, T., Nemoto, T., Satoh, S., Yoshikawa, N., Maruta, T., Shiraishi, S., Sugita, C., & Murakami, M. (2013) · InTech eBooks · doi:10.5772/54389 · Cited by 14
Davidy, T., Yore, I., Cukierman-Yaffe, T., Ravona-Springer, R., Livny, A., Lesman-Segev, O. H., Azuri, Y., Carmichael, O., Kapogiannis, D., Zetterberg, H., et al. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111898 · Cited by 13
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Wu, S., Stogios, N., Hahn, M., Navagnanavel, J., Emami, Z., Chintoh, A. F., Gerretsen, P., Graff‐Guerrero, A., Rajji, T. K., Remington, G. J., et al. (2023) · PLoS ONE · doi:10.1371/journal.pone.0286887 · Cited by 14
Deme, P., Rojas, C. J., Slusher, B. S., Rais, R., Afghah, Z., Geiger, J. D., & Haughey, N. J. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113181 · Cited by 10
Wang, Q., Lu, M., Zhu, X., Gu, X., Zhang, T., Xia, C., Li, Y., Xu, Y., & Zhou, M. (2022) · Aging and Disease · doi:10.14336/ad.2022.0221 · Cited by 11
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Landeiro, F. M., & Quarantini, L. D. C. (2011) · Revista de Ciências Médicas e Biológicas · doi:10.9771/cmbio.v10i3.5883 · Cited by 11
Cai, M., Wan, J., Cai, K., Li, S., Du, X., Song, H., Sun, W., & Hu, J. (2024) · International Journal of Obesity · doi:10.1038/s41366-024-01490-x · Cited by 11
Falling Short: The Contribution of Central Insulin Receptors to Gait Dysregulation in Brain Aging
Case, S. L., Frazier, H. N., Anderson, K. L., Lin, R., & Thibault, O. (2022) · Biomedicines · doi:10.3390/biomedicines10081923 · Cited by 10
Peripheral Signals Modifying Food Reward
Menzies, J. R. W., Skibicka, K. P., Egecioglu, E., Leng, G., & Dickson, S. L. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-24716-3_6 · Cited by 9
Role of metabolic dysfunction in treatment resistance of major depressive disorder
Toups, M. S., & Trivedi, M. H. (2011) · Neuropsychiatry · doi:10.2217/npy.11.49 · Cited by 9
Becerra, L. A., Gavrieli, A., Khan, F., Novák, P., Lioutas, V., Ngo, L. H., Novak, V., & Mantzoros, C. S. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.04.008 · Cited by 8
Botner, S. (2012) · Journal of Nanomedicine & Nanotechnology · doi:10.4172/2157-7439.1000136 · Cited by 7
Intranasal insulin for improving cognitive function in multiple sclerosis
Newsome, S. D., Fitzgerald, K. C., Hughes, A. J., Beier, M. L., Koshorek, J., Wang, Y., Maldonado, D. P., Shoemaker, T., Malik, T., Bayu, T., et al. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2025.e00581 · Cited by 6
Molecular mechanisms underlying obesity-induced memory dysfunction: a comprehensive narrative review
Golkar, A., Razazpour, F., Dalfardi, M., & Baghcheghi, Y. (2025) · Physiology & Behavior · doi:10.1016/j.physbeh.2025.115119 · Cited by 7
Brünner, Y. F., Benedict, C., & Freiherr, J. (2013) · Der Nervenarzt · doi:10.1007/s00115-013-3806-8 · Cited by 6
Self-citationShpakov, A. O., Derkach, K. V., Surkova, E. V., & Bespalov, A. I. (2019) · Problems of Endocrinology · doi:10.14341/probl9960 · Cited by 6
Davidy, T., Yore, I., Cukierman-Yaffe, T., Ravona-Springer, R., Livny, A., Lesman-Segev, O. H., Azuri, Y., Carmichael, O., Kapogiannis, D., Zetterberg, H., et al. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111825 · Cited by 3
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Gómez‐Guijarro, M. D., Cavero‐Redondo, I., Saz‐Lara, A., Pascual‐Morena, C., Álvarez-Bueno, C., & Martínez‐García, I. (2024) · Cognitive Neurodynamics · doi:10.1007/s11571-024-10138-5 · Cited by 5
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Oliphant, K., & Lu, J. N. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820602-7.00006-4 · Cited by 6
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da Silva, S. S., Silva, S. H., Aguiar, G. A., Batista, S. O., Santos, A. C. M., Bandeira, F. L. C., Alves, M. T., da Silva, Á. G. F., de Sousa, V. A., Rodrigues, C. N. D. S., et al. (2022) · Research Society and Development · doi:10.33448/rsd-v11i2.25621 · Cited by 7
Shevela, Е. Y., Degtyareva, V. G., Sosnovskaya, A. V., Voronova, E. V., Kafanova, M. Y., Ращупкин, И. М., Ostanin, A. A., & Chernykh, E. R. (2021) · Medical Immunology (Russia) · doi:10.15789/1563-0625-teo-2224 · Cited by 3
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Akintola, A. A., & van Heemst, D. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811353-0.00065-8 · Cited by 4
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Reagan, L. P. (2010) · Research and perspectives in Alzheimer's disease · doi:10.1007/978-3-642-04300-0_3 · Cited by 3
From conditioned hypoglycemia to obesity: Following the data
Woods, S. C. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.01.010 · Cited by 3
Central cytometabolic functional vascular coupling in health and disease
Sims, S. L., Lu, T., Weiss, B. E., Lin, R., Galopin, L. B., Wright, N. A., Norris, C. M., & Thibault, O. (2025) · npj Metabolic Health and Disease · doi:10.1038/s44324-025-00090-1 · Cited by 2
Skvortsova, A., Veldhuijzen, D. S., van Dillen, L. F., Zech, H., Derksen, S. M. J. C., Sars, R. H., Meijer, O. C., Pijl, H., & Evers, A. W. M. (2023) · Psychosomatic Medicine · doi:10.1097/psy.0000000000001216 · Cited by 2
Gladding, J. M., Rafiei, N., Mitchell, C. S., & Begg, D. P. (2024) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2024.107938 · Cited by 2
Exploring the effects of an insulin challenge on neuroimaging outcomes: A scoping review
Stogios, N., Wu, S., Hahn, M., Emami, Z., Navagnanavel, J., Korann, V., Prasannakumar, A., Remington, G. J., Graff‐Guerrero, A., & Agarwal, S. M. (2025) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2025.101187 · Cited by 2
Bonini, J. S., Goes, V. F., Bueno, C. F. D. O., Fréz, A. R., Nuñez, C. E. C., Mello‐Carpes, P. B., & da S., W. C. F. N. (2014) · Revista Brasileira de Ciências do Envelhecimento Humano · doi:10.5335/rbceh.2014.4432 · Cited by 2
Hunt, K. F., Cheah, Y. S., & Amiel, S. A. (2011) · Wiley eBooks · doi:10.1002/9781444347319.ch9 · Cited by 2
Dhindsa, S., Dhindsa, G., & Chemitiganti, R. (2015) · Diabetes · doi:10.2337/db15-0131 · Cited by 2
Ho, D., Won, H. Y., Kim, Y., & Lim, W. (2026) · Advances in experimental medicine and biology · doi:10.1007/978-981-95-6872-7_12 · Cited by 1
Bonini, J. S., Goes, V. F., Bueno, C. F. D. O., Fréz, A. R., Nuñez, C. E. C., Mello‐Carpes, P. B., & da Silva, W. C. F. N. (2014) · Americanae (AECID Library) · doi:10.5335/rbceh.v11i3.4432 · Cited by 1
Arora, D., Bhatt, S., Kumar, M., Gautam, R. K., Taneja, Y., & Chauhan, M. (2023) · Springer eBooks · doi:10.1007/978-981-99-2302-1_19 · Cited by 1
Von der Nase ins Gehirn: Effekte intranasal verabreichten Insulins
Brünner, Y. F., Benedict, C., & Freiherr, J. (2013) · Der Nervenarzt · Cited by 1
Self-citationInfluence of Selected Diets on Neural Insulin Activity and Cognitive Function
Parrott, M. D. (2014) · TSpace (University of Toronto) · Cited by 1
Dhuria, S. V. (2009) · University of Minnesota Digital Conservancy (University of Minnesota)
Poritsanos, N. J. (2010) · Mspace (University of Manitoba)
Ansätze wider den großen Appetit
Mai, K. (2016) · Info Diabetologie · doi:10.1007/s15034-016-0839-7
The Role of Insulin Resistance and Signaling in Dementia
Koenig, A. M., Arvanitakis, Z., & Arnold, S. E. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809454-9.00008-1
Słomińska, D., Manikowska, K., Hoszman, M., Mikołajczak, P. Ł., & Winiarska, H. (2021) · Pharmacotherapy in Psychiatry and Neurology · doi:10.33450/fpn.2021.02.003
Insulinwirkung im menschlichen Gehirn
Heni, M., Kullmann, S., Preissl, H. T., & Häring, H. (2013) · Der Diabetologe · doi:10.1007/s11428-013-1060-0
The Potential of Intranasal Insulin in the Management of Metabolic Disorders
Hallschmid, M., & Schultes, B. (2008) · US Endocrinology · doi:10.17925/use.2008.04.2.40
Self-citationRosenzweig, S. A. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.732579862.793572336
Guo, P., Gurney, J., Creasey, N., & Cheke, L. G. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4866100
Guo, P., Gurney, J., Creasey, N., & Cheke, L. G. (2026) · Psychology and Health · doi:10.1080/08870446.2026.2641819
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Malin, S. K., Battillo, D. J., Zald, D. H., & Ramirez, J. (2026) · Nutrients · doi:10.3390/nu18071072
Pratlong, M. (2014) · theses.fr (ABES) · doi:10.70675/02dafa47zd1cfz49e6z86a9zb57e2f9d693f
Malin, S. K., Zald, D. H., & Battillo, D. J. (2026) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00119.2026
Stogios, N., Hahn, M. K., Remington, G. J., Graff‐Guerrero, A., Lai, M., & Agarwal, S. M. (2026) · PLoS ONE · doi:10.1371/journal.pone.0352262
Metadata
- Authors
- Hallschmid, M., Benedict, C., Schultes, B., Born, J., & Kern, W.
- Affiliations
- University of Lübeck (DE)
- Kantonsspital St. Gallen (CH)
- Corresponding author
- Hallschmid, M
- Venue
- International Journal of Obesity
- Published
- 2007-09-11
- Volume
- 32
- Issue
- 2
- Pages
- 275-282
- ISSN
- 0307-0565 (ISSN-L)
- 1476-5497
- OpenAlex
- W2015016479
- Cited by
- 165
- References
- 46
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 4 · 2023: 14 · 2022: 6 · 2021: 9 · 2020: 9 · 2019: 8 · 2018: 11 · 2017: 14 · 2016: 9 · 2015: 9 · 2014: 10 · 2013: 13 · 2012: 8
- FWCI
- 2.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- International Journal of Obesity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- intranasal insulin, obesity, brain insulin signaling, declarative memory, hypothalamic-pituitary-adrenal axis, ACTH, cortisol, body weight regulation, energy homeostasis, sex differences
- MeSH terms
- Adipose Tissue, Administration, Intranasal, Adult, Affect, Body Weight, Brain, Cognition, Humans, Hypoglycemic Agents, Insulin, Male, Memory, Obesity, Treatment Outcome, Body Size
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