Role of metabolic dysfunction in treatment resistance of major depressive disorder
Abstract
Major depressive disorder (MDD) and metabolic syndrome (MetS) are both widespread and cause enormous morbidity. The presence of one syndrome approximately doubles the risk of the other. Standard antidepressant treatments lead to remission in less than a third of the patients; a majority of patients experience treatment resistance at some point during their illness.
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Chronic conditions such as coronary artery disease, fibromyalgia, rheumatoid arthritis, Major Depressive Disorder, and Post Traumatic Stress Disorder are associated with abnormally high cortisol levels and metabolic disruptions.
“chronic conditions such as coronary artery disease, fibromyalgia, rheumatoid arthritis, and mood disorders such as Major Depressive Disorder (MDD) and Post Traumatic Stress Disorder (PTSD) have also been associated with abnormally high CORT levels and metabolic disruptions ( 5-13 ).”
From Dynamic modulation of glucose utilisation by glucocorticoid rhythms in health and disease (2020) · cites this paper as [12]
In hypercortisolism, cortisol levels are higher than normal and in some cases display abnormal rhythmicity, varying by underlying condition.
“in hypercortisolism, it is not only that CORT levels are higher than normal, but in some cases, they also display abnormal rhythmicity. This varies depending on whether the underlying condition is associated with Cushing's syndrome, depression, PTSD, acute inflammation following major surgery, or chronic inflammatory diseases (e.g., rheumatoid arthritis) ( 2, 5-13, 57-60 ).”
From Dynamic modulation of glucose utilisation by glucocorticoid rhythms in health and disease (2020) · cites this paper as [12]
Many conditions associated with hypercortisolism are accompanied by disruption of normal glucose metabolism while preserving some degree of cortisol rhythmicity.
“many of these conditions are accompanied by a disruption of normal glucose metabolism while preserving some degree of CORT rhythmicity.”
From Dynamic modulation of glucose utilisation by glucocorticoid rhythms in health and disease (2020) · cites this paper as [12]
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Rethorst, C. D., Toups, M. S. P., GREER, T. L., Nakonezny, P. A., Carmody, T. J., Grannemann, B. D., Huebinger, R. M., Barber, R. C., & Trivedi, M. H. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.125 · Cited by 211 · see citing works
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Woo, Y., Seo, H.-J., McIntyre, R., & Bahk, W.-M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17010080 · Cited by 79 · see citing works
Toups, M. S. P., Myers, A. K., Wisniewski, S. R., Kurian, B., Morris, D. W., Rush, A. J., Fava, M., & Trivedi, M. H. (2013) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000000 · Cited by 59 · see citing works
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Kung, F.-H., Tsai, C., Cheng, C., Tsai, S., Su, T., Chen, T., Bai, Y., Liang, C., & Chen, M. (2024) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-024-02401-1 · Cited by 15 · see citing works
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Impact of Medical Comorbidity in Biomarker Discovery for Major Depressive Disorder
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- Authors
- Toups, M. S., & Trivedi, M. H.
- Venue
- Neuropsychiatry
- Publisher
- OMICS Publishing Group
- Published
- 2011-10
- Volume
- 1
- Issue
- 5
- Pages
- 441-455
- ISSN
- 1758-2008 (ISSN-L)
- OpenAlex
- W2055338611
- Cited by
- 9
- References
- 156
- Citations by year
- 2024: 2 · 2020: 3 · 2019: 1 · 2016: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychiatry (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- major depressive disorder, metabolic syndrome, metabolic dysfunction, antidepressant treatment resistance, comorbidities
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