Cited by 119Nitric Oxide and Endothelin EffectsObesity, Physical Activity, DietDiabetes, Cardiovascular Risks, and Lipoproteins

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Obesity reduces the bioavailability of nitric oxide in juveniles

Gruber, H-J, Mayer, C, Mangge, H, Fauler, G, Grandits, N, Wilders-Truschnig, M·2008·International Journal of Obesity

DOI 10.1038/sj.ijo.0803795

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Abstract

Objective There is growing evidence that nitric oxide (NO) is critically involved in obesity and its clinical consequences like cardiovascular disease, hypertension and diabetes. We hypothesize that NO is already involved in the pathophysiology of juvenile obesity. We here determined the role of NO, its metabolites arginine and citrulline in obese and normal weight children. Design We investigated 57 obese and 57 normal weight age- and gender-matched juveniles. Various clinical parameters as well as body measurements and intima media thickness were determined. Results Obese juveniles revealed highly significant alterations in the NO pathway. NOX and citrulline were decreased in obese compared to normal weight juveniles and negatively correlated with body weight. Arginine was increased in obese juveniles and positively correlated with body weight. We found a significant negative correlation between NOX and oxidized low-density lipoprotein. Analysis of gamma-aminobutyric acid (GABA) revealed correlations with the NO pathway as NOX and citrulline were negatively correlated with GABA and arginine showed a positive correlation. Conclusion We show here that NO and its metabolites arginine and citrulline are already involved in juvenile obesity that may contribute to atherogenesis via reduced bioavailability of NO. Moreover, we identify GABA as a new parameter in the mechanism of obesity-related NO reduction.

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Authors: Gruber, H.-J., Mayer, C., Mangge, H., Fauler, G., Grandits, N., & Wilders-Truschnig, M.
Affiliations: University of Graz (AT)
Corresponding author: Gruber, H-J
ORCID: Mayer, C
Mangge, H
Venue: International Journal of Obesity
Publisher: Springer Science and Business Media LLC
Published: 2008-01-15
Volume: 32
Issue: 5
Pages: 826-831
ISSN: 0307-0565 (ISSN-L)
1476-5497
DOI: 10.1038/sj.ijo.0803795
OpenAlex: W1993701796
Cited by: 119
References: 32
Citations by year: 2026: 3 · 2025: 2 · 2024: 1 · 2023: 7 · 2022: 7 · 2021: 8 · 2020: 13 · 2019: 6 · 2018: 4 · 2017: 8 · 2016: 7 · 2015: 8 · 2014: 9 · 2013: 6 · 2012: 6
FWCI: 5.43
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: International Journal of Obesity (publishedVersion)
PubMed (publishedVersion)
Funders: Bundesministerium für Gesundheit
Medizinische Universität Graz
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: nitric oxide bioavailability, youth obesity, children, L-arginine, citrulline, nitric oxide synthase, oxidized LDL, GABA, atherogenesis, intima-media thickness, body weight
MeSH terms: Adolescent, Arginine, Cardiovascular Diseases, Citrulline, Female, Humans, Insulin Resistance, Male, Nitric Oxide, Obesity

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Obesity reduces the bioavailability of nitric oxide in juveniles

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