The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Obesity reduces the bioavailability of nitric oxide in juveniles
Abstract
Objective There is growing evidence that nitric oxide (NO) is critically involved in obesity and its clinical consequences like cardiovascular disease, hypertension and diabetes. We hypothesize that NO is already involved in the pathophysiology of juvenile obesity. We here determined the role of NO, its metabolites arginine and citrulline in obese and normal weight children. Design We investigated 57 obese and 57 normal weight age- and gender-matched juveniles. Various clinical parameters as well as body measurements and intima media thickness were determined. Results Obese juveniles revealed highly significant alterations in the NO pathway. NOX and citrulline were decreased in obese compared to normal weight juveniles and negatively correlated with body weight. Arginine was increased in obese juveniles and positively correlated with body weight. We found a significant negative correlation between NOX and oxidized low-density lipoprotein. Analysis of gamma-aminobutyric acid (GABA) revealed correlations with the NO pathway as NOX and citrulline were negatively correlated with GABA and arginine showed a positive correlation. Conclusion We show here that NO and its metabolites arginine and citrulline are already involved in juvenile obesity that may contribute to atherogenesis via reduced bioavailability of NO. Moreover, we identify GABA as a new parameter in the mechanism of obesity-related NO reduction.
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“NO bioavailability is decreased in animal models of diet-induced obesity and in obese and insulin resistant patients”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [119]
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“diabetes [116,117] and in obese and diabetic humans [118,119].”
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Metadata
- Authors
- Gruber, H.-J., Mayer, C., Mangge, H., Fauler, G., Grandits, N., & Wilders-Truschnig, M.
- Affiliations
- University of Graz (AT)
- Corresponding author
- Gruber, H-J
- Venue
- International Journal of Obesity
- Published
- 2008-01-15
- Volume
- 32
- Issue
- 5
- Pages
- 826-831
- ISSN
- 0307-0565 (ISSN-L)
- 1476-5497
- OpenAlex
- W1993701796
- Cited by
- 119
- References
- 32
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 7 · 2022: 7 · 2021: 8 · 2020: 13 · 2019: 6 · 2018: 4 · 2017: 8 · 2016: 7 · 2015: 8 · 2014: 9 · 2013: 6 · 2012: 6
- FWCI
- 5.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- International Journal of Obesity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bundesministerium für Gesundheit
- Medizinische Universität Graz
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- nitric oxide bioavailability, youth obesity, children, L-arginine, citrulline, nitric oxide synthase, oxidized LDL, GABA, atherogenesis, intima-media thickness, body weight
- MeSH terms
- Adolescent, Arginine, Cardiovascular Diseases, Citrulline, Female, Humans, Insulin Resistance, Male, Nitric Oxide, Obesity
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