The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Proliferating Resident Microglia after Focal Cerebral Ischaemia in Mice
Abstract
Cerebral ischaemia usually results in the rapid death of neurons within the immediate territory of the affected artery. Neuronal loss is accompanied by a sequence of events, including brain oedema, blood-brain barrier (BBB) breakdown, and neuroinflammation, all of which contribute to further neuronal death. Although the role of macrophages and mononuclear phagocytes in the expansion of ischaemic injury has been widely studied, the relative contribution of these cells, either of exogenous or intrinsic central nervous system (CNS) origin is still not entirely clear. The purpose of this study, therefore, was to use different durations of transient middle cerebral artery occlusion (tMCAo) in the mouse to investigate fully post-occlusion BBB permeability and cellular changes in the brain during the 72 h post-MCAo period. This was achieved using in vivo magnetic resonance imaging (MRI) and cell labelling techniques. Our results show that BBB breakdown and formation of the primary ischaemic damage after tMCAo is not associated with significant infiltration of neutrophils, although more are observed with longer periods of MCAo. In addition, we observe very few infiltrating exogenous macrophages over a 72 h period after 30 or 60 mins of occlusion, instead a profound increase in proliferating resident microglia cells was observed. Interestingly, the more severe injury associated with 60 mins of MCAo leads to a markedly reduced proliferation of resident microglial cells, suggesting that these cells may play a protective function, possibly through phagocytosis of infiltrating neutrophils. These data further support possible beneficial actions of microglial cells in the injured brain.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Also, very few infiltrating exogenous macrophages were observed over the first 72 h period and, instead, a profound increase in proliferating resident microglia cells was observed (Denes et al., 2007).”
From The impact of microglial activation on blood-brain barrier in brain diseases (2014) · cites this paper as Denes et al., 2007
In the citing paper
“Denes and colleagues used cell tracking techniques and MRI imaging to describe that, despite of BBB breakdown caused by transient middle cerebral artery occlusion (tMCAo), the infiltration of neutrophils was more prominent only in longer periods of MCAo, with extensive BBB damage.”
From The impact of microglial activation on blood-brain barrier in brain diseases (2014) · cites this paper as Denes et al., 2007
Citations
Cites
Weissleder, R., Elizondo, G., WITTENBERG, J., Rabito, C. A., Bengele, H. H., & Josephson, L. (1990) · Radiology · doi:10.1148/radiology.175.2.2326474 · Cited by 1,027
The role of microglia and macrophages in the pathophysiology of the CNS
Stollg, G., & Jander, S. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00083-5 · Cited by 683
Barone, F. C., Hillegass, L. M., Price, W. J., White, R. F., Lee, E. V., FEUERSTEIN, G. Z., Sarau, H. M., Clark, R. K., & Griswold, D. E. (1991) · Journal of Neuroscience Research · doi:10.1002/jnr.490290309 · Cited by 381
Schilling, M., Besselmann, M., Leonhard, C., Mueller, M., Ringelstein, E. B., & Kiefer, R. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00082-7 · Cited by 375
Cellular forms and functions of brain microglia
Davis, E. J., Foster, T. D., & Thomas, W. E. (1994) · Brain Research Bulletin · doi:10.1016/0361-9230(94)90189-9 · Cited by 359
Tang, Y., Xu, H., Du, X. L., Lit, L., Walker, W. L., Lu, A., Ran, R., Gregg, J. P., Reilly, M., Pancioli, A., et al. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600264 · Cited by 326
Emsley, H. C. A. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(03)00134-6 · Cited by 302
Schilling, M., Besselmann, M., Müller, M., Strecker, J. K., Ringelstein, E. B., & Kiefer, R. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.08.004 · Cited by 288
Characterization of microglial reaction after middle cerebral artery occlusion in rat brain
Morioka, T., Kalehua, A. N., & Streit, W. J. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903270110 · Cited by 276
Local immune responses in the rat cerebral cortex after middle cerebral artery occlusion
Schroeter, M. L., Jander, S., Witte, O. W., & Stoll, G. (1994) · Journal of Neuroimmunology · doi:10.1016/0165-5728(94)90010-8 · Cited by 269
Flagged first, then by citations
Research works printed but not linked: 2
- Kavec M, 2004, Proc Intl Soc Magn Res Med, 12, 133
- Schroeter M, 2006, Proc Int Soc Magn Reson Med, 14, 1459
Cited by
Sorted by citations
Items 101–200 of 342
The role of peripheral monocytes and macrophages in ischemic stroke
Han, D., Liu, H., & Gao, Y. (2020) · Neurological Sciences · doi:10.1007/s10072-020-04777-9 · Cited by 86
Preconditioning paradigms and pathways in the brain.
Shpargel, K. B., Jalabi, W., Jin, Y., Dadabayev, A. R., Penn, M. S., & Trapp, B. D. (2008) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.75.suppl_2.s77 · Cited by 81
The Role of Inflammatory Response in Stroke Associated Programmed Cell Death
Ďuriš, K., Šplíchal, Z., & Jurajda, M. (2018) · Current Neuropharmacology · doi:10.2174/1570159x16666180222155833 · Cited by 82
Herbal Medicines for Ischemic Stroke: Combating Inflammation as Therapeutic Targets
Gu, Y., Chen, J., & Shen, J. (2014) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-014-9525-5 · Cited by 78
Wong, R., Lénárt, N., Hill, L., Toms, L., Coutts, G., Martinecz, B., Császár, E., Nyíri, G., Papaemmanouil, A., Waisman, A., et al. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.11.012 · Cited by 82
Self-citationMicroglial phagocytosis and regulatory mechanisms after stroke
Chen, W., Zhang, Y., Zhai, X., Xie, L., Guo, Y., Chen, C., Li, Y., Wang, F., Zhu, Z., Li, Z., et al. (2022) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x221098841 · Cited by 79
GPR18 in microglia: implications for the CNS and endocannabinoid system signalling
McHugh, D. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02019.x · Cited by 77
Dénes, Á., McColl, B. W., Leow‐Dyke, S., Chapman, K. Z., Humphreys, N. E., Grencis, R. K., Allan, S. M., & Rothwell, N. J. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.198 · Cited by 76
Self-citationMolecular magnetic resonance imaging of brain–immune interactions
Gauberti, M., Montagne, A., Quenault, A., & Vivien, D. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00389 · Cited by 84
Tobin, M. K., Stephen, T. K. L., Lopez, K. L., Pergande, M. R., Bartholomew, A. M., Cologna, S. M., & Lazarov, O. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.013583 · Cited by 75
Interaction of microglia with infiltrating immune cells in the different phases of stroke
Berchtold, D., Priller, J., Meisel, C., & Meisel, A. (2020) · Brain Pathology · doi:10.1111/bpa.12911 · Cited by 77
Li, Q., Ding, D., Wang, X., Sun, Y., & Wu, J. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113645 · Cited by 75
HMGB1: A New Target for Ischemic Stroke and Hemorrhagic Transformation
Li, J., Wang, Z., Li, J., Zhao, H., & Ma, Q. (2024) · Translational Stroke Research · doi:10.1007/s12975-024-01258-5 · Cited by 81
Simão, F., Matté, A., Pagnussat, A. S., Netto, C. A., & Salbego, C. G. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.06.009 · Cited by 76
Li, T., Zhao, J., Xie, W., Yuan, W., Guo, J., Pang, S., Gan, W.-B., Gómez-Nicola, D., & Zhang, S. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02127-w · Cited by 72
Microglia in Ischemic Stroke: Pathogenesis Insights and Therapeutic Challenges
Shui, X., Chen, J., Fu, Z., Zhu, H., Tao, H., & Li, Z. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s461795 · Cited by 80
Rosiglitazone-induced CD36 up-regulation resolves inflammation by PPARγ and 5-LO-dependent pathways
Ballesteros, I., Cuartero, M. I., Pradillo, J. M., de la Parra, J., Pérez‐Ruíz, A., Corbí, A. L., Ricote, M., Hamilton, J. A., Sobrado, M., Vivancos, J., et al. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.0613326 · Cited by 70
The spleen may be an important target of stem cell therapy for stroke
Wang, Z., He, D., Zeng, Y., Zhu, L., Yang, C., Lu, Y.-J., Huang, J., Cheng, X., Huang, X., & Tan, X. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1400-0 · Cited by 71
Systemic immune activation shapes stroke outcome
Murray, K. N., Buggey, H., Dénes, Á., & Allan, S. M. (2012) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2012.09.004 · Cited by 70
Self-citationDesestret, V., Brisset, J., Moucharrafie, S., Devillard, E., Nataf, S., Honnorat, J., Nighoghossian, N., Berthezène, Y., & Wiart, M. (2009) · Stroke · doi:10.1161/strokeaha.108.531269 · Cited by 69
Kim, D. H., Kim, S., Jung, W. Y., Park, S. J., Park, D. H., Kim, J. M., Cheong, J. H., & Ryu, J. H. (2009) · Food and Chemical Toxicology · doi:10.1016/j.fct.2009.03.028 · Cited by 67
Xu, Y., Qian, L., Zong, G., Ma, K., Zhu, X., Zhang, H., Li, N., Yang, Q., Bai, H., Ben, J., et al. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.05.036 · Cited by 66
Tang, M., Alexander, H. L., Clark, R. S. B., Kochanek, P. M., Kagan, V. E., & Bayır, H. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.194 · Cited by 66
Xu, H., Qin, W., Xiao, H., Mu, S., Zhu, J., Lu, W., & Luo, Y. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1117-5 · Cited by 66
Zhang, C., Zhou, L., Wang, Z., Gao, W., Chen, W., Zhang, H., Jing, B., Xu, Z., Chen, L., Zheng, C., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03644-5 · Cited by 64
Phytochemicals as regulators of microglia/macrophages activation in cerebral ischemia
Subedi, L., & Gaire, B. P. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105419 · Cited by 63
Neutrophil Heterogeneity and its Roles in the Inflammatory Network after Ischemic Stroke
Xie, M., Hao, Y., Feng, L., Wang, T., Yao, M., Li, H., Ma, D., & Feng, J. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220706115957 · Cited by 62
Self-citationGinseng: a promising neuroprotective strategy in stroke
Rastogi, V., Santiago‐Moreno, J., & Doré, S. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00457 · Cited by 61
McCarthy, C. A., Vinh, A., Broughton, B. R. S., Sobey, C. G., Callaway, J. K., & Widdop, R. E. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.199646 · Cited by 61
Imaging Neuroinflammation after Stroke: Current Status of Cellular and Molecular MRI Strategies
Deddens, L. H., van Tilborg, G. A. F., Mulder, W. J. M., de Vries, H. E., & Dijkhuizen, R. M. (2012) · Cerebrovascular Diseases · doi:10.1159/000336116 · Cited by 61
Yan, T., Chopp, M., & Chen, J. (2015) · Neuroscience Bulletin · doi:10.1007/s12264-015-1567-z · Cited by 61
Shi, Y., Chanana, V., Watters, J. J., Ferrazzano, P. A., & Sun, D. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07403.x · Cited by 60
Jiang, J., Luo, Y., Qin, W., Ma, H., Li, Q., Zhan, J., & Zhang, Y. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00363 · Cited by 61
Gao, J., Yao, M., Zhang, W., Yang, B., Yuan, G., Liu, J., & Zhang, Y. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113479 · Cited by 58
Zhang, X.-Y., Wang, X., Xu, D., Yu, S.-Y., Shi, Q., Zhang, L., Chen, L., Fang, S., Lu, Y., Zhang, W., et al. (2013) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.113.203604 · Cited by 56
AMPA-ergic regulation of amyloid-β levels in an Alzheimer’s disease mouse model
Hettinger, J. C., Lee, H. J., Bu, G., Holtzman, D. M., & Cirrito, J. R. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0256-6 · Cited by 54
Tóth, M., Little, P., Arnberg, F., Häggkvist, J., Mulder, J., Halldin, C., Gulyás, B. Z., & Holmin, S. (2015) · Brain Structure and Function · doi:10.1007/s00429-014-0970-y · Cited by 55
Yuan, Y., Fang, M., Wu, C., & Ling, E. (2016) · NeuroMolecular Medicine · doi:10.1007/s12017-016-8394-x · Cited by 55
Neuroprotective effect of forsythiaside against transient cerebral global ischemia in gerbil
Kim, J. M., Kim, S., Kim, D. H., Lee, C. H., Park, S. J., Jung, J. W., Ko, K. H., Cheong, J. H., Lee, S. H., & Ryu, J. H. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.03.051 · Cited by 54
CD8 signaling in microglia/macrophage M1 polarization in a rat model of cerebral ischemia
Boddaert, J., Bielen, K., ’s Jongers, B., Manocha, E., Yperzeele, L., Cras, P., Pirici, D., & Kumar-Singh, S. (2018) · PLOS ONE · doi:10.1371/journal.pone.0186937 · Cited by 54
Cai, M., Shin, B. Y., Kim, D. H., Kim, J. M., Park, S. J., Park, C. S., Won, D. H., Hong, N. D., Kang, D. H., Yamamoto, Y., et al. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.10.016 · Cited by 53
Silasi, G., & Colbourne, F. (2011) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.25 · Cited by 52
The Implications of Microglial Regulation in Neuroplasticity-Dependent Stroke Recovery
Qiao, C., Liu, Z., & Qie, S. (2023) · Biomolecules · doi:10.3390/biom13030571 · Cited by 55
The Role of the Neuroprotective Factor Npas4 in Cerebral Ischemia
Choy, F. C., Klarić, T., Koblar, S. A., & Lewis, M. D. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161226144 · Cited by 51
Anti-Inflammatory Effects of Flavonoids in Common Neurological Disorders Associated with Aging
Martínez‐Coria, H., Arrieta‐Cruz, I., Juárez, R. G., & López-Valdés, H. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054297 · Cited by 51
Schuette-Nuetgen, K., Strecker, J., Minnerup, J., Ringelstein, E. B., & Schilling, M. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.12.011 · Cited by 51
Halder, S. K., Matsunaga, H., Ishii, K. J., Akira, S., Miyake, K., & Ueda, H. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12262 · Cited by 49
Marinescu, M., Langer, M., Durand, A., Olivier, C., Chabrol, A., Rositi, H., Chauveau, F., Cho, T., Nighoghossian, N., Berthezène, Y., et al. (2013) · Molecular Imaging and Biology · doi:10.1007/s11307-013-0639-6 · Cited by 48
Desestret, V., Riou, A., Chauveau, F., Cho, T., Devillard, E., Marinescu, M., Ferrera, R., Rey, C., Chanal, M., Angoulvant, D., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067063 · Cited by 48
Tetracycline Inhibits Local Inflammation Induced by Cerebral Ischemia via Modulating Autophagy
Jiang, Y., Zhu, J., Wu, L., Xu, G., Dai, J., & Liu, X. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048672 · Cited by 38
Hypothermia and brain inflammation after cardiac arrest
Geocadin, R. G., Tahsili‐Fahadan, P., & Farrokh, S. (2018) · Brain Circulation · doi:10.4103/bc.bc_4_18 · Cited by 49
Borjini, N., Sivilia, S., Giuliani, A., Fernández, M., Giardino, L., Facchinetti, F., & Calzà, L. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1595-0 · Cited by 49
Ju, H., Park, K. W., Kim, I., Cave, J. W., & Cho, S. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02552-5 · Cited by 49
The association between laminin and microglial morphology in vitro
Tam, W. Y., Au, N. P. B., & Ma, C. H. E. (2016) · Scientific Reports · doi:10.1038/srep28580 · Cited by 46
Dang, D., Saiyin, H., Yu, Q. Z., & Liang, W. (2018) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12823 · Cited by 45
Langenfurth, A., Rinnenthal, J. L., Vinnakota, K., Prinz, V., Carlo, A.-S., Stadelmann, C., Siffrin, V., Peaschke, S., Endres, M., Heppner, F. L., et al. (2013) · Journal of Neuroscience Research · doi:10.1002/jnr.23288 · Cited by 45
PET of Glial Metabolism Using 2-18F-Fluoroacetate
Mařı́k, J., Ogasawara, A. K., Martin-McNulty, B., Ross, J., Flores, J. E., Gill, H. S., Tinianow, J. N., Vanderbilt, A. N., Nishimura, M. C., Peale, F. V., Jr., et al. (2009) · Journal of Nuclear Medicine · doi:10.2967/jnumed.108.057356 · Cited by 47
Lu, H. J., Ashiqueali, R., Lin, C.-I., Walchale, A., Clendaniel, V., Matheson, R., Fisher, M., Lo, E. H., Selim, M. H., & Shehadah, A. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03083-z · Cited by 43
Shin, Y., Choi, J., Choi, J.-Y., Hou, Y., Cha, J., Chun, M., & Lee, M. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.07.008 · Cited by 44
Inflammatory cell recruitment after experimental thromboembolic stroke in rats
Lehmann, J., Härtig, W., Seidel, A., Fueldner, C., Hobohm, C., Grosche, J., Krueger, M., & Michalski, D. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.08.023 · Cited by 41
Role of microglia in the process of inflammation in the hypoxic developing brain
Yi, Y. D. (2011) · Frontiers in Bioscience-Scholar · doi:10.2741/194 · Cited by 41
Xiang, Y., Zhao, H., Wang, J., Zhang, L., Liu, A., & Chen, Y. (2016) · Biomedical Reports · doi:10.3892/br.2016.677 · Cited by 42
Xu, H., Mu, S., & Qin, W. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.08.130 · Cited by 42
Xu, K., Lee, J.-Y., Kaneko, Y., Tuazon, J. P., Vale, F. Ĺ., van Loveren, H., & Borlongan, C. V. (2018) · Haematologica · doi:10.3324/haematol.2018.206581 · Cited by 41
Ma, Z., Zhang, Z.-L., Bai, F.-H., Jiang, T., Yan, C., & Wang, Q. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00537 · Cited by 39
Pathophysiological and pharmacological relevance of TLR4 in peripheral immune cells after stroke
Durán‐Laforet, V., Peña‐Martínez, C., García‐Culebras, A., Alzamora, L., Moro, M. Á., & Lizasoaín, I. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107933 · Cited by 41
Dhiraj, D., Chrysanthou, E., Mallucci, G. R., & Bushell, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083717 · Cited by 39
SPARC and GluA1-Containing AMPA Receptors Promote Neuronal Health Following CNS Injury
Jones, E. V., Bernardinelli, Y., Zarruk, J. G., Chierzi, S., & Murai, K. K. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00022 · Cited by 39
Interleukin-33 Protects Ischemic Brain Injury by Regulating Specific Microglial Activities
Luo, Q., Fan, Y., Lin, L., Wei, J., Li, Z., Li, Y., Nakae, S., Lin, W., & Chen, Q. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.05.047 · Cited by 41
Metabolism and inflammation: implications for traumatic brain injury therapeutics
Killen, M. J., Giorgi-Coll, S., Helmy, A. E., Hutchinson, P. J., & Carpenter, K. L. H. (2019) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2019.1582332 · Cited by 39
The role of microglia in ischemic preconditioning
McDonough, A., & Weinstein, J. R. (2019) · Glia · doi:10.1002/glia.23695 · Cited by 39
McDonough, A., Noor, S., Lee, R. V., Dodge, R. E., Strosnider, J. S., Shen, J., Davidson, S., Möller, T., Garden, G. A., & Weinstein, J. R. (2019) · Glia · doi:10.1002/glia.23701 · Cited by 40
Effects of Glial Cells on Electrode Impedance Recorded from Neural Prosthetic Devices In Vitro
Frampton, J. P., Hynd, M. R., Shuler, M. L., & Shain, W. G. (2010) · Annals of Biomedical Engineering · doi:10.1007/s10439-010-9911-y · Cited by 37
Inhibiting the Migration of M1 Microglia at Hyperacute Period Could Improve Outcome of tMCAO Rats
Huang, M., Wan, Y., Mao, L., He, Q., Xia, Y., Li, M., Li, Y., Jin, H., & Hu, B. (2016) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12665 · Cited by 36
Targeting mast cell as a neuroprotective strategy
Ocak, U., Ocak, P. E., Wang, A., Zhang, J. H., Boling, W., Wu, P., Mo, J., Zhang, T., & Huang, L. (2018) · Brain Injury · doi:10.1080/02699052.2018.1556807 · Cited by 35
The Yin and Yang of Innate Immunity in Stroke
Xu, X., & Jiang, Y. (2014) · BioMed Research International · doi:10.1155/2014/807978 · Cited by 33
Therapeutic Potential of Intravenous Immunoglobulin in Acute Brain Injury
Häußler, V., Arumugam, T. V., Magnus, T. U., & Gelderblom, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00875 · Cited by 34
Chan, M. W. Y., & Viswanathan, S. (2019) · Cytotherapy · doi:10.1016/j.jcyt.2019.02.002 · Cited by 34
Direct neuronal conversion of microglia/macrophages reinstates neurological function after stroke
Irie, T., Matsuda, T., Hayashi, Y., Matsuda‐Ito, K., Kamiya, A., Masuda, T., Prinz, M., Isobe, N., Kira, J., & Nakashima, K. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2307972120 · Cited by 37
Dose-Dependent Influences of Ethanol on Ischemic Stroke: Role of Inflammation
Xu, G., Li, C., Parsiola, A. L., Li, J., McCarter, K. D., Shi, R., Mayhan, W. G., & Sun, H. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00006 · Cited by 33
Positron Emission Tomography after Ischemic Brain Injury: Current Challenges and Future Developments
Wang, Z., Mascarenhas, C., & Jia, X.-F. (2020) · Translational Stroke Research · doi:10.1007/s12975-019-00765-0 · Cited by 28
Jin, R., Yu, S., Song, Z., Quillin, J., Deasis, D. P., Penninger, J. M., Nanda, A., Granger, D. N., & Li, G. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.07.116 · Cited by 33
Harms, C., Dätwyler, A. L., Wiekhorst, F., Trahms, L., Lindquist, R. L., Schellenberger, E. A., Mueller, S. G., Schütz, G., Roohi, F., Ide, A., et al. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.22 · Cited by 33
Microglia‐targeted stem cell therapies for Alzheimer disease: A preclinical data review
Shen, Z., Li, X., Bao, X., & Wang, R. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24066 · Cited by 32
Lelekov‐Boissard, T., Chapuisat, G., Boissel, J., Grenier, E., & Dronne, M.-A. (2009) · Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences · doi:10.1098/rsta.2009.0184 · Cited by 32
The immunology of stroke and dementia
Iadecola, C., & Anrather, J. (2025) · Immunity · doi:10.1016/j.immuni.2024.12.008 · Cited by 37
Pluta, R. M., Ouyang, L., Januszewski, S., Li, Y., & Czuczwar, S. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052460 · Cited by 31
Chen, F., Weng, Z., Xia, Q., Cao, C., Leak, R. K., Han, L., Xiao, J., Graham, S. H., & Cao, G. (2019) · Translational Stroke Research · doi:10.1007/s12975-019-00692-0 · Cited by 31
Zhao, C., Bai, X., Wen, A., Wang, J., & Ding, Y. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107527 · Cited by 32
Emerging Targets for Modulation of Immune Response and Inflammation in Stroke
Thapa, K., Shivam, K., Khan, H., Kaur, A., Dua, K., Singh, S. K., & Singh, T. G. (2023) · Neurochemical Research · doi:10.1007/s11064-023-03875-2 · Cited by 29
Chen, Y., Wu, K., Huang, W.-S., Hsieh, Y., Wang, Y., Tsai, H.-Y., & Lee, M.-M. (2016) · Biomedicine · doi:10.7603/s40681-016-0021-5 · Cited by 27
Senicapoc: Repurposing a Drug to Target Microglia KCa3.1 in Stroke
Staal, R. G. W., Weinstein, J. R., Nattini, M. E., Cajina, M., Chandresana, G., & Möller, T. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2223-y · Cited by 27
Cherchi, L., Anni, D., Buffelli, M., & Cambiaghi, M. (2022) · Biomolecules · doi:10.3390/biom12040588 · Cited by 28
Microglia–neuron–vascular interactions in ischemia
Lénárt, N., Cserép, C., Császár, E., Pósfai, B., & Dénes, Á. (2023) · Glia · doi:10.1002/glia.24487 · Cited by 28
Farr, T. D., Seehafer, J. U., Nelles, M., & Hoehn, M. (2010) · NMR in Biomedicine · doi:10.1002/nbm.1553 · Cited by 26
Regenerative repair of Pifithrin-α in cerebral ischemia via VEGF dependent manner
Zhang, P., Lei, X., Sun, Y., Zhang, H., Chang, L., Li, C., Liu, D., Bhatta, N., Zhang, Z., & Jiang, C. (2016) · Scientific Reports · doi:10.1038/srep26295 · Cited by 26
Li, D., He, T.-P., Zhang, Y., Liu, J.-R., Zhao, H.-Y., Wang, D.-L., Wang, Q., Yuan, Y., & Zhang, S.-X. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114464 · Cited by 24
Davies, C. L., Patir, A., & McColl, B. W. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01048 · Cited by 24
Self-citationLin, X., Zhan, J., Jiang, J., & Ren, Y. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s307841 · Cited by 27
Zhao, Y., Wang, P., Chen, S., Han, C., Yan, Q., Zheng, L. T., Jia, J., Ren, Z., & Zhen, X. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.03.034 · Cited by 24
Metadata
- Authors
- Denes, A., Vidyasagar, R., Feng, J., Narvainen, J., McColl, B. W., Kauppinen, R. A., & Allan, S. M.
- Affiliations
- Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
- University of Birmingham (GB)
- Chinese Academy of Sciences (CN)
- Faculty of Life Sciences, Michael Smith Building, University of Manchester, Manchester, UK
- University of Manchester (GB)
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 2007-12
- Volume
- 27
- Issue
- 12
- Pages
- 1941-1953
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W2001952628
- Cited by
- 342
- References
- 40
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 9 · 2023: 17 · 2022: 17 · 2021: 36 · 2020: 14 · 2019: 22 · 2018: 27 · 2017: 17 · 2016: 33 · 2015: 23 · 2014: 18 · 2013: 28 · 2012: 19
- FWCI
- 8.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Keywords
- microglial proliferation, focal cerebral ischemia, transient middle cerebral artery occlusion, blood-brain barrier disruption, neutrophil infiltration, macrophage infiltration, neuroinflammation, phagocytosis, neuroprotection, ischemic injury
- MeSH terms
- Animals, Antimetabolites, Bromodeoxyuridine, Ischemic Attack, Transient, Data Interpretation, Statistical, Dextrans, Fluorescent Antibody Technique, Iron, Macrophages, Magnetic Resonance Imaging, Male, Mice, Inbred C57BL, Monocytes, Oxides, Phagocytes, Microglia, Infarction, Middle Cerebral Artery, Neutrophil Infiltration, Cell Proliferation, Mice, Ferrosoferric Oxide, Magnetite Nanoparticles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
