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Tetracycline Inhibits Local Inflammation Induced by Cerebral Ischemia via Modulating Autophagy
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“Nonetheless, it would be prudent to keep in mind that SQSTM1 contains domains that interact with several signaling molecules [590], and SQSTM1 may be part of MTORC1 [591].”
From Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1 (2021) · cites this paper as [590]
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Citations
Cites
How to Interpret LC3 Immunoblotting
Mizushima, N., & Yoshimori, T. (2007) · Autophagy · doi:10.4161/auto.4600 · Cited by 2,595
Wu, Y.-T., Tan, H.-L., Shui, G., Bauvy, C., Huang, Q., Wenk, M. R., Ong, C.-N., Codogno, P., & Shen, H.-M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.080796 · Cited by 1,127
The many faces of tumor necrosis factor in stroke
Hallenbeck, J. M. (2002) · Nature Medicine · doi:10.1038/nm1202-1363 · Cited by 367
Proliferating resident microglia after focal cerebral ischaemia in mice
Denes, A., Vidyasagar, R., Feng, J., Narvainen, J., McColl, B. W., Kauppinen, R. A., & Allan, S. M. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600495 · Cited by 342
Age related macular degeneration and drusen: Neuroinflammation in the retina
Buschini, E., Piras, A., Nuzzi, R., & Vercelli, A. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.05.011 · Cited by 230 · cited 1×
“The possible reason was that autophagy was that autophagy induced by ischemia may trigger cell death by excessive self-digestion [25] and the dead cell which in turn activated microglia [26].”
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Research works printed but not linked: 42
- R Jin, 2010, Inflammatory mechanisms in ischemic stroke: role of inflammatory cells, J Leukoc Biol, 87, 779, 10.1189/jlb.1109766 · DOI · Paper page
- WD Hill, 2001, The NF-kappaB inhibitor diethyldithiocarbamate (DDTC) increases brain cell death in a transient middle cerebral artery occlusion model of ischemia, Brain Res Bull, 55, 375, 10.1016/S0361-9230(01)00503-2 · DOI
- MK McCoy, 2008, TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease, J Neuroinflammation, 5, 45, 10.1186/1742-2094-5-45 · DOI
- W Xia, 2010, Inflammation in ischaemic brain injury: current advances and future perspectives, Clin Exp Pharmacol Physiol, 37, 253, 10.1111/j.1440-1681.2009.05279.x · DOI
- TJ Kleinig, 2009, Suppression of inflammation in ischemic and hemorrhagic stroke: therapeutic options, Current Opinion in Neurology, 22, 294, 10.1097/WCO.0b013e32832b4db3 · DOI
- Q Sun, 2009, Regulation of Beclin 1 in autophagy, Autophagy, 5, 713, 10.4161/auto.5.5.8524 · DOI
- N Mizushima, 2011, Autophagy: renovation of cells and tissues, Cell, 147, 728, 10.1016/j.cell.2011.10.026 · DOI
- MT Viscomi, 2012, Stimulation of autophagy by rapamycin protects neurons from remote degeneration after acute focal brain damage, Autophagy, 8, 222, 10.4161/auto.8.2.18599 · DOI
- N Mizushima, 2008, Autophagy fights disease through cellular self-digestion, Nature, 451, 1069, 10.1038/nature06639 · DOI · Paper page
- J Puyal, 2009, Targeting autophagy to prevent neonatal stroke damage, Autophagy, 5, 1060, 10.4161/auto.5.7.9728 · DOI
- A Rami, 2008, Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death, Neurobiol Dis, 29, 132, 10.1016/j.nbd.2007.08.005 · DOI
- YD Wen, 2008, Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways, Autophagy, 4, 762, 10.4161/auto.6412 · DOI
- Q Meng, 2011, Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IkappaB kinase beta (IKKbeta)/NF-kappaB pathway, J Biol Chem, 286, 32324, 10.1074/jbc.M111.254417 · DOI
- J Yrjanheikki, 1999, A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window, Proc Natl Acad Sci U S A, 96, 13496, 10.1073/pnas.96.23.13496 · DOI
- Z Liu, 2007, Chronic treatment with minocycline preserves adult new neurons and reduces functional impairment after focal cerebral ischemia, Stroke, 38, 146, 10.1161/01.STR.0000251791.64910.cd · DOI
- HS Kim, 2009, Minocycline and neurodegenerative diseases, Behav Brain Res, 196, 168, 10.1016/j.bbr.2008.09.040 · DOI · Paper page
- Y Jiang, 2011, Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modulating local inflammation in rats, Neuroscience, 172, 398, 10.1016/j.neuroscience.2010.10.054 · DOI
- V Basic Kes, 2008, Pro-inflammatory and anti-inflammatory cytokines in acute ischemic stroke and their relation to early neurological deficit and stroke outcome, Clin Biochem, 41, 1330, 10.1016/j.clinbiochem.2008.08.080 · DOI
- CJ Smith, 2004, Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome, BMC Neurol, 4, 2, 10.1186/1471-2377-4-2 · DOI
- JH Lindeman, 2009, Clinical trial of doxycycline for matrix metalloproteinase-9 inhibition in patients with an abdominal aneurysm: doxycycline selectively depletes aortic wall neutrophils and cytotoxic T cells, Circulation, 119, 2209, 10.1161/CIRCULATIONAHA.108.806505 · DOI
- N Bostanci, 2011, Effects of low-dose doxycycline on cytokine secretion in human monocytes stimulated with Aggregatibacter actinomycetemcomitans, Cytokine, 56, 656, 10.1016/j.cyto.2011.08.039 · DOI
- LL Jantzie, 2005, Doxycycline reduces cleaved caspase-3 and microglial activation in an animal model of neonatal hypoxia-ischemia, J Cereb Blood Flow Metab, 25, 314, 10.1038/sj.jcbfm.9600025 · DOI
- Wideroe M, Havnes MB, Morken TS, Skranes J, Goa PE, <etal>et al</etal>.. (2012) Doxycycline treatment in a neonatal rat model of hypoxia-ischemia reduces cerebral tissue and white matter injury: a longitudinal magnetic resonance imaging study. Eur J Neurosci. · DOI
- A Piras, 2011, Activation of autophagy in a rat model of retinal ischemia following high intraocular pressure, PLoS One, 6, e22514, 10.1371/journal.pone.0022514 · DOI
- M Karin, 2008, The IkappaB kinase - a bridge between inflammation and cancer, Cell Res, 18, 334, 10.1038/cr.2008.30 · DOI
- Q Wang, 2007, The inflammatory response in stroke, J Neuroimmunol, 184, 53, 10.1016/j.jneuroim.2006.11.014 · DOI
- MS Hayden, 2008, Shared principles in NF-kappaB signaling, Cell, 132, 344, 10.1016/j.cell.2008.01.020 · DOI
- O Herrmann, 2005, IKK mediates ischemia-induced neuronal death, Nat Med, 11, 1322, 10.1038/nm1323 · DOI
- Z Cai, 2011, Increases in beta-amyloid protein in the hippocampus caused by diabetic metabolic disorder are blocked by minocycline through inhibition of NF-kappaB pathway activation, Pharmacol Rep, 63, 381, 10.1016/S1734-1140(11)70504-7 · DOI
- X Ci, 2011, Oxytetracycline attenuates allergic airway inflammation in mice via inhibition of the NF-kappaB pathway, J Clin Immunol, 31, 216, 10.1007/s10875-010-9481-7 · DOI
- JC Hoyt, 2006, Doxycycline modulates nitric oxide production in murine lung epithelial cells, J Immunol, 176, 567, 10.4049/jimmunol.176.1.567 · DOI
- Y Huang, 2011, Doxycycline up-regulates the expression of IL-6 and GM-CSF via MAPK/ERK and NF-kappaB pathways in mouse thymic epithelial cells, Int Immunopharmacol, 11, 1143, 10.1016/j.intimp.2011.03.011 · DOI
- PO Seglen, 1982, 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes, Proc Natl Acad Sci U S A, 79, 1889, 10.1073/pnas.79.6.1889 · DOI
- A Colleran, 2011, Autophagosomal IkappaB alpha degradation plays a role in the long term control of tumor necrosis factor-alpha-induced nuclear factor-kappaB (NF-kappaB) activity, J Biol Chem, 286, 22886, 10.1074/jbc.M110.199950 · DOI
- Liu B, Tan W, Barsoum A, Gu X, Chen K, <etal>et al</etal>.. (2010) IL-17 is a potent synergistic factor with GM-CSF in mice in stimulating myelopoiesis, dendritic cell expansion, proliferation, and functional enhancement. Exp Hematol 38: 877–884 e871. · DOI
- C Sperti, 2010, Parenchyma-sparing pancreatectomies for benign or border-line tumors of the pancreas, World J Gastrointest Oncol, 2, 272, 10.4251/wjgo.v2.i6.272 · DOI
- J Wang, 2008, Beclin 1 bridges autophagy, apoptosis and differentiation, Autophagy, 4, 947, 10.4161/auto.6787 · DOI
- JS Yao, 2004, Minocycline exerts multiple inhibitory effects on vascular endothelial growth factor-induced smooth muscle cell migration: the role of ERK1/2, PI3K, and matrix metalloproteinases, Circ Res, 95, 364, 10.1161/01.RES.0000138581.04174.2f · DOI
- JS Yao, 2007, Comparison of doxycycline and minocycline in the inhibition of VEGF-induced smooth muscle cell migration, Neurochem Int, 50, 524, 10.1016/j.neuint.2006.10.008 · DOI
- WT Liu, 2011, Minocycline inhibits the growth of glioma by inducing autophagy, Autophagy, 7, 166, 10.4161/auto.7.2.14043 · DOI
- Jiang Y, Wei N, Zhu J, Zhai D, Wu L, <etal>et al</etal>.. (2011) A new approach with less damage: intranasal delivery of tetracycline-inducible replication-defective herpes simplex virus type-1 vector to brain. Neuroscience. · DOI
- Y Jiang, 2010, Effects of brain-derived neurotrophic factor on local inflammation in experimental stroke of rat, Mediators Inflamm, 2010, 372423, 10.1155/2010/372423 · DOI
Cited by
Sorted by citations
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894
Self-citationGuidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,897
Self-citationAutophagy and Microglia: Novel Partners in Neurodegeneration and Aging
Plaza-Zabala, A., Sierra-Torre, V., & Sierra, A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030598 · Cited by 323
Ferreira Mello, B. S., Monte, A. S., McIntyre, R. S., Soczynska, J. K., Custódio, C. S., Cordeiro, R. C., Chaves, J. H., Mendes Vasconcelos, S. M., Nobre Júnior, H. V., Florenço de Sousa, F. C., et al. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.06.008 · Cited by 195
Metadata
- Authors
- Jiang, Y., Zhu, J., Wu, L., Xu, G., Dai, J., & Liu, X.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-11-07
- Volume
- 7
- Issue
- 11
- Pages
- e48672
- ISSN
- 1932-6203
- PMC
- PMC3492486
- Cited by
- 38
- References
- 5
- Language
- en
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