Plasma N terminal pro-brain natriuretic peptide levels and its determinants in a multi-ethnic population
Abstract
This study documents the determinants and plasma levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) among hypertensive and normotensive subjects in a multi-ethnic population in the United Arab Emirates (UAE). We obtained demographic, anthropometric and clinical data, together with fasting NT-proBNP and biochemical indices from 128 hypertensive patients and 138 normotensive subjects matched for age, gender and ethnicity. Plasma NT-proBNP levels were significantly (P<0.001), and several-fold higher among hypertensives (median 5.92, inter quartile range (IQR): 1.79-18.48 pmol/l) than normotensives (median 1.78, IQR: 0.59-4.32 pmol/l) in the total study population, and the same was true for the ethnic groups separately. Similarly, plasma levels of glucose, blood urea nitrogen (BUN) and creatinine, but not insulin, were significantly (P<0.05) higher among hypertensives than normotensives. For all subjects combined, log NT-proBNP correlated positively and significantly with age (P<0.01), log glucose (P<0.05), systolic blood pressure (SBP, P<0.001), log BUN (P<0.001) and log creatinine (P<0.001). Multivariate regression analysis showed that NT-proBNP levels were independently and positively correlated with SBP, age, gender, log BUN, Emirati and South East Asian ethnic groups and inversely associated with current exercise. In conclusion, we found circulating levels of NT-proBNP to be significantly increased in hypertensive versus normotensive subjects in the UAE and independently related to SBP, age, gender, indices of renal function and possibly exercise. Our results further suggest a possible modulating effect of ethnicity on NT-proBNP levels.
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Other studies found no correlation or even a positive correlation between BMI and plasma natriuretic peptide concentrations.
“Other studies, however, found no correlation or even a positive correlation between BMI and plasma NP concentrations94,95.”
From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [95]
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Obesity, kidney dysfunction and hypertension: mechanistic links
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- Authors
- Abdulle, A. M., Nagelkerke, N. J. D., Adem, A., Abouchacra, S., Pathan, J. Y., Al-Rukhaimi, M., Suleiman, M. N., Mathew, M. C., Nicholls, M. G., & Obineche, E. N.
- Affiliations
- United Arab Emirates University (AE)
- Tawam Hospital (AE)
- Dubai Hospital (AE)
- Christchurch Hospital (NZ)
- Corresponding author
- Obineche, E N
- Venue
- Journal of Human Hypertension
- Published
- 2007-04-26
- Volume
- 21
- Issue
- 8
- Pages
- 647-653
- ISSN
- 0950-9240 (ISSN-L)
- 1476-5527
- OpenAlex
- W2016628620
- Cited by
- 11
- References
- 37
- Citations by year
- 2020: 1 · 2019: 1 · 2017: 2 · 2014: 1 · 2012: 2
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Human Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Utah Agricultural Experiment Station
- Sheikh Hamdan Bin Rashid Al Maktoum Award for Medical Sciences
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- NT-proBNP, brain natriuretic peptide, hypertension, normotensive subjects, systolic blood pressure, renal function, blood urea nitrogen, creatinine, plasma glucose, ethnicity, physical activity, multi-ethnic population, United Arab Emirates
- MeSH terms
- Adult, Female, Humans, Hypertension, Male, Middle Aged, Peptide Fragments, United Arab Emirates, Exercise, Natriuretic Peptide, Brain
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