Impact of Body Mass and Body Composition on Circulating Levels of Natriuretic Peptides: Results From the Dallas Heart Study
Abstract
Background— The association between higher body mass index (BMI) and lower B-type natriuretic peptide (BNP) level is thought to be mediated by expression of the natriuretic peptide clearance receptor (NPR-C) in adipose tissue. To explore this association, we tested 2 hypotheses: (1) that N-terminal (NT)-proBNP, which is not believed to bind NPR-C, would not be associated with BMI and (2) that lower BNP would be more closely associated with fat mass than with lean mass. Methods and Results— Measurements of BNP, NT-proBNP, and body composition by direct dual energy x-ray absorptiometry (DEXA) were performed in 2707 subjects from the Dallas Heart Study. The associations between obesity and low BNP (<4 ng/L) or low NT-proBNP (lowest sex-specific quartile) were evaluated with multivariable logistic regression models stratified by sex and adjusted for age, race/ethnicity, hypertension, left ventricular mass, and end-diastolic volume. Higher BMI was independently associated with lower BNP and NT-proBNP (all P <0.001). When BMI was replaced with both DEXA-derived lean and fat mass, greater lean mass, but not fat mass, was associated with low BNP and NT-proBNP levels. Conclusions— In a large, population-based cohort, we confirm the previously described association between higher BMI and lower BNP and demonstrate a similar inverse association between BMI and NT-proBNP. Interestingly, both BNP and NT-proBNP are more closely associated with lean mass than with fat mass. These findings do not support the hypothesis that the lower BNP levels seen in obesity are driven by enhanced BNP clearance mediated via NPR-C.
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BNP levels are consistently reported to be in the normal range or below normal in the majority of obese subjects.
“Moreover, BNP levels are consistently reported to be in the normal range or below normal in the majority of obese subjects (66).”
From Cardiac remodeling in obesity (2008) · cites this paper as [66]
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- Authors
- Das, S. R., Drazner, M. H., Dries, D. L., Vega, G. L., Stanek, H. G., Abdullah, S. M., Canham, R. M., Chung, A. K., Leonard, D., Wians, F. H., & de Lemos, J. A.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- From the Donald W. Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, Tex.
- Venue
- Circulation
- Published
- 2005-10-04
- Volume
- 112
- Issue
- 14
- Pages
- 2163-2168
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2162422100
- Cited by
- 433
- References
- 19
- Citations by year
- 2026: 13 · 2025: 23 · 2024: 8 · 2023: 23 · 2022: 15 · 2021: 14 · 2020: 18 · 2019: 15 · 2018: 16 · 2017: 19 · 2016: 28 · 2015: 17 · 2014: 25 · 2013: 16 · 2012: 20
- FWCI
- 16.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Center for Research Resources (M01RR000633)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- body mass index, obesity, body composition, natriuretic peptides, brain natriuretic peptide, NT-proBNP, natriuretic peptide clearance receptor, adipose tissue, lean body mass, fat mass
- MeSH terms
- Adult, Aged, Body Composition, Body Weight, Female, Humans, Male, Middle Aged, Obesity, Peptide Fragments, Texas, Biomarkers, Absorptiometry, Photon, Natriuretic Peptide, Brain
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